562 research outputs found
Differential metabolism of deoxyribonucleosides by leukaemic T cells of immature and mature phenotype
Experimental evidence has indicated that T lymphoblasts are more sensitive to deoxynucleoside toxicity than are B lymphoblasts. These data have led to the use of purine enzyme inhibitors as selective chemotherapeutic drugs in the treatment of T cell malignancies ranging from T cell acute lymphoblastic leukaemia to cutaneous T cell lymphomas. We have compared the toxicities of 2′-deoxyadenosine, 2′-deoxyguanosine, and thymidine for T cell lines derived from patients with T cell acute lymphoblastic leukaemia with those for mature T cell lines derived from patients with cutaneous T cell leukaemia/lymphoma. We have found that both deoxynucleosides are far less toxic to the mature T cell lies than to T lymphoblasts and that the mature cells accumulate much lower amounts of dATP and dGTP when exposed to deoxyadenosine and deoxyguanosine, respectively. Similar studies performed on peripheral blood cells from patients with T cell leukaemias of mature phenotype and on peripheral blood T cells demonstrate similar low amounts of deoxynucleotide accumulation. Measurements of the activities of several purine metabolizing enzymes that participate in deoxynucleoside phosphorylation or degradation do not reveal differences which would explain the toxicity of deoxynucleosides for immature, as compared to mature, T cells. We conclude that deoxynucleoside metabolism in leukaemic T cells varies with their degree of differentiation. These observations may be relevant to the design of chemotherapeutic regimes for T cell malignancies.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72479/1/j.1365-2141.1985.tb04067.x.pd
Geometric Phase, Curvature, and Extrapotentials in Constrained Quantum Systems
We derive an effective Hamiltonian for a quantum system constrained to a
submanifold (the constraint manifold) of configuration space (the ambient
space) by an infinite restoring force. We pay special attention to how this
Hamiltonian depends on quantities which are external to the constraint
manifold, such as the external curvature of the constraint manifold, the
(Riemannian) curvature of the ambient space, and the constraining potential. In
particular, we find the remarkable fact that the twisting of the constraining
potential appears as a gauge potential in the constrained Hamiltonian. This
gauge potential is an example of geometric phase, closely related to that
originally discussed by Berry. The constrained Hamiltonian also contains an
effective potential depending on the external curvature of the constraint
manifold, the curvature of the ambient space, and the twisting of the
constraining potential. The general nature of our analysis allows applications
to a wide variety of problems, such as rigid molecules, the evolution of
molecular systems along reaction paths, and quantum strip waveguides.Comment: 27 pages with 1 figure, submitted to Phys. Rev.
An automatic architecture reconstruction and refactoring framework
A variety of sources have noted that a substantial proportion of non trivial software systems fail due to unhindered architectural erosion. This design deterioration leads to low maintainability, poor testability and reduced development speed. The erosion of software systems is often caused by inadequate understanding, documentation and maintenance of the desired implementation architecture. If the desired architecture is lost or the deterioration is advanced, the reconstruction of the desired architecture and the realignment of this desired architecture with the physical architecture both require substantial manual analysis and implementation effort. This paper describes the initial development of a framework for automatic software architecture reconstruction and source code migration. This framework offers the potential to reconstruct the conceptual architecture of software systems and to automatically migrate the physical architecture of a software system toward a conceptual architecture model. The approach is implemented within a proof of concept prototype which is able to analyze java system and reconstruct a conceptual architecture for these systems as well as to refactor the system towards a conceptual architecture
Measurement of Pion Enhancement at Low Transverse Momentum and of the Delta-Resonance Abundance in Si-Nucleus Collisions at AGS Energy
We present measurements of the pion transverse momentum (p_t) spectra in
central Si-nucleus collisions in the rapidity range 2.0<y<5.0 for p_t down to
and including p_t=0. The data exhibit an enhanced pion yield at low p_t
compared to what is expected for a purely thermal spectral shape. This
enhancement is used to determine the Delta-resonance abundance at freeze-out.
The results are consistent with a direct measurement of the Delta-resonance
yield by reconstruction of proton-pion pairs and imply a temperature of the
system at freeze-out close to 140 MeV.Comment: 12 pages + 4 figures (uuencoded at end-of-file
Social assistance performance in Central and Eastern Europe: A pre-transfer post-transfer comparison
The anti-poverty impact of national social assistance programmes in eight Central and Eastern European countries is examined using data from the European Union-Survey of Income and Living Conditions (EU-SILC). Results indicate that social assistance programmes achieve only limited poverty reduction, while spending a significant amount of their resources on the non-poor. The more extensive and generous programmes achieve higher effectiveness in reducing poverty. Efficiency on the other hand appears to be linked only to programme size and not to benefit levels. Unlike Western Europe, no trade-off between effectiveness and efficiency could be detected
Moon Shadow by Cosmic Rays under the Influence of Geomagnetic Field and Search for Antiprotons at Multi-TeV Energies
We have observed the shadowing of galactic cosmic ray flux in the direction
of the moon, the so-called moon shadow, using the Tibet-III air shower array
operating at Yangbajing (4300 m a.s.l.) in Tibet since 1999. Almost all cosmic
rays are positively charged; for that reason, they are bent by the geomagnetic
field, thereby shifting the moon shadow westward. The cosmic rays will also
produce an additional shadow in the eastward direction of the moon if cosmic
rays contain negatively charged particles, such as antiprotons, with some
fraction. We selected 1.5 x10^{10} air shower events with energy beyond about 3
TeV from the dataset observed by the Tibet-III air shower array and detected
the moon shadow at level. The center of the moon was detected
in the direction away from the apparent center of the moon by 0.23 to
the west. Based on these data and a full Monte Carlo simulation, we searched
for the existence of the shadow produced by antiprotons at the multi-TeV energy
region. No evidence of the existence of antiprotons was found in this energy
region. We obtained the 90% confidence level upper limit of the flux ratio of
antiprotons to protons as 7% at multi-TeV energies.Comment: 13pages,4figures; Accepted for publication in Astroparticle Physic
Closed circuits : kinship, neighborhood and incarceration in urban Portugal
The notion that prisons are a ‘world apart’, with their
walls severing prisoners from their external relationships, and
incarceration an interruption, ‘time away’ spent in a separate social
universe, has provided an adequate framework for understanding the
social realities of imprisonment in the past. But it has also created an
analytical dead angle that prevents us from identifying the ramifying
social effects of concentrated incarceration upon both the prison and
heavily penalized lower-class neighborhoods. This article addresses these
effects with data from an ethnographic revisit of a major women’s prison
in Portugal, where the recomposition of the inmate population that has
accompanied the rapid inflation of the country’s carceral population is
especially pronounced and entails the activation of wide-ranging
carceralized networks bringing kinship and neighborhood into the prison
as well as the prison into the domestic world. The analysis focuses on the
ways whereby these constellations have transformed the experience of
confinement and the texture of correctional life, calling for a
reconsideration of the theoretical status of the prison as a ‘total
institution’ and for exploring anew the boundary that separates it (or not)
from outside worlds.Wenner-Gren Foundation for Anthropological Research
Dilepton mass spectra in p+p collisions at sqrt(s)= 200 GeV and the contribution from open charm
The PHENIX experiement has measured the electron-positron pair mass spectrum
from 0 to 8 GeV/c^2 in p+p collisions at sqrt(s)=200 GeV. The contributions
from light meson decays to e^+e^- pairs have been determined based on
measurements of hadron production cross sections by PHENIX. They account for
nearly all e^+e^- pairs in the mass region below 1 GeV/c^2. The e^+e^- pair
yield remaining after subtracting these contributions is dominated by
semileptonic decays of charmed hadrons correlated through flavor conservation.
Using the spectral shape predicted by PYTHIA, we estimate the charm production
cross section to be 544 +/- 39(stat) +/- 142(syst) +/- 200(model) \mu b, which
is consistent with QCD calculations and measurements of single leptons by
PHENIX.Comment: 375 authors from 57 institutions, 18 pages, 4 figures, 2 tables.
Submitted to Physics Letters B. v2 fixes technical errors in matching authors
to institutions. Plain text data tables for the points plotted in figures for
this and previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Inclusive cross section and double helicity asymmetry for \pi^0 production in p+p collisions at sqrt(s)=200 GeV: Implications for the polarized gluon distribution in the proton
The PHENIX experiment presents results from the RHIC 2005 run with polarized
proton collisions at sqrt(s)=200 GeV, for inclusive \pi^0 production at
mid-rapidity. Unpolarized cross section results are given for transverse
momenta p_T=0.5 to 20 GeV/c, extending the range of published data to both
lower and higher p_T. The cross section is described well for p_T < 1 GeV/c by
an exponential in p_T, and, for p_T > 2 GeV/c, by perturbative QCD. Double
helicity asymmetries A_LL are presented based on a factor of five improvement
in uncertainties as compared to previously published results, due to both an
improved beam polarization of 50%, and to higher integrated luminosity. These
measurements are sensitive to the gluon polarization in the proton, and exclude
maximal values for the gluon polarization.Comment: 375 authors, 7 pages, 3 figures. Submitted to Phys. Rev. D, Rapid
Communications. Plain text data tables for the points plotted in figures for
this and previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
System Size and Energy Dependence of Jet-Induced Hadron Pair Correlation Shapes in Cu+Cu and Au+Au Collisions at sqrt(s_NN) = 200 and 62.4 GeV
We present azimuthal angle correlations of intermediate transverse momentum
(1-4 GeV/c) hadrons from {dijets} in Cu+Cu and Au+Au collisions at sqrt(s_NN) =
62.4 and 200 GeV. The away-side dijet induced azimuthal correlation is
broadened, non-Gaussian, and peaked away from \Delta\phi=\pi in central and
semi-central collisions in all the systems. The broadening and peak location
are found to depend upon the number of participants in the collision, but not
on the collision energy or beam nuclei. These results are consistent with sound
or shock wave models, but pose challenges to Cherenkov gluon radiation models.Comment: 464 authors from 60 institutions, 6 pages, 3 figures, 2 tables.
Submitted to Physical Review Letters. Plain text data tables for the points
plotted in figures for this and previous PHENIX publications are (or will be)
publicly available at http://www.phenix.bnl.gov/papers.htm
- …