830 research outputs found

    The underground economy : a selective history, theory and practical guide to localised underground deviance in New Zealand

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    In order to assist the reader in conceptualising the notions I wish to describe in this thesis, it may be useful to portray my ideas by way of this preface. This will take the form of the perspective, initial focus and development of my research. After completing my degree I initially lived with, and was consequently interested in looking at people and groups that did not want to interact within the mainstream New Zealand capitalistic infrastructure. These people (myself included) were largely made up of those who felt (idealistically?) that through focusing on money and material gain capitalism had lost most of its appeal as a way of life. Consequently these "hippies" and members of alternative communities choose to live in various differing fashions. I then came to realise that although many of these people felt they were no longer part of society, or more particularly capitalism (this appeared as a reoccurring theme among the people I spoke with), that was their one constraint. They had to have money in order to operate in relative autonomy from the rest of society. In order to get away from the "rat race" one had to purchase some land, which in turn needed developing. In order to gain money one usually had to participate in the "rat race". This led me to a change in philosophical tack; I began to see a difference in those that I (possibly unfairly) saw as running away from capitalism and those who cunningly hid from it. [From Preface

    Tony From America

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    https://digitalcommons.library.umaine.edu/mmb-vp/6383/thumbnail.jp

    Alien Registration- Monckton, Alexander (Portland, Cumberland County)

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    https://digitalmaine.com/alien_docs/26637/thumbnail.jp

    Complex patterns of male germline instability and somatic mosaicism in myotonic dystrophy type 1

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    The genetic basis of myotonic dystrophy type 1 (DM1) is the expansion of a CTG repeat in the 3' untranslated region of DM1PK . Once into the disease range, the repeat becomes highly unstable and is biased toward expansion in both somatic and germline tissues. Intergenerational differences usually reveal an increase in allele length, concordant with the clinical anticipation characteristic of DM1, but there have also been cases with intergenerational contractions of the repeat length, accompanied by apparent anticipation. In order to gain a better understanding of this intergenerational behaviour, we have obtained semen samples from six DM males and used single molecule analyses to compare the allele distributions present in their sperm and blood with those of their offspring. We have confirmed that the male germline mutational pathway is distinct from that of the soma, but the extent of variation is highly variable from one individual to another and not obviously correlated with progenitor allele length. Nonetheless, in all cases the alleles present in the father's sperm overlap with those observed in their offspring. These data also provide further indications that the interpretation of intergenerational transmissions by standard analyses is frequently compromised by the masking of germline differences by age-dependent somatic expansion in the parent

    Manage risk of accidental gene editing of germline

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    No abstract available

    Take A Step!

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    https://digitalcommons.library.umaine.edu/mmb-vp/6664/thumbnail.jp

    Rheingold

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    https://digitalcommons.library.umaine.edu/mmb-vp/6112/thumbnail.jp

    A Quaker Girl

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    https://digitalcommons.library.umaine.edu/mmb-vp/6093/thumbnail.jp
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