Signalétique et visibilité des collections: l'orientation des usagers de la Bibliothèque publique et universitaire de Neuchâtel

Ce travail part du constat que la signalétique actuelle à la Bibliothèque publique et universitaire de Neuchâtel n’est plus efficiente ni à jour, notamment en raison du manque de place chronique des collections en libre- accès. Une première partie est consacrée aux théories sur la signalétique en général, et à la mise en place d’une signalétique. Un chapitre est consacré aux nouvelles tendances dans ce domaine, dans les bibliothèques mais également dans d’autres branches. La troisième partie est consacrée à l’état des lieux de la signalétique actuelle de la BPU. Cette partie est illustrée par des photographies à la fin de ce travail. Enfin, le dernier chapitre développe les différentes solutions envisageables pour améliorer la signalétique, des solutions aisément applicables ou relevant d’une vision à plus long terme

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population