Arquitecturas miniaturizadas y su contextualización en el arte contemporáneo

Los últimos años nos han dejado numerosos ejemplos de trabajos artísticos consistentes en modelos de edificios a escala reducida, un ejemplo más del prolífico diálogo entre arte y arquitectura. En este artículo se analiza lo específico de estos trabajos por su escala reducida y, a partir de varios ejemplos, se plantean cuatro tendencias presentes en el arte contemporáneo, sintomáticas de una emancipación de las formas e ideas de la modernidad: su carácter narrativo, el retorno de la figuración, el gusto por lo artesanal y una actitud posindividualista. Se describe cómo estas tendencias están también presentes, con algunas diferencias, en la arquitectura contemporánea, por lo que puede hablarse de rasgos comunes a ambas disciplinas y de una retroalimentación bidireccional. Desde el punto de vista del arquitecto, estas obras artísticas amplían el potencial expresivo de la maqueta arquitectónica y le permiten replantearse su papel, teniendo en cuenta consideraciones más allá del diseño formal, tales como la percepción emocional, la percepción simbólica, etc. In recent years we have seen numerous examples of artwork consisting of small–scale models of buildings, another example of the close relationship between art and architecture. This article analyses the specifics of these pieces of work through their reduced scale using several examples to do so, addressing four trends that are currently present in contemporary art, symptomatic of an emancipation away from forms and ideas of modernity: their narrative character, the return to figuration, a taste for craft and a post–individualist attitude. We describe how these trends are also present in contemporary architecture, albeit with some differences, therefore enabling us to talk about features that are common to both disciplines and two–way feedback. From the point of view of architects these pieces of artwork amplify the expressive potential of architectural modelling and permit redefining their role, taking into account considerations that go beyond formal design, such as emotion perception, symbolic perception, etc

Possible ring material around centaur (2060) Chiron

We propose that several short duration events observed in past stellar occultations by Chiron were produced by rings material. From a reanalysis of the stellar occultation data in the literature we determined two possible orientations of the pole of Chiron's rings, with ecliptic coordinates l=(352+/-10) deg, b=(37+/-10) deg or l=(144+/-10) deg, b=(24+/-10) deg . The mean radius of the rings is (324 +/- 10) km. One can use the rotational lightcurve amplitude of Chiron at different epochs to distinguish between the two solutions for the pole. Both imply lower lightcurve amplitude in 2013 than in 1988, when the rotational lightcurve was first determined. We derived Chiron's rotational lightcurve in 2013 from observations at the 1.23-m CAHA telescope and indeed its amplitude is smaller than in 1988. We also present a rotational lightcurve in 2000 from images taken at CASLEO 2.15-m telescope that is consistent with our predictions. Out of the two poles the l=(144+/-10) deg, b=(24+/-10) deg solution provides a better match to a compilation of rotational lightcurve amplitudes from the literature and those presented here. We also show that using this preferred pole, Chiron's long term brightness variations are compatible with a simple model that incorporates the changing brightness of the rings as the tilt angle with respect to the Earth changes with time. Also, the variability of the water ice band in Chiron's spectra in the literature can be explained to a large degree by an icy ring system whose tilt angle changes with time and whose composition includes water ice, analogously to the case of Chariklo. We present several possible formation scenarios for the rings from qualitative points of view and speculate on the reasons why rings might be common in centaurs. We speculate on whether the known bimodal color distribution of centaurs could be due to presence of rings and lack of them

S194-P-FADD as a marker of aggressiveness and poor prognosis in human T-cell lymphoblastic lymphoma

T-cell lymphoblastic lymphoma is a haematological disease with an urgent need for reliable prognostic biomarkers that allow therapeutic stratification and dose adjustment. The scarcity of human samples is responsible for the delayed progress in the study and the clinical management of this disease, especially compared with T-cell acute lymphoblastic leukaemia, its leukemic counterpart. In the present work, we have determined by immunohistochemistry that S194-P-FADD protein is significantly reduced in a cohort of 22 samples from human T-cell lymphoblastic lymphoma. Notably, the extent of such reduction varies significantly among samples and has revealed determinant for the outcome of the tumour. We demonstrate that Fas-associated protein with death domain (FADD) phosphorylation status affects protein stability, subcellular localization and non-apoptotic functions, specifically cell proliferation. Phosphorylated FADD would be more stable and preferentially localized to the cell nucleus; there, it would favour cell proliferation. We show that patients with higher levels of S194-P-FADD exhibit more proliferative tumours and that they present worse clinical characteristics and a significant enrichment to an oncogenic signature. This supports that FADD phosphorylation may serve as a predictor for T-cell lymphoblastic lymphoma aggressiveness and clinical status. In summary, we propose FADD phosphorylation as a new biomarker with prognostic value in T-cell lymphoblastic lymphoma

SOCS2 (suppressor of cytokine signaling 2)

Review on SOCS2 (suppressor of cytokine signaling 2), with data on DNA, on the protein encoded, and where the gene is implicated

Acinetobacter Lwofii, an unusual cause of infectious pericarditis complicated with cardiac tamponade: a case report

Bacterial pericarditis can be considered a rare pathology, usually associated with cardiac procedures and, to a lesser extent, with immunosuppression and chronic diseases. The importance of its knowledge lies in the fact that mortality can reach up to 100% in untreated patients. Once diagnosed, pericardiocentesis and administration of intravenous antimicrobial therapy are mandatory for the prevention of its complications, which include cardiac tamponade and sepsis. Here we present an exceptional case of infectious pericarditis due to Acinetobacter Lwoffii in an older adult, which was complicated by pericardial effusion and cardiac tamponade