Pathways to mental well-being for graduates of mindfulness-based cognitive therapy (MBCT) and mindfulness-based stress reduction (MBSR): a mediation analysis of an RCT

Objective To explore mediated effects of Mindfulness-Based Cognitive Therapy-“Taking it Further” (MBCT-TiF) on mental well-being through changes in mindfulness, self-compassion, and decentering. Method A secondary analysis of an RCT using simple mediation, with 164 graduates of MBCT and mindfulness-based stress reduction (MBSR), was implemented whereby MBCT-TiF (vs ongoing mindfulness practice; OMP) was the independent variable; changes in mindfulness, self-compassion, and decentering during the intervention were the mediators; and mental well-being at post-intervention, whilst controlling for baseline, was the dependent variable. Secondary outcomes included psychological quality of life, depression, and anxiety. Results Compared to OMP, MBCT-TiF experienced significant improvements in mental well-being through changes in all three mediators (mindfulness: ab = 0.11 [0.03, 0.25]; decentering: ab = 0.16 [0.05, 0.33]; self-compassion: ab = 0.07 [0.01, 0.18]). A similar pattern was demonstrated for depression, but only mindfulness and decentering mediated effects on psychological quality of life and anxiety. Conclusion The findings provide preliminary support for all three mediators in driving change in mental well-being in a sample of MBCT/MBSR graduates. Future work must be theory-driven and powered to test all mediators in parallel and alongside other potential mediators (e.g., equanimity) to further understand independent contributions and interacting effects. Trial registration: ClinicalTrials.gov identifier: NCT05154266

Characteristic time in quasispecies evolution

Estudio del tiempo en que un fenotipo alcanza un estado estacionari

How to reduce the number of rating scale items without predictability loss?

Rating scales are used to elicit data about qualitative entities (e.g., research collaboration). This study presents an innovative method for reducing the number of rating scale items without the predictability loss. The "area under the receiver operator curve method" (AUC ROC) is used. The presented method has reduced the number of rating scale items (variables) to 28.57\% (from 21 to 6) making over 70\% of collected data unnecessary. Results have been verified by two methods of analysis: Graded Response Model (GRM) and Confirmatory Factor Analysis (CFA). GRM revealed that the new method differentiates observations of high and middle scores. CFA proved that the reliability of the rating scale has not deteriorated by the scale item reduction. Both statistical analysis evidenced usefulness of the AUC ROC reduction method.Comment: 14 pages, 5 figure

The finger flexors occlusion threshold in sport-climbers: an exploratory study on its indirect approximation

Blood flow partially determines specific climbing endurance (SCE) as it mediates oxygen bio-availability in the finger flexors. Blood flow is related to occlusion threshold (OT), which is defined as the contraction intensity at which intramuscular pressure exceeds perfusion blood pressure resulting in the cessation of local blood flow. The OT is represented as an inflection point on a force-time graph when isometric force is registered and applied through maximal and continuous tests. Endurance time (ET) to exhaustion is influenced by the relative isometric applied force and is different for each climber. The aim of this study was to explore whether an approximation of the finger flexors OT in sport climbers through records of ET to exhaustion at different isometric relative intensities was possible. We measured maximum finger hang ETs at 6 intensities ranging from 85% to 35% maximal force in 34 sport climbers of advanced and elite level. The values obtained were analysed by two different methods in an attempt to determine a change in the shape of the curve in the intensity-ET relationship graphs that approximated the OT for each climber. The results suggest that the finger flexors OT could be different among climbers, regardless of their strength and ability level. The presented methods do not accurately reflect the OT, but could indicate the intensity at which blood flow is restored in the active muscles. This is the first study to indirectly approximate the finger flexors OT in sport-climbers, a parameter that could be essential to assess SCE

A new performance threshold in sport climbing: A change in how climbing trainers work?

Objectives: Previous research has shown that the finger flexor's occlusion threshold (OT) could be different among sport climbers when expressed as a percentage of their maximum finger force (OT%), and that there is no association between the OT% and the climberś ability level. The aim of the present study was to evaluate the possible association between the relative finger force applied at the OT% (rff-OT%) and climbing ability level. Equipment and methods: WWe approximated the finger flexor's OT of 34 sport climbers by finger hang endurance test analyses at different intensities between 35% and 85% of their individual maximum finger force on a previously individually adapted edge depth, and we valued their rff-OT% as the relative force they could perform at that intensity. Results: We found a high correlation between the rff-OT% and climbing ability in elite climbers. These findings suggest that having an OT at the highest possible percentage is critical, in addition to having a high relative finger force, as this would enable climbers to express relative force at a wider range of intensities with favorable metabolic conditions

A Coupled Diffusion-Mechanical Lattice Model for the Degradation of Graphite Active Particles of Li-Ion Battery Anodes

The performance,durability of lithium-ion batteries (LIBs) are constrained by the degradation mechanisms that take place during charge,discharge cycles. Degradation of active particles (APs) of LIBs is a complex problem involving several physical phenomena (e.g.,diffusion,mechanical deformation,heat transfer,to cite a few). During lithium insertion,extraction cycles,volume changes in the AP result in high mechanical stresses and,consequently,mechanical damage that promotes capacity fade. In this work,we present a microscale 3D finite element model that takes into account the coupled effects between lithium diffusion,mechanical stress within the AP. Using the surface of an ellipsoid as the base for the geometrical construction,we are able to generate different shapes of APs,with both concave,convex surfaces. Porosity,other types of defects that may be present inside the AP are explicitly modeled,different volume fractions,shapes,orientations are also accounted for. In our approach,the material is discretized into a lattice of one-dimensional elements: we consider beam elements for the mechanical problem,while in the diffusive approach,the material is treated as an assembly of 'nanopipes' through which the flow of Li-ions takes place. The same lattice network is used for both simulations. We follow a classical lattice model approach to characterize the fracture behavior of a single AP of a LIB anode when subjected to charge/discharge cycles. The material of the APs analyzed in this work is graphite,which presents a brittle,disordered material structure,making it suitable for lattice modeling. The mechanical problem is solved,obtaining the crack patterns associated with specific charge,discharge strategies,potential initial defects. The simulation results correctly reproduce the experimental observations on mechanical stresses,the evolution of damage. This lattice model framework analyzing the degradation in the APs of LIBs (durability) can be used to provide more information regarding the microstructural evolution,morphological changes,mechanical degradation in APs,identify improvement strategies

Can an aerobic exercise programme improve the response of the growth hormone in fibromyalgia patients? a randomised controlled trial

Downgrade alterations in the growth hormone (GH) might be involved in the development of some of the fibromyalgia syndrome (FMS) symptoms. Our aim was to assess the effects of an aerobic exercise programme on the GH levels in patients with FMS. A randomised controlled trial was developed. Sixty-four Spanish women with FMS were randomly assigned to the experimental arm (n = 33) and treated with a 16-week group physical exercise programme based on low impact aerobic dance (three weekly sessions, one-hour each), or to the treatment-as-usual (TAU) control arm (n = 31). The primary outcome was the GH response to acute exercise. Secondary outcomes were GH basal, sensitivity to pain, body composition, aerobic capacity, and quality of life. The ANCOVA results showed a moderate effect of treatment improving the GH response to acute exercise. Other effects were substantial for aerobic capacity, quality of life, and body composition. Pre-intervention GH response to acute exercise was related to improvements in aerobic capacity and quality of life. An aerobic exercise programme may improve the response of the GH, aerobic capacity, body composition, and quality of life in women with FMS. The normalization of neuro-hormonal patterns involving the GH might be key for improving some FMS symptoms

Perceived Stress Latent Factors and the Burnout Subtypes: A Structural Model in Dental Students

Background: Students of health-professions suffer high levels of stress and burnout. the aim of the present study was to evaluate the relationship between perceived stress latent factors ('tenseness' and 'frustration') and the features ('overload', 'lack of development' and 'neglect') of the three burnout subtypes ('frenetic', 'under-challenged' and 'worn-out', respectively), in a sample of Spanish dental students.Methods: the study employed a cross-sectional design. A sample of Spanish dental students (n = 314) completed the 'Perceived Stress Questionnaire' and the 'Burnout Clinical Subtype Questionnaire Student Survey'. the associations among variables were observed by means of structural equation modelling using the unweighted least squares method from polychoric correlations.Results: Strong associations among perceived stress factors and the burnout characteristics were observed, although a distinct pattern of relations was observed for each burnout subtype. the 'overload' was moderately and positively associated with both 'tenseness' (0.45), and 'frustration' (0.38) dimensions of perceived stress; the 'lack of development' was positively associated with the 'frustration' dimension (0.72), but negatively associated with 'tenseness' (-0.69); the 'neglect' showed a weaker positive associated with 'frustration' (0.41), and a small negative association with 'tenseness' (-0.20). the model was a very good fit to the data (GFI = 0.96; RSMR = 0.07; AGFI = 0.96; NFI = 0.95; RFI = 0.95).Conclusions: the stress factors of 'frustration' and 'tenseness' seems to be related in a distinct way to the burnout subtypes in Spanish dental students. This finding suggests that intervention programs specifically tailored to these subtypes may be a promising future direction.Research Network on Preventative Activities and Health Promotion, Aragon Health Sciences Institute, Faculty of Health and Sports (University of Zaragoza)Faculty of Medicine and Dentistry (University of Santiago de Compostela)Fac Hlth & Sport Sci, Huesca, SpainUniversidade Federal de São Paulo UNIFESP, Dept Prevent Med, São Paulo, BrazilUniv Bristol, Sch Social & Community Med, Bristol, Avon, EnglandUniv New S Wales, Ctr Res Excellence Mental Hlth & Sustance Use, Sidney, BC, CanadaUniv Balearic Isl, Inst Univ Invest Ciencies Salut IUNICS, Mallorca, SpainUniv Zaragoza, Miguel Servet Univ Hosp, Zaragoza, SpainPrimary Care Prevent & Hlth Promot Res Network Re, Zaragoza, SpainUniversidade Federal de São Paulo UNIFESP, Dept Prevent Med, São Paulo, BrazilResearch Network on Preventative Activities and Health Promotion, Aragon Health Sciences Institute, Faculty of Health and Sports (University of Zaragoza): RD06/0018/0017Web of Scienc

Burnout subtypes and absence of self-compassion in primary healthcare professionals: A cross-sectional study

Background: Primary healthcare professionals report high levels of distress and burnout. A new model of burnout has been developed to differentiate three clinical subtypes: ‘frenetic’, ‘underchallenged’ and ‘worn-out’. The aim of this study was to confirm the validity and reliability of the burnout subtype model in Spanish primary healthcare professionals, and to assess the explanatory power of the self-compassion construct as a possible protective factor.Method: The study employed a cross-sectional design. A sample of n = 440 Spanish primary healthcare professionals (214 general practitioners, 184 nurses, 42 medical residents) completed the Burnout Clinical Subtype Questionnaire (BCSQ-36), the Maslach Burnout Inventory General Survey (MBI-GS), the Self-Compassion Scale (SCS), the Utrecht Work Engagement Scale (UWES) and the Positive and Negative Affect Schedule (PANAS). The factor structure of the BCSQ-36 was estimated using confirmatory factor analysis (CFA) by the unweighted least squares method from polychoric correlations. Internal consistency (R) was assessed by squaring the correlation between the latent true variable and the observed variables. The relationships between the BCSQ-36 and the other constructs were analysed using Spearman’s r and multiple linear regression models.Results: The structure of the BCSQ-36 fit the data well, with adequate CFA indices for all the burnout subtypes. Reliability was adequate for all the scales and sub-scales (R=0.75). Self-judgement was the self-compassion factor that explained the frenetic subtype (Beta = 0.36; p<0.001); isolation explained the underchallenged (Beta = 0.16; p = 0.010); and over-identification the worn-out (Beta = 0.25; p = 0.001). Other significant associations were observed between the different burnout subtypes and the dimensions of the MBI-GS, UWES and PANAS.Conclusions: The typological definition of burnout through the BCSQ-36 showed good structure and appropriate internal consistence in Spanish primary healthcare professionals. The negative self-compassion dimensions seem to play a relevant role in explaining the burnout profiles in this population, and they should be considered when designing specific treatments and interventions tailored to the specific vulnerability of each subtype

Validation of the Spanish Version of the Psychological Sense of School Membership (PSSM) Scale in Chilean Adolescents and Its Association with School-Related Outcomes and Substance Use.

School membership appears to be an important factor in explaining the relationship between students and schools, including school staff. School membership is associated with several school-related outcomes, such as academic performance and expectations. Most studies on school membership have been conducted in developed countries. The Psychological Sense of School Membership (PSSM) scale (18 items: 13 positively worded items, 5 negatively worded items) has been widely used to measure this construct, but no studies regarding its validity and reliability have been conducted in Spanish-speaking Latin American countries. This study investigates the psychometric properties, factor structure and reliability of this scale in a sample of 1250 early adolescents in Chile. Both exploratory and confirmatory factor analyses provide evidence of an excellent fit for a one-factor solution after removing the negatively worded items. The internal consistency of this new abbreviated version was 0.92. The association analyses demonstrated that high school membership was associated with better academic performance, stronger school bonding, a reduced likelihood of school misbehavior, and reduced likelihood of substance use. Analyses showed support for the reliability and validity of the PSSM among Chilean adolescents