Reduction of trichloromethyl to gem-dichloromethyl group with triphenylphosphine and water in ethyl acetate

En este trabajo se reporta un método de reducción de triclorometil compuestos bajo condiciones amigables al medio ambiente.A novel and efficient way of reducing trichloromethyl to gem-dichloromethyl compounds using environmentally friendly conditions has been developed. This reduction process consists of the treatment of a trichloromethyl compound with water and triphenylphosphine using ethyl acetate as solvent. This reaction proceeds in good yield when a strong electron-withdrawing group is attached to the trichloromethyl derivative.Conacy

Health + Efficiency House: A Take on the 50x50 Glass House

Under the guidance of Professor Edmond Saliklis and Professor Meredith Sattler, four Architectural Engineering students joined forces with three Architecture students from both Cal Poly and Vilnius Technical University in Lithuania. The portfolio exemplifies a complete reimagination of Mies van der Rohe and Myron Goldsmith\u27s 50x50 Glass House as if it were designed today in Palm Springs, CA. The work completed in this interdisciplinary studio includes historical context, abstract creation, architectural and structural design all relating back to the Glass House

Gestión administrativa y su mejora de calidad en el ISO 37001 del personal de la Dirección de Hidrografía y Navegación de la Marina de Guerra del Perú, 2021

La presente investigación tuvo el objetivo de establecer la relación entre la gestión administrativa y la mejora de la calidad en el ISO 37001 del personal de la Dirección de Hidrografía y Navegación. La investigación fue de tipo básica, con un nivel descriptivo – correlacional, de diseño no experimental, con corte transversal y enfoque cuantitativo. La población fue de 210 personas, optando por aplicar el censo a una muestra de 40 colaboradores dentro de las áreas administrativas tales como administración, abastecimiento, control interno y secretaría general de la Dirección de Hidrografía y Navegación. La técnica de recolección de datos a emplear fue la encuesta, con el instrumento del cuestionario de preguntas, éstos fueron validados por medio del juicio de expertos, y sobre el grado de confiabilidad, fue a través de la prueba estadística Alfa de Cronbach, obteniendo el resultado de un coeficiente de 0,915

BeCAPTCHA-Type: Biometric Keystroke Data Generation for Improved Bot Detection

This work proposes a data driven learning model for the synthesis of keystroke biometric data. The proposed method is compared with two statistical approaches based on Universal and User-dependent models. These approaches are validated on the bot detection task, using the keystroke synthetic data to improve the training process of keystroke-based bot detection systems. Our experimental framework considers a dataset with 136 million keystroke events from 168 thousand subjects. We have analyzed the performance of the three synthesis approaches through qualitative and quantitative experiments. Different bot detectors are considered based on several supervised classifiers (Support Vector Machine, Random Forest, Gaussian Naive Bayes and a Long Short-Term Memory network) and a learning framework including human and synthetic samples. The experiments demonstrate the realism of the synthetic samples. The classification results suggest that in scenarios with large labeled data, these synthetic samples can be detected with high accuracy. However, in few-shot learning scenarios it represents an important challenge. Furthermore, these results show the great potential of the presented models.Comment: Paper accepted in IEEE Computer Society Workshop on Biometrics (CVPRw) 202

Anthelmintic effects of Salix babylonica L. and Leucaena leucocephala Lam. extracts in growing lambs

In Mexico, small ruminant production has important social and economic functions, especially for small rural farmers who rely on these animals as a source of food and income. Production efficiency of ruminants has been limited by nutritional and sanitary problems with helminth infections being one of the major health conditions affecting humans and livestock. Exposure to nematode parasites depends on the husbandry system under which livestock are raised. In situations where Mexican farmers are almost entirely dependent on grazing, exposure to nematode larvae is continuous throughout the year. Gastrointestinal nematode parasitism is a major cause of sheep and goat mortality in tropical Mexico (Canul-Ku et al. 2012) and other tropical countries (Carvalho et al. 2012). The impacts of gastrointestinal nematode parasitism in practical systems has stimulated research into alternative medications, such as medicinal plants or tree leaf extracts, which are used in ruminants, donkeys, camels, and humans (Wabo-Pone et al. 2009; Carvalho et al. 2012).Twenty Katahdin×Pelibuey crossbreed male lambs, 3 to 4 months of age and 24±0.3 kg of body weight, were used to study the anthelmintic effects of administering extracts of Salix babylonica L. (SB) and Leucaena leucocephala Lam. (LL). Lambs had not been treated with anthelmintics previously and were randomly allocated into four groups of five lambs each in a completely randomized design. Treatments were as follows: control (lambs fed on total mixed ration without extracts), SB (as control plus S. babylonica L. extract at 30 ml/day), LL (as control plus L. leucocephala Lam. extract at 30 ml/day), and SBLL (as control plus 30 ml/day of S. babylonica L. and L. leucocephala Lam. extracts in a 1:1 (v/v) mixture) for 63 days. Extracts were orally administered before the 8:00 a.m. feeding to each lamb. Rectal fecal samples were collected from each lamb at day 22 (P1), day 43 (P2), and day 63 (P3) of the experiment. Adult worm and egg counts were determined in each fecal sample immediately after collection. Plant secondary metabolites of total phenolics, saponins, and the aqueous fraction were 50 % lower in the SB versus LL extracts. Overall, the oral administration of extracts has improved the egg and worm count reductions in lamb feces by 54, 47, and 40 % for LL, SB, and SBLL, respectively, versus the control lambs. Reductions of worm egg counts in lamb feces were higher (P <0.05) in P2 and P3 versus P1. Extracts of SB and LL or possibly isolated bioactive compounds could be a promising alternative to conventional anthelmintics to treat gastrointestinal parasites of small ruminants. Such treatments could be used in control strategies against gastrointestinal nematodes in organic and conventional production systems

Influence of Salix babylonica extract addition on in vitro rumen gas production and degradability of ryegrass silage harvested in different cutting days

Four cutoffs of ryegrass after 15 days (CD15), 30 days (CD30), 45 days (CD45), and 60 days (CD60) with Salix babylonica (SB) extract at 0, 30, and 60 ml/kg ryegrass silage were ensiled for 40 days and then evaluated for the in vitro dry matter (DM) digestibility and gas production (GP). No interactions occurred between cutting day and SB extract for silage’s nutrient contents and in vitro GP. The DM and organic matter (OM) contents were decreased linearly with decreased crude protein (CP), neutral detergent fibres, acid detergent fibres, and acid detergent lignin contents with advancing of days. In contrary, addition of SB extract increased silages’ OM and decreased CP contents. Addition of SB extract for CD15 and CD60 silages, quadratically decreased the lag time. However, SB extract increased the rate of GP and GP during the first 12 h of incubation at the level of 30 ml/kg with CD30 silage and asymptotic GP with the level 60 ml/kg of CD60 silage. Increased DM degradability (DMD) of CD30 and CD60 silages versus decreased DMD with CD15 with increased relative GP (ml gas/g DMD). It could be concluded that CD15 had the highest DM and OM content; however, higher GP was noted with CD45 and CD60. SB extract had weak effects on nutrient content and GP, and the level of 30 ml/kg DM was more effective than the level of 60 ml/kg DM

Propuesta de un sistema de gestión de calidad en la empresa METALPIN S.A.S. conforme a la Norma ISO 9001- 2015

Representación esquemática de los elementos de un procesos, Ciclo PHVA, evolución de la norma iso, mapa de proceso, gestión de riesgo, procesos operativos.El sistema de gestión de la calidad, es la forma mediante el cual una empresa u organización ordena sus procesos para intentar conseguir la satisfacción del cliente. Al Implementar un Sistema de Gestión puede generar diversos beneficios para la empresa. Dentro de los cuales podemos establecer la medición de los resultados, la fluidez de comunicación entre los procesos, y la mejora continua principalmente. Si decidimos implantar un Sistema de Gestión, debemos tener en cuenta que se puede conseguir un certificado ISO de la norma 9001:2015. Esto permitirá que tanto nuestros clientes, como proveedores o terceras partes relacionadas con la empresa, tengan una mejor imagen de nuestra empresa u organización. Es por esto que el tema central de la investigación de aplicación práctica, con metodología descriptiva y cualitativa, consistió en proponer un sistema de gestión de calidad para la empresa METALPIN S.A.S. en la ciudad de Cartagena de indias, de acuerdo con la norma ISO 9001 versión 2015, basada en gestión del riesgo o enfoque basado en riesgos. La finalidad de esta implantación es que se puedan optimizar los procesos y se consigne una mejora continua, para obtener un producto o un servicio conforme que nos genere un alto nivel de satisfacción de los clientes. El sistema de gestión de la calidad, es la forma mediante el cual una empresa u organización ordena sus procesos para intentar conseguir la satisfacción del cliente. Al Implementar un Sistema de Gestión puede generar diversos beneficios para la empresa. Dentro de los cuales podemos establecer la medición de los resultados, la fluidez de comunicación entre los procesos, y la mejora continua principalmente. Si decidimos implantar un Sistema de Gestión, debemos tener en cuenta que se puede conseguir un certificado ISO de la norma 9001:2015. Esto permitirá que tanto nuestros clientes, como proveedores o terceras partes relacionadas con la empresa, tengan una mejor imagen de nuestra empresa u organización. Es por esto que el tema central de la investigación de aplicación práctica, con metodología descriptiva y cualitativa, consistió en proponer un sistema de gestión de calidad para la empresa METALPIN S.A.S. en la ciudad de Cartagena de indias, de acuerdo con la norma ISO 9001 versión 2015, basada en gestión del riesgo o enfoque basado en riesgos. La finalidad de esta implantación es que se puedan optimizar los procesos y se consigne una mejora continua, para obtener un producto o un servicio conforme que nos genere un alto nivel de satisfacción de los clientes. Implementar un sistema de gestión de la calidad en una empresa del sector de la metalmecánica, es una oportunidad para aplicar la norma ISO 9001 versión 2015, y establecer los principios que conforman dicho sistema, además de obtener un producto conforme basado en los planes de mejora de la maquinaria, los materiales y los sistemas de producción. La norma ISO 9001 es una herramienta que toda empresa tanto de servicio como de productos debe implementar, si quiere posicionarse en el sector. En la actualidad el enfoque para el diseño de un sistema de gestión de la calidad está aumentando aun en las empresas más pequeñas, partiendo de la necesidad que obliga a los directivos a mejorar sus procesos y obtener un alto rendimiento en la productividad. Y más si el objetivo de esta norma en la versión 2015 es la de gestionar el riesgo, identificando los cuellos de botella en los procesos y gerenciar un plan de acción para cada riesgo.The quality management system is the way in which a company or organization organizes its processes to try to achieve customer satisfaction. Implementing a Management System can generate various benefits for the company. Within which we can establish the measurement of the results, the fluidity of communication between the processes, and the continuous improvement mainly. If we decide to implement a Management System, we must bear in mind that an ISO certificate of the 9001: 2015 standard can be obtained. This will allow our customers, suppliers or third parties related to the company, to have a better image of our company or organization. That is why the central theme of the research of practical application, with descriptive and qualitative methodology, consisted in implementing a quality management system for the company METALPIN S.A.S. from the city of Cartagena de Indias, according to ISO 9001 version 2015, based on risk management or risk-based approach. The purpose of this implementation is that processes can be optimized and continuous improvement is ensured, in order to obtain a product or a conforming service that generates a high level of customer satisfaction. design a quality management system in a company in the metalworking sector, is an opportunity to apply ISO 9001 version 2015, and establish the principles that make up this system, in addition to obtaining a conforming product based on improvement plans of machinery, materials and production systems. The ISO 9001 standard is a tool that every company of both service and products must implement, if it wants to position itself in the sector. At present, the approach to the implementation of a quality management system is increasing even in the smallest companies, starting from the need that forces the managers to improve their processes and obtain a high yield in productivity. And more if the objective of this standard in the 2015 version is to manage the risk, identifying the bottlenecks in the processes and manage an action plan for each risk