Analysis of CABP2 c.637+1G>T mutation in iranian patients with non-syndromic sporadic hearing loss

The most common sensorineural defect in human is congenital hearing loss and genes have an incontestable role in the development of this defect. Many genetic mutations are known to be responsible in this heterogeneous disease. The most frequent mutations are GJB2 mutations followed by the SLC26A4 mutations. Recently, we published a report regarding the role of c.637+1G>T mutation in CABP2 gene, causing hearing loss in three Iranian families. The present study was launched to analyze the role of this recently reported mutation in patients with sporadic hearing loss. One hundred and eighty three patients with moderate to profound sporadic hearing loss were included in this study. The mutation c.637+1 G>T was investigated in patients using the PCR-RFLP method. PCR-RFLP findings revealed that the considered mutation was absent in subjects with sporadic hereditary hearing loss. The mutation c.637+1 G>T in CABP2 gene did not play any roles in the investigated Iranian patients with sporadic hearing loss. Larger samples of different populations, and assessment of all exons and the promoter region of mentioned gene will help to determine the real role of this gene in producing hearing loss. © 2014, Iranian Neurogenetics Society. All rights reserved

A Case Report of A 2.5-Year-Old Girl with Angelman Syndrome (AS)

ObjectiveAngelman Syndrome (AS) is a genetically determined syndrome that has a unique behavioral phenotype. This syndrome is described as jerky ataxia and an unusual happy facial expression with pathological laughter. Severe mental retardation is a unique feature of the syndrome, together with microbrachycephaly and abnormal electroencephalographic findings with or without clinical seizures. The patients cannot speak or at most, they have a vocabulary consisting only of a few words. The genetic abnormality of AS has been located on chromosome 15q11-q13. Patients with AS mostly have deletions on the maternally derived allele (75-80%) while some of them show paternal  uniparental disomy (~2%) or a rare imprinting mutation developmental disorder caused by deletion of the maternally-inherited chromosome 15q11-13. A 2.5-year-old girl is presented. Clinical suspicion of AS was raised at the age of 27 months when she presented with mental retardation and epilepsy, absence of speech, inability to gait and paroxysmal episodes of laughter. Moreover, she had facial dysmorphic features such as microbrachycephaly,  mid-facial hypoplasia, macrostomia and a prominent mandible. Chromosomal analysis revealed 46 xx with the deletion of 15q chromosome (15q11q13-snrpn/ic) Our patient met the classical phenotype and genotype of AS

Optimization of transport system in cement industry: A Case study in Omid Siman Darab Cement Manufacturing Company

The aim of this research is to study transport system in Darab Siman Omid (cement) manufacturing Company where system optimization is carried out at 3 phases: we have implemented 3 phases of this point for December 2012 through August 2013 .Therefore, 3 phases are explained in the following: At the first phase, with respect to customers’ demand and by application of linear planning, quantity of the needed trucks for any route is identified in certain period of time. At the second phase, it is determined by goal programming model and the number of the existing trucks i.e., how many trucks should be allocated to any route. Moreover, at the second phase, quantity of deficiency or surplus of trucks will be obtained for each route within several periods as well and finally at the third phase, the extra trucks, which have been focused on by this method of allocation in the main base, will be allotted to the routes with respect to the shortages of these facilities obtained from the second phase of this problem. Currently, we compare the suggested system with the existing system. The acquired result from this part signifies that the given company should reduce the number of trucks from this system in order not to be compelled to incur their extra costs or it should meet more demands with this quantity of trucks at its disposal

Optimization of transport system in cement industry: A Case study in Omid Siman Darab Cement Manufacturing Company

The aim of this research is to study transport system in Darab Siman Omid (cement) manufacturing Company where system optimization is carried out at 3 phases: we have implemented 3 phases of this point for December 2012 through August 2013 .Therefore, 3 phases are explained in the following: At the first phase, with respect to customers’ demand and by application of linear planning, quantity of the needed trucks for any route is identified in certain period of time. At the second phase, it is determined by goal programming model and the number of the existing trucks i.e., how many trucks should be allocated to any route. Moreover, at the second phase, quantity of deficiency or surplus of trucks will be obtained for each route within several periods as well and finally at the third phase, the extra trucks, which have been focused on by this method of allocation in the main base, will be allotted to the routes with respect to the shortages of these facilities obtained from the second phase of this problem. Currently, we compare the suggested system with the existing system. The acquired result from this part signifies that the given company should reduce the number of trucks from this system in order not to be compelled to incur their extra costs or it should meet more demands with this quantity of trucks at its disposal

Optimization of transport system in cement industry: A Case study in Omid Siman Darab Cement Manufacturing Company

The aim of this research is to study transport system in Darab Siman Omid (cement) manufacturing Company where system optimization is carried out at 3 phases: we have implemented 3 phases of this point for December 2012 through August 2013 .Therefore, 3 phases are explained in the following: At the first phase, with respect to customers’ demand and by application of linear planning, quantity of the needed trucks for any route is identified in certain period of time. At the second phase, it is determined by goal programming model and the number of the existing trucks i.e., how many trucks should be allocated to any route. Moreover, at the second phase, quantity of deficiency or surplus of trucks will be obtained for each route within several periods as well and finally at the third phase, the extra trucks, which have been focused on by this method of allocation in the main base, will be allotted to the routes with respect to the shortages of these facilities obtained from the second phase of this problem. Currently, we compare the suggested system with the existing system. The acquired result from this part signifies that the given company should reduce the number of trucks from this system in order not to be compelled to incur their extra costs or it should meet more demands with this quantity of trucks at its disposal

A source driven adaptation technique for streaming of MPEG video over IP networks

Streamed MPEG video over IP networks, like any other information sent over "best effort" networks, is susceptible to loss and unpredictable delays. However, in MPEG video, loss and unacceptable delays are propagated to other frames due to Intra/Inter frame encoding nature of compression. Different adaptation techniques are used to enhance Quality of Service and provide "controlled" degradation on the streamed video. In this research we consider a source driven adaptation technique through a detailed simulation. Then we propose two schemes for encapsulation of MPEG video inside RTP/UDP/IP packets consistent with the standard and examine how this affects the network level QoS of the video before and after adaptation. A comparison between the two proposed encapsulation methods will also be done from bandwidth efficiency point of view. Effect of different network parameters on QoS for the both suggested encapsulations will be investigated too

Nanoporous Polyether Sulfone Membrane, Preparation and Characterization: Effect of Porosity and Mean Pore Size on Performance

Flat sheet membranes were prepared by phase inversion technique using polyether sulfone (PES) dissolved in dimethylacetamide (DMAc) with and without adding polyvinylpyrrolidone (PVP) or polyethyleneglycol (PEG). The characteristics of the prepared membranes were evaluated using Scanning Electron Microscope (SEM) images, Atomic Force Microscopy (AFM), and Optical Contact Angle (OCA) measurements, and porosity tests. The porosity test and SEM images show that increasing additives to a certain value increases the porosity of the membrane. Also, as the coagulation bath temperature is increased, the porosity of the membrane is increased. The roughness of the membrane is increased by increasing the additive concentration. The analysis of AFM images confirms the nanoporous structure of the prepared membranes, and that the membranes with appropriate pore size distribution can be prepared by the applied method. Permeability tests using single-layer membranes show that the direct relationship between porosity and the flux of pure water or salt solution is dominated by the effect of applied additive while the salt rejection shows an inverse relationship with the mean pore size regardless of the applied additive. The salt permeation flux is a function of total porosity while the salt rejection is a function of surface porosity. Pervaporation tests show that both permeation flux and enrichment factor depend on the total porosity of the support membrane

Effects of Pre-reading Activities on EFL Reading by Iranian College Students

Abstract This study investigated the effects of two pre-reading activities (class discussion and vocabulary definitions) and a control condition on the reading comprehension of 57 Iranian college freshmen. It also investigated the differential facilitative effect of the two pre-reading activities on the students' comprehension. Each student read an expository text under one of the three conditions and immediately afterwards answered a 9-item short answer test designed to measure comprehension of the text. A one-way ANOVA and a post-hoc comparison test were applied to the results. This revealed that the two pre-reading activities produced significantly higher comprehension scores than the control condition. Vocabulary definitions activity resulted in increased comprehension compared with the control condition, but was significantly less effective than the class discussion activity. Results of the study were interpreted in relation to the schema-theoretic view of the reading process, and to their implications for EFL reading instruction

The sagittal otolith morphology of four selected mugilid species from Iranian waters of the Persian Gulf (Teleostei: Mugilidae)

The members of mugilid species are usually difficult to recognize because of the well-known similarity observed in their external morphology. Nevertheless, their identification is very important for local fisheries management and conservation action. Therefore, in the present study we applied otolith morphology to evaluate its significance in identification of four selected mugilid species; Chelon subviridis (Valenciennes, 1836), Liza klunzingeri (Day, 1888), Ellochelon vaigiensis (Quoy & Gaimard, 1825) and Mugil cephalus Linnaeus, 1758 occurring in the Iranian waters of the Persian Gulf in southern Iran. The results indicated several otolith features to be important for identification of the selected mugilid species as follow; the position and sulcus centrality, the curvature of the cauda, and the type of anterior and posterior regions. Based on the total approach evidences, we conclude that otolith morphology in mugilid fishes can be evidently used for the species identification and probably estimation of their phylogeny. The findings are in agreement with the previous studies which documented taxonomic importance of otolith morphology