236 research outputs found
Real--time dynamics of a hot Yang-Mills theory: a numerical analysis
We discuss recent results obtained from simulations of high temperature,
classical, real time dynamics of SU(2) Yang-Mills theory at temperatures of the
order of the electroweak scale. Measurements of gauge covariant and gauge
invariant autocorrelations of the fields indicate that the ASY-Bodecker
scenario is irrelevant at these temperatures.Comment: 3 pages, 3 figures, Lattice2001(hitemp
An intermittent hypercaloric diet alters gut microbiota, prefrontal cortical gene expression and social behaviours in rats.
Objectives: Excessive consumption of high fat and high sugar (HFHS) diets alters reward processing, behaviour, and changes gut microbiota profiles. Previous studies in gnotobiotic mice also provide evidence that these gut microorganisms may influence social behaviour. To further investigate these interactions, we examined the impact of the intermittent access to a HFHS diet on social behaviour, gene expression and microbiota composition in adolescent rats.
Methods: Male rats were permitted intermittent daily access (2 h / day) to a palatable HFHS chow diet for 28 days across adolescence. Social interaction, social memory and novel object recognition were assessed during this period. Following testing, RT-PCR was conducted on hippocampal and prefrontal cortex (PFC) samples. 16S ribosomal RNA amplicon sequencing was used for identification and relative quantification of bacterial taxa in faecal samples.
Results: We observed reduced social interaction behaviours, impaired social memory and novel object recognition in HFHS diet rats compared to chow controls. RT-PCR revealed reduced levels of monoamine oxidase A (Maoa), catechol-O-methyltransferase (Comt) and brain derived neurotrophic factor (Bdnf) mRNA in the PFC of HFHS diet rats. Faecal microbiota analysis demonstrated that the relative abundance of a number of specific bacterial taxa differed significantly between the two diet groups, in particular, Lachnospiraceae and Ruminoccoceae bacteria.
Discussion: Intermittent HFHS diet consumption evoked physiological changes to the brain, particularly expression of mRNA associated with reward and neuroplasticity, and gut microbiome. These changes may underpin the observed alterations to social behaviours
An intermittent hypercaloric diet alters gut microbiota, prefrontal cortical gene expression and social behaviours in rats
Objectives: Excessive consumption of high fat and high sugar (HFHS) diets alters reward processing, behaviour, and changes gut microbiota profiles. Previous studies in gnotobiotic mice also provide evidence that these gut microorganisms may influence social behaviour. To further investigate these interactions, we examined the impact of the intermittent access to a HFHS diet on social behaviour, gene expression and microbiota composition in adolescent rats. Methods: Male rats were permitted intermittent daily access (2 h / day) to a palatable HFHS chow diet for 28 days across adolescence. Social interaction, social memory and novel object recognition were assessed during this period. Following testing, RT-PCR was conducted on hippocampal and prefrontal cortex (PFC) samples. 16S ribosomal RNA amplicon sequencing was used for identification and relative quantification of bacterial taxa in faecal samples. Results: We observed reduced social interaction behaviours, impaired social memory and novel object recognition in HFHS diet rats compared to chow controls. RT-PCR revealed reduced levels of monoamine oxidase A (Maoa), catechol-O-methyltransferase (Comt) and brain derived neurotrophic factor (Bdnf) mRNA in the PFC of HFHS diet rats. Faecal microbiota analysis demonstrated that the relative abundance of a number of specific bacterial taxa differed significantly between the two diet groups, in particular, Lachnospiraceae and Ruminoccoceae bacteria. Discussion: Intermittent HFHS diet consumption evoked physiological changes to the brain, particularly expression of mRNA associated with reward and neuroplasticity, and gut microbiome. These changes may underpin the observed alterations to social behaviours
First-line PARP inhibitors in ovarian cancer: summary of an ESMO Open - Cancer Horizons round-table discussion
Poly(ADP-ribose) polymerase (PARP) inhibitor maintenance
therapy is the latest breakthrough in the management of
newly diagnosed advanced ovarian cancer. The results
of the SOLO-1 trial in 2018 led to European Medicines
Agency and Food and Drug Administration approval of
olaparib as first-line maintenance therapy in patients with
BRCA1/2 mutation, establishing a new standard of care.
Subsequently, the results of three phase III trials (PRIMA,
PAOLA-1, VELIA) evaluating the use of first-line PARP
inhibitors beyond patients with BRCA1/2 mutations and as
combination strategies were presented in 2019, leading to
the recent approval of maintenance niraparib irrespective
of biomarker status and olaparib in combination with
bevacizumab in homologous recombination deficiencypositive-associated advanced ovarian cancer. An ESMO
Open - Cancer Horizons round-table expert panel
discussed the four phase III trials of first-line PARP
inhibitor therapy and how they are changing the clinical
management of advanced ovarian cancer
Longitudinal Associations of Neighborhood Crime and Perceived Safety with Blood Pressure: The Multi-Ethnic Study of Atherosclerosis (MESA)
Background: High neighborhood crime and low perceptions of safety may influence blood pressure (BP) through chronic stress. Few studies have examined these associations using longitudinal data. Methods: We used longitudinal data from 528 participants of the Multi-Ethnic Study of Atherosclerosis (aged 45-84, nonhypertensive at baseline) who lived in Chicago, Illinois. We examined associations of changes in individual-level perceived safety, aggregated neighborhood-level perceived safety, and past-year rates of police-recorded crime in a 1, =, or = mile buffer per 1,000 population with changes in systolic and diastolic BPs using fixed-effects linear regression. BP was measured five times between 2000 and 2012 and was adjusted for antihypertensive medication use (+10 mm Hg added to systolic and +5 mm Hg added to diastolic BP for participants on medication). Models were adjusted for time-varying sociodemographic and healthrelated characteristics and neighborhood socioeconomic status. We assessed differences by sex. Results: A standard deviation increase in individual-level perceived safety was associated with a 1.54 mm Hg reduction in systolic BP overall (95% confidence interval [CI]: 0.25, 2.83), and with a 1.24 mm Hg reduction in diastolic BP among women only (95% CI: 0.37, 2.12) in adjusted models. Increased neighborhood-level safety was not associated with BP change. An increase in police-recorded crime was associated with a reduction in systolic and diastolic BPs among women only, but results were sensitive to neighborhood buffer size. Conclusions: Results suggest individual perception of neighborhood safety may be particularly salient for systolic BP reduction relative to more objective neighborhood exposures
The Solution Space of the Unitary Matrix Model String Equation and the Sato Grassmannian
The space of all solutions to the string equation of the symmetric unitary
one-matrix model is determined. It is shown that the string equation is
equivalent to simple conditions on points and in the big cell \Gr
of the Sato Grassmannian . This is a consequence of a well-defined
continuum limit in which the string equation has the simple form \lb \cp
,\cq_- \rb =\hbox{\rm 1}, with \cp and \cq_- matrices of
differential operators. These conditions on and yield a simple
system of first order differential equations whose analysis determines the
space of all solutions to the string equation. This geometric formulation leads
directly to the Virasoro constraints \L_n\,(n\geq 0), where \L_n annihilate
the two modified-KdV \t-functions whose product gives the partition function
of the Unitary Matrix Model.Comment: 21 page
Polyakov Lines in Yang-Mills Matrix Models
We study the Polyakov line in Yang-Mills matrix models, which include the
IKKT model of IIB string theory. For the gauge group SU(2) we give the exact
formulae in the form of integral representations which are convenient for
finding the asymptotic behaviour. For the SU(N) bosonic models we prove upper
bounds which decay as a power law at large momentum p. We argue that these
capture the full asymptotic behaviour. We also indicate how to extend the
results to some correlation functions of Polyakov lines.Comment: 19 pages, v2 typos corrected, v3 ref adde
A new measurement of direct CP violation in two pion decays of the neutral kaon
The NA48 experiment at CERN has performed a new measurement of direct CP
violation, based on data taken in 1997 by simultaneously collecting K_L and K_S
decays into pi0pi0 and pi+pi-. The result for the CP violating parameter
Re(epsilon'/epsilon) is (18.5 +/- 4.5(stat)} +/- 5.8 (syst))x10^{-4}.Comment: 18 pages, 6 figure
Longitudinal HIV care outcomes by gender identity in the United States
Objective: Describe engagement in HIV care over time after initial engagement in HIV care, by gender identity.Design:Observational, clinical cohort study of people with HIV engaged in routine HIV care across the United States. Methods: We followed people with HIV who linked to and engaged in clinical care (attending ≥2 visits in 12 months) in cohorts in the North American Transgender Cohort Collaboration, 2000-2018. Within strata of gender identity, we estimated the 7-year (84-month) restricted mean time spent: lost-to-clinic (stratified by pre/postantiretroviral therapy (ART) initiation); in care prior to ART initiation; on ART but not virally suppressed; virally suppressed (≤200 copies/ml); or dead (pre/post-ART initiation). Results: Transgender women (N = 482/101 841) spent an average of 35.5 out of 84 months virally suppressed (this was 30.5 months for cisgender women and 34.4 months for cisgender men). After adjustment for age, race, ethnicity, history of injection drug use, cohort, and calendar year, transgender women were significantly less likely to die than cisgender people. Cisgender women spent more time in care not yet on ART, and less time on ART and virally suppressed, but were less likely to die compared with cisgender men. Other differences were not clinically meaningful. Conclusions: In this sample, transgender women and cisgender people spent similar amounts of time in care and virally suppressed. Additional efforts to improve retention in care and viral suppression are needed for all people with HIV, regardless of gender identity
Safety and Efficacy of Nivolumab Monotherapy in Recurrent or Metastatic Cervical, Vaginal, or Vulvar Carcinoma: Results From the Phase I/II CheckMate 358 Trial
Purpose: Nivolumab was assessed in patients with virus-associated tumors in the phase I/II CheckMate 358 trial (ClinicalTrials.gov identifier: NCT02488759). We report on patients with recurrent/metastatic cervical, vaginal, or vulvar cancers.
Patients and methods: Patients received nivolumab 240 mg every 2 weeks. Although patients with unknown human papillomavirus status were enrolled, patients known to have human papillomavirus-negative tumors were ineligible. The primary end point was objective response rate. Duration of response (DOR), progression-free survival, and overall survival were secondary end points. Safety and patient-reported outcomes were exploratory end points.
Results: Twenty-four patients (cervical, n = 19; vaginal/vulvar, n = 5) were enrolled. Most patients had received prior systemic therapy for metastatic disease (cervical, 78.9%; vaginal/vulvar, 80.0%). Objective response rates were 26.3% (95% CI, 9.1 to 51.2) for cervical cancer and 20.0% (95% CI, 0.5 to 71.6) for vaginal/vulvar cancers. At a median follow-up of 19.2 months, median DOR was not reached (range, 23.3 to 29.5+ months; + indicates a censored observation) in the five responding patients in the cervical cohort; the DOR was 5.0 months in the single responding patient in the vaginal/vulvar cohort. Median overall survival was 21.9 months (95% CI, 15.1 months to not reached) among patients with cervical cancer. Any-grade treatment-related adverse events were reported in 12 of 19 patients (63.2%) in the cervical cohort and all five patients in the vaginal/vulvar cohort; there were no treatment-related deaths. In the cervical cohort, nivolumab treatment generally resulted in stabilization of patient-reported outcomes associated with health status and health-related quality of life.
Conclusion: The efficacy of nivolumab in patients with recurrent/metastatic cervical and vaginal or vulvar cancers is promising and warrants additional investigation. No new safety signals were identified with nivolumab treatment in this population
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