17,328 research outputs found
Supporting arts and science communities on-line
This paper examines the use of the Web to support continuing professional development (CPD). It outlines the factors driving the adoption of CPD and highlights areas where the Web can aid in the development of successful professional communities. A survey examining the use of the Internet to support professionals working in the domains of the Arts and Science is presented. The study reviews twenty four sites for the presence and degree of adoption of several key features including: - community building, range and value of content, user friendliness and guidance, sophistication of employed Web technology
Domain Growth, Budding, and Fission in Phase Separating Self-Assembled Fluid Bilayers
A systematic investigation of the phase separation dynamics in self-assembled
multi-component bilayer fluid vesicles and open membranes is presented. We use
large-scale dissipative particle dynamics to explicitly account for solvent,
thereby allowing for numerical investigation of the effects of hydrodynamics
and area-to-volume constraints. In the case of asymmetric lipid composition, we
observed regimes corresponding to coalescence of flat patches, budding,
vesiculation and coalescence of caps. The area-to-volume constraint and
hydrodynamics have a strong influence on these regimes and the crossovers
between them. In the case of symmetric mixtures, irrespective of the
area-to-volume ratio, we observed a growth regime with an exponent of 1/2. The
same exponent is also found in the case of open membranes with symmetric
composition
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Non-traumatic chest pain in patients presenting to an urban emergency Department in sub Saharan Africa: a prospective cohort study in Tanzania.
BACKGROUND:Non-traumatic chest pain (NTCP) is a common reason for emergency department (ED) attendance in high-income countries, with the primary concern focused on life threatening cardiovascular diseases. There is general lack of data on aetiologies, diagnosis and management of NTPC in Sub Sahara African (SSA) countries. We aimed to describe evaluation, diagnosis and outcomes of adult patients presenting with NTCP to an urban ED in Tanzania. METHOD:This was a prospective observational cohort study of consecutive adult (≥18 years) patients presenting with non-traumatic chest pain to the Emergency Medicine Department (EMD) of Muhimbili National Hospital (MNH) in Dar es salaam from September 2017 to April 2018. Structured case report form was used to collected demographics, clinical presentation, investigations, diagnosis, and EMD disposition and in hospital mortality. We determined frequency of NTCP among our patients, aetiologies, 24-h and 7-day in-hospital mortality, and predictors for mortality. RESULTS:We screened 29,495 adults attending EMD-MNH during the study and 389 (1.3%) presented with NTCP of these, 349 (90%) were enrolled. The median age was 45 (IQR 29-60) years and 177 (50.7%) were female. Overall, 69.1% patients received electrocardiography (ECG) in the EMD and 34.1% had a troponin test. Heart failure and pulmonary tuberculosis (PTB) were the leading hospital diagnoses (12.6% each), followed by chronic kidney disease (10%) and acute coronary syndrome (ACS) (9.6%). Total of 167 (48%) patients were admitted, and the 24-h and 7-day in-hospital mortality were 5 (3%) and 16 (9.6%) respectively. Univariate risk factors for mortality were a Glasgow Coma Scale of < 15 [RR = 3.4 (95%CI 3.2-23)], Acute Coronary Syndrome [RR = 5.7 (95% CI 1.7-11.8) and Troponin > 0.04 ng/ml [RR 2.9 (95%CI 1.2-7.3)]. Features distinguishing cardiovascular from other causes were: bradycardia [RR = 2.6 (95%CI 2.1-3.2)], heart beat awareness [RR = 2.3 (95%CI 1.7-3.2)] and history of diabetic mellitus [RR = 2.2 (95% CI 1.6-3.0)]. CONCLUSION:In this ED of SSA country, heart failure and pulmonary tuberculosis were the leading causes of NCTP, and ACS was present in 9.6%. NTCP in this setting carries high mortality, and ACS was the leading risk factor for death. ED providers in SSA must increasingly consider cardiovascular causes of NTCP
Linear-nonlinear stiffness responses of carbon fiber-reinforced polymer composite materials and structures: a numerical study
The stiffness response or load-deformation/displacement behavior is the most important mechanical behavior that frequently being utilized for validation of the mathematical-physical models representing the mechanical behavior of solid objects in numerical method, compared to actual experimental data. This numerical study aims to investigate the linear-nonlinear stiffness behavior of carbon fiber-reinforced polymer (CFRP) composites at material and structural levels, and its dependency to the sets of individual/group elastic and damage model parameters. In this regard, a validated constitutive damage model, elastic-damage properties as reference data, and simulation process, that account for elastic, yielding, and damage evolution, are considered in the finite element model development process. The linear-nonlinear stiffness responses of four cases are examined, including a unidirectional CFRP composite laminate (material level) under tensile load, and also three multidirectional composite structures under flexural loads. The result indicated a direct dependency of the stiffness response at the material level to the elastic properties. However, the stiffness behavior of the composite structures depends both on the structural configuration, geometry, lay-ups as well as the mechanical properties of the CFRP composite. The value of maximum reaction force and displacement of the composite structures, as well as the nonlinear response of the structures are highly dependent not only to the mechanical properties, but also to the geometry and the configuration of the structures
Trends in world cephalopod fisheries and India’s status
Globally cephalopods are an important fishery
resource and many species are taken in directed and
bycatch fisheries around the world. Cephalopods make
up only a small proportion (nearly 3 %) of the world
capture fisheries landings , but there hav e been
substantial increases during the last three decades
New heat treatment to prepare high quality polycrystalline and single crystal MgB2 in single process
We report here on a new heat treatment to prepare both dense polycrystalline
and single crystal MgB2 high quality samples in one single process. Resistivity
measurements for polycrystalline part of the sample gives a residual
resistivity ratio RRR=16.6 and a very low normal state resistivity rho(40K)=
0.28 microOhmcm. Both SEM and SQUID study on polycrystals reveal the high
quality, dense character and well coupling of grain boundaries. On the other
hand, the high quality single crystals have a unique shape that resembles the
hexagonal crystal structure. SQUID measurements reveals very weak flux pinning
character implying our single crystals to be very clean. In this study, we
conclude that heat treatment is playing a major rule on the characteristics of
both polycrystalline and single crystal MgB2. Samples are thoroughly
characterized by x-ray, resistivity, dc SQUID and SEM
Particle bombardment as a strategy for the production of transgenic high oleic sunflower (Helianthus annuus L.)
In order to develop an efficient and reproducible protocol for genetic engineering of high oleic Helianthus annuus L. genotypes (cv. capella and SWSR2 inbred line) important parameters of a particle bombardment strategy have been optimized, such as gold particle size, particle acceleration pressure, distance between macrocarrier assembly and target plate, pre-culture period of the explant and number of bombardments per explant. These parameters were evaluated on the basis of resulting GUS activity coupled with regeneration frequency and efficiency as well as plant cell vitality. Split shoot apices were used as explants. The maximum GUS activity was observed at 1550 psi acceleration pressure combined with 6 cm target distance and 1.6 μm gold particle size. A pre-culture of one day prior to bombardment gave the best results. In addition, two subsequent bombardments increased the GUS activity of cv.capella and SWSR2 inbred line 1.6 and 2.1 fold, respectively, compared to explants bombarded once. The optimized bombardment conditions were applied for estimating the transformation frequency which reached 3.1 and 4.5 % for high oleic cv.capella and SWSR2 inbred line, respectively. This frequency was calculated on the basis of positive PCR results of putative transgenic plants and in relation to the total number of bombarded explants.Abbreviations: MUG – 4-methylumbelliferyl-ß-glucuronide; 4-MU – 4-methylumbelliferone; BAP – 6-benzylaminopurine; gus – β- glucuronidase; MS – Murashige and Skoog; nos – nopaline synthase gene; nptII – neomycin phosphotransferase gene; psi – pounds per square inch; SE – standard error; SIM – shoot induction mediu
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