Hypoxia and risk preferences: Mild hypoxia impacts choices for low-probability high-payoff bets

Mild degrees of hypoxia are known to exert a detrimental effect on cognitive functions. In a lab study, we assessed the effect of mild hypoxia on risk-taking behavior. Participants (N = 25) were presented with pairs of bets of equal expected monetary value, one having a higher probability of winning/losing a lower payoff (safer bet) and one having a lower probability of winning/losing a higher payoff (riskier bet). We systematically varied the ratio of the probabilities (and corresponding payoffs) of the two bets and examined how this affected participants' choice between them. Following a familiarization session, participants performed the task twice: once in a normoxic environment (20.9% oxygen concentration) and once in a mildly hypoxic environment (14.1% oxygen concentration). Participants were not told and could not guess which environment they were in. We found a higher preference for the riskier bet in the mild hypoxic than normoxic environment but only in the loss domain. Furthermore, as the probability ratio increased, mild hypoxia increased the preference for the riskier bet in the domain of losses but decreased it for gains. The present findings support that mild hypoxia promotes riskier choices in the loss domain and provide new insights into the impact of mild hypoxia in moderating the effect of probability ratio on risky choices

Effects of moderate and low frequency recreational football on cardiovascular risk: a dose-response study

Introduction. Physical inactivity ranks fourth as a risk factor for global mortality. World Health Organisation (WHO) physical activity guidelines recommend at least 150 min/wk of moderate or 75 min/wk of vigorous intensity aerobic physical activity for \u201csubstantial health benefits\u201d. Lack of time and motivation are often a barrier to meeting these recommendations. Aims. There is abundant evidence that recreational football (RF) at moderate and high frequency is effective to improve cardiovascular health, however, data are scarce regarding the effects of low frequency training (once a week).The aims of the present study were to: 1) compare the effects of low and moderate RF training volume (1 and 2 times a week for 12 weeks) on cardiovascular risk factors, 2) assess changes in inflammatory status after RF training, and 3) determine what cardiac and peripheral adaptations occur. The study population was 40 healthy, sedentary men (age range 35 - 55 years). Study 1. We compared the outcome of 12 weeks RF training in three groups: moderate frequency group (MFG, training twice a week), low frequency group (LFG, training once a week), and control group (CG, no training). As compared with the CG, the fat mass was decreased in both the LFG and the MFG, whereas body mass and body-mass index (BMI, weight in kg divided by height in meters squared) were decreased only in the MFG. Maximal oxygen consumption was higher in both the LFG and the MFG. Arterial blood pressure and blood lipid profile remained unchanged. Study 2. Endothelial function impairment and atherosclerosis are precursors of many cardiovascular events. Despite the consistent body of literature on inflammatory markers and their relationship with physical exercise, it is not clear how RF influences them. We measured inflammatory markers white blood count (WBC), neutrophil-lymphocyte ratio (NLR), and C-reactive protein (CRP). No differences among the three groups were found at 12 weeks. Comparison of CG with the merged LFG and MFG groups (FG), revealed differences only for WBC. This difference probably had no remarkable meaning. Study 3. To better understand the adaptations that lead to improvement in cardiovascular risk factors, we evaluated microvascular responsiveness by near-infrared spectroscopy (NIRS) and cardiac function and structure by echocardiography. At 12 weeks we recorded changes in area under the curve (AUC) and increased hyperaemia reserve in the MFG and the LFG, respectively, versus the CG. This increase was also noted when the FG was compared versus the CG, suggesting a possible improvement in hyperaemic response. Echocardiography showed an increase in cardiac dimensions in both the LFG and the MFG versus the CG. Cardiac function parameters remained unchanged, except for a difference in right ventricular systolic function between the FG and the CG. Conclusion. The main, novel finding of these studies is that low frequency RF training produces beneficial effects on some cardiovascular risk factors in sedentary, healthy, and untrained middle-aged men. No beneficial effects on inflammatory conditions (CRP, WBC, NLR) were noted. In addition, echocardiographic assessment showed ventricular remodelling in the FG, as demonstrated by increased left and right ventricular diameters and left ventricular mass. Diastolic function remained unchanged, indicating that low frequency RF training for 12 weeks was not sufficient to further improve normal diastolic function in this healthy sample. Finally, a small positive effect on endothelial function was detected, but further investigations are needed to explain this observation

Immersions and Dives: From the Environment to Virtual Reality, Vol. 2, no. II (2023)

The present volume Immersions and Dives: From the Environment to Virtual Reality of the journal AN-ICON: Studies in Environmental Images is divided into two issues, each one dedicated to a specific thematic analysis, originated by the same conceptual core. The volume reflects on the concept of immersivity, which has become increasingly prominent in many different fields, including contemporary art. The constant reference to immersive experience is redefining the boundaries of artistic practice and fruition, highlighting the complex relationships between art, environments, and human perception

How do elite female athletes cope with symptoms of their premenstrual period? A study on Rugby Union and Football players’ perceived physical ability and well-being

Women’s participation in sports has recently grown worldwide, including in sports typically associated with men (e.g., rugby and football). Similarly, literature on female athletes has increased, but how they cope with premenstrual (PM) physical and affective symptoms remains a poorly studied topic. Our study aimed to explain which coping strategies elite female rugby and football players use during their PM period to maintain perceived physical ability (PPA) and well-being. A mediation model analysis considering coping strategies (i.e., avoiding harm, awareness and acceptance, adjusting energy, self-care, and communicating) as independent variables, PPA and well-being as dependent variables, and PM physical and affective symptoms and PM cognitive resources as mediators was run on the data collected via an anonymous online survey. A dysfunctional impact of avoiding harm (indirect) and adjusting energy (both direct and indirect) and a functional indirect influence of awareness and acceptance, self-care, and communicating as coping strategies were found on PPA and well-being during the PM period. As predicted, PM physical and affective symptoms as mediators reduced PPA and well-being, while PM cognitive resources enhanced them. These results may inform practitioners on how to support elite female athletes’ PPA and well-being by knowing and reinforcing the most functional PM coping strategies for them

Talent development in young cross-country skiers: longitudinal analysis of anthropometric and physiological characteristics

Introduction: Very little is known about talent development and selection processes in young cross-country skiers. Aim: (1) to analyze the effect of age on anthropometric and physiological parameters in medium-to-high level cross-country skiers during the late teenage period; (2) to describe parameters' trend in selected talents after the late teenage period; (3) to define which characteristics during the late teenage period could discriminate against further talent selection. Method: We found 14 male (M) and nine (F) athletes in our database, identified as talents by regional teams during the late teenage period, who performed the same diagonal-stride roller-skiing incremental test to exhaustion at 17 and 18 years old. Of these, four M and three F teenagers performed four further evaluations, and were selected by the national team. Age effect during the late teenage period was verified on anthropometric and physiological parameters measured at maximal intensity (MAX), first (VT1), and second (VT2) ventilatory thresholds, and 3\ub0 and 6\ub0 of treadmill incline. An observational analysis allowed to evaluate parameters' trend after the late teenage period in selected athletes, and to determine possible characteristics early discriminating further selection. Results: During the late teenage period, height, weight, and BMI was still raising in M as well as V'O2 at VT2 and 6\ub0 of treadmill incline (all P > 0.05). In F, mass-scaled V'O2 MAX increased while heart rate (HR) at MAX and VT2 decreased (all P > 0.05). Since the late teenage period, all selected males showed maximal ventilation volumes, absolute V'O2 at MAX, VT1, and VT2 that were within or above the 75th percentile of their group; the same was found in selected females for mass-scaled V'O2 MAX, VT1, and VT2 time. After the late teenage period, all selected athletes showed an increasing trend for VT2 time, while a decreasing trend for sub-maximal energetic cost, %V'O2 and HR. Discussion: During the late teenage period, males are still completing their maturation process. Since the late teenage period, some physiological parameters seem good indicators to early discriminate for further talents. A progressive increase in skiing efficiency was demonstrated in developing talents of both sexes after the late teenage period

Predictive value of HDL function in patients with coronary artery disease: relationship with coronary plaque characteristics and clinical events

BACKGROUND: HDL is endowed with several metabolic, vascular, and immunoinflammatory protective functions. Among them, a key property is to promote reverse cholesterol transport from cells back to the liver. The aim of this study was to estimate the association of scavenger receptor class B type I (SR-BI)- and ATP binding cassette transporter A1 (ABCA1)-mediated cholesterol efflux (the two major routes for cholesterol efflux to HDL) with the presence, extent, and severity of coronary artery disease (CAD), vascular wall remodelling processes, coronary plaque characteristics, and the incidence of myocardial infarction in the different subgroups of patients from the CAPIRE study. METHODS: Patients (n = 525) from the CAPIRE study were divided into two groups: low-risk factors (RF), with 0–1 RF (n = 263), and multiple-RF, with ≥2 RFs; within each group, subjects were classified as no-CAD or CAD based on the segment involvement score (SIS) evaluated by coronary computed tomography angiography (SIS = 0 and SIS > 5, respectively). SR-BI- and ABCA1-mediated cholesterol efflux were measured using the plasma of all patients. RESULTS: SR-BI-mediated cholesterol efflux was significantly reduced in patients with CAD in both the low-RF and multiple-RF groups, whereas ABCA1-mediated cholesterol efflux was similar among all groups. In CAD patients, multivariable analysis showed that SR-BI-mediated cholesterol efflux <25(th) percentile predicted cardiovascular outcome (odds ratio 4.1; 95% CI: 1.3–13.7; p = .019), whereas ABCA-1-mediated cholesterol efflux and HDL-C levels significantly did not. Despite this finding, reduced SR-BI-mediated cholesterol efflux was not associated with changes in high-risk plaque features or changes in the prevalence of elevated total, non-calcified, and low-attenuation plaque volume. CONCLUSION: KEY MESSAGES: Increased cholesterol efflux capacity, an estimate of HDL function, is associated with a reduced CVD risk, regardless of HDL-C levels. HDL-C levels are significantly lower in patients with CAD. Lower SR-BI-mediated cholesterol efflux capacity is observed in patients with diffuse coronary atherosclerosis and is associated with the worst clinical outcomes in patients with CAD, independently of atherosclerotic plaque features

The UEFA Heading Study: Heading incidence in children's and youth' football (soccer) in eight European countries

To assess the real‐life magnitude of the heading incidence in children's and youth’ football in eight European countries with different “football cultures,” a cross‐sectional observational design, in which one match per team in 480 different teams from eight European countries (2017/18‐2018/19), was recorded by video. One training session was recorded in 312 teams. Clubs with Under‐10, Under‐12 (female/male/mixed), and Under‐16 female and male teams were eligible to participate. Heading frequencies and types were analyzed. Results are presented as headers per match/training and per team. Incidence rates (IR) per 1000 match/training hours were calculated. Under‐10 teams carried out the lowest average number of headers per match (8.8), followed by Under‐16 female (17.7), Under‐12 (18.4), and Under‐16 male (35.5). Total number of headers per match and team varied between countries. 80% of the total number of headers were single intentional headers, 12% heading duels, 3% unintentional headers by getting hit, and 5% others (trends apparent in all age groups). Three head injuries occurred during match play corresponding to an IR of 0.70 (95% CI, 0.23‐2.16). The lowest number of headers per training and team was found in Under‐10 (21.3), followed by Under‐16 females (34.1), Under‐12 (35.8), and Under‐16 males (45.0). In conclusion, this large‐scale study presents novel data about the number and type of headers in youth’ football throughout Europe. A more precise understanding of the heading incidence, specifically in young players, is mandatory for the debate of restrictions on heading in youth football

The UEFA Heading Study:Heading incidence in children's and youth' football (soccer) in eight European countries

To assess the real-life magnitude of the heading incidence in children's and youth' football in eight European countries with different "football cultures" a cross-sectional observational design, in which one match per team in 480 different teams from eight European countries (2017/18-2018/19) was recorded by video. One training session was recorded in 312 teams. Clubs with Under-10, Under-12 (female/male/mixed) and Under-16 female and male teams were eligible to participate. Heading frequencies and types were analysed. Results are presented as headers per match/training and per team. Incidence rates (IR) per 1000 match/training hours were calculated. Under-10 teams carried out the lowest average number of headers per match (8.8), followed by Under-16 female (17.7), Under-12 (18.4), and Under-16 male (35.5). Total number of headers per match and team varied between countries. 80% of the total number of headers were single intentional headers, 12% heading duels, 3% unintentional headers by getting hit and 5% others (trends apparent in all age groups). Three head injuries occurred during match play corresponding to an IR of 0.70 (95% CI, 0.23-2.16). The lowest number of headers per training and team was found in Under-10 (21.3), followed by Under-16 females (34.1), Under-12 (35.8), and Under-16 males (45.0). In conclusion, this large-scale study presents novel data about the number and type of headers in youth' football throughout Europe. A more precise understanding of the heading incidence, specifically in young players, is mandatory for the debate of restrictions on heading in youth football

Efeito da osteotomia intertrocantérica no femur proximal de coelhos: avaliação com utra-sonografia power Doppler e cintilografia

OBJECTIVE: In bone injury, repair results in local increased vascularity and bone marrow remodeling. Characterizing the vascular and metabolic imaging patterns of the proximal femur following an intertrochanteric osteotomy may help clinicians decide proper management of the patient. Our objective was to measure Doppler sonography and scintigraphy interval changes in the proximal femur following intertrochanteric osteotomy and compare imaging and histomorphometric measurements in the late post-operative stage (6 weeks after surgery) in a rabbit model of bone injury. MATERIALS AND METHODS: Both hips of 12 adult rabbits were imaged with power Doppler sonography and scintigraphy prior to and after (7 days and 6 weeks) unilateral osteotomy. Accuracy of the imaging methods was evaluated using hip operative status and histomorphometric results (vascular fractional area and number of vessels per area unit) as reference standard measures. RESULTS: A significant difference in the mean number of pixels was noted between operated and non-operated femura in late post-operative power Doppler examinations (P=0.049). Although without reaching statistical significance, the AUC of Doppler measurements (AUC=0.99) was numerically greater than the AUC of scintigraphy measurements (AUC=0.857&plusmn;0.099) (P=0.15) in differentiating proximal femura with regard to their fractional vascular areas in the late post-operative stage. In contrast, scintigraphy tended to perform better (AUC=0.984&plusmn;0.022) than Doppler ultrasound (AUC=0.746&plusmn;0.131) to demonstrate the vascularity intensity per area unit (P=0.07) in the late stage. CONCLUSION: Our results warrant further investigation to determine the value of different imaging modalities for assessment of pathologic changes following hip surgery. Power Doppler sonography demonstrated larger AUCs (representing higher accuracy) for the discrimination of vascular fractional areas and scintigraphy, for discrimination of the number of vessels per area unit.OBJETIVO: Regeneração em casos de lesão óssea resulta em aumento da vascularização local e remodelamento da medula óssea adjacente. A caracterização imagenológica de padrões vasculares e metabólicos no fêmur proximal após uma osteotomia intertrocantérica pode auxiliar ortopedistas a decidirem qual a terapêutica mais apropriada. O objetivo deste estudo foi avaliar as alterações temporais observadas por ultra-sonografia Doppler e cintilografia no fêmur proximal após a realização de uma osteotomia intertrocantérica; e comparar achados imagenológicos e histomorfométricos no estágio pós-operatório tardio (6 semanas após a cirurgia) num modelo animal de lesão óssea. MATERIAIS AND MÉTODOS: Ambos os quadris de 12 coelhos adultos foram examinados por ultra-sonografia power Doppler e cintilografia antes e após (7 dias e 6 semanas) uma osteotomia unilateral. A acurácia dos métodos de imagem foi avaliada usando-se o status operatório dos quadris and os resultados histomorfométricos (área vascular fracional e número de vasos/unidade de área) como medidas de referência. RESULTADOS: Uma diferença significativa foi observada entre o número médio de pixels presentes no fêmur proximal operado e não-operado ao exame de power Doppler obtido no estágio pós-operatório tardio (P=0.049). Embora ser atingir significância estatística, a área abaixo da curva ("area-under-the-curve") dos exames de power Doppler (AUC=0.99) for numericamente superior à área abaixo da curva dos exames de cintilografia (AUC= 0.857&plusmn;0.099) (P=0.15) para diferenciar fêmures proximais com relação a suas áreas vasculares fracionais no estágio pós-operatório tardio. Ao contrário, a cintilografia tendeu a apresentar uma "performance" diagnóstica superior (AUC=0.984&plusmn;0.022) em relação ao Doppler (AUC=0.746&plusmn;0.131) para demonstrar a quantidade de vasos por unidade de área (P=0.07) no estágio tardio. CONCLUSÃO: Nossos resultados despertam a importância de continuar-se investigando o valor de diferentes métodos de imagem para se avaliar achados patológicos após a realização de cirurgias do quadril. A ultra-sonografia power Doppler demonstrou maiores áreas abaixo da curva (representando maior acurácia) para discriminar áreas vasculares fracionais e cintilografia, para discriminar quantidade de vasos/unidade de área

Coronary atherosclerosis in outlier subjects at the opposite extremes of traditional risk factors: Rationale and preliminary results of the Coronary Atherosclerosis in outlier subjects: Protective and novel Individual Risk factors Evaluation (CAPIRE) study

Although it is generally accepted that cardiac ischemic events develop when coronary atherosclerosis (coronary artery disease [CAD]) has reached a critical threshold, this is true only to a first approximation. Indeed, there are patients with severe CAD who do not develop ischemic events; conversely, at the other extreme, individuals with minimal CAD may do. Similar exceptions to this paradigm include patients with diffuse CAD with a low risk factor (RF) profile and others with multiple RFs who develop only mild or no CAD. Therefore, the CAPIRE project was designed to investigate whether the specific study of these extreme outlier populations could provide clues for identification of yet unknown risk or protective factors for CAD and ischemic events. In the CAPIRE study, 481 subjects without previous symptoms or history of ischemic heart disease and normal left ventricular systolic function undergoing coronary computed tomography angiography have been selected based on coronary computed tomography angiography findings and cardiovascular RF profile. Therefore, in the whole population, 2 extreme outlier populations have been identified: (1) subjects with no CAD despite multiple RFs, and (2) at the opposite extreme, subjects with diffuse CAD despite a low-risk profile. Each subject has been characterized by clinical, anatomical imaging variables of CAD and baseline circulating biomarkers. Blood samples were collected and stored in a biological bank for further advanced investigations. The project is designed as a prospective, observational, international multicenter study with an initial cross-sectional analysis of clinical, imaging, and biomolecular variables in the selected groups and a longitudinal 5-year follow-up