1,346 research outputs found

    List Online Classification

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    We study multiclass online prediction where the learner can predict using a list of multiple labels (as opposed to just one label in the traditional setting). We characterize learnability in this model using the bb-ary Littlestone dimension. This dimension is a variation of the classical Littlestone dimension with the difference that binary mistake trees are replaced with (k+1)(k+1)-ary mistake trees, where kk is the number of labels in the list. In the agnostic setting, we explore different scenarios depending on whether the comparator class consists of single-labeled or multi-labeled functions and its tradeoff with the size of the lists the algorithm uses. We find that it is possible to achieve negative regret in some cases and provide a complete characterization of when this is possible. As part of our work, we adapt classical algorithms such as Littlestone's SOA and Rosenblatt's Perceptron to predict using lists of labels. We also establish combinatorial results for list-learnable classes, including an list online version of the Sauer-Shelah-Perles Lemma. We state our results within the framework of pattern classes -- a generalization of hypothesis classes which can represent adaptive hypotheses (i.e. functions with memory), and model data-dependent assumptions such as linear classification with margin

    GIS approach to estimation of the total phosphorous transfer in the Pilica River lowland catchment

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    In this paper, the Pilica River catchment (central Poland) is analyzed with a focus on understanding the total phosphorous transfer along the river system which also contains the large artificial SulejĂłw Reservoir. The paper presents a GIS method for estimating the total phosphorous (TP) load from proxy data representing sub-catchment land use and census data. The modelled load of TP is compared to the actual transfer of TP in the Pilica River system. The results shows that the metrics of connectivity between river system and dwelling areas as well as settlement density in the sub-catchments are useful predictors of the total phosphorous load. The presence of a large reservoir in the middle course of the river can disrupt nutrient transport along a river continuum by trapping and retaining suspended sediment and its associated TP load. Analysis of the indirect estimation of TP loads with the GIS analysis can be useful for identifying beneficial reservoir locations in a catchment. The study has shown that the SulejĂłw Reservoir has been located in a subcatchment with a largest load of the TP, and this feature helps determine the problem of reservoir eutrphication

    From pedagogical confrontations to pedagogical invitations: A self-study of teacher educators' work

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    For teacher educators, ethical dilemmas, tensions and 'pedagogical confrontations' (PCs) often arise in day-to-day teaching practice. Education research reveals that self-study researchers usually have a heightened awareness of their obligations to both identify and subsequently act on these dilemmas, tensions and confrontations (Berry, 2007; Bullough & Pinnegar, 2004; East, Fitzgerald & Heston, 2009; LaBoskey, 2004; Loughran, 2006; Pinnegar & Hamilton, 2009, 2015; Samaras, 2011 ). This self-study research focuses on the identification, categorization and analysis of 'pedagogical confrontations' (PCs) and asks what they mean for teacher educators. Through selfstudy and analysis of these 'pedagogical confrontations' we have come to understand more about the sophisticated and complex nature of teaching. Furthermore, we explore the way in which the use of PCs as a lens for researching practice, has subsequently led to new insights and led to an 'enactment in practice' (Loughran, 2006)

    General practitioners' views of clinically led commissioning: cross-sectional survey in England.

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    OBJECTIVES: Involving general practitioners (GPs) in the commissioning/purchasing of services has been an important element in English health policy for many years. The Health and Social Care Act 2012 handed responsibility for commissioning of the majority of care for local populations to GP-led Clinical Commissioning Groups (CCGs). In this paper, we explore GP attitudes to involvement in commissioning and future intentions for engagement. DESIGN AND SETTING: Survey of a random sample of GPs across England in 2015. METHOD: The Eighth National GP Worklife Survey was distributed to GPs in spring 2015. Responses were received from 2611 respondents (response rate = 46%). We compared responses across different GP characteristics and conducted two sample tests of proportions to identify statistically significant differences in responses across groups. We also used multivariate logistic regression to identify the characteristics associated with wanting a formal CCG role in the future. RESULTS: While GPs generally agree that they can add value to aspects of commissioning, only a minority feel that this is an important part of their role. Many current leaders intend to quit in the next 5 years, and there is limited appetite among those not currently in a formal role to take up such a role in the future. CCGs were set up as 'membership organisations' but only a minority of respondents reported feeling that they had 'ownership' of their local CCG and these were often GPs with formal CCG roles. However, respondents generally agree that the CCG has a legitimate role in influencing the work that they do. CONCLUSION: CCGs need to engage in active succession planning to find the next generation of GP leaders. GPs believe that CCGs have a legitimate role in influencing their work, suggesting that there may be scope for CCGs to involve GPs more fully in roles short of formal leadership

    Lysosome-Associated Membrane Protein-1 (LAMP-1) Is the Melanocyte Vesicular Membrane Glycoprotein Band II

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    Coated vesicles play a critical role in the process of melanogenesis. Antisera raised against a coated vesicle fraction from mouse melanoma cells recognize two major glycoprotein antigens, band I (47-55 kd) and band II (90-120 kd). We demonstrate that band II is lysosome-associated membrane protein 1 (LAMP-1) by the following criteria: 1) the molecular weight and abundance of LAMP-1 varies among tissues but is always identical to that of band II; 2) band II and LAMP-1 co-migrate in sucrose gradient sedimentation studies; 3) immunodepletion of cell extracts with antivesicle serum removes all LAMP-1; and 4) intact organelles immunoisolated with antivesicle serum contain band II and LAMP1. Our results further confirm the long-suspected relationship between melanosomes and the lysosomal lineage of organelles
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