Análisis comparativo de los modelos dinámicos de una turbina eólica de velocidad fija

En este artículo, se presenta un análisis comparativo del comportamiento dinámico de los modelos reducido y completo de una turbina eólica de velocidad fija. La herramienta informática utilizada en la realización de simulaciones es la plataforma Simulink/Matlab. El principal objetivo de este estudio es demostrar la influencia del flujo del estator y del acoplamiento mecánico en la respuesta transitoria de las turbinas eólicas de velocidad fija. Asimismo, se ha analizado la influencia en el comportamiento dinámico de otros parámetros característicos de la turbina eólica, como la potencia reactiva aportada por la batería de condensadores y la inercia del generador y de las palas del rotor eólico. // In this article, a comparative analysis of the dynamic behavior of reduced and full of a wind turbine fixed speed models are presented. The tool used in performing simulations is the Simulink/Matlab platform. The main objective of this study is to demonstrate the influence of the stator flux and the mechanical coupling of fixed speed wind turbine dynamic response. It has also analyzed the influence on the dynamic behavior of other characteristic parameters of the wind turbine, such as reactive power supplied by the capacitor bank and the inertia of the generator and wind rotor blades

Economic evaluation of several commercial compounded concentrates as supplements for growing crossbred heifers in confinement

To evaluate three different supplements in terms of body growth and economic benefit, 21 crossbred heifers of initial body weight (BW) 198.4 ± 49.5 kg (yearlings) and 280.4 ± 19.3 kg (older animals) were assigned to three balanced groups for use in an 84-d experiment, conducted in a tropical dry forest climatic zone. The individually penned animals received water and fresh gramineous forage cut daily ad libitum; also, a daily supplement of 2 kg of one of the three commercial concentrates: (T0, T1, and T2) of respective percentage composition (CP 19.2, 14.5, and 16.2; Ca 1.83, 3.59, and 1.81; P 1.75, 1.52, and 1.77). Wither height was measured fortnightly and BW, supplement intake (SI) and forage intake (FI) were determined weekly. Data were analyzed according to a completely randomized experimental design, with repeated observations, and Tukey HSD test. The economic evaluation was based on the criteria partial budget and gross margin, in which three animal selling prices (7.1, 40, and 70 Bs/kg BW) were tested. Daily BW gain (mean 0.52 kg) did not differ (P > 0.05) among treatments. SI was complete in all three treatments. FI also showed no treatment effects with respective means of 11.22, 11.28, and 11.26 kg/d as fed. The economic evaluation revealed that the best biological performance does not always coincide with the greatest economic benefit and that selection of the most favorable supplement depends on the animal selling price. When the latter was six times the cost of the supplement (kg/kg) supplementation was profitable

Naturally occurring deamidated triosephosphate isomerase is a promising target for cell-selective therapy in cancer

Human triosephosphate isomerase (HsTIM) is a central glycolytic enzyme and is overexpressed in cancer cells with accelerated glycolysis. Triple-negative breast cancer is highly dependent on glycolysis and is typically treated with a combination of surgery, radiation therapy, and chemotherapy. Deamidated HsTIM was recently proposed as a druggable target. Although thiol-reactive drugs affect cell growth in deamidated HsTIM-complemented cells, the role of this protein as a selective target has not been demonstrated. To delve into the usefulness of deamidated HsTIM as a selective target, we assessed its natural accumulation in breast cancer cells. We found that deamidated HsTIM accumulates in breast cancer cells but not in noncancerous cells. The cancer cells are selectively programmed to undergo cell death with thiol-reactive drugs that induced the production of methylglyoxal (MGO) and advanced glycation-end products (AGEs). In vivo, a thiol-reactive drug effectively inhibits the growth of xenograft tumors with an underlying mechanism involving deamidated HsTIM. Our findings demonstrate the usefulness of deamidated HsTIM as target to develop new therapeutic strategies for the treatment of cancers and other pathologies in which this post translationally modified protein accumulates

Inflammatory-related clinical and metabolic outcomes in Covid-19 patients

Background. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection elicits inflammatory manifestations that relate with a “cytokine storm.” Objective. The aim of this research was to assess the role of circulating interleukin 6 (IL-6) levels and other inflammatory markers in patients with coronavirus disease 2019 (COVID-19) on metabolic functions and accompanying clinical complications. Patients and Methods. A total of 165 patients diagnosed with COVID-19 pneumonia were examined for medical features and inflammatory markers such as blood IL-6, CRP, ferritin, LDH, neutrophil/lymphocyte index (NLI), D-Dimer, and Red Cell Distribution Width (RDW). Regression analyses concerning electronically collected medical data were adjusted by appropriate factors and confounding variables. Results. Plasma IL-6 determinations evidenced a consistent association with hospital stay days, Intensive Care Unit (ICU) admission, and mortality rates. Similar trends were found for other proinflammatory variables, where ferritin and NLI showed a remarkable value as surrogates. Hyperglycaemia and the Charlson Comorbidity Index Score were positively associated with the inflammatory response induced by the SARS-COV-2 infection. An unhealthy lifestyle such as smoking and alcoholic drinks consumption as well as excessive body adiposity influenced inflammatory-related outcomes in the screened patients. Conclusion. IL-6 together with other inflammatory biomarkers accompanied poor clinical and metabolic outcomes in COVID-19-infected patients. IL-6 may result in a suitable proxy to individually categorise patients in order to manage this infectious pandemic.CIBERon Instituto Carlos III in Madrid is credited for institutional support

Factibilidad para proponer sustitutos del vinipel en almacenamiento de mercancías.

El objetivo del presente trabajo es identificar y proponer alternativas que permitan sustituir el uso y consumo de vinipel en el embalaje de mercancía almacenada, utilizando productos reutilizables que permitan reducir el impacto ambiental. En este sentido, Se justifica por la necesidad que se presenta en los procesos de embalaje de mercancías almacenadas que tienen un alto consumo del plástico. El problema es que una vez que cumplió su función, se convierte en un peligro para el medio ambiente, por su bajo costo no es reutilizable y su degradación afecta a la naturaleza.The objective of this work is to identify and propose alternatives that allow substituting the use and consumption of vinyl in the packaging of stored merchandise, using reusable products that allow reducing the environmental impact. In this sense, it is justified by the need that arises in the packaging processes of stored goods that have a high consumption of plastic. The problem is that once it has fulfilled its function, it becomes a danger to the environment, due to its low cost it is not reusable, and its degradation affects natureEspecialista en Gerencia LogísticaEspecializació

La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia en los departamentos de Huila, Tolima, Quindío, Putumayo y Bogotá

El desarrollo de este trabajo permite evidenciar los casos dados en los escenarios de violencia del conflicto armado como se evidencia en la masacre del salado y muchas otras donde la población asido afectada por las FARC – ELN – CLAN DEL GOLFO – ORGANIZACIONES CRIMINALES AL MARGEN DE LA LEY, nos permite evidenciar las violencias psicosociales desde como la violencia afecto a personas desde violaciones a los DDHH-DIH-DICA donde hubieron violaciones, abusos sexuales, homicidio a personal protegida, el desplazamiento forzada en desarrollo de la masacre del 16 de febrero de 2000, donde asesinan a pobladores que eran oriundos de la comunidad, las comunidades que fueron desplazadas donde dicha población afectada, es evidente los cambios ideológicos, psicosociales desde las comunidades contadas desde el relato de víctimas, las comunidades en busca del desarrollo de una paz verdadera, una justicia social, una integridad de sus derechos como grupos colectivos, buscando la reparación capacidad de procesos de transformación de la población que vivió los deja menes del conflicto armado, que sus victimarios pidan un perdón verdadero y una verdad de lo sucedido ya que es una memoria histórica para que no haya una repetición de estos actos de violencia y estos actos que generan cambios en las estructuras sociales, culturales, históricas y de salud mental en la población afectada por los grupos alzados en Colombia.The development of this work allows to demonstrate the cases given in the scenarios of violence of the armed conflict as evidenced in the massacre of Salado and many others where the seized population affected by the FARC - ELN - CLAN DEL GOLFO - CRIMINAL ORGANIZATIONS ON THE MARGIN OF THE LAW, allows us to demonstrate psychosocial violence from how violence affected people since violations of Human Rights-DIH-DICA where there were rapes, sexual abuse, homicide of protected personnel, forced displacement in the development of the massacre of February 16, 2000 , where residents who were natives of the community are murdered, the communities that were displaced where said population was affected, the ideological, psychosocial changes are evident from the communities told from the victims' report, the communities in search of the development of true peace, social justice, integrity of their rights as collective groups, seeking reparation, capacity for transformation processes of the population that lived through the armed conflict, that their perpetrators ask for true forgiveness and a truth about what happened, since it is a historical memory so that there is no repetition of these acts of violence and these acts that generate changes in the social, cultural, historical and mental health structures in the population affected by the rebel groups in Colombia

La no pérdida neta de la biodiversidad como objetivo de la gestión ambiental estratégica del territorio

The Biodiversity Consultancy (2015), define la Jerarquía de la Mitigación como un marco lógico para gestionar riesgos e impactos potenciales vinculados a la biodiversidad y los servicios ecosistémicos. Se emplea al planificar e implementar proyectos de desarrollo ofreciendo un planteamiento lógico y efectivo destinado a conservar la biodiversidad y mantener servicios ecosistémicos. De esta manera se constituye en una herramienta que propende por la gestión sostenible del medio ambiente, ofreciendo un mecanismo para la toma de decisiones explícitas que equilibren las necesidades de conservación con las prioridades de desarrollo.Bogotá D. C

Sequential oral antibiotic in uncomplicated Staphylococcus aureus bacteraemia: a propensity-matched cohort analysis

Objectives: We aimed to analyse the efficacy and safety of oral sequential therapy (OST) in uncomplicated Staphylococcus aureus bacteraemia (SAB). Methods: Single-centre observational cohort at a tertiary hospital in Spain, including all patients with the first SAB episode from January 2015 to December 2020. We excluded patients with complicated SAB and those who died during the first week. Patients were classified into the OST group (patients who received oral therapy after initial intravenous antibiotic therapy [IVT]), and IVT group (patients who received exclusively IVT). We performed a propensity-score matching to balance baseline differences. The primary composite endpoint was 90-day mortality or microbiological failure. Secondary endpoints included 90-day SAB relapse. Results: Out of 407 SAB first episodes, 230 (56.5%) were included. Of these, 112 (n = 48.7%) received OST and 118 (51.3%) IVT exclusively. Transition to oral therapy was performed after 7 days (interquartile range, 4–11). The primary endpoint occurred in 10.7% (11/112) in OST vs. 30.5% (36/118) in IVT (p < 0.001). SAB relapses occurred in 3.6% (4/112) vs. 1.7% (2/118) (p 0.436). None of the deaths in OST were related to SAB or its complications. After propensity-score matching, the primary endpoint was not more frequent in the OST group (relative risk, 0.42; 95% CI, 0.22–0.79). Ninety-day relapses occurred similarly in both groups (relative risk, 1.35; 95% CI, 0.75–2.39). Discussion: After an initial intravenous antibiotic, patients with uncomplicated SAB can safely be switched to oral antibiotics without apparent adverse outcomes. This strategy could save costs and complications of prolonged hospital stays. Prospective randomized studies are needed

Situación actual de la población adolescente en Costa Rica. Estudio realizado en centros educativos de Guanacaste, Puntarenas y Limón

En 1991 y 2006, los profesionales de la Clínica de Adolescentes del Hospital Nacional de Niños realizaron dos investigaciones sobre población escolarizada de la provincia de San José, con el objetivo de identificar un perfil de adolescentes, dada la escasa información existente. Posteriormente, en el año 2013, se aplicó un instrumento similar a estudiantes de la Gran Área Metropolitana. En este artículo se presentan los resultados de la investigación desarrollada en 2015 con estudiantes de las provincias de Guanacaste, Puntarenas y Limón; se compararán los resultados previos para actualizar el estado de la situación integral de la población adolescente, explorando conocimientos y prácticas en sexualidad, violencia, consumo de drogas, nutrición, protección y riesgo. Se aplicó una encuesta a estudiantes de secundaria, hombres y mujeres, en edades comprendidas entre los 12 y los 18 años, en 31 colegios públicos y privados, para un total de 3074 estudiantes. Los resultados evidencian conocimientos deficientes en temas de desarrollo puberal y en información protectora en sexualidad; prácticas alimentarias de riesgo; incremento significativo en el consumo de drogas lícitas e ilícitas; exposición elevada a la pornografía; porcentaje bajo de inicio de actividad sexual coital; cifras altas de agresión, desesperanza e ideación suicida; elevado porcentaje de portación de armas, percepción positiva del papel del grupo de pares, la familia y el colegio. Asimismo, carencias en la formación integral y la adquisición de hábitos saludables, mediadas por la presión social que los promueve y debilidades significativas de sectores que deben brindar contención, apoyo y protección

Evaluation of climatic seasonal influence on the quality of water for human consumption in a San José (Costa Rica) supply system, 2017-2018

Objetivo: Analizar el estado y la influencia de la variabilidad climática en la calidad del agua de un sistema de abastecimiento para consumo humano en San José, Costa Rica, captado en cuatro microcuencas del cantón Vásquez de Coronado, en el periodo 2017-2018, para brindar recomendaciones al operador y promover la protección de la población abastecida Métodos: Estudio descriptivo de los parámetros de calidad básicos de agua para consumo humano (Escherichia coli, coliformes fecales, turbidez, conductividad, pH, color, temperatura y cloro residual). Los análisis se realizaron siguiendo el Standard Methods for the Examination of Water and Wastewater. Se delimitaron las zonas de captación utilizando sistemas de información geográfica. Se utilizó estadística descriptiva e inferencial para describir la calidad del agua y su variabilidad espacial y estacional. Resultados: La concentración de coliformes fecales en el agua superficial fue > 103 NMP/100 mL y la turbidez >5 UTN en el 76% de las muestras. En la red de distribución se encontraron concentraciones de clororesidual y turbidez (>5 UTN) por encima de los límites recomendados para agua de consumo humano . Se encontró diferencias significativas en todos los parámetros básicos de calidad de agua entre las distintas zonas de captación (p<0,05 en todos los casos), asícomo entre épocas climáticas por zona de captación. Conclusión: Estos resultados indican que se estáutilizando agua de calidad inadecuada para uso y consumo humano, por lo cual se recomienda unmonitoreo intensivo y sectorizado de las fuentes paralocalizar puntos de contaminación.Objective: Analyze the water quality and the influence of the climatic variability in supply system for the human consume in San José, Costa Rica, in four catchment areas in Vasquez of Coronado in the period 2017-2018 to give recommendations to the operator and promote the protection of the supplied population. Methods: Descriptive study of the basic parameters of the drinking water (Escherichia coli, fecal coliforms, turbidity, conductivity, pH, color, temperature, and residual chlorine). The analyses were done following Standard Methods for the examination of Water and Wastewater. The catchment areas were delimited using geographic information systems (GIS). Descriptive and inferential statistic was used to describe the water quality, spatial and seasonal variability. Results: The concentration of fecal coliforms in the catchment areas was >10 3 NMP/100 mL and the turbidity >5 UTN in 76% of the samples. In the distribution system were found concentrations of the residual chlorine and turbidity (>5 UTN) above according to recommended limits for drinking water in the country. The results showed significant differences in all of the basic parameters of the water quality between catchment areas (p<0, 05 in all cases) and between climatic periods for catchment areas. Conclusion: These results indicate that water of inadequate quality is being used for human use and consumption, for which reason intensive and sectorized source monitoring is recommended to locate contamination points.UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)UCR::Vicerrectoría de Docencia::Salud::Facultad de MicrobiologíaUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Tecnologías en Salu