成人用過剰適応傾向尺度 (Over-Adaptation Tendency Scale for Adults : OATSAS) の開発

関西学院大

Development of novel one-step, fully automated in-situ hybridization of HER2 using non-contact alternating current electric field mixing

Human epidermal growth factor receptor 2 (HER2)-targeted agents are effective treatment for patients with HER2-positive breast cancer. However, the lack of survival benefit in HER2-negative patients as well as the toxic effects and high cost of these drugs highlight the need for accurate and prompt assessment of HER2 status. Our aim was to evaluate the clinical utility of a novel one-step, fully automated in-situ hybridization (Auto-RISH) method developed to facilitate hybridization. This method takes advantage of the non-contact mixing effect of an alternating current electric field. Eighteen specimens from patients diagnosed with primary breast cancer identified immunohistochemically as HER2 (2+) or (3+) were used. The specimens were all tested using DISH with an automated slide stainer (DISH-ASS), fluorescence in-situ hybridization, and Auto-RISH. With RISH the HER2 test was completed within 6 h, as compared to 20-22 h needed for the standard protocol. We found 88.8% agreement between standard DISH-ASS and Auto-RISH based on the status of the HER2 signals, and both methods stained nearly all samples from HER2-IHC 3+ patients equally well. These findings suggest Auto-RISH could potentially serve as an automated clinical tool for prompt determination of HER2 status in breast cancer samples

Urinary tract infection associated with bacteremia caused by vancomycin‐resistant enterococcus following continent urinary diversion

Key Clinical Message Even in a country where vancomycin–resistant enterococcus is rare, multidrug‐resistant organism precautions are necessary when admitting patients with a history of medical exposure in other countries. On admission, screening is necessary and if infection is confirmed, a multidisciplinary approach involving different specialists is required. Abstract The patient was a 49‐year‐old Japanese female living in the United States. Total pelvic exenteration for cervical carcinoma, Miami pouch formation, and ileostomy had been performed in the United States. She returned to Japan to undergo postoperative adjuvant chemotherapy. Fever and abdominal pain occurred 42 days after surgery. She consulted the fever outpatient clinic, and a diagnosis of urinary retention‐associated acute renal failure and pyelonephritis was made. We detected vancomycin‐resistant enterococcus on urine/blood culture 5 days after admission. Infection control measures were implemented, and the ward was closed for 3 days. We administered linezolid, which was effective for pyelonephritis and bacteremia

神戸女子短期大学学生の食事に対する意識の現状（第1報）

　食生活をめぐる現状は，複雑化・多様化に加えて，著しい情報の氾濫によって正しい情報の取捨選択も難しくなっている。そのため，健全な食生活を実践するには，単に食べ物や栄養の知識だけでなく，文化や国際理解など多方面にわたる実践的な教育が求められている。そこで，食に関連する科目の教育内容を検討する手がかりを得るものとして，女子学生の食事の現状と意識および食生活への興味についてアンケート調査を行なった。その中から，第一段階として女子学生の食事に対する意識の現状を概観し検証した結果， 規則正しい食生活の習慣をつけるスキル，食生活の現実に即した知識，日本の食文化の教養，共食の検討などの必要性が高いことが導出できた