Efficacy of standard and low drift nozzles for insecticide applications against Aonidiella aurantii (Maskell) in citrus

Drift is especially critical when spraying fruit, vine and citrus orchards where pesticides are intensively used. In this context, cone low drift nozzles (LDN) intended for spraying tree crops, have been evaluated relating to cone standard nozzles (STN) in laboratory and deciduous fruit orchards (Van de Zande et al. 2012); (Planas et al., 2013)

Ambrisentan use in a HIV-1 infected patient with end-stage renal disease and pulmonary hypertension : minimal removal by hemodialysis - a case report

Ambrisentan is a selective endothelin receptor antagonist used for the treatment of pulmonary arterial hypertension (PAH). Little is known about ambrisentan removal by hemodialysis in patients with end-stage renal disease (ESRD). A 53-year-old woman with HIV/hepatitis C virus (HCV) co-infection, PAH and ESRD on regular hemodialyis was admitted in our hospital due to refractory heart failure while on treatment with bosentan (125 mg twice daily) and tadalafil (20 mg once daily) for PAH and antiretroviral treatment (cART) including darunavir/cobicistat (800/150 mg once daily). Excessive exposure to bosentan due to drug interactions between bosentan and darunavir/cobicistat was suspected. Bosentan was replaced by ambrisentan, with progressive improvement in her clinical condition. Pre- and postdialyzer cocentrations of ambrisentan in plasma were determined and hemodialysis extraction ratio for ambrisentan was 2%. Our results suggest that hemodialysis results in minimal ambrisentan removal, and therefore no specific ambrisentan dosage adjustment seems to be required in ESRD patients undergoing hemodialysis

Dynamic management of virtual infrastructures

The final publication is available at Springer via http://dx.doi.org/10.1007/s10723-014-9296-5Cloud infrastructures are becoming an appropriate solution to address the computational needs of scientific applications. However, the use of public or on-premises Infrastructure as a Service (IaaS) clouds requires users to have non-trivial system administration skills. Resource provisioning systems provide facilities to choose the most suitable Virtual Machine Images (VMI) and basic configuration of multiple instances and subnetworks. Other tasks such as the configuration of cluster services, computational frameworks or specific applications are not trivial on the cloud, and normally users have to manually select the VMI that best fits, including undesired additional services and software packages. This paper presents a set of components that ease the access and the usability of IaaS clouds by automating the VMI selection, deployment, configuration, software installation, monitoring and update of Virtual Appliances. It supports APIs from a large number of virtual platforms, making user applications cloud-agnostic. In addition it integrates a contextualization system to enable the installation and configuration of all the user required applications providing the user with a fully functional infrastructure. Therefore, golden VMIs and configuration recipes can be easily reused across different deployments. Moreover, the contextualization agent included in the framework supports horizontal (increase/decrease the number of resources) and vertical (increase/decrease resources within a running Virtual Machine) by properly reconfiguring the software installed, considering the configuration of the multiple resources running. This paves the way for automatic virtual infrastructure deployment, customization and elastic modification at runtime for IaaS clouds.The authors would like to thank to thank the financial support received from the Ministerio de Economia y Competitividad for the project CodeCloud (TIN2010-17804).Caballer Fernández, M.; Blanquer Espert, I.; Moltó, G.; Alfonso Laguna, CD. (2015). Dynamic management of virtual infrastructures. Journal of Grid Computing. 13(1):53-70. https://doi.org/10.1007/s10723-014-9296-5S5370131de Alfonso, C., Caballer, M., Alvarruiz, F., Molto, G., Hernández, V.: Infrastructure deployment over the cloud. In: 2011 IEEE 3rd International Conference on Cloud Computing Technology and Science, pp. 517–521. IEEE. (2011). doi: 10.1109/CloudCom.2011.77Alvarruiz, F., De Alfonso, C., Caballer, M., Hernández, V.: An energy manager for high performance computer clusters. 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Micromechanical behaviour of apple tissue in tensile and compression tests: Storage conditions and cultivar effect

The micromechanical behaviour of apple tissue was studied using a miniature tensile stage positioned underneath a microscope that allowed for simultaneous acquisition of force-displacement curves while the deformation of the individual cells was followed and recorded. Tensile and compression tests were performed on small samples of apple parenchyma of two different cultivars (Jonagored and Braeburn) and two storage conditions (control and shelf-life). Tests on the repeatability of the methods has provided satisfactory results and will allow the reduction of samples in further experiments. Under tensile loading, no differences for any of the mechanical parameters were found between cultivars, while a significant storage effect was observed for both cultivars. This opens the possibility of developing new sensors for quality assessment. Differences were found when studying the relationship of mechanical properties at the micro- and macro-level, which requires further investigation. The insights gained in this research will be useful when developing mathematical models based upon the mechanical behaviour of apple tissue

Effects of Spirotetramat on Aonidiella aurantii (Homoptera: Diaspididae) and Its Parasitoid, Aphytis melinus (Hymenoptera: Aphelinidae)

Laboratory and field studies were conducted to measure the effects of spirotetramat on life stages of California red scale, Aonidiella aurantii (Maskell), and a primary parasitoid, Aphytis melinus DeBach. Organophosphate-resistant and -susceptible populations responded similarly to spirotetramat, suggesting there is no cross-resistance between these insecticide classes. First and second instar male and female A. aurantii were 10- and 32-fold more susceptible to spirotetramat (LC50 = 0.1-0.2 ppm) compared with early third (LC50 = 1.5 ppm) and late third instar females (LC50 = 5.3 ppm). The LC99 value indicated that late stage third instar females would not be fully controlled by a field rate of spirotetramat; however, spirotetramat would reduce their fecundity by 89%. Field applications of spirotetramat in two water volumes and using two adjuvants (oil and a nonionic spray adjuvant) showed similar reduction in A. aurantii numbers, even though the higher water volume demonstrated more complete coverage. These data suggest that this foliarly applied systemic insecticide can be applied in as little as 2,340 liters/ha of water volume, minimizing application costs, and that the two adjuvants acted similarly. The endoparasitoid, A. melinus, was unaffected by the field rate of spirotetramat when it was applied to the host when the parasitoid was in the egg or larval stage. Adult A. melinus showed 2 wk of moderate reductions in survival when exposed to leaves with field-weathered residues. Spirotetramat is an integrated pest management compatible insecticide, effective in reducing A. aurantii stages and allowing survival of its primary parasitoid A. melinus