206 research outputs found
How to Create this Gynecological Task Trainer
This document contains instructions for how to create a gynecological task trainer with a 3D-printed uterus and silicone cervix.https://digitalcommons.unmc.edu/com_obgyn_pres/1000/thumbnail.jp
Exploring the phase diagram of fully turbulent Taylor-Couette flow
Direct numerical simulations of Taylor–Couette flow, i.e. the flow between two coaxial and independently rotating cylinders, were performed. Shear Reynolds numbers of up to 3×105, corresponding to Taylor numbers of Ta=4.6×1010, were reached. Effective scaling laws for the torque are presented. The transition to the ultimate regime, in which asymptotic scaling laws (with logarithmic corrections) for the torque are expected to hold up to arbitrarily high driving, is analysed for different radius ratios, different aspect ratios and different rotation ratios. It is shown that the transition is approximately independent of the aspect and rotation ratios, but depends significantly on the radius ratio. We furthermore calculate the local angular velocity profiles and visualize different flow regimes that depend both on the shearing of the flow, and the Coriolis force originating from the outer cylinder rotation. Two main regimes are distinguished, based on the magnitude of the Coriolis force, namely the co-rotating and weakly counter-rotating regime dominated by Rayleigh-unstable regions, and the strongly counter-rotating regime where a mixture of Rayleigh-stable and Rayleigh-unstable regions exist. Furthermore, an analogy between radius ratio and outer-cylinder rotation is revealed, namely that smaller gaps behave like a wider gap with co-rotating cylinders, and that wider gaps behave like smaller gaps with weakly counter-rotating cylinders. Finally, the effect of the aspect ratio on the effective torque versus Taylor number scaling is analysed and it is shown that different branches of the torque-versus-Taylor relationships associated to different aspect ratios are found to cross within 15 % of the Reynolds number associated to the transition to the ultimate regime. The paper culminates in phase diagram in the inner versus outer Reynolds number parameter space and in the Taylor versus inverse Rossby number parameter space, which can be seen as the extension of the Andereck et al. (J. Fluid Mech., vol. 164, 1986, pp. 155–183) phase diagram towards the ultimate regime
Sliding of a single lac repressor protein along DNA is tuned by DNA sequence and molecular switching
Application of Synchrotron Radiation-Based Micro-Analysis on Cadmium Yellows in Pablo Picasso's Femme
The cultural heritage community is increasingly exploring synchrotron radiation (SR) based techniques for the study of art and archaeological objects. When considering heterogeneous and complex micro-samples, such as those from paintings, the combination of different SR X-ray techniques is often exploited to overcome the intrinsic limitations and sensitivity of the single technique. Less frequently, SR X-ray analyses are combined with SR micro-photoluminescence or micro-Fourier Transform Infrared spectroscopy, which provide complementary information on the molecular composition, offering a unique integrated analysis approach. Although the spatial correlation between the maps obtained with different techniques is not straightforward due to the different volumes probed by each method, the combination of the information provides a greater understanding and insight into the paint chemistry. In this work, we discuss the advantages and disadvantages of the combination of X-ray techniques and SR-based photoluminescence through the study of two paint micro-samples taken from Pablo Picasso's Femme (1907). The painting contains two cadmium yellow paints (based on CdS): one relatively intact and one visibly degraded. SR micro-analyses demonstrated that the two Cd-yellow paints differ in terms of structure, chemical composition, and photoluminescence properties. In particular, on the basis of the combination of different SR measurements, we hypothesize that the degraded yellow is based on nanocrystalline CdS with high presence of Cd(OH)Cl. These two characteristics have enhanced the reactivity of the paint and strongly influenced its stability
Visual Analysis of Spatia-temporal Relations of Pairwise Attributes in Unsteady Flow
Despite significant advances in the analysis and visualization of unsteady flow, the interpretation of it’s behavior still remains a challenge.In this work, we focus on the linear correlation and non-linear dependency of different physical attributes of unsteady flows to aid theirstudy from a new perspective. Specifically, we extend the existing spatial correlation quantification, i.e. the Local Correlation Coefficient(LCC), to the spatio-temporal domain to study the correlation of attribute-pairs from both the Eulerian and Lagrangian views. To studythe dependency among attributes, which need not be linear, we extend and compute the mutual information (MI) among attributes overtime. To help visualize and interpret the derived correlation and dependency among attributes associated with a particle, we encodethe correlation and dependency values on individual pathlines. Finally, to utilize the correlation and MI computation results to identifyregions with interesting flow behavior, we propose a segmentation strategy of the flow domain based on the ranking of the strengthof the attributes relations. We have applied our correlation and dependency metrics to a number of 2D and 3D unsteady flows withvarying spatio-temporal kernel sizes to demonstrate and assess their effectiveness
Effect of Tofacitinib on One-Year Colectomy Risk in Anti-TNF Refractory Ulcerative Colitis: A Prospective Multicenter Italian Study
Background: Tofacitinib is an oral Janus kinase inhibitor recently approved to induce and maintain remission in ulcerative colitis (UC).
Aims: Considering the number of anti-TNF non-responders, this study aims to assess the effectiveness and safety of tofacitinib in a cohort of multi-failure patients with moderate-to-severe UC at 52 weeks. Methods: From January 2021 to March 2023, we performed a prospective multicenter study observing adult patients with moderate-to-severe UC starting tofacitinib after an anti-TNF failure for a 52-week-long period. Effectiveness and safety were assessed in terms of colectomy rate, clinical remission and response, endoscopic remission, steroid-free clinical remission, and rate of adverse events. Results: We included 58 patients with UC with an age of 42 ± 14.4 years, 59% males, 96.6% left-sided or pancolitis, who were failure to a single (65.5%) or more than one anti-TNF (34.5%). Only 6 (10.3%) patients underwent colectomy. Colectomy was clinically associated with the necessity and the number of extra cycles of tofacitinib 10 mg bid at W8 (p = 0.023) and W24 (p = 0.004), and with a higher partial Mayo score at W8 (p = 0.025). At W52, clinical remission, clinical response, and steroid-free clinical remission were 53.4%, 43.1%, and 48.3%, respectively. Of 22 performed colonoscopies at W52, 11 (50%) showed endoscopic remission. Adverse events occurred in 14 (24.1%) patients, but only 2 (3.4%) led to tofacitinib discontinuation. Conclusions: In a real-life setting of patients with anti-TNF refractory UC, tofacitinib has proved to be effective in preventing colectomy and inducing clinical and endoscopic remission at 52 weeks with a good safety profile
Integração de redes GNSS: uma proposta metodológica de densificação da rede SIRGAS na América do Sul
A caracterÃstica continental do Brasil implica na necessidade de constantes desafios cientÃficos em pesquisas espaciais e tecnológicas, que visam contribuir ao engajamento de centros de pesquisas, fornecendo instrumentos à s atividades espaciais no paÃs e no mundo, ampliando as perspectivas de aplicação de técnicas geodésicas como o GPS (Global Positioning System). Neste contexto, destaca-se a contribuição ao IGS (International GNSS Service) dos centros de locais de análise SIRGAS (Sistema de Referência Geocêntrico para as Américas) e o IGS-RNAACSIR (IGS Regional Network Associate Analysis Centre for SIRGAS), que disponibilizam soluções semanais no formato SINEX (Software INdependent EXchange Format), referenciadas ao ITRS (International Terrestrial Reference System), que posteriormente são integradas no contexto de uma solução regional pelo DGFI (Deutsches Geodätiches Forschungsinstitut), denominada IGS-RNAACSIR. Nesta perspectiva, este projeto apresenta uma metodologia de integração de redes GNSS locais no contexto de uma solução regional para o Brasil, com base em dados gerados pelas redes ativas RBMC (Rede Brasileira de Monitoramento ContÃnuo), GNSS SP (Rede GPS Ativa do Oeste do Estado de São Paulo, e em soluções SIRGAS no formato SINEX, utilizando o princÃpio da combinação das equações normais pelo MMQ (Método dos MÃnimos Quadrados), contribuindo com a manutenção e densificação da rede SIRGAS na América Latina
Caracterização da resistência em populações das pragas de grãos armazenados Tribolium castaneum, Oryzaephilus surinamensis e Lasioderma serricorne ao inseticida deltametrina.
Editado por Hugo Soares Kern, Regina Maria Villas Bôas de Campos Leite
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