Randomized Clinical Trial of the Need for Antibiotic Treatment for Low-Risk Catheter-Related Bloodstream Infection Caused by Coagulase-Negative Staphylococci

According to clinical guidelines, the management of catheter-related bloodstream infections (CRBSI) due to coagulase-negative staphylococci (CoNS) includes catheter removal and antibiotic treatment for 5 to 7 days. However, in low-risk episodes, it remains uncertain whether antibiotic therapy is necessary. This randomized clinical trial aims to determine whether the non-administration of antibiotic therapy is as safe and effective as the recommended strategy in low-risk episodes of CRBSI caused by CoNS. With this purpose, a randomized, open-label, multicenter, non-inferiority clinical trial was conducted in 14 Spanish hospitals from 1 July 2019 to 31 January 2022. Patients with low-risk CRBSI caused by CoNS were randomized 1:1 after catheter withdrawal to receive/not receive parenteral antibiotics with activity against the isolated strain. The primary endpoint was the presence of any complication related to bacteremia or to antibiotic therapy within 90 days of follow-up. The secondary endpoints were persistent bacteremia, septic embolism, time until microbiological cure, and time until the disappearance of a fever. EudraCT: 2017-003612-39 INF-BACT-2017. A total of 741 patients were assessed for eligibility. Of these, 27 were included in the study; 15 (55.6%) were randomized to the intervention arm (non-antibiotic administration) and 12 (44.4%) to the control arm (antibiotic therapy as per standard practice). The primary endpoint occurred in one of the 15 patients in the intervention group (septic thrombophlebitis) and in no patients in the control group. The median time until microbiological cure was 3 days (IQR 1-3) in the intervention arm and 1.25 days (IQR 0.5-2.62) in the control arm, while the median time until fever resolution was zero days in both arms. The study was stopped due to the insufficient number of recruited patients. These results seem to indicate that low-risk CRBSI caused by CoNS can be managed without antibiotic therapy after catheter removal; efficacy and safety are not affected

Aplicación del proceso analítico en red ANP para la selección de un project manager

Trabajo presentado al XV Congreso Internacional de Ingeniería de Proyectos (AEIPRO), celebrado en Huesca (España) del 6 al 8 de julio de 2011.[EN]: The management of human resources plays an important role in the company. That management has become more complex due the increased weight of the interpersonal skills of the general level of educational qualifications of the candidates that has led to increased competition. In addition, the current economic crisis has strengthened the weight of the departments of of recruitment, since the companies need to have their employees to have personal skills (ability to work in multidisciplinary teams, leadership, in addition to the techniques. For this reason when it comes to select a candidate to lead a project, it is necessary to take into account different criteria. In this work will use the Analytic Network Process (ANP), developed by Professor Thomas L. Saaty, to select a Project Manager for an international company. This method allows have a thorough analysis of the different approaches, its influences and the valuations of the candidates in a manner that can be drawn conclusions theoretical and methodological to resolve this type of problems.[ES]: La gestión de los recursos humanos tiene una gran importancia en la empresa. Dicha gestión se ha vuelto más compleja por el aumento del peso de las habilidades interpersonales del nivel general de la formación académica de los candidatos que ha hecho que se incremente la competencia. Además, la crisis económica actual ha reforzado el peso de los departamentos de selección de personal, puesto que las empresas necesitan que sus empleados tengan habilidades personales (capacidad de trabajar en equipos multidisciplinares, liderazgo…) además de las técnicas. Por esta razón cuando hay que seleccionar un candidato para dirigir un proyecto, es necesario tener en cuenta diferentes criterios. En este trabajo se va utilizar el Proceso Analítico en Red (Analytic Network Process, ANP), desarrollados por el profesor Thomas L. Saaty, para seleccionar un Project Manager para una empresa internacional. Este método permite realizar un profundo análisis de los diferentes criterios, sus influencias y de las valoraciones de los candidatos de manera que se puedan extraer conclusiones teóricas y metodológicas para resolver este tipo de problemas.Peer Reviewe

EFT analysis of New Physics at COHERENT

International audienceUsing an effective field theory approach, we study coherent neutrino scattering on nuclei, in the setup pertinent to the COHERENT experiment. We include non-standard effects both in neutrino production and detection, with an arbitrary flavor structure, with all leading Wilson coefficients simultaneously present, and without assuming factorization in flux times cross section. A concise description of the COHERENT event rate is obtained by introducing three generalized weak charges, which can be associated (in a certain sense) to the production and scattering of $\nu_e$, $\nu_\mu$ and $\bar{\nu}_\mu$ on the nuclear target. Our results are presented in a convenient form that can be trivially applied to specific New Physics scenarios. In particular, we find that existing COHERENT measurements provide percent level constraints on two combinations of Wilson coefficients. These constraints have a visible impact on the global SMEFT fit, even in the constrained flavor-blind setup. The improvement, which affects certain 4-fermion LLQQ operators, is significantly more important in a flavor-general SMEFT. Our work shows that COHERENT data should be included in electroweak precision studies from now on