2,192 research outputs found
Investigating use of the Behavior Education Program for students with internalizing behavioral concerns
Title from PDF of title page (University of Missouri--Columbia, viewed on March 1, 2013).The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.Dissertation advisor: Dr. Melissa A. StormontIncludes bibliographical references.Vita.Ph. D. University of Missouri--Columbia 2012."December 2012"This study investigated the effects of the Behavior Education Program (BEP), also known as check-in/check-out (CICO), on internalizing problems and academic engaged time exhibited by elementary school students identified at risk for developing anxiety or mood disorders. Descriptive data for teacher ratings of student internalizing problems were collected pre and post intervention. A single-subject multiple baseline design was used to examine effects of the Behavior Education Program (BEP) on student academic engagement. Student, parent, and teacher perceptions of intervention acceptability and fidelity of implementation also were measured. Overall, the intervention had a positive impact on teachers' perceptions of student problems and also on academic engaged time. In addition, student and parent participants generally viewed the intervention favorably and school personnel were able to implement a majority of intervention components with high levels of fidelity.Includes bibliographical references
Preface: Social and Technical Issues in Testing: Implications for Test Construction and Usage
Tests are constructed and used to facilitate assessment and understanding of human beings in all their multifaceted complexity. Hence, testing by its very nature is both a scientific and a social endeavor.
The interplay between testing and society has resulted in both praise and criticism from concerned citizens, psychologists, educators, and numerous other professional and consumer groups. For over 40 years, Oscar K. Buros, as Director of The Institute of Mental Measurements and Editor of the Mental Measurements Yearbooks. contributed immensely to this interplay between testing practices and societal issues. On March 19, 1978, Oscar Buros died. Luella Buros , his wife and lifelong helpmate, completed the work on The Eighth Mental Measurements Yearbook with the support of the Institute\u27s devoted staff. She also took steps to relocate the Institute to ensure the continuation of the Institute\u27s scholarly work and services for test consumers. The new Buros Institute of Mental Measurements is now at the University of Nebraska- Lincoln and is under grant from The University of Nebraska Foundation.
An important objective of the new Buros Institute is to conduct an extended outreach effort that will help communicate more effectively with test users about contemporary issues in testing . Thus, it was the combination of recent social issues focusing on testing and our desire to fulfill more vigorously the mission of the Buros Institute that motivated the development of an annual scholarly symposium and this series on measurement and testing.
We intend each symposium and volume in this series to present state-of-the art knowledge that will contribute to the improvement of test construction and test usage. Such a schema will incorporate topics across a broad spectrum such as theoretical models of human behavior, test standardization procedures, social and legal factors in testing, administration of testing programs , and test-based decision making. Thus, the series will be focused thematically and yet be flexible enough to integrate current and future measurement and testing issues into its schema.
The success of our first Buros- Nebraska symposium and this volume is the result of the efforts of many individuals. We thank Luella Buros for having faith in us to carryon and extend a tradition that has become so important to the measurement field and to test users. Barbara Plake , as editor of the first volume in the series, made conceptual and editorial contributions that were of critical importance to its success. Finally, we want to thank Larry Erlbaum for his support, encouragement, and commitment to the project and to its timely completion
A time transect of exomes from a Native American population before and after European contact
A major factor for the population decline of Native Americans after European contact has been attributed to infectious disease susceptibility. To investigate whether a pre-existing genetic component contributed to this phenomenon, here we analyse 50 exomes of a continuous population from the Northwest Coast of North America, dating from before and after European contact. We model the population collapse after European contact, inferring a 57% reduction in effective population size. We also identify signatures of positive selection on immune-related genes in the ancient but not the modern group, with the strongest signal deriving from the human leucocyte antigen (HLA) gene HLA-DQA1. The modern individuals show a marked frequency decrease in the same alleles, likely due to the environmental change associated with European colonization, whereby negative selection may have acted on the same gene after contact. The evident shift in selection pressures correlates to the regional European-borne epidemics of the 1800s.Full Tex
Hair of the Dog: Obtaining Samples From Coyotes and Wolves Noninvasively
Canids can be difficult to detect and their populations difficult to monitor. We tested whether hair samples could be collected from coyotes (Canis latrans) in Texas, USA and gray wolves (C. lupus) in Montana, USA using lure to elicit rubbing behavior at both man-made and natural collection devices. We usedmitochondrial and nuclearDNA to determine whether collected hair samples were from coyote, wolf, or nontarget species. Both coyotes and wolves rubbed on man-made barbed surfaces but coyotes in Texas seldom rubbed on hanging barbed surfaces. Wolves in Montana showed a tendency to rub at stations where natural material collection devices (sticks and debris) were present. Time to detection was relatively short (5 nights and 4 nights for coyotes and wolves, respectively) with nontarget and unknown species comprising approximately 26% of the detections in both locations. Eliciting rubbing behavior from coyotes and wolves using lures has advantages over opportunistic genetic sampling methods (e.g., scat transects) because it elicits a behavior that deposits a hair sample at a fixed sampling location, thereby increasing the efficiency of sampling for these canids. Hair samples from rub stations could be used to provide estimates of abundance, measures of genetic diversity and health, and detection–nondetection data useful for cost-effective population monitoring
Informing investment to reduce inequalities: a modelling approach
Background: Reducing health inequalities is an important policy objective but there is limited quantitative information about the impact of specific interventions.
Objectives: To provide estimates of the impact of a range of interventions on health and health inequalities.
Materials and methods: Literature reviews were conducted to identify the best evidence linking interventions to mortality and hospital admissions. We examined interventions across the determinants of health: a ‘living wage’; changes to benefits, taxation and employment; active travel; tobacco taxation; smoking cessation, alcohol brief interventions, and weight management services. A model was developed to estimate mortality and years of life lost (YLL) in intervention and comparison populations over a 20-year time period following interventions delivered only in the first year. We estimated changes in inequalities using the relative index of inequality (RII).
Results: Introduction of a ‘living wage’ generated the largest beneficial health impact, with modest reductions in health inequalities. Benefits increases had modest positive impacts on health and health inequalities. Income tax increases had negative impacts on population health but reduced inequalities, while council tax increases worsened both health and health inequalities. Active travel increases had minimally positive effects on population health but widened health inequalities. Increases in employment reduced inequalities only when targeted to the most deprived groups. Tobacco taxation had modestly positive impacts on health but little impact on health inequalities. Alcohol brief interventions had modestly positive impacts on health and health inequalities only when strongly socially targeted, while smoking cessation and weight-reduction programmes had minimal impacts on health and health inequalities even when socially targeted.
Conclusions: Interventions have markedly different effects on mortality, hospitalisations and inequalities. The most effective (and likely cost-effective) interventions for reducing inequalities were regulatory and tax options. Interventions focused on individual agency were much less likely to impact on inequalities, even when targeted at the most deprived communities
Generation and characterization of β1,2-gluco-oligosaccharide probes fromBrucella abortuscyclic β-glucan and their recognition by C-type lectins of the immune system
The β1,2-glucans produced by bacteria are important in invasion, survival and immunomodulation in infected hosts be they mammals or plants. However, there has been a lack of information on proteins which recognize these molecules. This is partly due to the extremely limited availability of the sequence-defined oligosaccharides and derived probes for use in the study of their interactions. Here we have used the cyclic β1,2-glucan (CβG) of the bacterial pathogen Brucella abortus, after removal of succinyl side chains, to prepare linearized oligosaccharides which were used to generate microarrays. We describe optimized conditions for partial depolymerization of the cyclic glucan by acid hydrolysis and conversion of the β1,2-gluco-oligosaccharides, with degrees of polymerization 2-13, to neoglycolipids for the purpose of generating microarrays. By microarray analyses we show that the C-type lectin receptor DC-SIGNR, like the closely related DC-SIGN we investigated earlier, binds to the β1,2-gluco-oligosaccharides, as does the soluble immune effector serum mannose-binding protein. Exploratory studies with DC-SIGN are suggestive of the recognition also of the intact CβG by this receptor. These findings open the way to unravelling mechanisms of immunomodulation mediated by β1,2-glucans in mammalian systems
Genetic structure of First Nation communities in the Pacific Northwest
This study presents genetic data for nine Native American populations from northern North America. Analyses of genetic variation focus on the Pacific Northwest (PNW). Using mitochondrial, Y chromosomal and autosomal DNA variants, we aim to more closely address the relationships of geography and language with present genetic diversity among the regional PNW Native American populations. Patterns of genetic diversity exhibited by the three genetic systems were consistent with our hypotheses, in that we expected genetic variation to be more strongly explained by geographic proximity than linguistic structure. Our findings were corroborated through a variety on analytic approaches, with the unrooted trees for the three genetic systems consistently separating inland from coastal PNW populations. Furthermore, the AMOVA tests support the trends exhibited by the unrooted trees, with geographic partitioning of PNW populations (FCT = 19.43%, p = 0.010 ± 0.009) accounting for over twice as much of the observed genetic variation compared with linguistic partitioning of the same populations (FCT = 9.15%, p = 0.193 ± 0.013). These findings demonstrate a consensus with previous PNW population studies examining the relationships of genome-wide variation, mitochondrial haplogroup frequencies, and skeletal morphology with geography and language
A new approach to construct pathway connected networks and its application in dose responsive gene expression profiles of rat liver regulated by 2,4DNT
<p>Abstract</p> <p>Background</p> <p>Military and industrial activities have lead to reported release of 2,4-dinitrotoluene (2,4DNT) into soil, groundwater or surface water. It has been reported that 2,4DNT can induce toxic effects on humans and other organisms. However the mechanism of 2,4DNT induced toxicity is still unclear. Although a series of methods for gene network construction have been developed, few instances of applying such technology to generate pathway connected networks have been reported.</p> <p>Results</p> <p>Microarray analyses were conducted using liver tissue of rats collected 24h after exposure to a single oral gavage with one of five concentrations of 2,4DNT. We observed a strong dose response of differentially expressed genes after 2,4DNT treatment. The most affected pathways included: long term depression, breast cancer regulation by stathmin1, WNT Signaling; and PI3K signaling pathways. In addition, we propose a new approach to construct pathway connected networks regulated by 2,4DNT. We also observed clear dose response pathway networks regulated by 2,4DNT.</p> <p>Conclusions</p> <p>We developed a new method for constructing pathway connected networks. This new method was successfully applied to microarray data from liver tissue of 2,4DNT exposed animals and resulted in the identification of unique dose responsive biomarkers in regards to affected pathways.</p
Unknowable bodies, unthinkable sexualities: lesbian and transgender legal invisibility in the Toronto women's bathhouse raid
Although litigation involving sexual orientation and gender identity discrimination claims has generated considerable public attention in recent years, lesbian and transgender bodies and sexualities still remain largely invisible in Anglo-American courts. While such invisibility is generally attributed to social norms that fail to recognize lesbian and transgender experiences, the capacity to 'not see' or 'not know' queer bodies and sexualities also involves wilful acts of ignorance. Drawing from R. v Hornick (2002) a Canadian case involving the police raid of a women's bathhouse, this article explores how lesbian and transgender bodies and sexualities are actively rendered invisible via legal knowledge practices, norms and rationalities. It argues that limited knowledge and limited thinking not only regulate the borders of visibility and belonging, but play an active part in shaping identities, governing conduct and producing subjectivity
Self-Care for the Prevention and Management of Cardiovascular Disease and Stroke: A Scientific Statement for Healthcare Professionals from the American Heart Association
Self‐care is defined as a naturalistic decision‐making process addressing both the prevention and management of chronic illness, with core elements of self‐care maintenance, self‐care monitoring, and self‐care management. In this scientific statement, we describe the importance of self‐care in the American Heart Association mission and vision of building healthier lives, free of cardiovascular diseases and stroke. The evidence supporting specific self‐care behaviors such as diet and exercise, barriers to self‐care, and the effectiveness of self‐care in improving outcomes is reviewed, as is the evidence supporting various individual, family‐based, and community‐based approaches to improving self‐care. Although there are many nuances to the relationships between self‐care and outcomes, there is strong evidence that self‐care is effective in achieving the goals of the treatment plan and cannot be ignored. As such, greater emphasis should be placed on self‐care in evidence‐based guidelines
- …