26 research outputs found
ACER: developing Adaptive Capacity to Extreme events in the Rhine basin
Het algemene doel van het ACER project is om de gevolgen van klimaatverandering en adaptatie strategieën te onderzoeken voor het Rijnstroomgebied, zowel grensoverschrijdend in Duitsland en Frankrijk als voor het regionale waterbeheer in Nederland. ACER gebruikt een scenario analyse om effecten en oplossing te analyseren en vergelijken, onder de veronderstelling van verschillende klimaatverandering en sociaal-economische scenario’s voor 2050. Aan de basis van deze scenario aanpak staat een internationale groep van belanghebbenden en waterbeheerders uit verschillende bestuurslagen in het Rijnstroomgebied. Het is de vraag of de maatregelen die momenteel stroomopwaarts in Duitsland worden uitgevoerd positieve of negatieve effecten op de piekavoeren benedenstrooms hebbe
Comprehensive Biomarker Testing of Glycemia, Insulin Resistance, and Beta Cell Function Has Greater Sensitivity to Detect Diabetes Risk Than Fasting Glucose and HbA1c and Is Associated with Improved Glycemic Control in Clinical Practice
Reflections on the Future of Pharmaceutical Public-Private Partnerships: From Input to Impact
ACER: developing Adaptive Capacity to Extreme events in the Rhine basin
Het algemene doel van het ACER project is om de gevolgen van klimaatverandering en adaptatie strategieën te onderzoeken voor het Rijnstroomgebied, zowel grensoverschrijdend in Duitsland en Frankrijk als voor het regionale waterbeheer in Nederland. ACER gebruikt een scenario analyse om effecten en oplossing te analyseren en vergelijken, onder de veronderstelling van verschillende klimaatverandering en sociaal-economische scenario’s voor 2050. Aan de basis van deze scenario aanpak staat een internationale groep van belanghebbenden en waterbeheerders uit verschillende bestuurslagen in het Rijnstroomgebied. Het is de vraag of de maatregelen die momenteel stroomopwaarts in Duitsland worden uitgevoerd positieve of negatieve effecten op de piekavoeren benedenstrooms hebbe
ACER: Developing Adaptive Capacity to Extreme events in the Rhine basin
Water managers in the Rhine basin are increasingly confronted with information on the impact of climate change and climate variability on the discharge regime of their river system. The river Rhine has a long history of flooding events that caused casualties and severe damage. The question remains whether measures that are currently implemented upstream in Germany have either positive or negative effects on peak water levels downstream. Adaptation can significantly reduce impacts of climate change and is seen as an important part of societal response to global climate change. Planned adaptation implies decisions and measures within society that help to anticipate to climate related risks. The overall aim of ACER is to investigate the impact of climate change and to explore adaptation strategies for the Rhine basin under climate change, for both basin wide as well as regional water managers. The ACER project follows a so-called scenario analysis whereby solution trajectories are analyzed and compared, under the assumption of various long-term climate change and socio-economic scenarios. At the core of the ACER scenario approach are a group of stakeholders representing water managers at different levels in the Rhine basin. The results can be grouped in two themes: 1) Modeling processes - a trade-off. Instead of creating an overall new "Rhine model" for this project, we realized there is a trade-off between model complexity and the ability to run long time series and/or large ensembles of climate change scenarios. Considering model performance, focus and scale of the problem, a unique model set-up had to be optimized for each project objective. We coupled two complex models to simulate and investigate land surface - atmosphere feedback mechanisms. However, to simulate the combined effect of climate change and flood management measures, another model was developed that can be forced with output from a rainfall generator (10.000 year series of meteorological daily data). This model set-up aims to capture only the most relevant processes when assessing the effects on low-probability flood events, in a so-called "process-based" approach. 2) Effects of climate change and adaptation strategies. We project that climate change may increase flood probabilities with a factor 2.5 to 4.7 in 2050, which may strongly influence the expected annual losses due to flooding. The currently implemented and proposed measures in the Action Plan on Floods by the International Commission for the Protection of the Rhine (IKSR), as well as several additional measures we evaluated may be inadequate to cope with the increased flood probabilities. At the regional scale of a Dutch Water Board, the effects of climate change on polder hydrology is more intense than expected, caused by the dependence on both local climate conditions and water levels of the Rhine and Meuse rivers, which are mutually reinforcing
STochastic Optical Reconstruction Microscopy (STORM) reveals the nanoscale organization of pathological aggregates in human brain
Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes
CREB-regulated transcription coactivator 3 (CRTC3) polymorphism associated with type 2 diabetes and hyperlipidemia in the Taiwanese population
Neural Correlates Related to Anxiety in Attentional Inhibition Control: an ERP Study
We investigated the effect of anxiety on attentional inhibitory control using event-related
potentials (ERPs) and measuring the response time. Nineteen participants performed a multisource interference task; three-digit numbers and emotional faces were used as visual stimuli.
The P100 and P300 ERP-components and response time values were used to evaluate whether
ERP parameters and behavioral responses are associated with increased anxiety. Higher
anxiety was associated with a longer latency and reduced amplitude of the P300 component
at F3, whereas higher anxiety was associated with a shorter latency and higher amplitude of
P300 at F4. The longer P300 latency at F3 was especially related to the response time to the
target number with negative-expression faces as distracters.Ми досліджували вплив рівня тривожності на гальмівний
контроль уваги з використанням реєстрації пов’язаних із
подією потенціалів (ППП) та вимірювання часу реакції.
19 тестованих виконували мультистимульний тест з інтерференцією; як візуальні стимули застосовували зображення тризначних чисел та облич з емоціональними виразами.
Параметри Р100 та Р300 компонентів ППП та час реакції
брали до уваги для того, щоб визначити можливість асоційованості параметрів ППП та поведінкових відповідей з рівнем тривожності. Підвищена тривожність була асоційована
з довшими латентними періодами та зниженою амплітудою
компонента Р300 у відведенні F3, тоді як такий рівень тривожності асоціювався з меншими величинами латентного
періоду цієї ж самої хвилі та її вищою амплітудою у відведенні F4. Більший латентний період Р300 у відведенні F3
особливо чітко корелював із часом відповіді на цільове число на тлі облич із негативними виразами як відволікаючих
факторів