Bauxitas kársticas jurásicas en la zona subbética (Zarzadilla de Totana, prov. de Murcia, sureste de España): Interpretación paleogeográfica

Los yacimientos de bauxitas de Zarzadilla de Totana (Murcia) selocalizan en materiales jurásicos del Subbético interno. Las bauxitas se emplazan rellenando cavidades kársticas en el seno de calizas del Lias infradomerense indicando claramente una etapa de emersión de un umbral pelágico que pudo durar parte del Lias superior y del Dogger

A CFD-based Approach to Predict Explosion Overpressure: A Comparison to Current Methods

A CFD-based approach has been developed in this work to predict the overpressure produced during an explosion. An adiabatic exothermal reaction allows computing the explosion energy release. To validate the proposed CFD approach, overpressure predictions based on this methodology are compared with results produced with the TNObased method. It is demonstrated that the physics adopted in our model produces satisfactory predictions in the open area. The CFD simulations were carried out in the ANSYS CFX tool. The source of energy corresponds to the one produced by a stoichiometric proportion in reactants without energy generation. The explosion analysis considered that explosion occurs geometrically as a sequence of control volumes. Thus, the explosion in a volume is assumed to occur when the maximum pressure is achieved in the previous control volume. This way, the explosion is propagated and it is shown that it is equivalent to conventional predicting methods

The Presence of Precursors of Benign Pre-B Lymphoblasts (Hematogones) in the Bone Marrow of a Paediatric Patient with Cytomegalovirus Infection

Hematogones are normal B-lymphoid precursors that multiply in the bone marrow of small children and of adults with ferropenic anaemia, neuroblastoma or idiopathic thrombocytopenic purpura. They are not normally found in peripheral blood, and the immunophenotype is virtually indistinguishable from that of B lymphoblasts. We discuss the case of a 3-month infant with an active cytomegalovirus infection, with hepatitis and pancytopenia associated with 13% hematogones in the bone marrow

Caracterización de las ganaderías de vacuno de carne en la zona de la Cooperativa Andaluza Ganadera del Valle de los Pedroches

publishedTomo I. Sección: Sistemas Ganaderos - Economía y Gestión. Sesión: Vacuno carne

Unify Markov model for Rational Design and Synthesis of More Safe Drugs. Predicting Multiple Drugs Side Effects

The 9th International Electronic Conference on Synthetic Organic Chemistry session Computational ChemistryMost of present mathematical models for rational design and synthesis of new drugs consider just the molecular structure. In the present article we pretend extending the use of Markov Chain models to define novel molecular descriptors, which consider in addition other parameters like target site or biological effect. Specifically, this model takes into consideration not only the molecular structure but the specific biological system the drug affects too. Herein, it is developed a general Markov model that describes 19 different drugs side effects grouped in 8 affected biological systems for 178 drugs, being 270 cases finally. The data was processed by Linear Discriminant Analysis (LDA) classifying drugs according to their specific side effects, forward stepwise was fixed as strategy for variables selection. The average percentage of good classification and number of compounds used in the training/predicting sets were 100/95.8% for endocrine manifestations(18 out of 18)/(13 out of 14); 90.5/92.3% for gastrointestinal manifestations (38 out of 42)/(30 out of 32); 88.5/86.5% for systemic phenomena (23 out of 26)/(17 out of 20); 81.8/77.3% for neurological manifestations (27 out of 33)/(19 out of 25); 81.6/86.2% for dermal manifestations (31 out of 38)/(25 out of 29); 78.4/85.1% for cardiovascular manifestation (29 out of 37)/(24 out of 28); 77.1/75.7% for breathing manifestations (27 out of 35)/(20 out of 26) and 75.6/75% for psychiatric manifestations (31 out of 41)/(23 out of 31). Additionally a Back-Projection Analysis (BPA) was carried out for two ulcerogenic drugs to prove in structural terms the physic interpretation of the models obtained. This article develops a model that encompasses a large number of drugs side effects grouped in specifics biological systems using stochastic absolute probabilities of interaction (Apk (j)) by the first time

Antarctic root endophytes improve physiological performance and yield in crops under salt stress by enhanced energy production and Na+ sequestration

Molina Montenegro, Marco A. Universidad de Talca. Instituto de Ciencias Biológicas. Campus Talca, Chile.Acuña Rodríguez, Ian S. Universidad de Talca. Instituto de Ciencias Biológicas. Campus Talca, Chile.Torres Díaz, Cristian. Universidad del Bío-Bío. Departamento de Ciencias Básicas. Grupo de Biodiversidad y Cambio Global (BCG). Chillán, Chile.Gundel, Pedro Emilio. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura (IFEVA). Buenos Aires, Argentina.Dreyer, Ingo. Universidad de Talca. Facultad de Ingeniería. Centro de Bioinformática y Simulación Molecular (CBSM). Campus Talca, Chile.10Climatic change is pointed as one of the major challenges for global food security. Based on current models of climate change, reduction in precipitations and in turn, increase in the soil salinity will be a sharp constraint for crops productivity worldwide. In this context, root fungi appear as a new strategy to improve plant ecophysiological performance and crop yield under abiotic stress. In this study, we evaluated the impact of the two fungal endophytes Penicillium brevicompactum and P. chrysogenum isolated from Antarctic plants on nutrients and Na+ contents, net photosynthesis, water use efficiency, yield and survival in tomato and lettuce, facing salinity stress conditions. Inoculation of plant roots with fungal endophytes resulted in greater fresh and dry biomass production, and an enhanced survival rate under salt conditions. Inoculation of plants with the fungal endophytes was related with a higher up/down-regulation of ion homeostasis by enhanced expression of the NHX1 gene. The two endophytes diminished the effects of salt stress in tomato and lettuce, provoked a higher efficiency in photosynthetic energy production and an improved sequestration of Na+ in vacuoles is suggested by the upregulating of the expression of vacuolar NHX1 Na+/H+ antiporters. Promoting plant-beneficial interactions with root symbionts appears to be an environmentally friendly strategy to mitigate the impact of climate change variables on crop production

Treatment with Enterococcus faecalis CECT7121 Is Not Effective as Therapy in Mice with an Established Allergy Status

In allergies, an unbalanced immune response towards a T helper (Th) 2 profile with high levels of Immunoglobulin (Ig) E is produced. We have demonstrated that the pre-administration of Enterococcus faecalis CECT7121 prevents the development of allergy in ovalbumin-immunized mice. In this work, we evaluated whether this bacterium can also revert an established allergic status. Mice were immunized with ovalbumin (OVA) and after that, were inoculated with an E. faecalis CECT7121 suspension. In immunized animals, serum specific immune response, proliferative activity of memory splenocytes, and levels of Th2 cytokines were assessed. The in vivo active cutaneous anaphylaxis test was also performed. The treatment with E. faecalis CECT7121 only increased anti-OVA IgG2a levels. No differences were observed in other specific immunological parameters. Probiotic-treatment did not prove to have any desensitizing effect on mice. These results, together with those recently published, can be concluded that this bacterium would not be appropriate for the treatment of allergic symptoms.Facultad de Ciencias Médicas (FCM