Higgs bosons near 125 GeV in the NMSSM with constraints at the GUT scale

We study the NMSSM with universal Susy breaking terms (besides the Higgs sector) at the GUT scale. Within this constrained parameter space, it is not difficult to find a Higgs boson with a mass of about 125 GeV and an enhanced cross section in the diphoton channel. An additional lighter Higgs boson with reduced couplings and a mass <123 GeV is potentially observable at the LHC. The NMSSM-specific Yukawa couplings lambda and kappa are relatively large and tan(beta) is small, such that lambda, kappa and the top Yukawa coupling are of order 1 at the GUT scale. The lightest stop can be as light as 105 GeV, and the fine-tuning is modest. WMAP constraints can be satisfied by a dominantly higgsino-like LSP with substantial bino, wino and singlino admixtures and a mass of ~60-90 GeV, which would potentially be detectable by XENON100.Comment: 20 pages, 14 figure

Exploring the effects of real-time online cardiac telerehabilitation using wearable devices compared to gym-based cardiac exercise in people with a recent myocardial infarction: a randomised controlled trial

BackgroundExercise-based cardiac rehabilitation (CR) is a non-pharmacological multidisciplinary programme for individuals after myocardial infarction (MI) that offers multiple health benefits. One of the greatest barriers to CR participation is the travel distance to the rehabilitation centre. Remotely monitored CR appears to be at least as effective in improving cardiovascular risk factors and exercise capacity as traditional centre-based CR. Nevertheless, the efficacy of remotely monitored CR in individuals with a recent MI has yet to be examined.MethodsA total of 30 individuals (8 women, 22 men) after a recent (i.e., &lt;4 weeks) MI were randomly allocated into two groups (online home-based and gym-based groups). Both groups underwent a 26-week CR programme three times per week. All patients performed baseline and 24-week follow-up measurements where peak oxygen uptake (VO2peak), mean daily steps, distance, and calories were assessed.ResultsThe online group showed an improvement in mean daily steps (p &lt; 0.05) and mean daily distance (p &lt; 0.05) at 24 weeks compared to the gym-based group. The paired-sample t-test showed that all the assessed variables were statistically (p &lt; 0.001) improved for both groups at 24 weeks. Pearson's r demonstrated positive correlations between VO2peak and mean daily distance (r = 0.375), and negative correlations between VO2peak and muscle (r = −0.523) and fat masses (r = −0.460). There were no exercise-induced adverse events during the study.ConclusionOur findings might indicate that a real-time online supervised CR exercise programme using wearable technology to monitor the haemodynamic responses in post-MI patients is equally effective as a gym-based exercise programme

Учебная история болезни по внутренним болезням и военно-полевой терапии

ВНУТРЕННИЕ БОЛЕЗНИВОЕННО-ПОЛЕВАЯ ТЕРАПИЯИСТОРИЯ БОЛЕЗНИМЕТОДИЧЕСКИЕ УКАЗАНИЯМетодические указания учат студентов правильно оформлять историю болезни пациента

Exploring the feasibility, acceptability, and safety of a real-time cardiac telerehabilitation and tele coaching programme using wearable devices in people with a recent myocardial infarction

Background:Cardiac rehabilitation (CR) constitutes the recommended nonpharmacological approach for cardiac patients with cardiovascular disease such as people following a recent (i.e., &lt; 4 week) myocardial infarction (MI). Recent evidence suggests that cardiac telerehabilitation may be as effective as traditional (i.e., in person) CR in people following a recent MI. Nevertheless, the feasibility, acceptability, and safety of such an exercise programme has yet to be examined. Methods: Forty-four (11 women, 33 men) people following a recent MI were randomly allocated into two groups (online home-based and gym-based groups). The groups underwent a 24-week CR programme thrice per week. All patients performed the baseline, and 24 weeks follow up measurements where feasibility, acceptability, and safety were assessed. Results: Eligibility and recruitment rates were found to be 61.5% and 42%, respectively. Compliance to the thrice weekly, 24-week exercise programme for the online- and gym-based groups were 91.6% and 90.9%, respectively. There were no dropouts during the exercise programmes, however four participants, two from each group, were lost to follow up at 6 months. The average percentage of peak HR (% HRpeak) for the online group was 66.6% ± 4.5 and for the gym-based group was 67.2% ± 5. The average RPE and affect during exercise was for both groups 12 ± 1 (“somewhat hard”) and 3 ± 1 (“good”), respectively. During the 6-month exercise intervention period for both groups, the exercise-induced symptoms were minimal to none. The user suitability evaluation questionnaire revealed that the online real time telerehabilitation and tele coaching programme was enjoyable (4.85 ± 0.37) and did not induce general discomfort (1.20 ± 0.41). Conclusion: Our cardiac telerehabilitation programme seems to be feasible, acceptable, safe, and enjoyable for people with a recent MI. Our participants had an overall positive experience and acceptability of the cardiac telerehabilitation and tele coaching using wearable devices. Trial registration: ClinicalTrial.gov, ID NCT06071273, 10/02/2023, retrospectively registered.</p

Проектирование системы электроснабжения машиностроительного завода

Объект исследования- электроснабжение машиностроительного завода, подробное рассмотрение цеха твердой изоляции. Цель работы: разработка системы электроснабжения промышленного предприятия. В процессе исследования произведен поэтапный расчет электрических нагрузок завода и рассматриваемого цеха, выбор оборудования и его проверка при различных режимах работы. В результате исследования была спроектирована конкретная модель электроснабжения промышленного предприятия, представлена ее техническая целесообразность и безопасность для окружающей среды. Основные характеристики: исследуемый завод состоит из 16 цехов, относящихся ко 2 категории по степени надежности электроснабжения, напряжение питающей линии 110 кВ; рабочие напряжения внутри завода:0,4 кВ; схема внутризаводской сети– радиальная.Object of research - power supply of engineering plant, detailed consideration of shop of firm isolation. Work purpose: development of the system of power supply of industrial enterprise. In the course of research staged billing of electric loadings of plant and the considered shop, the choice of the equipment and its check in case of various operating modes is made. As a result of research the specific model of power supply of industrial enterprise has been designed, its technical feasibility and safety for environment is provided. Main characteristics: the researched plant consists of 16 shops belonging to the 2nd category on degrees of reliability of power supply, tension of the feeding line of 110 kV; working tension inside zavoda:0,4 kV; the scheme of an intra factory network – radia

Identification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach

Cancer, like many common disorders, has a complex etiology, often with a strong genetic component and with multiple environmental factors contributing to susceptibility. A considerable number of genomic variants have been previously reported to be causative of, or associated with, an increased risk for various types of cancer. Here, we adopted a next-generation sequencing approach in 11 members of two families of Greek descent to identify all genomic variants with the potential to predispose family members to cancer. Cross-comparison with data from the Human Gene Mutation Database identified a total of 571 variants, from which 47 % were disease-associated polymorphisms, 26 % disease-associated polymorphisms with additional supporting functional evidence, 19 % functional polymorphisms with in vitro/laboratory or in vivo supporting evidence but no known disease association, 4 % putative disease-causing mutations but with some residual doubt as to their pathological significance, and 3 % disease-causing mutations. Subsequent analysis, focused on the latter variant class most likely to be involved in cancer predisposition, revealed two variants of prime interest, namely MSH2 c.2732T>A (p.L911R) and BRCA1 c.2955delC, the first of which is novel. KMT2D c.13895delC and c.1940C>A variants are additionally reported as incidental findings. The next-generation sequencing-based family genomics approach described herein has the potential to be applied to other types of complex genetic disorder in order to identify variants of potential pathological significance

Field demonstration of a fully managed, L1 encrypted 3-node network with hybrid relayed-QKD and centralized symmetric classical key management

We successfully demonstrated a fully-managed, field-deployed, three-node QKD ring network with L1-OTNsec encryption, that employs a hybrid scheme of QKD and classical yet quantum-safe centrally-generated symmetric keys to support point-to-point and relay consumers

In the wake of austerity: social impact bonds and the financialisation of the welfare state in Britain

This paper provides an analysis of the financialisation of the British welfare state. In a continuation of neo-liberal privatisation and labour market activation, the financialised welfare state pursues a policy of welfare retrenchment, while engaging in forms of social engineering aimed at producing self-responsibilised individuals and communities who are financially literate, ‘investment-ready’ and economically productive. New financial instruments such as social impact bonds are deployed to these ends, both to ‘solve social problems’ and enable cost saving. Through the use of such financial instruments, the implementation of regulatory infrastructures and tax incentives, the financialised welfare state becomes a vehicle for the transfer of wealth from the public to private investors, while subjecting the domain of social policy to the vicissitudes of global financial markets. This paper offers a critique of these developments, situating the case of Britain within the broader global context and with regard to the implications for understanding the current political economy of the welfare state