Do Maternal Investments in Human Capital Affect Childrens' Academic Achievement?

Children of educated mothers fare better on a variety of educational outcomes. However, little research has been done on the effects of human capital investments undertaken by mothers with children at home. Such investments have a theoretically ambiguous effect on child outcomes, since human capital investment reduces time spent with children but may have positive spillover effects on child investment. Using childand sibling-fixed effects models to deal with unobserved heterogeneity, we find that cumulative maternal schooling undertaken during a child's lifetime has significant positive effects on child outcomes, and that negative time allocation effects are minimal.

Measurement of vacuum pressure with a magneto-optical trap : a pressure-rise method

This research was supported by UK EPSRC grant GR/T08272/01, IOP Scotland and the Leverhulme Trust Research Project Grant RPG-2013-074.The lifetime of an atom trap is often limited by the presence of residual background gases in the vacuum chamber. This leads to the lifetime being inversely proportional to the pressure. Here we use this dependence to estimate the pressure and to obtain pressure rate-of-rise curves, which are commonly used in vacuum science to evaluate the performance of a system. We observe different rates of pressure increase in response to different levels of outgassing in our system. Therefore we suggest that this is a sensitive method which will find useful applications in cold atom systems, in particular where the inclusion of a standard vacuum gauge is impractical.Peer reviewe

Tax me, but spend wisely? Sources of public finance and government accountability

Existing evidence suggests that extra grant revenues lead to little improvements in public services in developing countries - but would governments spend tax revenues differently? This paper considers a program that invests in the tax capacity of Brazilian municipalities. Using variations in the timing of program uptake I find that it raises local tax revenues and that the increase in taxes is used to improve both the quantity and quality of municipal education infrastructure. In contrast increases in grants over which municipalities have the same discretion as over taxes have no impact on any measure of local public infrastructure. These results suggest that the way governments are financed matters: governments spend increases in tax revenues more towards expenditures that benefit citizens than increases in grant revenues

ORIE Nigeria: Quantitative Impact Evaluation Baseline Report

This report presents the findings from the baseline survey of the quantitative impact evaluation of the Working to Improve Nutrition in Northern Nigeria (WINNN) Programme interventions in Northern Nigeria. The household survey data collection was conducted in June 2013 and a final round of data collection is scheduled for June 2016. Both baseline and endline survey data will be used to estimate the collective impact of the WINNN Programme interventions that are focused at the level of the Local Government Area – Community Management of Acute Malnutrition (CMAM) and Infant and Young Child Feeding (IYCF).UK Ai

Interaction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis.

Inflammation is involved in the pathogenesis of many disorders. However, the underlying mechanisms are often unknown. Here, we test whether cystinosin, the protein involved in cystinosis, is a critical regulator of galectin-3, a member of the β-galactosidase binding protein family, during inflammation. Cystinosis is a lysosomal storage disorder and, despite ubiquitous expression of cystinosin, the kidney is the primary organ impacted by the disease. Cystinosin was found to enhance lysosomal localization and degradation of galectin-3. In Ctns-/- mice, a mouse model of cystinosis, galectin-3 is overexpressed in the kidney. The absence of galectin-3 in cystinotic mice ameliorates pathologic renal function and structure and decreases macrophage/monocyte infiltration in the kidney of the Ctns-/-Gal3-/- mice compared to Ctns-/- mice. These data strongly suggest that galectin-3 mediates inflammation involved in kidney disease progression in cystinosis. Furthermore, galectin-3 was found to interact with the pro-inflammatory cytokine Monocyte Chemoattractant Protein-1, which stimulates the recruitment of monocytes/macrophages, and proved to be significantly increased in the serum of Ctns-/- mice and also patients with cystinosis. Thus, our findings highlight a new role for cystinosin and galectin-3 interaction in inflammation and provide an additional mechanistic explanation for the kidney disease of cystinosis. This may lead to the identification of new drug targets to delay cystinosis progression

Generating demand for and use of evaluation evidence in government health ministries: Lessons from a pilot programme in Uganda and Zambia

Background The Demand-Driven Evaluations for Decisions (3DE) programme was piloted in Zambia and Uganda in 2012-2015. It aimed to answer evaluative questions raised by policymakers in Ministries of Health, rapidly and with limited resources. The aim of our evaluation was to assess whether the 3DE model was successful in supporting and increasing evidence-based policymaking, building capacity and changing behaviour of Ministry staff. Methods Using mixed methods, we compared the ex-ante theory of change with what had happened in practice, why and with what results (intended and unintended), including a qualitative assessment of 3DE's contribution. Data sources included a structured quality assessment of the five impact evaluations produced, 46 key informant interviews at national and international levels, structured extraction from 170 programme documents, a wider literature review of relevant topics, and a political economy analysis conducted in Zambia. Results We found that 3DE had a very limited contribution to changing evidence-based policymaking, capacity and behaviour in both countries as a result of having a number of aspirations not all compatible with one another. Co-developing evaluation questions was more time-consuming than anticipated, Ministry evidence needs did not fit neatly into questions suitable for impact evaluations and constricted timeframes for undertaking trials did not necessarily produce the most effective results and value for money. The evaluation recommended a focusing of objectives and a more strategic approach to strengthening evaluative demand and capacity. Conclusions Lessons emerge that are likely to apply in other low- and middle-income settings, such as the importance of supporting evaluative thinking and capacity within wider institutions, of understanding the political economy of evidence use and its uptake, and of allowing for some flexibility in terms of programme targets. Fixating on one type of evidence is unhelpful in the context of institutions like ministries of health, which require a wide range of evidence to plan and deliver programmes. In addition, having success tied to indicators, such as number of 'policy decisions made', provides potentially perverse incentives and neglects arguably more important aspects such as incremental programmatic adjustments and improved implementation.sch_iih15 [86]pub4897pu

Associations among socioeconomic status, perceived neighborhood control, perceived individual control, and self-reported health

Recent research has suggested that perceived control and a person's perceptions of their neighborhood environment may mediate the association between socioeconomic status (SES) and health. This cross-sectional study assessed whether perceptions of informal social control mediated the association between SES and self-reported health, and if these two constructs represented distinct mechanisms linking SES with self-reported health. The sample consisted of 869 adults residing in 300 census tracts in Montreal, Canada. Multilevel methods were used to assess the associations among self-reported health, SES, perceived control, and perceived informal social control adjusting for sociodemographic variables. Perceived control (mediation estimate=-0.06,p<.001) and perceived informal social control (mediation estimate=-0.05, p<.05) partially mediated the association between SES and self-reported health. Perceived control did not mediate the association of perceived informal social control with self-reported health. Perceived informal social control may act alongside but distinct from perceived control as a mechanism linking SES to self-reported health

Novel benzothiazole-based ureas as 17β-HSD10 inhibitors, a potential Alzheimer’s disease treatment

Funding: This work was supported by Alzheimer’s Society (specifically The Barcopel Foundation), Scottish Universities Life Science Alliance (SULSA), The Rosetrees Trust, WT-ISSF and RS MacDonald Charitable Trust, Ministry of Education, Youth and Sports of Czech Republic (project ESF no. CZ.02.1.01/0.0/0.0/18_069/0010054), and University of Hradec Kralove (Faculty of Science, no. VT2019-2021, SV2115-2018, and Postdoctoral job positions at UHK).It has long been established, that mitochondrial dysfunction in Alzheimer’s disease (AD) patients can trigger pathological changes in cell metabolism by altering metabolic enzymes such as the mitochondrial 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) also known as amyloid-binding alcohol dehydrogenase (ABAD). We and others have shown that frentizole and riluzole derivatives can inhibit 17β-HSD10 and that this inhibition is beneficial and holds therapeutic merit for the treatment of AD. Here we evaluate several novel series based on benzothiazolylurea scaffold evaluating key structural and activity relationships required for the inhibition of 17β-HSD10. Results show that the most promising of these compounds have markedly increased potency on our previously published inhibitors, with the most promising exhibiting advantageous features like low cytotoxicity and target engagement in living cells.Publisher PDFPeer reviewe