Alveolar bone repair with strontium- containing nanostructured carbonated hydroxyapatite

Objective: This study aimed to evaluate bone repair in rat dental sockets after implanting nanostructured carbonated hydroxyapatite/sodium alginate (CHA) and nanostructured carbonated hydroxyapatite/sodium alginate containing 5% strontium microspheres (SrCHA) as bone substitute materials. Methods: Twenty male Wistar rats were randomly divided into two experimental groups: CHA and SrCHA (n=5/period/group). After one and 6 weeks of extraction of the right maxillary central incisor and biomaterial implantation, 5 μm bone blocks were obtained for histomorphometric evaluation. The parameters evaluated were remaining biomaterial, loose connective tissue and newly formed bone in a standard area. Statistical analysis was performed by Mann-Withney and and Wilcoxon tests at 95% level of significance. Results: The histomorphometric results showed that the microspheres showed similar fragmentation and bio-absorbation (p>;0.05). We observed the formation of new bones in both groups during the same experimental periods; however, the new bone formation differed significantly between the weeks 1 and 6 (p=0.0039) in both groups. Conclusion: The CHA and SrCHA biomaterials were biocompatible, osteoconductive and bioabsorbable, indicating their great potential for clinical use as bone substitutes

18 Years of Medication-Related Osteonecrosis of the Jaw (MRONJ) Research: Where Are We Now?—An Umbrella Review

From MDPI via Jisc Publications RouterHistory: accepted 2021-09-16, pub-electronic 2021-09-23Publication status: PublishedBackground: Osteonecrosis of the jaw (ONJ) is a condition affecting patients exposed to medications used to treat benign and malignant conditions of bone tissue. Many studies have highlighted that ONJ is a severe condition, which is very challenging to manage, especially in individuals with oncologic disease. The aim of this umbrella review is to analyze all available interventional and non-interventional systematic reviews published on medication-related osteonecrosis of the jaw (MRONJ) and summarize this evidence. Material and methods: A multi-database search (PubMed, MEDLINE, EMBASE and CINAHL) was performed to identify related multi-language papers published from January 2003 until June 2021. An additional manual search was also performed in systematic review registries (PROSPERO, INPLASY, JBI and OFS) to identify possible missing reviews. Data were extracted from relevant papers and analyzed according to the outcomes selected in this review. Results: The search generated 25 systematic reviews eligible for the analysis. The total number of patients included in the analysis was 80,840. Of the reviews, 64% (n = 16) were non-interventional and 36% (n = 9) were interventional. Study designs included case series 20.50% (n = 140), retrospective cohort studies 12.30% (n = 84) and case reports 12.20% (n = 83). It was unclear what study design was used for 277 studies included in the 25 systematic reviews. Conclusions: The data reviewed confirmed that the knowledge underpinning MRONJ in the last 20 years is still based on weak evidence. This umbrella review highlighted a widespread low-level quality of studies and many poorly designed reviews

Preliminary evaluation of cervical adaptation of the conjunt implant-abutment comercialized in Brazil

Made available in DSpace on 2016-05-11T12:45:54Z (GMT). No. of bitstreams: 2 Innov_Implant_J_7-8_16-21.pdf: 757412 bytes, checksum: 79be2baa30f4ceeea4eaad1999e37290 (MD5) license.txt: 1914 bytes, checksum: 7d48279ffeed55da8dfe2f8e81f3b81f (MD5) Previous issue date: 2013Universidade Federal Fluminense. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Odontologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Metrologia, Normalização e Qualidade Industrial. Duque de Caxias, RJ, Brasil / Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Niterói, RJ, Brasil.O objetivo deste estudo foi avaliar a adaptação cervical de implantes de hexágono externo, plataforma regular, com seus respectivos intermediários através da microscopia eletrônica de varredura (MEV). Foram estudados quinze conjuntos de implante/intermediário/parafuso de fixação (plataforma 4.1, hexágono externo), sendo 3 amostras de cada marca e, tendo como critério de seleção das marcas avaliadas, o menor custo de aquisição disponível no mercado nacional no momento da realização deste estudo. Os cinco conjuntos foram organizados da seguinte forma: Implante 1 (I1); Implante 2 (I2); Implante 3 (I3); Implante 4 (I4); Implante 5 (I5). As avaliações foram realizadas após a aplicação de dois níveis de torque, respectivamente 20 e 32 N. Na primeira etapa, foi realizado o torque manual de 20 N em cada conjunto e procedeu-se a medição do gap existente entre o intermediário e o implante com auxílio do MEV. Em cada amostra o gap foi mensurado em dois pontos distintos no aumento de 500X para cálculo da média/erro padrão (n = 6), seguido de análise de variância a dois critérios e teste de Bonferroni (α = 0,05). Posteriormente, os conjuntos foram submetidos a novo aperto com torque de 32 N e reavaliados. Para os implantes I1, I2, I3 e I5, a média do gap foi de 7.39 (20 N) e 5.18 µm (32 N), em oposição aos valores de 96.01 (20 N) e 95.69 µm (32 N) para o I4. Os dados obtidos permitem concluir que, independente do torque empregado, o implante I4 apresenta um gap cerca de 13 vezes maior que o dos outros implantes avaliados.The aim of this study was to evaluate the suitability of cervical external hex implants, regular platform with their intermediaries by scanning electron microscopy (SEM). We studied fifteen sets of implant/intermediate/screw (platform 4.1, external hexagon), 3 samples of each brand and with the selection criteria of the brands evaluated, the lowest cost available in the domestic market at the time of realization this study. The five sets were organized as follows: first Implant (I1); Implant second (I2); Implant third (I3); Implant fourth (I4); Implant fifth (I5). Evaluations were performed after applying two levels of torque, respectively 20 and 32 N. In the first step, we performed a manual torque of 20 N each set and proceeded to measure the gap between the intermediary and the implant with the aid of SEM .In each sample the gap was measured at two different points in increased 500X for calculating the average /standard error (n = 6), followed by two way analysis of variance and the Bonferroni test criteria (α= 0.05). Subsequently, the sets were submitted to further tightening torque of 32 N and reassessed. For implants I1, I2, I3 and I5, the average gap was 7.39 (20 N) and 5.18 micrometre (32 N), as opposed to values of 96.01 (20 N) and 95.69 micrometre (32 N) for I4.The data indicate that, regardless of the employee torque, the implant I4 has a gap about 13 times that of other implants evaluated

Does Platelet-Rich Fibrin Decrease Dimensional Changes and Improve Postoperative Comfort in Post-Extraction Sockets? An Overview of Systematic Reviews

This overview aimed to evaluate the methods, quality, and outcomes of systematic reviews (SRs) conducted to investigate the effects of platelet-rich fibrin (PRF) in dental sockets on promoting bone regeneration and soft tissue healing and diminishing the incidence of pain, swelling, trismus, and alveolar osteitis after tooth extraction. An electronic search without date or language restriction was done in PubMed/MEDLINE, Cochrane, and Web of Science until March 2020. Eligibility criteria included SRs that assessed the effect of PRF for human alveolar socket preservation. The quality assessment of the included studies was performed using AMSTAR 2 guidelines. The protocol of this overview was recorded in PROSPERO under the number CRD42018089617. The search and selection process yielded 13 studies published between 2011 and 2018. The analysis of the studies showed inconclusive data for the effect of the PRF and the dimensional changes. There is no definitive evidence for the impact of using PRF alone on bone regeneration in post-extraction sockets. The use of PRF improves soft tissue healing and reduces pain, bleeding, and osteitis in post-extraction sockets

Effectiveness of connective tissue graft substitutes for the treatment of gingival recessions compared with coronally advanced flap: a network meta-analysis.

OBJECTIVES This study aimed to conduct a network comparison of the clinical effect of connective tissue graft (CTG) substitutes on the treatment of gingival recessions using coronally advanced flap. MATERIALS AND METHODS An electronic search without language or dates restrictions was performed in five databases and in Grey literature for articles published until May, 2020. The eligibility criteria comprised randomized controlled trials (RCTs) that analyzed the clinical outcomes of CTG substitutes when compared with coronally advanced flap (CAF) for the treatment of Miller class I and II (Cairo RT I) gingival recessions. A pairwise and network meta-analysis were conducted for each periodontal parameters to assess and compare the outcomes among different treatment arms for the primary and secondary outcomes. This systematic review (SR) was registered in INPLASY under number INPLASY202060075. RESULTS Twenty-seven studies were included in the present SR. All analyzed CTG substitutes showed superior results when comparing with CAF alone for all periodontal parameters. However, when compared in a network, the acellular dermal matrix (ADM) demonstrated the best treatment ranking of probability results, followed by platelet-rich fibrin (PRF), enamel matrix derivative (EMD), and xenogeneic collagen matrix (XCM) for root coverage (RC). CONCLUSION This SR observed that the association of biomaterials increases the effectiveness of RC in comparison with CAF alone. Based on the treatment ranking, although all the biomaterials analyzed showed a positive effect for RC, the ADM demonstrated the best results. CLINICAL RELEVANCE To know the effectiveness of CTG substitutes for the treatment of gingival recessions

In Vivo Evaluation of Permeable and Impermeable Membranes for Guided Bone Regeneration

Background: The degree of biodegradation and the inflammatory response of membranes employed for guided bone regeneration directly impact the outcome of this technique. This study aimed to evaluate four different experimental versions of Poly (L-lactate-co-Trimethylene Carbonate) (PTMC) + Poly (L-lactate-co-glycolate) (PLGA) membranes, implanted in mouse subcutaneous tissue, compared to a commercially available membrane and a Sham group. Methods: Sixty Balb-C mice were randomly divided into six experimental groups and subdivided into 1, 3, 6 and 12 weeks (n = 5 groups/period). The membranes (1 cm2) were implanted in the subcutaneous back tissue of the animals. The samples were obtained for descriptive and semiquantitative histological evaluation (ISO 10993-6). Results: G1 and G4 allowed tissue adhesion and the permeation of inflammatory cells over time and showed greater phagocytic activity and permeability. G2 and G3 detached from the tissue in one and three weeks; however, in the more extended periods, they presented a rectilinear and homogeneous aspect and were not absorbed. G2 had a major inflammatory reaction. G5 was almost completely absorbed after 12 weeks. Conclusions: The membranes are considered biocompatible. G5 showed a higher degree of biosorption, followed by G1 and G4. G2 and G3 are considered non-absorbable in the studied periods

Alveolar bone repair with strontium- containing nanostructured carbonated hydroxyapatite

<div><p>ABSTRACT Objective: This study aimed to evaluate bone repair in rat dental sockets after implanting nanostructured carbonated hydroxyapatite/sodium alginate (CHA) and nanostructured carbonated hydroxyapatite/sodium alginate containing 5% strontium microspheres (SrCHA) as bone substitute materials. Methods: Twenty male Wistar rats were randomly divided into two experimental groups: CHA and SrCHA (n=5/period/group). After one and 6 weeks of extraction of the right maxillary central incisor and biomaterial implantation, 5 μm bone blocks were obtained for histomorphometric evaluation. The parameters evaluated were remaining biomaterial, loose connective tissue and newly formed bone in a standard area. Statistical analysis was performed by Mann-Withney and and Wilcoxon tests at 95% level of significance. Results: The histomorphometric results showed that the microspheres showed similar fragmentation and bio-absorbation (p>0.05). We observed the formation of new bones in both groups during the same experimental periods; however, the new bone formation differed significantly between the weeks 1 and 6 (p=0.0039) in both groups. Conclusion: The CHA and SrCHA biomaterials were biocompatible, osteoconductive and bioabsorbable, indicating their great potential for clinical use as bone substitutes.</p></div

In Vivo Biological Evaluation of Orthodontically Moved Incisors after Replantation

Background and Objectives: There is still considerable controversy regarding the possibility of submitting replanted teeth to orthodontic movement (OM). The purpose of the present study was to evaluate the tissue response after orthodontic movement on replanted teeth. Materials and Methods: Sixty Wistar rats were randomly assigned to four groups (n = 15): G1, replantation without OM after 30 days; G2, replantation with OM after 30 days; G3, replantation without OM after 60 days, and G4, replantation with OM after 60 days. The maxillary left central incisors were extracted and the teeth were stored in milk media. After 30 min, the teeth were replanted and fixed with non-rigid immobilization. All specimens were observed after 30 and 60 days of replantation and then subdivided into two subgroups (with OM or without OM). The animals were euthanized after seven days of the OM started, and the maxillary bone blocks were processed for histological evaluation. Results: The histological results showed periodontal ligament repair in both periods studied without OM; however, ankylosis and root resorption was seen in all orthodontically moved teeth. Conclusions: The orthodontic movement did not favor tissue response in all replanted teeth, regardless of the experimental periods