Consistency in a Partitioned Network: A Survey

Recently, several strategies for transaction processing in partitioned distributed database systems with replicated data have been proposed. We survey these strategies in light of the competing goals of maintaining correctness and achieving high availability. Extensions and combinations are then discussed, and guidelines for the selection of a strategy for a particular application are presented

Assessing Instrumental Weapons Violence against Teachers

Violence against teachers is a critical issue for learning communities. Among the most serious forms of harm include weapon violence. While there has been extensive research on weapon carrying and traditional weapon use within schools, there has been little investigation into instrumental weapon violence against teachers. The current study utilizes qualitative survey data to investigate contributing conditions related to teacher’s experiences of instrumental weapon’s violence through direct content analysis. Results from this study aim to expand our understanding of the nature and nuance of teacher-directed instrumental weapon violence

Gestión integral de residuos sólidos

La cartilla 1 considera la evolución histórica de la generación y manejo de los residuos sólidos, haciendo una corta reseña de la forma como el hombre desde la antigüedad hasta nuestros días ha realizado el manejo de los residuos. Aquí también se referencian los marcos legales e institucionales, existentes en Colombia partiendo desde la Ley 23 de 1973 hasta el Decreto 2981 del 20 de diciembre del 2013, además se muestra la estructura institucional para el manejo de los residuos sólidos a nivel nacional. En un tercer momento académico, se definen términos como el manejo integral y sustentable de los residuos sólidos, los planes de manejo integral de residuos sólidos PMIRS y la clasificación de los residuos sólidos según su origen y tipo de manejo.El contenido de los documentos publicados en el repositorio, es de exclusiva responsabilidad de los autores y no expresa necesariamente, el pensamiento de la Fundación Universitaria del Área Andina.UNIDAD 1 Gestión de los residuos sólidos -- UNIDAD 2 Cadena de generación de residuos -- UNIDAD 3 Sistema de manejo de residuos sólidos -- UNIDAD 4 Planes de gestión integral de residuos (PGIRS) -

The influence of body mass index and age on C-peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial-type 1

BACKGROUND/OBJECTIVE: The extent of influence of BMI and age on C-peptide at the diagnosis of type 1 diabetes (T1D) is unknown. We thus studied the impact of body mass index Z-scores (BMIZ) and age on C-peptide measures at and soon after the diagnosis of T1D. METHODS: Data from Diabetes Prevention Trial-Type 1 (DPT-1) participants <18.0 years at diagnosis was analyzed. Analyses examined associations of C-peptide measures with BMIZ and age in 2 cohorts: oral glucose tolerance tests (OGTTs) at diagnosis (n = 99) and mixed meal tolerance tests (MMTTs) <6 months after diagnosis (n = 80). Multivariable linear regression was utilized. RESULTS: Fasting and area under the curve (AUC) C-peptide from OGTTs (n = 99) at diagnosis and MMTTs (n = 80) after diagnosis were positively associated with BMIZ and age (P < .001 for all). Associations persisted when BMIZ and age were included as independent variables in regression models (P < .001 for all). BMIZ and age explained 31%-47% of the variance of C-peptide measures. In an example, 2 individuals with identical AUC C-peptide values had an approximate 5-fold difference in values after adjustments for BMIZ and age. The association between fasting glucose and C-peptide decreased markedly when fasting C-peptide values were adjusted (r = 0.30, P < .01 to r = 0.07, n.s.). CONCLUSIONS: C-peptide measures are strongly and independently related to BMIZ and age at and soon after the diagnosis of T1D. Adjustments for BMIZ and age cause substantial changes in C-peptide values, and impact the association between glycemia and C-peptide. Such adjustments can improve assessments of β-cell impairment at diagnosis

Calcium stone lithoptysis in primary ciliary dyskinesia

An association between lithoptysis and primary ciliary dyskinesia (PCD) has not been previously reported. However, reports of lithoptysis from 2 older patients (>60 yr) prompted a study of this association. We performed a prospective study of all PCD patients presenting to our institution between August 2003 and March 2006, seeking the symptom of lithoptysis or calcium deposition on radiology. A retrospective analysis of all PCD patients presenting prior to August 2003 was also performed. Patients age > or = 40 previously reviewed were recontacted. If a history of lithoptysis or calcium deposition was present, we further reviewed radiographic, microbiologic, and biochemical data, including serum calcium and phosphate. Broncholiths were analyzed by light and electron microscopy- and electron-dispersive X-ray analysis. In total, 142 patients (n=28 age > or = 40) were included, 41 in the prospective and 91 in the retrospective study. Lithoptysis was reported in 5 patients (all age > or = 40). Chest CT scans identified calcification (4/5), involving bronchiectatic airways in 3 patients and focal nodular calcification in 1 patient. Two other patients (age 46, 59) were identified with airway calcification without lithoptysis. Available broncholiths from 2 of these patients were composed of calcite, whereas a broncholith from 1 patient with focal nodular calcification contained calcium phosphate. Sputum was positive for Pseudomonas aeruginosa in all 7 patients, but negative for mycobacterial and fungal cultures. There is an association between lithoptysis and PCD in patients age > or = 40. We hypothesize that calcite stone formation is a biomineralization response to chronic airway inflammation and retention of infected airway secretions in PCD in a subset of PCD patients

Calcium stone lithoptysis in primary ciliary dyskinesia

An association between lithoptysis and primary ciliary dyskinesia (PCD) has not been previously reported. However, reports of lithoptysis from 2 older patients (>60 yr) prompted a study of this association. We performed a prospective study of all PCD patients presenting to our institution between August 2003 and March 2006, seeking the symptom of lithoptysis or calcium deposition on radiology. A retrospective analysis of all PCD patients presenting prior to August 2003 was also performed. Patients age > or = 40 previously reviewed were recontacted. If a history of lithoptysis or calcium deposition was present, we further reviewed radiographic, microbiologic, and biochemical data, including serum calcium and phosphate. Broncholiths were analyzed by light and electron microscopy- and electron-dispersive X-ray analysis. In total, 142 patients (n=28 age > or = 40) were included, 41 in the prospective and 91 in the retrospective study. Lithoptysis was reported in 5 patients (all age > or = 40). Chest CT scans identified calcification (4/5), involving bronchiectatic airways in 3 patients and focal nodular calcification in 1 patient. Two other patients (age 46, 59) were identified with airway calcification without lithoptysis. Available broncholiths from 2 of these patients were composed of calcite, whereas a broncholith from 1 patient with focal nodular calcification contained calcium phosphate. Sputum was positive for Pseudomonas aeruginosa in all 7 patients, but negative for mycobacterial and fungal cultures. There is an association between lithoptysis and PCD in patients age > or = 40. We hypothesize that calcite stone formation is a biomineralization response to chronic airway inflammation and retention of infected airway secretions in PCD in a subset of PCD patients

Metabolomics Analysis Reveals Altered Metabolic Pathways and Response to Doxorubicin in Drug-Resistant Triple-Negative Breast Cancer Cells

This study aimed to investigate metabolic changes following the acquisition of resistance to doxorubicin in the triple-negative breast cancer (TNBC) cell line MDA-MB-231. Two drug-resistant cell lines, DOX-RES-50 and DOX-RES-100, were generated by treating MDA-MB-231 cells with doxorubicin for 24 h and allowing them to recover for six weeks. Both drug-resistant cell lines demonstrated an increase in doxorubicin IC50 values, indicating acquired drug resistance. Metabolomics analysis showed clear separation between the parental MDA-MB-231 cell line and the drug-resistant cell lines. Pathway analysis revealed that arginine and proline metabolism, glutathione metabolism, and beta-alanine metabolism were significantly perturbed in the drug-resistant cell lines compared to the parental cell line. After matching signals to an in-house library of reference standards, significant decreases in short- and medium-chain acylcarnitines and significant increases in long-chain acylcarnitines, 5-oxoproline, and 7-ketodeoxycholic acid were observed in the resistant cell lines as compared to the parental MDA-MB-231 cell line. In addition to baseline metabolic differences, we also investigated differences in metabolic responses in resistant cell lines upon a second exposure at multiple concentrations. Results indicate that whereas the parental MDA-MB-231 cell line had many metabolites that responded to doxorubicin in a dose-dependent manner, the two resistant cell lines lost a dose-dependent response for the majority of these metabolites. The study’s findings provide insight into how metabolism is altered during the acquisition of resistance in TNBC cells and how the metabolic response to doxorubicin changes upon repeated treatment. This information can potentially identify novel targets to prevent or reverse multi-drug resistance in TNBC, and also demonstrate the usefulness of metabolomics technology in identifying new mechanisms of drug resistance in cancer and potential drug targets

Disfunción familiar y rendimiento académico en estudiantes de la Institución Educativa N° 162 “San José Obrero” San Juan de Lurigancho-2020

La siguiente investigación tuvo como objetivo general determinar la relación que existe entre la disfunción familiar y el rendimiento académico en el área de matemática en los estudiantes de 5to de secundaria de la I.E N° 162 “San José Obrero” en san juan de Lurigancho-2020, dicha investigación es de tipo básica de nivel correlacional, con un enfoque cuantitativo, de diseño no experimental y de corte transversal. La técnica que se aplico fue la encuesta, con un instrumento que es el cuestionario que está diseñado con 22 ítems, la población estuvo conformada por 73 estudiantes de la Institución Educativa Estatal la cual se trabajó con toda la muestra. Los resultados obtenidos de este estudio, se reflejó que si existe una relación significativa entre la disfunción familiar y el rendimiento académico en el área de matemática en los estudiantes de 5to de secundaria, teniendo con un valor de p = 0,000 siendo este menor al valor de significancia p= 0,05, teniendo así una correlación de 0,625 lo cual indica que es positiva moderada entre ambas variables. Se concluye que la disfunción familiar afecta directamente en el rendimiento académico del estudiante de la Institución Educativa San José Obrero