Evolution of the decay mechanisms in central collisions of XeXe + SnSn from E/AE/A = 8 to 29 MeVMeV

Collisions of Xe+Sn at beam energies of $E/A$ = 8 to 29 $MeV$ and leading to fusion-like heavy residues are studied using the $4\pi$ INDRA multidetector. The fusion cross section was measured and shows a maximum at $E/A$ = 18-20 $MeV$. A decomposition into four exit-channels consisting of the number of heavy fragments produced in central collisions has been made. Their relative yields are measured as a function of the incident beam energy. The energy spectra of light charged particles (LCP) in coincidence with the fragments of each exit-channel have been analyzed. They reveal that a composite system is formed, it is highly excited and first decays by emitting light particles and then may breakup into 2- or many- fragments or survives as an evaporative residue. A quantitative estimation of this primary emission is given and compared to the secondary decay of the fragments. These analyses indicate that most of the evaporative LCP precede not only fission but also breakup into several fragments.Comment: Invited Talk given at the 11th International Conference on Nucleus-Nucleus Collisions (NN2012), San Antonio, Texas, USA, May 27-June 1, 2012. To appear in the NN2012 Proceedings in Journal of Physics: Conference Series (JPCS

Incidence of depression and associated factors in patients with type 2 diabetes in Quebec, Canada

It has been reported that the risk of depression is higher among people with type 2 diabetes compared with a nondiabetic population. Among diabetic patients, depression has been associated with worse self-care behaviors, poor glycemic control, and an increased risk of diabetes complications. Identifying factors associated with the occurrence of depression may help physicians identify earlier diabetic patients at a high risk of developing depression, improve prevention, and accelerate proper treatment. To our knowledge, very few population-based studies have reported on the incidence of clinically diagnosed depression as a consequence of type 2 diabetes over a long follow-up period. The objective of this study was to estimate the incidence of clinically diagnosed depression among type 2 diabetic patients newly treated with oral antidiabetic drugs (ADs) and to identify factors associated with the occurrence of depression. Administrative claims data from the public health insurance plan were used to identify a cohort of new oral AD users aged ≥18 years between 2000 and 2006. Patients were followed from oral AD treatment initiation until the diagnosis of depression, ineligibility for the public drug plan, death, or the end of the study, whichever came first. Incidence rates were determined using person-time analysis. Factors associated with depression were identified using multivariable Cox regression analysis. We identified 114,366 new oral AD users, of which 4808 had a diagnosis of depression. The overall incidence rate of depression was 9.47/1000 person-years (PYs) (10.72/1000 PYs for women and 8.27/1000 PYs for men). The incidence of depression was higher during the year after oral AD treatment initiation. Independent factors associated with depression included having had mental disorders other than depression, hospitalization, a higher number of different drugs taken and of physicians visited during the year before oral AD initiation. Moreover, we observed a statistically significant age-by-socioeconomic status interaction. The incidence of diagnosed depression is higher during the first year after oral AD treatment initiation. Clinicians could pay particular attention to women, patients starting an AD at a young age, those with a low socioeconomic status, and especially those with a history of anxiety or dementia

Factors associated with antidiabetic medication non-adherence in patients with incident comorbid depression

Aim To identify factors associated with antidiabetic drug (AD) non-adherence among patients with type 2 diabetes and depression. Study Design and Settings We conducted a population-based retrospective cohort study among new AD users with a diagnosis of depression following AD initiation. We used public health insurance data from Quebec. The dependent variable was non-adherence (i.e., < 90% of days covered by ≥ 1 AD) in the year after a depression diagnosis. Different sociodemographic, clinical and medication-related variables were assessed as potential factors of non-adherence to AD treatment. We performed univariate and multivariate logistic regressions. Results We identified 3106 new users of ADs with a diagnosis of depression between 2000 and 2006. Of these individuals, 52% were considered non-adherent to their ADs. Baseline non-adherence, younger age, the addition of another AD to the initial treatment, < 4 drug claims, visits with several different physicians, high socioeconomic status, and a small number of diabetes complications were associated with AD non-adherence. Conclusions The factors identified in the present study may help clinicians recognize patients with type 2 diabetes and incident depression at increased risk for non-adherence. In these patients, close follow-up and targeted interventions could help improve adherence to AD treatment, improve glycemic control and reduce complications

Mortality in kittens is associated with a shift in ileum mucosa-associated enteroccoci from E. hirae to biofilm-forming E. faecalis and adherent E. coli

Approximately ~15% of foster kittens die before 8-wks of age with most of these kittens demonstrating clinical signs or post-mortem evidence of enteritis. While a specific cause of enteritis is not determined in most cases; these kittens are often empirically administered probiotics that contain enterococci. The enterococci are members of the commensal intestinal microbiota but can also function as opportunistic pathogens. Given the complicated role of enterococci in health and disease, it would be valuable to better understand what constitutes a “healthy” enterococcal community in these kittens and how this microbiota is impacted by severe illness. In this study, we characterize the ileum mucosa-associated enterococcal community of 50 apparently healthy and 50 terminally ill foster kittens. In healthy kittens, E. hirae was the most common species of ileum mucosa-associated enterococci and was often observed to adhere extensively to the small intestinal epithelium. These E. hirae isolates generally lacked virulence traits. In contrast, non-E. hirae enterococci, notably E. faecalis, were more commonly isolated from the ileum mucosa of kittens with terminal illness. Isolates of E. faecalis had numerous virulence traits and multiple antimicrobial resistance. Moreover, attachment of E. coli to the intestinal epithelium was significantly associated with terminal illness and was not observed in any kitten with adherent E. hirae. These findings identify a significant difference in species of enterococci cultured from the ileum mucosa of kittens with terminal illness compared to healthy kittens. In contrast to prior case studies that associate enteroadherent E. hirae with diarrhea in young animals, these controlled studies identified E. hirae as more often isolated from healthy kittens and adherence of E. hirae as more common and extensive in healthy compared to sick kittens

Neutron to proton ratios of quasiprojectile and midrapidity emission in the 64^{64}Zn + 64^{64}Zn reaction at 45 MeV/nucleon

Simultaneous measurement of both neutrons and charged particles emitted in the reaction $^{64}$Zn + $^{64}$Zn at 45 MeV/nucleon allows comparison of the neutron to proton ratio at midrapidity with that at projectile rapidity. The evolution of N/Z in both rapidity regimes with increasing centrality is examined. For the completely re-constructed midrapidity material one finds that the neutron-to-proton ratio is above that of the overall $^{64}$Zn + $^{64}$Zn system. In contrast, the re-constructed ratio for the quasiprojectile is below that of the overall system. This difference provides the most complete evidence to date of neutron enrichment of midrapidity nuclear matter at the expense of the quasiprojectile

Scaling migrations to communities: An empirical case of migration network in the Arctic

Seasonal migrants transport energy, nutrients, contaminants, parasites and diseases, while also connecting distant food webs between communities and ecosystems, which contributes to structuring meta-communities and meta-ecosystems. However, we currently lack a framework to characterize the structure of the spatial connections maintained by all migratory species reproducing or wintering in a given community. Here, we use a network approach to represent and characterize migratory pathways at the community level and provide an empirical description of this pattern from a High-Arctic terrestrial community. We define community migration networks as multipartite networks representing different biogeographic regions connected with a focal community through the seasonal movements of its migratory species. We focus on the Bylot Island High-Arctic terrestrial community, a summer breeding ground for several migratory species. We define the non-breeding range of each species using tracking devices, or range maps refined by flyways and habitat types. We show that the migratory species breeding on Bylot Island are found across hundreds of ecoregions on several continents during the non-breeding period and present a low spatial overlap. The migratory species are divided into groups associated with different sets of ecoregions. The non-random structure observed in our empirical community migration network suggests evolutionary and geographic constraints as well as ecological factors act to shape migrations at the community level. Overall, our study provides a simple and generalizable framework as a starting point to better integrate migrations at the community level. Our framework is a far-reaching tool that could be adapted to address the seasonal transport of energy, contaminants, parasites and diseases in ecosystems, as well as trophic interactions in communities with migratory species

Impact of a Community Pharmacist-Delivered Information Program on the Follow-up of Type-2 Diabetic Patients: A Cluster Randomized Controlled Study.

Low-quality communication between patients and care providers and limited patient knowledge of the disease and the therapy are important factors associated with poor glycemic control in patients with type 2 diabetes. We conducted a multicenter study to determine whether structured and tailored information delivered by pharmacists to type 2 diabetic patients could improve patient treatment adherence, hemoglobin A1c (HbA1c) levels and knowledge about diabetes. One hundred seventy-four pharmacies were randomized to deliver an educational program on diet, drug treatment, disease and complications during three 30-min interviews over a 6-month period, or to provide no intervention, to type 2 diabetic patients treated with oral antidiabetic agents. Medication adherence was assessed by measuring the medication possession ratio and diabetes control by collecting HbA1c values. Levels of patient treatment self-management and disease knowledge were assessed using self-questionnaires. Three hundred seventy-seven patients were analyzed. The medication possession ratio, already very high at baseline in the intervention (94.8%) and control (92.3%) groups, did not vary significantly after 6 months with no difference between the two groups. Significant decreases in HbA1c were observed in both groups at 6 months (p < 0.001) and 12 months (p < 0.01), with significantly greater changes from baseline in the intervention group than in the control group at 6 months (- 0.5% vs. - 0.2%, p = 0.0047) and 12 months (- 0.6% vs. - 0.2%, p = 0.0057). Patients in the intervention group showed greater improvement in their ability to self-manage treatment (+ 4.86 vs. + 1.58, p = 0.0014) and in the extent of their knowledge about diabetes (+ 0.6 vs. + 0.2, p < 0.01) at 6 months versus baseline compared with the control group. Tailored information provided by the pharmacist to patients with type 2 diabetes did not significantly improve the already high adherence rates, but was associated with a significant decrease in HbA1c and an improvement of patient knowledge about diabetes. ISRCTN33776525. MSD France

Tuning a Schottky barrier in a photoexcited topological insulator with transient Dirac cone electron-hole asymmetry

The advent of Dirac materials has made it possible to realize two dimensional gases of relativistic fermions with unprecedented transport properties in condensed matter. Their photoconductive control with ultrafast light pulses is opening new perspectives for the transmission of current and information. Here we show that the interplay of surface and bulk transient carrier dynamics in a photoexcited topological insulator can control an essential parameter for photoconductivity - the balance between excess electrons and holes in the Dirac cone. This can result in a strongly out of equilibrium gas of hot relativistic fermions, characterized by a surprisingly long lifetime of more than 50 ps, and a simultaneous transient shift of chemical potential by as much as 100 meV. The unique properties of this transient Dirac cone make it possible to tune with ultrafast light pulses a relativistic nanoscale Schottky barrier, in a way that is impossible with conventional optoelectronic materials.Comment: Nature Communications, in press (12 pages, 6 figures