Effects of MDMA on blood glucose levels and brain glucose metabolism

Purpose This study was designed to assess changes in glucose metabolism in rats administered single or repeated doses of MDMA. Methods Two different experiments were performed: (1) A single-dose study with four groups receiving 20 mg/kg, 40 mg/kg, saline or heat, and (2) a repeated-dose study with two groups receiving three doses, at intervals of 2 h, of 5 mg/kg or saline. Rats were imaged using a dedicated small-animal PET scanner 1 h after single-dose administration or 7 days after repeated doses. Glucose metabolism was measured in 12 cerebral regions of interest. Rectal temperature and blood glucose were monitored. Results Peak body temperature was reached 1 h after MDMA administration. Blood glucose levels decreased significantly after MDMA administration. In the single-dose experiment, brain glucose metabolism showed hyperactivation in cerebellum and hypo-activation in the hippocampus, amygdala and auditory cortex. In the repeated-dose experiment, brain glucose metabolism did not show any significant change at day 7. Conclusion These results are the first to indicate that MDMA has the potential to produce significant hypoglycaemia. In addition, they show that MDMA alters glucose metabolism in components of the motor, limbic and somatosensory systems acutely but not on a long-term basisPublicad

Detection of small murine lung tumours by FDG-PET

[Abstract] AMI International Conference 2003, September 21 - 27, Madrid, Spain: "High Resolution Molecular Imaging: from Basic Science to Clinical Applications"The functional information provided by 2-deoxy-2- [18F]fluoro-D-Glucose (FDG) positron emission tomography (PET) is commonly used to detect primary tumours and metastases in clinical studies. The aim of this work is to assess the possibilities of FDG-PET studies to detect small lung tumour lesions in mice, using a dedicated small animal PET scannerPublicad

Research at the medical imaging laboratory, CIBERSAM CB07/09/0031

The Medical Imaging Laboratory is a research group within the Hospital General Universitario Gregorio Marañón. The main research line of the group is focused towards the development and exploitation of medical imaging techniques, including the development of new processing tools for image analysis in clinical and preclinical research. The group has a multi-disciplinary profile and a priority for translational research topics, derived from real problems faced by the clinical specialists. One of the main research areas is the development of technologies for molecular imaging, some of which have been transferred to the industry and are now among the top products of the market. These systems include high-resolution PET, CT and PET-CT. Over the last years the group has developed several software tools to enable quantification of multimodal brain images using morphometric and functional data. Some research applications of these hardware and software tools are illustrated in the paper“Ministerio de Sanidad y Consumo”, CDTEAM Programa CÉNIT, Ministerio de Industria. FIS PI052271 “Ministerio de Sanidad y Consumo”. CIBER Salud Mental (CIBERSAM) “Ministerio de Sanidad y Consumo” and Fundación Mutua MadrileñaPublicad

Detection of rat brain activation using statistical parametric mapping analysis in FDG-PET studies

[Abstract] AMI International Conference 2003, September 21 - 27, Madrid, Spain: High Resolution Molecular Imaging: from Basic Science to Clinical ApplicationsStatistical parametric mapping (SPM) is an analysis technique long been used in clinical research to detect subtle activity changes in brain; it is an excellent exploratory tool as it does not require a priori assumptions about the expected brain region activations. Research in animal imaging may also take benefit from this technique, if properly adapted to the new scenario. This is the case of brain activation studies in murine models using PET tracers and dedicated imaging devices. This work proposes the use of an SPM methodology adapted to the analysis of 2-deoxy-2-[18F] fluoro-D-Glucose (FDG) positron emission tomography (PET) scans of rat brains. Advantages over conventional region of interest (ROI) based analysis were assessed in an experiment addressing the detection of brain activation in of rats which underwent three different visual stimulation paradigmsPublicad

Proyecto de grado Maderera Ltda.

Mapa, tablas, graficas, imágenesEste proyecto se encuentra enfocado en la fabricación y suministro de estibas de madera, elaborado en materiales generados como residuos de operaciones logísticas, como lo es el empaque de materias primas, dicho material es procesado de forma manual con el fin de retirar todas las puntillas, grapas y elementos metálicos para posteriormente ensamblar el producto final de acuerdo a los requerimientos del cliente, cumpliendo las condiciones de calidad y diseño. Dado que la materia prima es madera residual se obtienen menores costos en la fabricación del producto generado una ventaja competitiva y adicional a esto se brinda un impacto positivo al medio ambiente. De acuerdo al estudio económico y geográfico del área que comprende la sabana de Bogotá, se obtiene como resultado que el municipio de Chía presenta varios aspectos favorables para la ubicación de la planta, dichos aspectos se describen a lo largo del presente documento.No Abstrac

WALLABY Pilot Survey: H i gas disc truncation and star formation of galaxies falling into the Hydra I cluster

We present results from our analysis of the Hydra I cluster observed in neutral atomic hydrogen (HI) as part of the Widefield ASKAP L-band Legacy All-sky Blind Survey (WALLABY). These WALLABY observations cover a 60-square-degree field of view with uniform sensitivity and a spatial resolution of 30 arcsec. We use these wide-field observations to investigate the effect of galaxy environment on HI gas removal and star formation quenching by comparing the properties of cluster, infall and field galaxies extending up to ∼5R200 from the cluster centre. We find a sharp decrease in the HI-detected fraction of infalling galaxies at a projected distance of ∼1.5R200 from the cluster centre from ∼0.85% to ∼0.35%. We see evidence for the environment removing gas from the outskirts of HI-detected cluster and infall galaxies through the decrease in the HI to r-band optical disc diameter ratio. These galaxies lie on the star forming main sequence, indicating that gas removal is not yet affecting the inner star-forming discs and is limited to the galaxy outskirts. Although we do not detect galaxies undergoing galaxy-wide quenching, we do observe a reduction in recent star formation in the outer disc of cluster galaxies, which is likely due to the smaller gas reservoirs present beyond the optical radius in these galaxies. Stacking of HI non-detections with HI masses below MHI≲108.4M⊙ will be required to probe the HI of galaxies undergoing quenching at distances ≳60 Mpc with WALLABY

En-tender los textos : ¿Tender a qué? Construyendo categorías sociales; el foco: la enseñanza de los deportes

En este momento de la investigación, el equipo se encuentra trabajando en el análisis y categorización de entrevistas realizadas a entrenadores destacados de nuestro país; paralelamente se está realizando el mismo trabajo metodológico en investigaciones sobre la enseñanza de los deportes y a su vez se está trabajando en fichajes y categorización de textos técnicos específicos de la enseñanza de los deportes. Este trabajo presentará el estado de avance actual con respecto a las categorías sociales relevadas en el trabajo de los fichajes; fichajes que fueron realizados sobre un total de 20 libros y 18 textos referidos a 10 deportes. A partir de este trabajo hemos podido detectar, hasta este momento, 4 categorías sociales: Etapas evolutivas, Fases del aprendizaje, Fases de la enseñanza y Talento Natural. En el desarrollo del trabajo entonces, expondremos el contenido de cada una de las categorías sociales, y los análisis que hemos construidos a partir de las mismas.Departamento de Educación Físic

La enseñanza de los deportes : Lógica homologada. La misma mirada

En este momento de la investigación, el equipo se encuentra trabajando en el análisis y categorización de entrevistas realizadas a entrenadores destacados de nuestro país; paralelamente se está realizando el mismo trabajo metodológico en investigaciones sobre la enseñanza de los deportes y a su vez se está trabajando en fichajes y categorización de textos técnicos específicos de la enseñanza de los deportes. El presente trabajo evidenciará el estado de avance actual con respecto a las categorías analíticas construidas a partir de dotar de sentido y significado, cargando de teoría las categorías sociales ya relevadas en el trabajo de los fichajes, dando cuenta de 6 categorías analíticas que hemos podido construir. Es así, que expondremos el modo metodológico de construcción de las mencionadas categorías; así como también expondremos el contenido teórico de cada una e ellas.Panel: "Teoría, epistemología e investigación"Departamento de Educación Físic

A spect scanner for rodent imaging based on small-area gamma cameras

We developed a cost-effective SPECT scanner prototype (rSPECT) for in vivo imaging of rodents based on small-area gamma cameras. Each detector consists of a position-sensitive photomultiplier tube (PS-PMT) coupled to a 30 30 NaI(Tl) scintillator array and electronics attached to the PS-PMT sockets for adapting the detector signals to an in-house developed data acquisition system. The detector components are enclosed in a leadshielded case with a receptacle to insert the collimators. System performance was assessed using for a high-resolution parallel- hole collimator, and for a 0.75-mm pinhole collimator with a 60 aperture angle and a 42-mm collimator length. The energy resolution is about 10.7% of the photopeak energy. The overall system sensitivity is about and planar spatial resolution ranges from 2.4 mm at 1 cm source-to-collimator distance to 4.1 mm at 4.5 cm with parallel-hole collimators. With pinhole collimators planar spatial resolution ranges from 1.2 mm at 1 cm source-to-collimator distance to 2.4 mm at 4.5 cm; sensitivity at these distances ranges from 2.8 to . Tomographic hot-rod phantom images are presented together with images of bone, myocardium and brain of living rodents to demonstrate the feasibility of preclinical small-animal studies with the rSPECT.This work was supported in part by the CD-TEAM project, CENIT program, Spanish Ministerio de Industria and with grants from the Ministerio de Educación y Ciencia, Projects TEC2007-64731/TCM, TEC2008-06715-C02-01, SAF2009-08076, program ARTEMIS S2009/DPI-1802, Comunidad de Madrid, and the RECAVA-RETIC NetworkPublicad

A consensus statement for trauma surgery capacity building in Latin America.

Funder: Gates Cambridge Trust; doi: http://dx.doi.org/10.13039/501100005370BACKGROUND: Trauma is a significant public health problem in Latin America (LA), contributing to substantial death and disability in the region. Several LA countries have implemented trauma registries and injury surveillance systems. However, the region lacks an integrated trauma system. The consensus conference's goal was to integrate existing LA trauma data collection efforts into a regional trauma program and encourage the use of the data to inform health policy. METHODS: We created a consensus group of 25 experts in trauma and emergency care with previous data collection and injury surveillance experience in the LA. region. Experts participated in a consensus conference to discuss the state of trauma data collection in LA. We utilized the Delphi method to build consensus around strategic steps for trauma data management in the region. Consensus was defined as the agreement of ≥ 70% among the expert panel. RESULTS: The consensus conference determined that action was necessary from academic bodies, scientific societies, and ministries of health to encourage a culture of collection and use of health data in trauma. The panel developed a set of recommendations for these groups to encourage the development and use of robust trauma information systems in LA. Consensus was achieved in one Delphi round. CONCLUSIONS: The expert group successfully reached a consensus on recommendations to key stakeholders in trauma information systems in LA. These recommendations may be used to encourage capacity building in trauma research and trauma health policy in the region