KLINIČKE PRIČE I MEDICINSKE ANAMNEZE KOJE JE ZABILJEŽIO RHAZES (865.–925.), IRANSKO‑ISLAMSKI LIJEČNIK SREDNJEGA VIJEKA

Recording medical histories of patients is not a new issue in clinical medicine. However, the method practiced by the Iranian chemist physician, Rhazes, in the ninth century A.D is incredible. Rhazes has written several textbooks in clinical medicine, but a particular one, “Clinical Stories and Medical Histories” (Qesas va hekayat al-marazi), is a classical case book describing precise clinical courses of thirty three patients. Each chapter includes a title, the name and demographic data about a patient, his/her history of present illness, past medical and family history, findings of physical exam, impression and interventions by the physician, including pharmacological or surgical management. The reasons for each decision made by Rhazes as well as the outcomes are clearly discussed. This book review will shed light on the unknown medical practice methods in Islamic-Iranian golden era.Bilježenje medicinske anamneze pacijenata nije novo pitanje kliničke medicine. Kako bilo, metoda koju je prakticirao Rhazes, iranski kemičar i liječnik, u devetom stoljeću zadivljujuća je. Rhazes je napisao nekoliko udžbenika iz kliničke medicine, ali ona kratka, Kliničke priče i medicinske anamneze, klasična je knjiga prikaza slučajeva koja opisuje točan klinički tijek kod trideset i tri pacijenta. Svako poglavlje uključuje naslov, ime i demografske podatke o pacijentu, njenu/njegovu povijest trenutne bolesti, prošlu medicinsku i obiteljsku povijest bolesti, nalaze fizikalnog pregleda, utiske i intervencije liječnika, uključujući farmakološke i/ili kirurške postupke. Razlozi su svake Rhazesove odluke kao i rezultati jasno raspravljeni. Čitanje zabilješki u ovoj knjizi pomaže osvijetliti nepoznate kutke koji se tiču metoda medicinskih praksi u vrijeme rađanja islamskoiranske civilizacije

Recombinant production of Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (sTRAIL) as a therapeutic protein

Abstract:  Successfully cancer therapies aim to induce apoptosis in cancer cell lines. Recent advances in cancer therapy based on the use of some recombinant proteins such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). TRAIL is a new member of the TNF superfamily. In this paper, we report the expression, purification, and  preparation of a recombinant form of the extracelluar domain of the TRAIL (sTRAIL) in Escherichia coli rosetta gami under the control of T7 promoter; which  may selectively induce apoptosis of tumor cells in vitro. To obtain recombinant sTRAIL protein, the encoding region for sTRAIL was cloned between Xho1 and BamHI in pET28a expression vector. The results showed that the recombinant sTRAIL was efficiently produced in Ecoli rosetta gami strain.                               Introduction: Apoptosis is an evolutionarily conserved and essential for maintenance of  tissue homeostasis and removal of unwanted cells. TRAIL belongs to the group of therapeutic agents selectively targeting a wide variety of cancer cells without affecting the normal cells .The therapeutic potential of TRAIL is attributed to its receptor expression in a variety of tissues; which initiates apoptosis in cancer cells through interaction with the death receptors DR4 and DR5. Due to its selective nature, it is considered as a significant therapeutic agent in cancer therapy. The purpose of this study was to produce recombinant human sTRAIL in Rosetta Gami2 E.coli strain and its functions on cancerous cells in vitro. Methods and results:  we optimized the coding sequence of this protein. The recombinant plasmid was transformed into Rosetta Gami2 E.coli strain for expression. The transformed bacteria which contain recombinant plasmid were cultured in 37ºC with 250 rpm in LB and in 20ºC in TB medium for 18 hours. TRAIL was purified by Ni sepharose column, and the presence of the recombinant protein was confirmed by SDS-PAGE. The concentration of purified protein was measured by Bradford assay. Our finding showed that the recombinant protein (34kD) has been successfully produced for next experiments, the purified protein was desalted and applied toward cancerous cells. Conclusions: In summary, TRAIL can be considered as a promising therapeutic agent for effective, targeted and less toxic agents for treatment of cancers

KLINIČKE PRIČE I MEDICINSKE ANAMNEZE KOJE JE ZABILJEŽIO RHAZES (865.–925.), IRANSKO‑ISLAMSKI LIJEČNIK SREDNJEGA VIJEKA

Recording medical histories of patients is not a new issue in clinical medicine. However, the method practiced by the Iranian chemist physician, Rhazes, in the ninth century A.D is incredible. Rhazes has written several textbooks in clinical medicine, but a particular one, “Clinical Stories and Medical Histories” (Qesas va hekayat al-marazi), is a classical case book describing precise clinical courses of thirty three patients. Each chapter includes a title, the name and demographic data about a patient, his/her history of present illness, past medical and family history, findings of physical exam, impression and interventions by the physician, including pharmacological or surgical management. The reasons for each decision made by Rhazes as well as the outcomes are clearly discussed. This book review will shed light on the unknown medical practice methods in Islamic-Iranian golden era.Bilježenje medicinske anamneze pacijenata nije novo pitanje kliničke medicine. Kako bilo, metoda koju je prakticirao Rhazes, iranski kemičar i liječnik, u devetom stoljeću zadivljujuća je. Rhazes je napisao nekoliko udžbenika iz kliničke medicine, ali ona kratka, Kliničke priče i medicinske anamneze, klasična je knjiga prikaza slučajeva koja opisuje točan klinički tijek kod trideset i tri pacijenta. Svako poglavlje uključuje naslov, ime i demografske podatke o pacijentu, njenu/njegovu povijest trenutne bolesti, prošlu medicinsku i obiteljsku povijest bolesti, nalaze fizikalnog pregleda, utiske i intervencije liječnika, uključujući farmakološke i/ili kirurške postupke. Razlozi su svake Rhazesove odluke kao i rezultati jasno raspravljeni. Čitanje zabilješki u ovoj knjizi pomaže osvijetliti nepoznate kutke koji se tiču metoda medicinskih praksi u vrijeme rađanja islamskoiranske civilizacije

Associations between Potential Inflammatory Properties of the Diet and Frequency, Duration, and Severity of Migraine Headaches: A Cross-Sectional Study

Despite a large body of literature on the association between the dietary inflammatory index (DII) and various chronic diseases, limited knowledge is available regarding the association between DII and migraine. Therefore, we assessed the relationship between the DII and migraine characteristics, including duration, frequency, and severity of migraine headaches, Headache Impact Test-6 (HIT-6), and serum levels of nitric oxide (NO). This population-based cross-sectional study was conducted from August 2019 to June 2020 among 262 patients (38 men and 224 women; 20-50 years). A 168-item semiquantitative food frequency questionnaire (FFQ) was gathered to evaluate dietary intake, and subsequently, an energy-adjusted DII score was calculated. After controlling for potential confounders, an increase of 3.48 in headache frequency was observed when the DII score increased from - 4.04 to - 1.83 (β = 3.48; 95% CI 1.43, 5.54). In the crude model, headache duration tended to be inversely associated with DII in the subjects with the pro-inflammatory diet compared to those with the anti-inflammatory diet (β = - 0.22; 95% CI - 0.46, 0.02). After adjustment for confounders, those with the highest DII values were at a higher risk of severe headaches than those with the lowest values (OR = 2.25; 95% CI 1.17, 4.32). No other significant results were found in terms of the association between DII and HIT-6 or serum NO levels. We found evidence suggesting that higher adherence to a diet with anti-inflammatory properties was significantly and inversely related to headache frequency. Furthermore, our results suggest that the DII score is substantially related to migraine severity

Comparing the Effects of Aquatic and Land-based Exercises on the Bio-motor Abilities of Elderly Men

Background: Physical activity, whether in water or on land, can improve motor disorders in the elderly. However, the more effective type of exercise remains inconspicuous. Aim: To compare the effects of aquatic and land-based exercises on the bio-motor abilities of elderly men. Method: This clinical trial was performed on 60 elderly men visiting Imamat and Daneshamuz health centers in Mashhad, Iran, in 2016. The eligible volunteers were randomly assigned to two groups (n=30 each). In one group, the subjects attended aquatic exercise sessions for six weeks, while the other group participated a land-based exercise program. Bio-motor abilities of the subjects including motor ability, flexibility, and general endurance were evaluated before and immediately after the intervention and recorded in a researcher-made checklist. Data were analyzed in SPSS, version 16, using the independent t-test, paired t-test, Chi-square test, Fisher’s exact test, and exact Chi-square test. Results: The mean ages of the aquatic exercise and land-based exercise groups were respectively 69.9±5.1 and 68.0±5.0 years. Post-intervention, the aquatic exercise group showed significantly higher motor ability (P=0.01) and general endurance (P=0.02) than did the other group. However, the difference in final flexibility of the groups was not significant (P=0.252). Paired t-test showed a significant improvement in bio-motor abilities of both groups post-intervention (

Comparison ability of algae and nanoparticles on nitrate and phosphate removal from aquaculture wastewater

Background: Aquaculture wastewater contains high levels of phosphate and nitrate. The reuse of this water requires standards beyond the secondary standards to eliminate more organic pollutants from aquaculture effluents. In this research, the removal of these pollutants from wastewater using Chlorella vulgaris and Fe3O4 nanoparticles in the reactor space was investigated. Methods: This study was conducted on fish farms effluent in the laboratory system. For this purpose, a 5-L semi-industrial reactor with a mixer blade, porous plate, and a compressor was designed. Chlorella vulgaris samples were collected from the natural environment and cultured in the laboratory environment. Also, Fe3O4 nanoparticles were prepared from Iranian Nano Pishgaman Company to make the desired solution. During the experiment (3 weeks), samples were taken weekly (in one phase) from the effluent. Dissolved oxygen (DO), pH, nitrate (NO3), and phosphate (PO4) factors from the influent and effluent of the farms were measured. The statistical data were analyzed using SPSS version 21 and Excel 2013. Results: The amounts of nitrate and phosphate were decreased by about 80.76 and 80.55% in the biological reactor, whereas these amounts were 70.52 and 70.48% in the nanoparticle reactor, respectively. Also, there were significant differences in the amounts of NO3 and PO4 between the control treatment and weekly treatment (P < 0.05). Conclusion: Based on the results, both reactors were able to reduce nitrate and phosphate from aquaculture wastewater, but the efficiency of the biological reactor was higher than that of the nanoparticle reactor. Keywords: Nitrate, Phosphate, Fe3O4 nanoparticle, Chlorella vulgaris, Biological refinemen

Interpretation of Rock Mass Behaviour via Multiple Graph Approach: Adit P-C9 of the Alborz Tunnel

The current paper focuses on the application and advantages of the “multiple graph” approach for interpretation of surrounding rock mass behaviour in underground structures. Behaviour of the Argillitic rock mass surrounding Adit P-CP9 of the Alborz Tunnel was interpreted via the “multiple graph” approach resulting in interestingly accurate prediction. The accuracy of the estimation was later observed in the excavation process and afterwards. The observed results are presented which verifies that the “multiple graph” approach can cope satisfactorily with various geological conditions

Challenges in Translation of Proper Nouns: A Case Study in Persian Translation of George Orwell’s Animal Farm

Nowadays, one of the important problems in translation field will be Translation of Proper Nouns. This is an arduous task in Translation Studies to convey the main essence of the nouns amongst cultures. This is somehow due to the fact that every culture has its own system of rendering of proper nouns. Longman Dictionary of Language Teaching and Applied Linguistics (Richards Schmidt, 2002, p.429) defines the proper name as "a name which is the name of a particular person, place, or thing. Proper nouns have disparate allusions such as age, sex, specific connotations, and geographical regions. This study scrutinized two major translations of Animal Farm of George Orwell. The first rendering is pertained to Amirshahi (2010) and the second one Firuzbakht (1988). Finally, this study seeks to investigate the translation procedures of proper nouns in accordance with Newmark and Vermeer’s (Skopos) theories of translation. This study shows that Newmark mostly peruses proper noun artificially to saturate the taste of the reader. While, Vermeer sets up the mutual agreement between the reader as the client and the translator in this process.