Empréstimos com arte: criação de valor partilhado multidimensional entre público(s) e privado(s)

Este projeto de Mestrado tem como finalidade criar uma entidade que promova e execute exposições temporárias em Museus Públicos do país com obras provenientes de coleções privadas, contribuindo assim para a diversificação de fontes de financiamento e sustentabilidade dos mesmos. Este projeto insere-se, assim, numa discussão mais vasta que se debruça sobre a relação entre a sociedade e as empresas e a possibilidade de harmonização dos seus objetivos. Neste projeto, partir-se-á de um quadro teórico norteado pela teoria de criação de valor partilhado para um Modelo de negócio que permita articular entre si quatro quadrantes que são parte integrante do projeto: os públicos visitantes das exposições, os privados colecionadores de obras, o setor público, no qual se inserem os museus de arte públicos, e o setor privado no seu todo. Este projeto tem, assim, a finalidade de promover uma forma mais conscienciosa de olhar para o investimento em arte, apresentando os múltiplos benefícios para os quadrantes acima mencionados e uma visão holística da criação de valor, ou seja, uma visão que não contempla apenas as métricas monetárias, mas que apresenta e inclui outros componentes de valor tais como o social e o cultural.The following Master's degree project aims at creating an entity that is able to promote and run temporary exhibitions at Portuguese Public Museums, exhibiting works from private collections, thus contributing to the diversification of funding sources and to the sustainability of those museums. This project departs from is part of like a more problematic discussion that takes into account the discussions between company / firm, and its confluence of objectives This is based on a theoretical framework guided by shared value creation theory for a Business model that allowed coordinate among themselves four quadrants that are directly related with the project: visitors to the public exhibitions, private collectors of works, the public sector in which they operate public art museums, and the private sector as a whole. This project has a purpose of promoting a more conscientious way of looking at investing in art thus presenting multiple benefits of various orders and a holistic view of value creation, not only take into account monetary metrics, but also has several components value components such as social and cultura

Tumor-associated and immunochemotherapy-dependent long-term alterations of the peripheral blood NK cell compartment in DLBCL patients

Natural Killer (NK) cells are a key component of tumor immunosurveillance and thus play an important role in rituximab-dependent killing of lymphoma cells via an antibody-dependent cellular cytotoxicity (ADCC) mechanism. We evaluated the phenotypic and functional assets of peripheral blood NK cell subsets in 32 newly-diagnosed diffuse large B-cell lymphoma (DLBCL) patients and in 27 healthy controls. We further monitored long-term modifications of patient NK cells for up to 12 months after rituximab-based immunochemotherapy. At diagnosis, patients showed a higher percentage of CD56dim and CD16C NK cells, and a higher frequency of GrzBC cells in CD56dim, CD56bright, and CD16C NK cell subsets than healthy controls. Conversely, DLBCL NK cell killing and interferon g (IFNg) production capability were comparable to those derived from healthy subjects. Notably, NK cells from refractory/relapsed patients exhibited a lower “natural” cytotoxicity. A marked and prolonged therapy-induced reduction of both “natural” and CD16- dependent NK cytotoxic activities was accompanied by the down-modulation of CD16 and NKG2D activating receptors, particularly in the CD56dim subset. However, reduced NK cell killing was not associated with defective lytic granule content or IFNg production capability. This study firstly describes tumor-associated and therapy-induced alterations of the systemic NK cell compartment in DLBCL patients. As these alterations may negatively impact rituximab-based therapy efficacy, our work may provide useful information for improving immunochemotherapeutic strategies

Glucocorticoids and Antivirals for HBV Reactivation in Onco-Hematologic Patients.

Patients with inactive or occult hepatitis B virus infection and onco-hematological malignancies are at risk of hepatitis flare, hepatic failure and death due to chemotherapy-mediated reactivation. Nucleot(s)ide analogues can reduce reactivation risks and/or hepatitis. However, immuno-mediated phenomena combine to determine liver damage and clinical outcome. We describe in this report two patients with onco-hematological malignancies and hepatitis B reactivation after chemotherapy in whom glucocorticoids were added to nucleot(s)ide. Antiviral therapy was effective on replication, while glucocorticoids managed hyperergic response. One patient without underlying liver disease survived, while the second died and the autopsy demonstrated cirrhosis undetected before death. This clinical trial suggests that in patients with onco-hematological malignancies and altered liver function tests in spite of effective antiviral response, glucocorticoids could control the effects of immune response. However prognosis and survival are related to the underlying liver status

MAMMALS IN PORTUGAL : A data set of terrestrial, volant, and marine mammal occurrences in P ortugal

Mammals are threatened worldwide, with 26% of all species being includedin the IUCN threatened categories. This overall pattern is primarily associatedwith habitat loss or degradation, and human persecution for terrestrial mam-mals, and pollution, open net fishing, climate change, and prey depletion formarine mammals. Mammals play a key role in maintaining ecosystems func-tionality and resilience, and therefore information on their distribution is cru-cial to delineate and support conservation actions. MAMMALS INPORTUGAL is a publicly available data set compiling unpublishedgeoreferenced occurrence records of 92 terrestrial, volant, and marine mam-mals in mainland Portugal and archipelagos of the Azores and Madeira thatincludes 105,026 data entries between 1873 and 2021 (72% of the data occur-ring in 2000 and 2021). The methods used to collect the data were: live obser-vations/captures (43%), sign surveys (35%), camera trapping (16%),bioacoustics surveys (4%) and radiotracking, and inquiries that represent lessthan 1% of the records. The data set includes 13 types of records: (1) burrowsjsoil moundsjtunnel, (2) capture, (3) colony, (4) dead animaljhairjskullsjjaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8),observation in shelters, (9) photo trappingjvideo, (10) predators dietjpelletsjpine cones/nuts, (11) scatjtrackjditch, (12) telemetry and (13) vocalizationjecholocation. The spatial uncertainty of most records ranges between 0 and100 m (76%). Rodentia (n=31,573) has the highest number of records followedby Chiroptera (n=18,857), Carnivora (n=18,594), Lagomorpha (n=17,496),Cetartiodactyla (n=11,568) and Eulipotyphla (n=7008). The data setincludes records of species classified by the IUCN as threatened(e.g.,Oryctolagus cuniculus[n=12,159],Monachus monachus[n=1,512],andLynx pardinus[n=197]). We believe that this data set may stimulate thepublication of other European countries data sets that would certainly contrib-ute to ecology and conservation-related research, and therefore assisting onthe development of more accurate and tailored conservation managementstrategies for each species. There are no copyright restrictions; please cite thisdata paper when the data are used in publications.info:eu-repo/semantics/publishedVersio

Mammals in Portugal: a data set of terrestrial, volant, and marine mammal occurrences in Portugal

Mammals are threatened worldwide, with ~26% of all species being included in the IUCN threatened categories. This overall pattern is primarily associated with habitat loss or degradation, and human persecution for terrestrial mammals, and pollution, open net fishing, climate change, and prey depletion for marine mammals. Mammals play a key role in maintaining ecosystems functionality and resilience, and therefore information on their distribution is crucial to delineate and support conservation actions. MAMMALS IN PORTUGAL is a publicly available data set compiling unpublished georeferenced occurrence records of 92 terrestrial, volant, and marine mammals in mainland Portugal and archipelagos of the Azores and Madeira that includes 105,026 data entries between 1873 and 2021 (72% of the data occurring in 2000 and 2021). The methods used to collect the data were: live observations/captures (43%), sign surveys (35%), camera trapping (16%), bioacoustics surveys (4%) and radiotracking, and inquiries that represent less than 1% of the records. The data set includes 13 types of records: (1) burrows | soil mounds | tunnel, (2) capture, (3) colony, (4) dead animal | hair | skulls | jaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8), observation in shelters, (9) photo trapping | video, (10) predators diet | pellets | pine cones/nuts, (11) scat | track | ditch, (12) telemetry and (13) vocalization | echolocation. The spatial uncertainty of most records ranges between 0 and 100 m (76%). Rodentia (n =31,573) has the highest number of records followed by Chiroptera (n = 18,857), Carnivora (n = 18,594), Lagomorpha (n = 17,496), Cetartiodactyla (n = 11,568) and Eulipotyphla (n = 7008). The data set includes records of species classified by the IUCN as threatened (e.g., Oryctolagus cuniculus [n = 12,159], Monachus monachus [n = 1,512], and Lynx pardinus [n = 197]). We believe that this data set may stimulate the publication of other European countries data sets that would certainly contribute to ecology and conservation-related research, and therefore assisting on the development of more accurate and tailored conservation management strategies for each species. There are no copyright restrictions; please cite this data paper when the data are used in publications

Studio multicentrico su un preparato topico ad azione linfodrenante nel trattamento dell’ulcera flebostatica degli arti inferiori

Le ulcere flebostatiche degli arti inferiori rappresentano una tipica complicanza dell’insufficienza venosa cronica e il loro trattamento è tuttora controverso. Infatti le comuni terapie non sono ancora standardizzate e non mostrano una totale efficacia. Tra il 2005 e il 2007 è stato condotto presso il Dipartimento di Chirurgia Plastica e Ricostruttiva della “Sapienza”, Università di Roma e presso il Dipartimento di Chirurgia Plastica e Ricostruttiva dell’Università di Perugina, uno studio multicentrico volto a valutare l’efficacia della crema linfodrenante Idrastin® in pazienti affetti da ulcere flebostatiche degli arti inferiori. Lo studio è stato condotto su 80 pazienti, suddivisi in 2 gruppi omogenei di 40 pazienti: il gruppo A è stato trattato unicamente con terapia elastocompressiva, il gruppo B con terapia elastocompressiva associata all’utilizzo di Idrastin®. L’analisi multicentrica ha preso in considerazione parametri quali il dolore locale, la flogosi perilesionale, la comparsa di tessuto di granulazione, il trofismo dei tessuti perilesionali e il tempo di guarigione. I risultati evidenziati nel gruppo B sono: riduzione del dolore locale fino alla scomparsa in 72 ore; decremento dell’infiammazione con scomparsa in una settimana; crescita di tessuto di granulazione in una settimana; guarigione della lesione in 4 settimane. Questi risultati confermano la significatività statistica delle variabili prese in considerazione. Riteniamo che, relativamente ai composti contenuti nell’Idrastin®, i fitoestratti di luppolo e di edera hanno contribuito all’effetto analgesico; i fitoestratti di Aesculus hippocastanum, di Vitis vinifera e di Ruscus aculeatus hanno mostrato attività antiflogistica; l’allantoina, la Centella asiatica l’acido ialuronico hanno coadiuvato la guarigione delle ulcere. Idrastin® fornisce un efficace supporto al trattamento delle ulcere flebostatiche garantendo un processo di guarigione più veloce e più efficace rispetto alle lesioni trattate con la sola elastocompressione

Hemipelvectomy and reconstruction in a patient with advanced Marjolin's ulcer: a case report.

Patients with squamous cell carcinoma of the lower limb may exhibit locally advanced or metastatic disease. Surgical resection to control the primary tumor is often extensive.The case of a 51-year-old man with squamous cell carcinoma on Marjolin?€™s ulcer affected, rapidly growing, and involving soft and bone tissues is described. Treatment required performing a hemipelvectomy. Immediate reconstruction was chosen as surgical procedure planning the harvest of 4 superficial muscles and 1 deep muscle of the abdomen to protect the pelvic content and to eliminate the dead spaces.The chosen technique minimized postoperative complications, and at 7 years follow-up, the patient is disease free