International Research Symposium on Talent Education, Part 5: The challenges of offering group class

This is the fifth installment in a series of articles reporting on a large‐scale demographic survey of North American Suzuki teachers. The last article in this series examined some of the perceived benefits of group class. In this article, we will review participants’ perceptions of the challenges of group class. Participating teachers were asked to respond to the open‐ended question, "What is the greatest challenge of group class?" Their responses were coded and analyzed for important themes

International Research Symposium on Talent Education, Part 6: Parent education in Suzuki studios

This is the sixth installment in a series of articles reporting on a large‐scale demographic survey of North American Suzuki teachers. The previous article in this series examined some of the perceived challenges of group class. In this article, we will review teachers' descriptions of the parent education offerings within their studios. Teachers were asked to provide information about the structure, content, and intensity of their parent education programs. The survey questions included both initial education for new families entering their studios, as well as ongoing education for returning families

Guest Editorial: Satellite Systems, Applications and Networking.

yesGuest Editorial of Special Issue (featuring eight original papers, comprising 133 pages in total). Whilst satellite systems continue to be at the forefront of broadcast communication service provision, they have an increasingly important role to play in the provision of global Internet services. There has been a strong trend towards convergence of communication services in recent times, with the Internet providing the ideal platform on which to base such convergence. Even traditional circuit-switched applications (such as voice and video streaming) have been shown to work effectively over the Internet. Although the Internet is prevalent in the developed world, satellites are vital to extending this into more remote and sparsely populated regions of the world. It is therefore important that satellite technology is advanced to provide seamless interoperability with the Internet and adequate Quality of Service (QoS) support. The purpose of this special issue is to present research devoted to furthering satellite technology and networking to support the provision of both current and future applications

International Research Symposium on Talent Education, Part 4: The joys and benefits of Suzuki group class

This is the fourth article in a series reporting the findings of a large-scale demographic study of Suzuki teachers in Canada and the United States. Previous articles introduced the research, reporting on basic demographic statistics, teacher training, studio size, and structure of group classes. In this article we report on the results of an open-ended response question regarding the benefits of student participation in Suzuki group class

Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms

MEDLINE® is the source for the MeSH terms of this document.Objective-: The goal of this study was to examine the effect of chronic heterogeneous shear stress, applied using an orbital shaker, on endothelial cell morphology and the expression of cyclooxygenases 1 and 2. Methods and results-: Porcine aortic endothelial cells were plated on fibronectin-coated Transwell plates. Cells were cultured for up to 7 days either under static conditions or on an orbital shaker that generated a wave of medium inducing shear stress over the cells. Cells were fixed and stained for the endothelial surface marker CD31 or cyclooxygenases 1 and 2. En face confocal microscopy and scanning ion conductance microscopy were used to show that endothelial cells were randomly oriented at the center of the well, aligned with shear stress nearer the periphery, and expressed cyclooxygenase-1 under all conditions. Lipopolysaccharide induced cyclooxygenase-2 and the production of 6-keto-prostaglandin F1α in all cells. Conclusion-: Cyclooxygenase-1 is expressed in endothelial cells cultured under chronic shear stress of high or low directionality.Peer reviewedSubmitted Versio

Baryonic mass budgets for haloes in the EAGLE simulation, including ejected and prevented gas

Galaxie

International Research Symposium on Talent Education, Part 3: What do Suzuki studios look like?

This is the third article in a series reporting the findings of a large-scale demographic study of 1128 North American SAA member teachers. The first article introduced the International Research Symposium on Talent Education and the group's current research interests. The second installment in the series focused on Suzuki teachers and included basic demographic information and information on teachers' training. In this article, we will explore what Suzuki studios look like, examining data such as studio size and structure of group classes

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

<p>Rationale: Dedifferentiation of vascular smooth muscle cells (VSMC) leading to a proliferative cell phenotype significantly contributes to the development of atherosclerosis. Mitogen-activated protein kinase (MAPK) phosphorylation of proteins including connexin 43 (Cx43) has been associated with VSMC proliferation in atherosclerosis.</p> <p>Objective: To investigate whether MAPK phosphorylation of Cx43 is directly involved in VSMC proliferation.</p> <p>Methods and Results: We show in vivo that MAPK-phosphorylated Cx43 forms complexes with the cell cycle control proteins cyclin E and cyclin-dependent kinase 2 (CDK2) in carotids of apolipoprotein-E receptor null (ApoE−/−) mice and in C57Bl/6 mice treated with platelet-derived growth factor–BB (PDGF). We tested the involvement of Cx43 MAPK phosphorylation in vitro using constructs for full-length Cx43 (Cx43) or the Cx43 C-terminus (Cx43CT) and produced null phosphorylation Ser>Ala (Cx43MK4A/Cx43CTMK4A) and phospho-mimetic Ser>Asp (Cx43MK4D/Cx43CTMK4D) mutations. Coimmunoprecipitation studies in primary VSMC isolated from Cx43 wild-type (Cx43+/+) and Cx43 null (Cx43−/−) mice and analytic size exclusion studies of purified proteins identify that interactions between cyclin E and Cx43 requires Cx43 MAPK phosphorylation. We further demonstrate that Cx43 MAPK phosphorylation is required for PDGF-mediated VSMC proliferation. Finally, using a novel knock-in mouse containing Cx43-MK4A mutation, we show in vivo that interactions between Cx43 and cyclin E are lost and VSMC proliferation does not occur after treatment of carotids with PDGF and that neointima formation is significantly reduced in carotids after injury.</p> <p>Conclusions: We identify MAPK-phosphorylated Cx43 as a novel interacting partner of cyclin E in VSMC and show that this interaction is critical for VSMC proliferation. This novel interaction may be important in the development of atherosclerotic lesions.</p&gt