DESARROLLO E IMPLEMENTACIÓN DE UN SISTEMA PARA LA ADMINISTRACIÓN DE LA INFORMACIÓN DE UN BANCO DE TESIS

Desarrollo e implantación de un sistema de cómputo para la administración de la información del banco de tesis de egresados de los cuatro programas educativos de licenciatura y tres de Maestría; para apoyar al proceso administrativo que se realiza en la Subdirección de Integración de las Funciones Sustantivas (SIFS), de la UAI de la UAGro. Con esto se pretende; sistematizar el proceso de titulación, tener un libre acceso a las tesis, digitalizarlas; para su rápido acceso, una consulta precisa al momento de buscar temas duplicados, un registro de directores de tesis, una biblioteca virtual para la Unidad Académica, que permita generar reportes, estadísticas y gráficas de resultados

FAS system deregulation in T-cell lymphoblastic lymphoma

The acquisition of resistance towards FAS-mediated apoptosis may be required for tumor formation. Tumors from various histological origins exhibit FAS mutations, the most frequent being hematological malignancies. However, data regarding FAS mutations or FAS signaling alterations are still lacking in precursor T-cell lymphoblastic lymphomas (T-LBLs). The available data on acute lymphoblastic leukemia, of precursor origin as well, indicate a low frequency of FAS mutations but often report a serious reduction in FAS-mediated apoptosis as well as chemoresistance, thus suggesting the occurrence of mechanisms able to deregulate the FAS signaling pathway, different from FAS mutation. Our aim at this study was to determine whether FAS-mediated apoptotic signaling is compromised in human T-LBL samples and the mechanisms involved. This study on 26 T-LBL samples confirms that the FAS system is impaired to a wide extent in these tumors, with 57.7% of the cases presenting any alteration of the pathway. A variety of mechanisms seems to be involved in such alteration, in order of frequency the downregulation of FAS, the deregulation of other members of the pathway and the occurrence of mutations at FAS. Considering these results together, it seems plausible to think of a cumulative effect of several alterations in each T-LBL, which in turn may result in FAS/FASLG system deregulation. Since defective FAS signaling may render the T-LBL tumor cells resistant to apoptotic cell death, the correct prognosis, diagnosis and thus the success of anticancer therapy may require such an in-depth knowledge of the complete scenario of FAS-signaling alterations.S

HADES RV Programme with HARPS-N at TNG VI. GJ 3942 b behind dominant activity signals

Short- to mid-term magnetic phenomena on the stellar surface of M-type stars cannot only resemble the effects of planets in radial velocity data, but also may hide them. We analyze 145 spectroscopic HARPS-N observations of GJ 3942 taken over the past five years and additional photometry to disentangle stellar activity effects from genuine Doppler signals as a result of the orbital motion of the star around the common barycenter with its planet. To achieve this, we use the common methods of pre-whitening, and treat the correlated red noise by a first-order moving average term and by Gaussian-process regression following an MCMC analysis. We identify the rotational period of the star at 16.3 days and discover a new super-Earth, GJ 3942 b, with an orbital period of 6.9 days and a minimum mass of 7.1 Me. An additional signal in the periodogram of the residuals is present but we cannot claim it to be related to a second planet with sufficient significance at this point. If confirmed, such planet candidate would have a minimum mass of 6.3 Me and a period of 10.4 days, which might indicate a 3:2 mean-motion resonance with the inner planet

In vitro anti-canine distemper virus activity of fucoidan extracted from the brown alga Cladosiphon okamuranus

Canine distemper virus (CDV) is a morbillivirus related to measles virus that infects dogs and other carnivores. CDV has a significant global impact on animal health; however, there is no current antiviral treatment for CDV infection. In recent years, it has been demonstrated that sulfated polysaccharides exhibit antiviral properties both in vivo and in vitro, despite their low cytotoxicity to host cells. Fucoidan is a sulfated polysaccharide found in the cell wall matrix of brown algae. In this study, we evaluated in vitro anti-CDV activity of fucoidan, which was derived from Cladosiphon okamuranus. Fucoidan actively inhibited CDV replication in Vero cells at a 50% inhibitory concentration (IC50) of 0.1 lg/ml. The derived selectivity index (SI50) was[20,000. This polysaccharide likely inhibits viral infection by interference in the early steps and by inhibiting CDV-mediated cell fusion. Fucoidan may be useful in development of pharmacological strategies to treat and control CDV infection

The HADES RV Programme with HARPS-N@TNG II. Data treatment and simulations

The distribution of exoplanets around low-mass stars is still not well understood. Such stars, however, present an excellent opportunity of reaching down to the rocky and habitable planet domains. The number of current detections used for statistical purposes is still quite modest and different surveys, using both photometry and precise radial velocities, are searching for planets around M dwarfs. Our HARPS-N red dwarf exoplanet survey is aimed at the detection of new planets around a sample of 78 selected stars, together with the subsequent characterization of their activity properties. Here we investigate the survey performance and strategy. From 2700 observed spectra, we compare the radial velocity determinations of the HARPS-N DRS pipeline and the HARPS-TERRA code, we calculate the mean activity jitter level, we evaluate the planet detection expectations, and we address the general question of how to define the strategy of spectroscopic surveys in order to be most efficient in the detection of planets. We find that the HARPS-TERRA radial velocities show less scatter and we calculate a mean activity jitter of 2.3 m/s for our sample. For a general radial velocity survey with limited observing time, the number of observations per star is key for the detection efficiency. In the case of an early M-type target sample, we conclude that approximately 50 observations per star with exposure times of 900 s and precisions of about 1 m/s maximizes the number of planet detections

Association of HIV-1 Infection and Antiretroviral Therapy With Type 2 Diabetes in the Hispanic Population of the Rio Grande Valley, Texas, USA

The Rio Grande Valley (RGV) in South Texas has one of the highest prevalence of obesity and type 2 diabetes (T2D) in the United States (US). We report for the first time the T2D prevalence in persons with HIV (PWH) in the RGV and the interrelationship between T2D, cardiometabolic risk factors, HIV-related indices, and antiretroviral therapies (ART). The PWH in this study received medical care at Valley AIDS Council (VAC) clinic sites located in Harlingen and McAllen, Texas. Henceforth, this cohort will be referred to as Valley AIDS Council Cohort (VACC). Cross-sectional analyses were conducted using retrospective data obtained from 1,827 registries. It included demographic and anthropometric variables, cardiometabolic traits, and HIV-related virological and immunological indices. For descriptive statistics, we used mean values of the quantitative variables from unbalanced visits across 20 months. Robust regression methods were used to determine the associations. For comparisons, we used cardiometabolic trait data obtained from HIV-uninfected San Antonio Mexican American Family Studies (SAMAFS; N = 2,498), and the Mexican American population in the National Health and Nutrition Examination Survey (HHANES; N = 5,989). The prevalence of T2D in VACC was 51% compared to 27% in SAMAFS and 19% in HHANES, respectively. The PWH with T2D in VACC were younger (4.7 years) and had lower BMI (BMI 2.43 units less) when compared to SAMAFS individuals. In contrast, VACC individuals had increased blood pressure and dyslipidemia. The increased T2D prevalence in VACC was independent of BMI. Within the VACC, ART was associated with viral load and CD4+ T cell counts but not with metabolic dysfunction. Notably, we found that individuals with any INSTI combination had higher T2D risk: OR 2.08 (95%CI 1.67, 2.6; p \u3c 0.001). In summary, our results suggest that VACC individuals may develop T2D at younger ages independent of obesity. The high burden of T2D in these individuals necessitates rigorously designed longitudinal studies to draw potential causal inferences and develop better treatment regimens

Critical properties of the optical field localization in a three-dimensional percolating system: Theory and experiment

We systematically study the optical field localization in an active three-dimensional (3D) disordered percolating system with light nanoemitters incorporated in percolating clusters. An essential feature of such a hybrid medium is that the clusters are combined into a fractal radiation pattern, in which light is simultaneously emitted and scattered by the disordered structures. Theoretical considerations, based on systematic 3D simulations, reveal nontrivial dynamics in the form of propagation of localized field bunches in the percolating material. We obtain the length of the field localization and dynamical properties of such states as functions of the occupation probability of the disordered clusters. A transition between the dynamical states and narrow point-like fields pinned to the emitters is found. The theoretical analysis of the fractal field properties is followed by an experimental study of the light generation by nanoemitters incorporated in the percolating clusters. The experimental results corroborate theoretical predictions.Comment: 10 pages, 14 figures, to be published Chaos, Solitons & Fractal

Follow-up care over 12months of patients with prostate cancer in Spain A multicenter prospective cohort study

The therapeutic approach is crucial to prostate cancer prognosis. We describe treatments and outcomes for a Spanish cohort of patients with prostate cancer during the first 12 months after diagnosis and identify the factors that influenced the treatment they received. This multicenter prospective cohort study included patients with prostate cancer followed up for 12 months after diagnosis. Treatment was stratified by factors such as hospital, age group (<70 and ≥70 years), and D'Amico cancer risk classification. The outcomes were Eastern Cooperative Oncology Group (ECOG) performance status, adverse events (AEs), and mortality. The patient characteristics associated with the different treatment modalities were analyzed using multivariate logistic regression. We included 470 men from 7 Spanish tertiary hospitals (mean (standard deviation) age 67.8 (7.6) years), 373 (79.4%) of which received treatment (alone or in combination) as follows: surgery (n = 163; 34.7%); radiotherapy (RT) (n = 149; 31.7%); and hormone therapy (HT) (n = 142; 30.2%). The remaining patients (n = 97) were allocated to no treatment, that is, watchful waiting (14.0%) or active surveillance (5.7%). HT was the most frequently administered treatment during follow-up and RT plus HT was the most common therapeutic combination. Surgery was more frequent in patients aged <70, with lower histologic tumor grades, Gleason scores <7, and lower prostate-specific antigen levels; while RT was more frequent in patients aged ≥70 with histologic tumor grade 4, and higher ECOG scores. HT was more frequent in patients aged ≥70, with histologic tumor grades 3 to 4, Gleason score ≥8, ECOG ≥1, and higher prostate-specific antigen levels. The number of fully active patients (ECOG score 0) decreased significantly during follow-up, from 75.3% at diagnosis to 65.1% at 12 months (P <.001); 230 (48.9%) patients had at least 1 AE, and 12 (2.6%) patients died. Surgery or RT were the main curative options. A fifth of the patients received no treatment. Palliative HT was more frequently administered to older patients with higher tumor grades and higher Gleason scores. Close to half of the patients experienced an AE related to their treatment

Synthesis and characterization of iron oxide derivatized mutant cowpea mosaic virus hybrid nanoparticles

The enhanced local magnetic field strength was qualitatively analyzed by magnetic force microscopy (MFM), demonstrating a characteristic advantage for attaching derivatized magnetic iron oxide (IO) nanoparticles in an organic medium. the synthesis of 11 nm size IO nanoparticles was carried out under nitrogen atmosphere using standard schlenk technique. The biocompatible γ-Fe2O3-COOH nanoparticles were synthesized by thermal decomposition of Fe(CO)5 and surface modified. Atomic force microscopy (AFM) was used to characterize structurally the as-synthesized IO nanoparticles on a silicon substrate. The histogram of the size distribution of the IO nanoparticles determined from 68 individual measurements on single IO nanoparticles exhibited a mean size of δ11 nm. MFM showed that the textured regions observed on each hybrid are indicative of IO nanoclusters decorating the surface of single virions