248 research outputs found

    Effects of interedge scattering on the Wigner crystallization in graphene nanoribbons

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    We investigate the effects of coupling between the two zigzag edges of graphene nanoribbons on the Wigner crystallization of electrons and holes using a combination of tight-binding, mean field Hubbard and many-body configuration interaction methods. We show that the thickness of the nanoribbon plays a crucial role in the formation of Wigner crystal. For ribbon widths smaller than 16 \mbox{\AA}, increased kinetic energy overcomes the long-range Coulomb repulsion and suppresses the Wigner crystallization. For wider ribbons up to 38 \mbox{\AA} wide, strong Wigner localization is observed for even number of electrons, revealing an even-odd effect also found in Coulomb blockade addition spectrum. Interedge correlations are found to be strong enough to allow simultaneous crystallization on both edges, although an applied electric field can decouple the two edges. Finally, we show that Wigner crystallization can also occurs for holes, albeit weaker than for electrons.Comment: Accepted for publication in PR

    Effect of long-range structural corrugations on magnetotransport properties of phosphorene in tilted magnetic field

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    Rippling is an inherent quality of two-dimensional materials playing an important role in determining their properties. Here, we study the effect of structural corrugations on the electronic and transport properties of monolayer black phosphorus (phosphorene) in the presence of tilted magnetic field. We follow a perturbative approach to obtain analytical corrections to the spectrum of Landau levels induced by a long-wavelength corrugation potential. We show that surface corrugations have a non-negligible effect on the electronic spectrum of phosphorene in tilted magnetic field. Particularly, the Landau levels are shown to exhibit deviations from the linear field dependence. The observed effect become especially pronounced at large tilt angles and corrugation amplitudes. Magnetotransport properties are further examined in the low temperature regime taking into account impurity scattering. We calculate magnetic field dependence of the longitudinal and Hall resistivities and find that the nonlinear effects reflecting the corrugation might be observed even in moderate fields (\mbox{B<10B<10 T})

    Spectral Analysis of Multi-dimensional Self-similar Markov Processes

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    In this paper we consider a discrete scale invariant (DSI) process {X(t),tR+}\{X(t), t\in {\bf R^+}\} with scale l>1l>1. We consider to have some fix number of observations in every scale, say TT, and to get our samples at discrete points αk,kW\alpha^k, k\in {\bf W} where α\alpha is obtained by the equality l=αTl=\alpha^T and W={0,1,...}{\bf W}=\{0, 1,...\}. So we provide a discrete time scale invariant (DT-SI) process X()X(\cdot) with parameter space {αk,kW}\{\alpha^k, k\in {\bf W}\}. We find the spectral representation of the covariance function of such DT-SI process. By providing harmonic like representation of multi-dimensional self-similar processes, spectral density function of them are presented. We assume that the process {X(t),tR+}\{X(t), t\in {\bf R^+}\} is also Markov in the wide sense and provide a discrete time scale invariant Markov (DT-SIM) process with the above scheme of sampling. We present an example of DT-SIM process, simple Brownian motion, by the above sampling scheme and verify our results. Finally we find the spectral density matrix of such DT-SIM process and show that its associated TT-dimensional self-similar Markov process is fully specified by {RjH(1),RjH(0),j=0,1,...,T1}\{R_{j}^H(1),R_{j}^H(0),j=0, 1,..., T-1\} where RjH(τ)R_j^H(\tau) is the covariance function of jjth and (j+τ)(j+\tau)th observations of the process.Comment: 16 page

    Two-Dimensional Chromium Bismuthate: A Room-Temperature Ising Ferromagnet with Tunable Magneto-Optical Response

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    We present a density-functional-theory-based study of a two-dimensional phase of chromium bismuthate (CrBi), a previously unknown material with exceptional magnetic and magneto-optical characteristics. Monolayer CrBi is a ferromagnetic metal with strong spin-orbit coupling induced by the heavy bismuth atoms, resulting in a strongly anisotropic Ising-type magnetic ordering with the Curie temperature estimated to be higher than 300 K. The electronic structure of the system is topologically nontrivial, giving rise to a nonzero Berry curvature in the ground magnetic state, leading to the anomalous Hall effect with a conductivity plateau of about 1.5e2/h at the Fermi level. Remarkably, the Hall conductivity and the magneto-optical constant are found to be strongly dependent on the direction of magnetization. Besides, monolayer CrBi demonstrates the polar magneto-optical Kerr effect in the visible and near-ultraviolet spectral ranges with the maximum rotation angles of up to 10 mrad. Our findings suggest that monolayer CrBi is a promising system for practical applications in magneto-optical and spintronic devices. © 2021 American Physical Society.The authors acknowledge the Ankara University for high performance computing facility through the AYP under Grant No. 17A0443001. This work is supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under Project No. 119F361. The numerical calculations reported in this paper were partially performed at TUBITAK ULAKBIM, High Performance and Grid Computing Center (TRUBA resources)

    MEK 1 inhibition and bleeding in hereditary haemorrhagic telangiectasia

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    Lateral Spin Valve Based on the Two-Dimensional CrN/P/CrN Heterostructure

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    We propose a spin valve based on a blue-phosphorus monolayer sandwiched between two half-metallic two-dimensional CrN layers. We use density-functional theory combined with Boltzmann transport theory to investigate both the structural and the magnetic stability of the CrN/P/CrN heterostructure and to study its spin-dependent transport properties. Among the different possible layer stackings considered, only one is shown to be thermodynamically stable, corresponding to the AA stacking. In this geometry, the critical temperature of magnetic ordering is estimated to be around 150 K. The electronic structure of CrN/P/CrN is strongly dependent on the mutual orientation of the magnetic moments in individual CrN layers. If the alignment is parallel, only one spin channel predominantly contributes to the electronic bands in the vicinity of the Fermi energy. In the case of an antiparallel alignment, both spin channels contribute to the electronic states. The alteration of magnetic moments affects electronic transport, causing magnetoresistance of up to 12% at moderate dopings. © 2019 American Physical Society.The authors acknowledge Ankara University for use of the high-performance computing facility through the AYP under Grant No. 17A0443001. A.N.R. acknowledges support from the FLAG-ERA JTC2017 Project “Gransport”

    Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis

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    Background. Alzheimer's disease (AD) is a devastating neurological disorder and the main cause of dementia in the elderly population worldwide. Adult neurogenesis appears to be upregulated very early in AD pathogenesis in response to some specific aggregates of beta-amyloid (Aβ) peptides, exhausting the neuronal stem cell pools in the brain. Previously, we characterized a conserved nonprotein-coding antisense transcript for β-secretase-1 (BACE1), a critical enzyme in AD pathophysiology. We showed that the BACE1-antisense transcript (BACE1-AS) is markedly upregulated in brain samples from AD patients and promotes the stability of the (sense) BACE1 transcript. In the current paper, we examine the relationship between BACE1, BACE1-AS, adult neurogenesis markers, and amyloid plaque formation in amyloid precursor protein (APP) transgenic mice (Tg-19959) of various ages. Results. Consistent with previous publications in other APP overexpressing mouse models, we found adult neurogenesis markers to be noticeably upregulated in Tg-19959 mice very early in the development of the disease. Knockdown of either one of BACE1 or BACE1-AS transcripts by continuous infusion of locked nucleic acid- (LNA-) modified siRNAs into the third ventricle over the period of two weeks caused concordant downregulation of both transcripts in Tg-19959 mice. Downregulation of BACE1 mRNA was followed by reduction of BACE1 protein and insoluble Aβ. Modulation of BACE1 and BACE1-AS transcripts also altered oligomeric Aβ aggregation pattern, which was in turn associated with an increase in neurogenesis markers at the RNA and protein level. Conclusion. We found alterations in the RNA and protein concentrations of several adult neurogenesis markers, as well as non-protein-coding BACE1-AS transcripts, in parallel with the course of β-amyloid synthesis and aggregation in the brain of Tg15999 mice. In addition, by knocking down BACE1 or BACE1-AS (thereby reducing Aβ production and plaque deposition), we were able to modulate expression of these neurogenesis markers. Our findings suggest a distortion of adult neurogenesis that is associated with Aβ production very early in amyloid pathogenesis. We believe that these alterations, at the molecular level, could prove useful as novel therapeutic targets and/or as early biomarkers of AD

    Cellular Senescence and Their Role in Liver Metabolism in Health and Disease: Overview and Future Directions

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    Chronic liver disease has globally risen mainly due to a prevalent hepatitis C virus (HCV) infection rate and an epidemic of obesity. It is estimated by the year 2030, 2.2 billion people around the world will be overweight and 1.1 billion people will be obese. Diabetes and obesity are the main risk factors for the development of the metabolic syndrome and in the liver of non-alcoholic fatty liver disease (NAFLD) which could progress to non-alcoholic fatty steatohepatitis (NASH) related cirrhosis and liver malignancy. At present there is not effective therapy for NASH besides loss of weight and exercise. Furthermore, optimal management of HCC with curative intent includes resection or liver transplantation. Nevertheless, these therapies are limited because the degree of liver dysfunction or the medical conditions at the time of diagnosis and the scarcity of available liver grafts. The role of cellular lipid management and metabolism in human health and disease is taking a center stage. The present overview articulates the current pathophysiology of fatty liver disease under the aging processes, potential biological markers of liver disease diagnosis and progression and future therapies

    From embodiment to metaphor: A study on social cognitive development and conceptual metaphor in Persian-speaking children

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    This study explores the metaphoric comprehension of normal Persian-speaking children, as well as theories of cognitive development and cultural and social impacts. The researchers discuss the improvement of the understanding of ontological conceptual metaphors through age growth and cognitive development, and how it helps to expand children�s thoughts and knowledge of the world. In this study, 121 normal native Persian-speaking children from the age of 5 to 13 with no language and cognitive disorders participated. Pearson correlation and one-way ANOVA were used to examine the relationships between pairs of variables. The results showed that children start to comprehend abstract concepts and primary ontological metaphors at about 5 years of age, which is in contrast with what Piaget has implied. Children�s metaphorical comprehension improved progressively with age, social, and cognitive development as other studies have also implied, and they understood more complex types of metaphors by age growth. © 2020 IJSCL. All rights reserved
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