Ag nanoparticle promoted synthesis of 1,8-dioxo-decahydroacridines at room temperature

The three component condensation reaction of aldehydes with dimedone and ammonium acetate or anilines happened in the presence of Ag nanoparticles as a heterogeneous catalyst at room temperature in ethanol.Ag nanoparticles can suitably be handled and removed from the reaction mixture, generating the experimental process simple and green.The significant features of this method are suitable conversions, cleaner reaction profiles and short reaction time. The catalyst is recycled and reused for five successive times without loss of structure and significant activity

Disability and therapeutic response in paediatric neuromyelitis optica spectrum disorder: A case series from Iran

                                                                                         ABSTRACT Objectives:The characteristics of paediatric neuromyelitis optica spectrum disorder (NMOSD) may indicate the degree of disability and identify factors that predict the response to treatment.Materials & MethodsAmong 114 NMOSD patients in an acquired demyelinating syndromes registry at the Sina Hospital, in Tehran, Iran, 10 paediatric NMOSD patients with longitudinal follow-up from 2005 to 2016 were retrospectively identified. The median time between disease onset and diagnosis was 18 months (range 1-108 months).ResultsAll patients had a relapsing course, which resulted in disability in six with severe visual impairment and functional blindness in one and impaired ambulation in five patients during follow-up. Azathioprine (AZA) was first drug of choice for prophylaxis, but in five patients new attacks occurred and therapy was switched to rituximab (RTX) with no further relapses after median two years (range 1-3 y) follow-up.Conclusion:Paediatric onset of NMOSD was associated with severe attacks and poor response in 50 % of cases to AZA, RTX seemed to decrease the relapse rate

tert-Butyl 6-benzoyl-5-hydr­oxy-2-oxo-2H-chromene-4-carboxyl­ate

In the title compound, C21H18O6, a previously unknown coumarin derivative, the benzoyl substitutent makes a dihedral angle of 53.80 (16)° with the plane of the coumarin rings. An intramolecular O—H⋯O hydrogen bond is observed

(E)-Dimethyl 2-(6-benzoyl-7-hydr­oxy-4-methoxy­carbonyl-2-oxo-2H-chromen-8-yl)but-2-enedioate

The mol­ecule of the title compound, C24H18O10, a previously unknown coumarin derivative, contains methoxy­carbonyl, 2-butenedioate and benzoyl groups aligned at angles of 28.04 (2), 76.89 (3) and 42.48 (13)°, respectively, to the plane of the coumarin ring system. Intra­molecular O—H⋯O hydrogen bonding between hydr­oxy and carbonyl groups and weak inter­molecular C—H⋯O hydrogen bonding is present in the crystal structure. The two carbon atoms and attached H atom of the ethylene bond are disordered over two positions, with site occupancy factors of ca 0.9 and 0.1

Epidemiology of familial multiple sclerosis in Iran: a national registry-based study

Background Admittedly, little is known about the epidemiological signatures of familial multiple sclerosis (FMS) in different geographical regions of Iran. Objective To determine the epidemiology and the risk of FMS incidence in several provinces of Iran with a different ethnic population including, Fars, Tehran, Isfahan (Persians), and Mazandaran (Mazanis), Kermanshah (Kurds), and Chaharmahal and Bakhtiari (Lors). Methods This cross-sectional registry-based study was performed on nationwide MS registry of Iran (NMSRI) data collected from 2018 to 2021. This system, registers baseline characteristics, clinical presentations and symptoms, diagnostic and treatments at regional and national levels. Results A total of 9200 patients including, 7003 (76.1%) female and 2197 (23.9%) male, were participated. About 19% of patients reported a family history of MS; the order from highest to lowest FMS prevalence was as follows: Fars (26.5%), Chaharmahal and Bakhtiari (21.1%), Tehran (20.5%), Isfahan (20.3%), Mazandaran (18.0%), and Kermanshah (12.5%). Of all FMS cases, 74.7% (1308 cases) were female and 25.3% (442 cases) were male. FMS occurrence was much more common in females than males (P-value = 0.001). Further, the mean age at onset was 30 years among FMS cases. A substantially higher probability of relapsing-remitting MS and secondary-progressive MS was found among FMS cases than sporadic MS (SMS) (P_value = 0.001). There was no significant difference in Expanded Disability Status Scale (EDSS) scores between FMS and SMS. The majority of FMS cases were observed among first-degree relatives, with the highest rate in siblings. There was a significant association between MS risk and positive familial history in both maternal and paternal aunt/uncle (P_value = 0.043 and P_value = 0.019, respectively). Multiple sclerosis occurrence among offspring of females was higher than males (P_value = 0.027). Conclusions In summary, our findings imply a noteworthy upward trend of FMS in Iran, even more than the global prevalence, which suggests a unique Atlas of FMS prevalence in this multi-ethnic population. Despite the highest rate of FMS within Persian and Lor ethnicities, no statistically significant difference was observed among the provinces

Ag nanoparticle promoted synthesis of 1,8-dioxo-decahydroacridines at room temperature

1303-1308The three component condensation reaction of aldehydes with dimedone and ammonium acetate or anilines happened in the presence of Ag nanoparticles as a heterogeneous catalyst at room temperature in ethanol.Ag nanoparticles can suitably be handled and removed from the reaction mixture, generating the experimental process simple and green.The significant features of this method are suitable conversions, cleaner reaction profiles and short reaction time. The catalyst is recycled and reused for five successive times without loss of structure and significant activity