Wisebite: la gestió intel·ligent de restaurants

La tecnologia està evolucionant de forma exponencial en els últims anys. Tot i així, sembla que hi ha un seguit de sectors en la societat que no s’acaben d’adaptar a aquest canvi. Un d’aquests sectors és el de la restauració. Ja poden existir sistemes d’Intel·ligència Artificial que et realitzen la comanda al supermercat de forma automàtica o bé aplicacions de Realitat Virtual que et permeten estar on vulguis, però encara avui en dia es veuen establiments com bars i restaurants que encara realitzen les comandes a bolígraf i paper. La pregunta que ens realitzem és: per què està passant això? En aquest treball final de grau s’ha estudiat els motius i s’ha analitzat com podria ser la millor solució pel problema comentat. Wisebite, la plataforma que gestiona de forma intel·ligent els establiments de restauració, té com a objectiu solucionar aquesta problemàtica. Així, no només modernitzaria el sector, sinó que també podria oferir millors resultats en qualitat de servei, eficiència i beneficis econòmics als establiments que decideixin implantar-la. Aquesta aplicació, disponible en plataformes Android, et permetrà gestionar internament el teu establiment administrant les comandes dia a dia, et facilitarà un recull de les estadístiques per millorar el teu restaurant i els teus clients podran interaccionar amb l’establiment creant ells mateixos les comandes i valorant el teu restaurant. Amb la realització d’aquest treball final de grau es pretén marcar èmfasi en el concepte que els informàtics tenim més poder en la societat del que pensem. Moltes aplicacions han aparegut del desconeixentment i han generat necessitats que mai pensàvem que existirien. Wisebite té com a objectiu principal millorar el món de la restauració aportant un sistema plenament genèric i personalitzable a l’usuari, que aquest es pugui fer seva la plataforma, i que amb ella pugui millorar el seu establiment. Convertir una simple aplicació en una eina més del dia quotidià de les persones relacionades amb el sector. Dit d’una altra manera, canviar el món.La tecnología está evolucionando de forma exponencial en los últimos años. Sin embargo, parece que hay una serie de sectores en la sociedad que no acaban de adaptarse a este cambio. Uno de estos sectores es el de la restauración. Ya pueden existir sistemas de Inteligencia Artificial que te realizan el pedido en el supermercado de forma automática o bien aplicaciones de Realidad Virtual que te permitan estar donde quieras, pero aún hoy en día se ven establecimientos como bares y restaurantes que aún realizan los pedidos a bolígrafo y papel. La pregunta que nos realizamos es: ¿por qué está pasando esto? En este trabajo final de grado se ha estudiado los motivos y se ha analizado como podría ser la mejor solución para el problema comentado. Wisebite, la plataforma que gestiona de forma inteligente los establecimientos de restauración, tiene como objetivo solucionar esta problemática. Así, no sólo modernizaría el sector, sino que también podría ofrecer mejores resultados en calidad de servicio, eficiencia y beneficios económicos a los establecimientos que decidan implantarla. Esta aplicación, disponible en plataformas Android, te permitirá gestionar internamente tu establecimiento administrando los pedidos día a día, te facilitará una recopilación de las estadísticas para mejorar tu restaurante y tus clientes podrán interaccionar con el establecimiento creando ellos mismos los pedidos y valorando tu restaurante. Con la realización de este trabajo final de grado se pretende poner hincapié en el concepto de que los informáticos tenemos más poder en la sociedad de lo que pensamos. Muchas aplicaciones han aparecido del desconocimiento y han generado necesidades que nunca pensábamos que existirían. Wisebite tiene como objetivo principal mejorar el mundo de la restauración aportando un sistema plenamente genérico y personalizable al usuario, que éste se pueda hacer suya la plataforma, y que con ella pueda mejorar su establecimiento. Convertir una simple aplicación en una herramienta más del día cotidiano de las personas relacionadas con el sector. Dicho de otro modo, cambiar el mundo.Technology has been evolving exponentially in last years. However, it seems that there are a lot of fields in society that have not adapted to this change yet. One of these fields is the restoration. There are Artificial Intelligence systems that make the order in the supermarket automatically or there are Virtual Reality applications that allow you to be where you want, but still today you can see establishments like bars and restaurants that still work with pen and paper. The question that we might ask ourselves is: why is this happening? In this degree final project the reasons have been studied and it has been analysed how it could be the best solution for the commented problem. Wisebite, the platform that intelligently manages restoration establishments, wants to solve this problem. Thus, it would not only modernize the sector, but could also offer better results in terms of service quality, efficiency and economic benefits to establishments that decide to implement it. This application, available on Android platforms, will allow you to manage internally your establishment managing the orders day by day, will provide a set of statistics to improve your restaurant and your customers can interact with the establishment by creating the orders themselves and valuing your restaurant. With the completion of this degree final project, it is intended to emphasize in the concept that we have more power in society than we think. Many applications have appeared out of ignorance and generated needs that we never thought would exist. Wisebite’s main objective is to improve the world of restoration by providing a fully generic and customizable system to the user, so that the user can make the platform his own, and with it can improve its establishment. Convert a simple application into a tool of the daily day of the people related to the sector. Put another way, change the world

Toxines et Transferts ioniques

Collection Rencontres en Toxinologie, ISSN 1760-6004 ; http://sfet.asso.fr/international/images/stories/SFET/pdf/Ebook-RT19-2011-signets.pdfInternational audienc

Inositol Trisphosphate Receptor Mediated Ca2+ Signalling Stimulates Mitochondrial Function and Gene Expression in Core Myopathy Patients

Core myopathies are a group of childhood muscle disorders caused by mutations of the ryanodine receptor (RyR1), the Ca2+ release channel of the sarcoplasmic reticulum. These mutations have previously been associated with elevated inositol trisphosphate receptor (IP3R) levels in skeletal muscle myotubes derived from patients. However, the functional relevance and the relationship of IP3R mediated Ca2+ signalling with the pathophysiology of the disease is unclear. It has also been suggested that mitochondrial dysfunction underlies the development of central and diffuse multi-mini-cores, devoid of mitochondrial activity, which is a key pathological consequence of RyR1 mutations. Here we used muscle biopsies of central core and multi-minicore disease patients with RyR1 mutations, as well as cellular and in vivo mouse models of the disease to characterise global cellular and mitochondrial Ca2+ signalling, mitochondrial function and gene expression associated with the disease. We show that RyR1 mutations that lead to the depletion of the channel are associated with increased IP3-mediated nuclear and mitochondrial Ca2+ signals and increased mitochondrial activity. Moreover, western blot and microarray analysis indicated enhanced mitochondrial biogenesis at the transcriptional and protein levels and was reflected in increased mitochondrial DNA content. The phenotype was recapitulated by RYR1 silencing in mouse cellular myotube models. Altogether, these data indicate that remodelling of skeletal muscle Ca2+ signalling following loss of functional RyR1 mediates bioenergetic adaptation

Brevenal Inhibits Pacific Ciguatoxin-1B-Induced Neurosecretion from Bovine Chromaffin Cells

Ciguatoxins and brevetoxins are neurotoxic cyclic polyether compounds produced by dinoflagellates, which are responsible for ciguatera and neurotoxic shellfish poisoning (NSP) respectively. Recently, brevenal, a natural compound was found to specifically inhibit brevetoxin action and to have a beneficial effect in NSP. Considering that brevetoxin and ciguatoxin specifically activate voltage-sensitive Na+ channels through the same binding site, brevenal has therefore a good potential for the treatment of ciguatera. Pacific ciguatoxin-1B (P-CTX-1B) activates voltage-sensitive Na+ channels and promotes an increase in neurotransmitter release believed to underpin the symptoms associated with ciguatera. However, the mechanism through which slow Na+ influx promotes neurosecretion is not fully understood. In the present study, we used chromaffin cells as a model to reconstitute the sequence of events culminating in ciguatoxin-evoked neurosecretion. We show that P-CTX-1B induces a tetrodotoxin-sensitive rise in intracellular Na+, closely followed by an increase in cytosolic Ca2+ responsible for promoting SNARE-dependent catecholamine secretion. Our results reveal that brevenal and β-naphtoyl-brevetoxin prevent P-CTX-1B secretagogue activity without affecting nicotine or barium-induced catecholamine secretion. Brevenal is therefore a potent inhibitor of ciguatoxin-induced neurotoxic effect and a potential treatment for ciguatera

Detection of Anatoxin-a and Three Analogs in Anabaena spp. Cultures: New Fluorescence Polarization Assay and Toxin Profile by LC-MS/MS

Anatoxin-a (ATX) is a potent neurotoxin produced by several species of Anabaena spp. Cyanobacteria blooms around the world have been increasing in recent years; therefore, it is urgent to develop sensitive techniques that unequivocally confirm the presence of these toxins in fresh water and cyanobacterial samples. In addition, the identification of different ATX analogues is essential to later determine its toxicity. In this paper we designed a fluorescent polarization (FP) method to detect ATXs in water samples. A nicotinic acetylcholine receptor (nAChR) labeled with a fluorescein derivative was used to develop this assay. Data showed a direct relationship between the amount of toxin in a sample and the changes in the polarization degree of the emitted light by the labeled nAChR, indicating an interaction between the two molecules. This method was used to measure the amount of ATX in three Anabaena spp. cultures. Results indicate that it is a good method to show ATXs presence in algal samples. In order to check the toxin profile of Anabaena cultures a LC-MS/MS method was also developed. Within this new method, ATX-a, retention time (RT) 5 min, and three other molecules with a mass m/z 180.1 eluting at 4.14 min, 5.90 min and 7.14 min with MS/MS spectra characteristic of ATX toxin group not previously identified were detected in the Anabaena spp. cultures. These ATX analogues may have an important role in the toxicity of the sampleThe research leading to these results has received funding from the following FEDER cofunded-grants: From Ministerio de Ciencia y Tecnología, Spain: AGL2009-13581-CO2-01, AGL2012-40485-CO2-01. From Xunta de Galicia, Spain: 10PXIB261254 PR. From the European Union’s Seventh Framework Programme managed by REA—Research Executive Agency http://ec.europa.eu/research/rea (FP7/2007-2013) under grant agreement Nos. 211326—CP (CONffIDENCE), 265896 BAMMBO, 265409 µAQUA, and 262649 BEADS, 315285 Ciguatools and 312184 PharmaSea. From the Atlantic Area Programme (Interreg IVB Trans-national): 2008-1/003 (Atlantox) and 2009-1/117 (Pharmatlantic)S

Síndrome de Cushing durante el embarazo: manifestaciones cutáneas secundarias a un tumor suprarrenal

El síndrome de Cushing secundario a tumor suprarrenal es una patología infrecuente en el embarazo. Su presencia se traduce en un aumento significativo de la morbimortalidad materna y fetal. Muchas de sus características clínicas son enmascaradas por los cambios propios de una gestación fisiológica, lo que dificulta el diagnóstico. En este contexto las manifestaciones dermatológicas pueden ser de gran utilidad en la sospecha clínica precoz. Se presenta el caso de una paciente de 26 años de edad que en el segundo trimestre de embarazo inicia un cuadro caracterizado por acné inflamatorio severo e hirsutismo. La gestación se interrumpe a las 35 semanas por síndrome hipertensivo del embarazo y rotura prematura de membranas. Durante el puerperio consulta al dermatólogo presentando aún las lesiones descritas, además de estrías violáceas gruesas en abdomen, facie de luna, obesidad centrípeta y máculas purpúricas en zonas de presión. Se diagnóstica síndrome de Cushing. El estudio confirmatorio y etiológico dirigido evidenció un adenoma de corteza suparrenal. El diagnóstico de laboratorio es difícil debido a los cambios físicos y de laboratorio habituales del embarazo que pueden mimetizar los hallazgos propios de la enfermedad. Los hallazgos dermatológicos pueden ser de gran valor para un diagnóstico y tratamiento precoz. Las lesiones dermatológicas secundarias al hipercortisolismo fueron de difícil manejo

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

SummaryMechanisms that regulate cellular metabolism are a fundamental requirement of all cells. Most eukaryotic cells rely on aerobic mitochondrial metabolism to generate ATP. Nevertheless, regulation of mitochondrial activity is incompletely understood. Here we identified an unexpected and essential role for constitutive InsP3R-mediated Ca2+ release in maintaining cellular bioenergetics. Macroautophagy provides eukaryotes with an adaptive response to nutrient deprivation that prolongs survival. Constitutive InsP3R Ca2+ signaling is required for macroautophagy suppression in cells in nutrient-replete media. In its absence, cells become metabolically compromised due to diminished mitochondrial Ca2+ uptake. Mitochondrial uptake of InsP3R-released Ca2+ is fundamentally required to provide optimal bioenergetics by providing sufficient reducing equivalents to support oxidative phosphorylation. Absence of this Ca2+ transfer results in enhanced phosphorylation of pyruvate dehydrogenase and activation of AMPK, which activates prosurvival macroautophagy. Thus, constitutive InsP3R Ca2+ release to mitochondria is an essential cellular process that is required for efficient mitochondrial respiration and maintenance of normal cell bioenergetics

The young open cluster NGC 7067 using Strömgren photometry

© 2016 The Authors. NGC 7067 is a young open cluster located in the direction between the first and the second Galactic quadrants and close to the Perseus spiral arm. This makes it useful for studies of the nature of the MilkyWay spiral arms. Strömgren photometry taken with theWide Field Camera at the Isaac Newton Telescope allowed us to compute individual physical parameters for the observed stars and hence to derive the cluster's physical parameters. Spectra from the 1.93-m telescope at the Observatoire de Haute-Provence helped to check and improve the results. We obtained photometry for 1233 stars, individual physical parameters for 515 and spectra for 9 of them. The 139 selected cluster members lead to a cluster distance of 4.4 ±0.4 kpc, with an age below log10(t(yr)) = 7.3 and a present mass of 1260 ± 160 M⊙. The morphology of the data reveals that the centre of the cluster is at (α, δ) = (21: 24: 13.69, +48: 00: 39.2) J2000, with a radius of 6.1 arcmin. Strömgren and spectroscopic data allowed us to improve the previous parameters available for the cluster in the literature