Finite-size critical scaling in Ising spin glasses in the mean-field regime

We study in Ising spin glasses the finite-size effects near the spin-glass transition in zero field and at the de Almeida-Thouless transition in a field by Monte Carlo methods and by analytical approximations. In zero field, the finite-size scaling function associated with the spin-glass susceptibility of the Sherrington-Kirkpatrick mean-field spin-glass model is of the same form as that of one-dimensional spin-glass models with power-law long-range interactions in the regime where they can be a proxy for the Edwards-Anderson short-range spin-glass model above the upper critical dimension. We also calculate a simple analytical approximation for the spin-glass susceptibility crossover function. The behavior of the spin-glass susceptibility near the de Almeida-Thouless transition line has also been studied, but here we have only been able to obtain analytically its behavior in the asymptotic limit above and below the transition. We have also simulated the one-dimensional system in a field in the non-mean-field regime to illustrate that when the Imry-Ma droplet length scale exceeds the system size one can then be erroneously lead to conclude that there is a de Almeida-Thouless transition even though it is absent.Comment: 10 pages, 7 figure

Using Modeling and Simulation to Examine the Benefits of a Network Tasking Order

The Global Information Grid (GIG) is the military’s computer and communications network which supports the myriad of military missions. Military missions are highly planned, passing through many hands in the strategy-to-task methodology to ensure completeness, accuracy, coordination, cohesion, and appropriateness. A benefit of this planning is the possibility to collect knowledge of future conditions that could be of use to network designers whose goals include optimizing and protecting the GIG. This advanced knowledge includes which networked military equipment will be involved, what their capabilities are, where they will be, when they will be there, and particulars on the required data flows. A Network Tasking Order process is proposed as a means of collecting this information, analyzing the information to generate network taskings, and disseminating those taskings. Tactical integration of assets in mobile networks is introduced as another planning variable in the battlefield; not unlike logistical considerations such as fuel, ammunition, water, and so on used currently in operation planning. Modeling and simulation is used to support the proposed benefits

Development and Validation of a State-Based Measure of Emotion Dysregulation: The State Difficulties in Emotion Regulation Scale (S-DERS)

Existing measures of emotion dysregulation typically assess dispositional tendencies and are therefore not well suited for study designs that require repeated assessments over brief intervals. The aim of this study was to develop and validate a state-based multidimensional measure of emotion dysregulation. Psychometric properties of the State Difficulties in Emotion Regulation Scale (S-DERS) were examined in a large representative community sample of young adult women drawn from four sites (N = 484). Exploratory factor analysis suggested a four-factor solution, with results supporting the internal consistency, construct validity, and predictive validity of the total scale and the four subscales: Nonacceptance (i.e., nonacceptance of current emotions), Modulate (i.e., difficulties modulating emotional and behavioral responses in the moment), Awareness (i.e., limited awareness of current emotions), and Clarity (i.e., limited clarity about current emotions). S-DERS scores were significantly associated with trait-based measures of emotion dysregulation, affect intensity/reactivity, experiential avoidance, and mindfulness, as well as measures of substance use problems. Moreover, significant associations were found between the S-DERS and state-based laboratory measures of emotional reactivity, even when controlling for the corresponding original DERS scales. Results provide preliminary support for the reliability and validity of the S-DERS as a state-based measure of emotion regulation difficulties

From Mission to Competition: The Experiences of 10 LDS Missionary Student-Athletes Returning to Competition in the National Collegiate Athletic Association Division I

The purpose of the current study was to explore the experiences of LDS missionary student-athletes returning to competition in the National Collegiate Athletic Association (NCAA) Division I (DI). Using Consensual Qualitative Research methods (CQR; Hill, 2012) including a semi-structured interview guide, 10 DI student-athletes/returned LDS missionaries were interviewed regarding their experience (i.e., mean age of 25 years; baseball, cross-country/track and field, football, and swimming). A research team with five members constructed four domains and 16 categories representing DI student-athlete/returned LDS missionary chronological identity changes during this experience: (a) the development of an LDS missionary identity; (b) challenges associated with returning to DI student-athlete identity; (c) benefits of mission identity on DI student-athlete identity; and (d) practical implications for sport psychology professionals and other support staff. Suggestions for future research are also given

Rescue of the MERTK phagocytic defect in a human iPSC disease model using translational read-through inducing drugs.

Inherited retinal dystrophies are an important cause of blindness, for which currently there are no effective treatments. In order to study this heterogeneous group of diseases, adequate disease models are required in order to better understand pathology and to test potential therapies. Induced pluripotent stem cells offer a new way to recapitulate patient specific diseases in vitro, providing an almost limitless amount of material to study. We used fibroblast-derived induced pluripotent stem cells to generate retinal pigment epithelium (RPE) from an individual suffering from retinitis pigmentosa associated with biallelic variants in MERTK. MERTK has an essential role in phagocytosis, one of the major functions of the RPE. The MERTK deficiency in this individual results from a nonsense variant and so the MERTK-RPE cells were subsequently treated with two translational readthrough inducing drugs (G418 & PTC124) to investigate potential restoration of expression of the affected gene and production of a full-length protein. The data show that PTC124 was able to reinstate phagocytosis of labeled photoreceptor outer segments at a reduced, but significant level. These findings represent a confirmation of the usefulness of iPSC derived disease specific models in investigating the pathogenesis and screening potential treatments for these rare blinding disorders

Shotgun metagenomic analysis of microbial communities from the Loxahatchee nature preserve in the Florida Everglades.

BackgroundCurrently, much is unknown about the taxonomic diversity and the mechanisms of methane metabolism in the Florida Everglades ecosystem. The Loxahatchee National Wildlife Refuge is a section of the Florida Everglades that is almost entirely unstudied in regard to taxonomic profiling. This short report analyzes the metagenome of soil samples from this Refuge to investigate the predominant taxa, as well as the abundance of genes involved in environmentally significant metabolic pathways related to methane production (nitrogen fixation and dissimilatory sulfite reduction).MethodsShotgun metagenomic sequencing using the Illumina platform was performed on 17 soil samples from four different sites within the Loxahatchee National Wildlife Refuge, and underwent quality control, assembly, and annotation. The soil from each sample was tested for water content and concentrations of organic carbon and nitrogen.ResultsThe three most common phyla of bacteria for every site were Actinobacteria, Acidobacteria, and Proteobacteria; however, there was variation in relative phylum composition. The most common phylum of Archaea was Euryarchaeota for all sites. Alpha and beta diversity analyses indicated significant congruity in taxonomic diversity in most samples from Sites 1, 3, and 4 and negligible congruity between Site 2 and the other sites. Shotgun metagenomic sequencing revealed the presence of biogeochemical biomarkers of particular interest (e.g., mrcA, nifH, and dsrB) within the samples. The normalized abundances of mcrA, nifH, and dsrB exhibited a positive correlation with nitrogen concentration and water content, and a negative correlation with organic carbon concentration.ConclusionThis Everglades soil metagenomic study allowed examination of wetlands biological processes and showed expected correlations between measured organic constituents and prokaryotic gene frequency. Additionally, the taxonomic profile generated gives a basis for the diversity of prokaryotic microbial life throughout the Everglades

Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling.

AIMS: Patients with conditions that are associated with insulin resistance such as obesity, type 2 diabetes mellitus, and polycystic ovary syndrome have an increased risk of thrombosis and a concurrent hyperactive platelet phenotype. Our aim was to determine whether insulin resistance of megakaryocytes/platelets promotes platelet hyperactivation. METHODS AND RESULTS: We generated a conditional mouse model where the insulin receptor (IR) was specifically knocked out in megakaryocytes/platelets and performed ex vivo platelet activation studies in wild-type (WT) and IR-deficient platelets by measuring aggregation, integrin αIIbβ3 activation, and dense and α-granule secretion. Deletion of IR resulted in an increase in platelet count and volume, and blocked the action of insulin on platelet signalling and function. Platelet aggregation, granule secretion, and integrin αIIbβ3 activation in response to the glycoprotein VI (GPVI) agonist collagen-related peptide (CRP) were significantly reduced in platelets lacking IR. This was accompanied by a reduction in the phosphorylation of effectors downstream of GPVI. Interestingly, loss of IR also resulted in a reduction in insulin-like growth factor-1 (IGF-1)- and insulin-like growth factor-2 (IGF-2)-mediated phosphorylation of IRS-1, Akt, and GSK3β and priming of CRP-mediated platelet activation. Pharmacological inhibition of IR and the IGF-1 receptor in WT platelets recapitulated the platelet phenotype of IR-deficient platelets. CONCLUSIONS: Deletion of IR (i) increases platelet count and volume, (ii) does not cause platelet hyperactivity, and (iii) reduces GPVI-mediated platelet function and platelet priming by IGF-1 and IGF-2

Bose-Fermi duality and entanglement entropies

Entanglement (Renyi) entropies of spatial regions are a useful tool for characterizing the ground states of quantum field theories. In this paper we investigate the extent to which these are universal quantities for a given theory, and to which they distinguish different theories, by comparing the entanglement spectra of the massless Dirac fermion and the compact free boson in two dimensions. We show that the calculation of Renyi entropies via the replica trick for any orbifold theory includes a sum over orbifold twists on all cycles. In a modular-invariant theory of fermions, this amounts to a sum over spin structures. The result is that the Renyi entropies respect the standard Bose-Fermi duality. Next, we investigate the entanglement spectrum for the Dirac fermion without a sum over spin structures, and for the compact boson at the self-dual radius. These are not equivalent theories; nonetheless, we find that (1) their second Renyi entropies agree for any number of intervals, (2) their full entanglement spectra agree for two intervals, and (3) the spectrum generically disagrees otherwise. These results follow from the equality of the partition functions of the two theories on any Riemann surface with imaginary period matrix. We also exhibit a map between the operators of the theories that preserves scaling dimensions (but not spins), as well as OPEs and correlators of operators placed on the real line. All of these coincidences can be traced to the fact that the momentum lattice for the bosonized fermion is related to that of the self-dual boson by a 45 degree rotation that mixes left- and right-movers.Comment: 40 pages; v3: improvements to presentation, new section discussing entanglement negativit