11,487 research outputs found
Electronic structure of the ferromagnetic superconductor UCoGe from first principles
The superconductor UCoGe is analyzed with electronic structure calculations
using Linearized Augmented Plane Wave method based on Density Functional
Theory. Ferromagnetic and antiferromagnetic calculations with and without
correlations (via LDA+U) were done. In this compound the Fermi level is
situated in a region where the main contribution to DOS comes from the U-5f
orbital. The magnetic moment is mainly due to the Co-3d orbital with a small
contribution from the U-5f orbital. The possibility of fully non-collinear
magnetism in this compound seems to be ruled out. These results are compared
with the isostructural compound URhGe, in this case the magnetism comes mostly
from the U-5f orbital
The loss of anisotropy in MgB2 with Sc substitution and its relationship with the critical temperature
The electrical conductivity anisotropy of the sigma-bands is calculated for
the (Mg,Sc)B2 system using a virtual crystal model. Our results reveal that
anisotropy drops with relatively little scandium content (< 30%); this
behaviour coincides with the lowering of Tc and the reduction of the Kohn
anomaly. This anisotropy loss is also found in the Al and C doped systems. In
this work it is argued that the anisotropy, or 2D character, of the sigma-bands
is an important parameter for the understanding of the high Tc found in MgB2
Onset and Heterogeneity of Responsiveness to FSH in Mouse Preantral Follicles in Culture
The obligatory role of follicle-stimulating hormone (FSH) in normal development and function of
ovarian antral follicles is well recognized, but its function in preantral growth is less clear. The
specific objective of this study was to investigate the response, in culture, to FSH of mouse preantral
follicles of increasing size, focusing particularly on growth rate and gene expression. Preantral
follicles were mechanically isolated from ovaries of C57BL/6 mice, 12 to 16 days postpartum, and
single follicles cultured for up to 96 hours in medium alone (n = 511) or with recombinant human FSH
10 ng/mL (n = 546). Data were grouped according to initial follicle diameter in 6 strata ranging
from ,100 to .140 mm. Follicles of all sizes grew in the absence of FSH (P , 0.01, paired t test). All
follicles grew at a faster rate (P , 0.0001) in the presence of 10 ng/mL FSH but larger follicles showed
the greatest change in response to FSH. Even the smallest follicles expressed FSH receptor messenger
RNA (mRNA). FSH-induced growth was inhibited by KT5720, an inhibitor of protein kinase A (PKA),
implicating the PKA pathway in FSH-induced follicle growth. In response to FSH in vitro, FSH receptor
mRNA (measured by quantitative polymerase chain reaction) was reduced (P , 0.01), as was
Amh (P , 0.01), whereas expression of StAR (P , 0.0001) and the steroidogenic enzymes Cyp11a1
(P , 0.01) and Cyp19 (P , 0.0001) was increased. These results show heterogeneous responses to FSH
according to initial follicle size, smaller follicles being less FSH dependent than larger preantral
follicles. These findings strongly suggest that FSH has a physiological role in preantral follicle growth
and function
Mouse Models of Genomic Syndromes as Tools for Understanding the Basis of Complex Traits: An Example with the Smith-Magenis and the Potocki-Lupski Syndromes
Each human's genome is distinguished by extra and missing DNA that can be “benign” or powerfully impact everything from development to disease. In the case of genomic disorders DNA rearrangements, such as deletions or duplications, correlate with a clinical specific phenotype. The clinical presentations of genomic disorders were thought to result from altered gene copy number of physically linked dosage sensitive genes. Genomic disorders are frequent diseases (~1 per 1,000 births). Smith-Magenis syndrome (SMS) and Potocki-Lupski syndrome (PTLS) are genomic disorders, associated with a deletion and a duplication, of 3.7 Mb respectively, within chromosome 17 band p11.2. This region includes 23 genes. Both syndromes have complex and distinctive phenotypes including multiple congenital and neurobehavioral abnormalities. Human chromosome 17p11.2 is syntenic to the 32-34 cM region of murine chromosome 11. The number and order of the genes are highly conserved. In this review, we will exemplify how genomic disorders can be modeled in mice and the advantages that such models can give in the study of genomic disorders in particular and gene copy number variation (CNV) in general. The contributions of the SMS and PTLS animal models in several aspects ranging from more specific ones, as the definition of the clinical aspects of the human clinical spectrum, the identification of dosage sensitive genes related to the human syndromes, to the more general contributions as the definition of genetic locus impacting obesity and behavior and the elucidation of general mechanisms related to the pathogenesis of gene CNV are discussed
Effects of light and group size on the activity of wood frog tadpoles (Rana sylvatica) and their response to a shadow stimulus
Tadpoles are known to behaviorally respond to cues from aquatic predators. However, there are several additional factors that might affect tadpole behavior. We examined the influence of light conditions and group size on the activity of wood frog (Rana sylvatica) tadpoles and their response to a simulated non-aquatic predator (i.e., a shadow stimulus). Activity levels of undisturbed wood frog tadpoles were higher in larger groups (15 tadpoles) than in the smaller groups (5 tadpoles). Activity following exposure to a simulated aerial predator (i.e., a shadow stimulus) was also higher in the larger groups of tadpoles than in the smaller groups. Light conditions did not influence activity level in undisturbed tadpoles, but did affect the response to the shadow stimulus, with the greatest responses being observed under bright light conditions. Our results suggest that the factors influencing tadpole activity can include a diverse range of factors and cues, including lighting conditions and group size
Influence of carbon on intraband scattering in Mg(B1-xCx)2
We report data on the Hall coefficient (RH) of the carbon substituted
Mg(B1-xCx)2 single crystals with x in the range from 0 to 0.1. The temperature
dependences of RH obtained for the substituted crystals differ systematically
at low temperatures, but all of them converge to the value of 1.8 x 10^-10
m^3/C at room temperature. The RH(T) data together with results of the
thermoelectric power and electrical resistivity measurements are interpreted
within a quasi-classical transport approach, where the presence of four
different conducting sheets is considered. The main influence of the carbon
substitution on the transport properties in the normal state is associated with
enhanced scattering rates, rather than modified concentration of charge
carriers. Presumably the carbon substitution increases the electron-impurity
scattering mainly in the pi band.Comment: 16 pages, 3 figure
Self-organization of ultrasound in viscous fluids
We report the theoretical and experimental demonstration of pattern formation
in acoustics. The system is an acoustic resonator containing a viscous fluid.
When the system is driven by an external periodic force, the ultrasonic field
inside the cavity experiences different pattern-forming instabilities leading
to the emergence of periodic structures. The system is also shown to possess
bistable regimes, in which localized states of the ultrasonic field develop.
The thermal nonlinearity in the viscous fluid, together with the
far-from-equilibrium conditions, are is the responsible of the observed
effects
Dynamics of the circumstellar gas in the Herbig Ae stars BF Orionis, SV Cephei, WW Vulpeculae and XY Persei
We present high resolution (lambda / Delta_lambda = 49000) echelle spectra of
the intermediate mass, pre-main sequence stars BF Ori, SV Cep, WW Wul and XY
Per. The spectra cover the range 3800-5900 angstroms and monitor the stars on
time scales of months and days. All spectra show a large number of Balmer and
metallic lines with variable blueshifted and redshifted absorption features
superimposed to the photospheric stellar spectra. Synthetic Kurucz models are
used to estimate rotational velocities, effective temperatures and gravities of
the stars. The best photospheric models are subtracted from each observed
spectrum to determine the variable absorption features due to the circumstellar
gas; those features are characterized in terms of their velocity, v, dispersion
velocity, Delta v, and residual absorption, R_max. The absorption components
detected in each spectrum can be grouped by their similar radial velocities and
are interpreted as the signature of the dynamical evolution of gaseous clumps
with, in most cases, solar-like chemical composition. This infalling and
outflowing gas has similar properties to the circumstellar gas observed in UX
Ori, emphasizing the need for detailed theoretical models, probably in the
framework of the magnetospheric accretion scenario, to understand the complex
environment in Herbig Ae (HAe) stars. WW Vul is unusual because, in addition to
infalling and outflowing gas with properties similar to those observed in the
other stars, it shows also transient absorption features in metallic lines with
no obvious counterparts in the hydrogen lines. This could, in principle,
suggest the presence of CS gas clouds with enhanced metallicity around WW Vul.
The existence of such a metal-rich gas component, however, needs to be
confirmed by further observations and a more quantitative analysis.Comment: 21 pages, 13 figures. Accepted for publication by Astronomy &
Astrophysic
Functional Liftings of Vectorial Variational Problems with Laplacian Regularization
We propose a functional lifting-based convex relaxation of variational
problems with Laplacian-based second-order regularization. The approach rests
on ideas from the calibration method as well as from sublabel-accurate
continuous multilabeling approaches, and makes these approaches amenable for
variational problems with vectorial data and higher-order regularization, as is
common in image processing applications. We motivate the approach in the
function space setting and prove that, in the special case of absolute
Laplacian regularization, it encompasses the discretization-first
sublabel-accurate continuous multilabeling approach as a special case. We
present a mathematical connection between the lifted and original functional
and discuss possible interpretations of minimizers in the lifted function
space. Finally, we exemplarily apply the proposed approach to 2D image
registration problems.Comment: 12 pages, 3 figures; accepted at the conference "Scale Space and
Variational Methods" in Hofgeismar, Germany 201
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