Recent advances in the molecular understanding of glioblastoma

Glioblastoma is the most common and most aggressive primary brain tumor. Despite maximum treatment, patients only have a median survival time of 15 months, because of the tumor’s resistance to current therapeutic approaches. Thus far, methylation of the O6-methylguanine-DNA methyltransferase (MGMT) promoter has been the only confirmed molecular predictive factor in glioblastoma. Novel “genome-wide” techniques have identified additional important molecular alterations as mutations in isocitrate dehydrogenase 1 (IDH1) and its prognostic importance. This review summarizes findings and techniques of genetic, epigenetic, transcriptional, and proteomic studies of glioblastoma. It provides the clinician with an up-to-date overview of current identified molecular alterations that should ultimately lead to new therapeutic targets and more individualized treatment approaches in glioblastoma

Understanding and strengthening European Union-Canada relations in Law of the Sea and Ocean Governance

The recent history of international ocean relations between Canada and the European Union (EU) merits particular scholarly attention. The headlines in the media have tended to focus on differences rather than commonalities, and in particular those few differences that led to confrontation, probably not without some assistance from the media. The “Turbot War” in the 1990s is by now a classic case of confrontation on the high seas motivated by conflicting fisheries and related conservation interests.https://digitalcommons.schulichlaw.dal.ca/faculty_books/1080/thumbnail.jp

Willingness to Share Research Data Is Related to the Strength of the Evidence and the Quality of Reporting of Statistical Results

Background The widespread reluctance to share published research data is often hypothesized to be due to the authors' fear that reanalysis may expose errors in their work or may produce conclusions that contradict their own. However, these hypotheses have not previously been studied systematically. Methods and Findings We related the reluctance to share research data for reanalysis to 1148 statistically significant results reported in 49 papers published in two major psychology journals. We found the reluctance to share data to be associated with weaker evidence (against the null hypothesis of no effect) and a higher prevalence of apparent errors in the reporting of statistical results. The unwillingness to share data was particularly clear when reporting errors had a bearing on statistical significance. Conclusions Our findings on the basis of psychological papers suggest that statistical results are particularly hard to verify when reanalysis is more likely to lead to contrasting conclusions. This highlights the importance of establishing mandatory data archiving policies

Higher levels of CO2 during late incubation alter the hatch time of chicken embryos

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Forced Expiratory Volume in One Second (Fev-1) Pada Penduduk Yang Tinggal Di Dataran Tinggi

: Livingin highlands as geographical factors related to the nature of the climate influences the shape of the human body. There is a tendency of people who live in the highlands have bigger circle chest and lungs than the people who live in the lowlands. Numerous studies shows the degree of lung function in people living at highlandsare greater than the people living in the lowlands. This study aims to determine the profile of FEV-1 of the people who lives in highlands. This is a descriptive type of research that uses distribution tables. The subject of this researchare people aged 20-70 years made ​​up of 30 womens who live in the highlands. The data is obtained through the measurement of FEV-1 using Spirometer Sibel TS8248 / 1. Different fromthe results of previous studies and based on the results of the measurement and distribution table of FEV-1 obstructive degree, 29 people of the population have normal value and 1 person has a mild obstructive value. The is, almost all of the subjectsthat were studied has normal value of FEV-1

Do We Hold Males and Females to the Same Standard? A Measurement Invariance Study on the Psychopathy Checklist-Revised

ABSTRACT Psychopathy in females has been understudied. Extant data on gender comparisons using the predominant measure of assessment in clinical practice, the Psychopathy Checklist Revised (PCL-R), points to a potential lack of measurement invariance (MI). If indeed the instrument does not perform equally (well) in both genders, straightforward comparison of psychopathy scores in males and females is unwarranted. Using a sample of female and male forensic patients (N ¼ 110 and N ¼ 147 respectively), we formally tested for MI in a structural equation modeling framework. We found that the PCL-R in its current form does not attain full MI. Four items showed threshold biases and particularly Factor 2 (the Social Deviance Factor) is gender biased. Based on our findings, it seems reasonable to expect that specific scoring adjustments might go a long way in bringing about more equivalent assessment of psychopathic features in men and women. Only then can we begin to meaningfully compare the genders on the prevalence, structure, and external correlates of psychopath