Impact of Organization Commitment on Turnover Intention: Mediating Role of Job Contentment

Basis purpose of this research is to find out the impact of organizational commitment on turnover intension. Literature on organizational commitment and turnover intention depicted that organizational commitment has profound impact on turnover intension. Further influence of job satisfaction as mediator was also investigated. Data was collected through the questionnaires from 200 employees of banking sector of Faisalabad. To test the hypothesis, correlation and regression analysis is carried out using SPSS 20.0. Results of the statistical analysis indicated significantly negative relationship between organizational commitment and turnover intension and significant positive relationship between organizational commitment and job satisfaction. Result of the research concludes that job satisfaction partially mediates the relationship between organizational commitment and turnover intension. Keywords: Organizational commitment, affective commitment, continuous commitment, normative commitment, Job satisfaction, turnover intension

Impact of COVID-19 on Ophthalmologists

Objectives: To determine the effects of COVID 19 pandemic on the professional lives of ophthalmologists Methods: This cross sectional survey was conducted for 6 months in late 2020 and used google forms for data collection. Results: Total 68 respondents gave their likert response for each of the 20 statements. No. %, median, mode and interquartile range, of all respondents likert sentiment for each statement, were calculated. Survey results showed general, ‘consent and consensus’. Conclusion: Covid-19 has influenced professional lives of ophthalmologists

Frequency of Raised Intraocular Pressure and its Correlations to the energy used following Neodymium YAG Laser Posterior Capsulotomy in Pseudophakes

Objective: To determine the frequency of raised intraocular pressure in pseudophakic undergoing Nd YAG laser posterior capsulotomy. To compare the frequency of raised intraocular pressure in pseudophakic undergoing high and low energy Nd YAG laser posterior capsulotomy Methods: This Descriptive case series included 140 patients with pseudophakic posterior capsular opacity. After dilating the pupils with tropicamide Nd YAG laser posterior capsulotomy was performed and the total amount of energy used was noted. The frequency of raised IOP in post-laser patients and comparison of frequencies of raised IOP undergoing high and low energy Nd YAG laser posterior capsulotomies (≤ 50 MJ labeled as low energy and > 50 MJ labeled as high energy) were calculated Results: The mean age was 57.37 ±8.74. Mean pre laser IOP was 15.15 and post-laser IOP was 17.50. The rise in IOP was normal in 82.9% and raised in 17.1%. In lower energy group normal IOP was found in 35.7% and raised in 2.9%. In a higher energy group, normal IOP was found in 47.1%, and raised IOP was found to be 14.3%. Conclusion: Higher the energy used during the Nd YAG laser posterior capsulotomy procedure, more is the chance of a rise in post-laser intraocular pressure as compared to those in which lesser energy was being used

Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial

Background: Tranexamic acid reduces surgical bleeding and reduces death due to bleeding in patients with trauma. Meta-analyses of small trials show that tranexamic acid might decrease deaths from gastrointestinal bleeding. We aimed to assess the effects of tranexamic acid in patients with gastrointestinal bleeding. Methods: We did an international, multicentre, randomised, placebo-controlled trial in 164 hospitals in 15 countries. Patients were enrolled if the responsible clinician was uncertain whether to use tranexamic acid, were aged above the minimum age considered an adult in their country (either aged 16 years and older or aged 18 years and older), and had significant (defined as at risk of bleeding to death) upper or lower gastrointestinal bleeding. Patients were randomly assigned by selection of a numbered treatment pack from a box containing eight packs that were identical apart from the pack number. Patients received either a loading dose of 1 g tranexamic acid, which was added to 100 mL infusion bag of 0·9% sodium chloride and infused by slow intravenous injection over 10 min, followed by a maintenance dose of 3 g tranexamic acid added to 1 L of any isotonic intravenous solution and infused at 125 mg/h for 24 h, or placebo (sodium chloride 0·9%). Patients, caregivers, and those assessing outcomes were masked to allocation. The primary outcome was death due to bleeding within 5 days of randomisation; analysis excluded patients who received neither dose of the allocated treatment and those for whom outcome data on death were unavailable. This trial was registered with Current Controlled Trials, ISRCTN11225767, and ClinicalTrials.gov, NCT01658124. Findings: Between July 4, 2013, and June 21, 2019, we randomly allocated 12 009 patients to receive tranexamic acid (5994, 49·9%) or matching placebo (6015, 50·1%), of whom 11 952 (99·5%) received the first dose of the allocated treatment. Death due to bleeding within 5 days of randomisation occurred in 222 (4%) of 5956 patients in the tranexamic acid group and in 226 (4%) of 5981 patients in the placebo group (risk ratio [RR] 0·99, 95% CI 0·82–1·18). Arterial thromboembolic events (myocardial infarction or stroke) were similar in the tranexamic acid group and placebo group (42 [0·7%] of 5952 vs 46 [0·8%] of 5977; 0·92; 0·60 to 1·39). Venous thromboembolic events (deep vein thrombosis or pulmonary embolism) were higher in tranexamic acid group than in the placebo group (48 [0·8%] of 5952 vs 26 [0·4%] of 5977; RR 1·85; 95% CI 1·15 to 2·98). Interpretation: We found that tranexamic acid did not reduce death from gastrointestinal bleeding. On the basis of our results, tranexamic acid should not be used for the treatment of gastrointestinal bleeding outside the context of a randomised trial

Success rate of Nasolacrimal Duct Probing in children with Congenital Nasolacrimal Duct Obstruction after the age of one year

Introduction: The objective of this study was to determine the success rate of nasolacrimal duct probing for congenital nasolacrimal duct obstruction in children after the age of one year.Materials and Methods: It was a descriptive case series conducted on 145 children presented to Ophthalmology Department, Allied Hospital, Faisalabad with CNLDO. The probing and syringing of the nasolacrimal duct were performed under general anesthesia. The patency of the nasolacrimal system was evaluated by irrigation of saline stained with pyodine through the superior punctum, flow of saline into the nose was confirmed by soaking of throat gauze with pyodine stained fluid and/or oozing of pyodine stained fluid through nose. Patients were advised topical antibiotics and steroids for 3 weeks after the probing and follow-up checkups after 6 weeks. Data were analyzed using SPSS computer software version 17.0. Effect modifier like age and gender was controlled by stratification. The post-stratification chi-square test was applied. P-value <0.05 was considered significant.Results: In our study, the frequency of success of nasolacrimal duct probing for congenital nasolacrimal duct obstruction in children between 1 to 2 years was 80.3%, children between 2 to 3 years of age were 53.1%, and children between 3 to 4 years of age were 32.4%.Conclusion: We concluded that the success rate of nasolacrimal duct probing for congenital nasolacrimal duct obstruction is higher in children after the age of one year and decreases gradually as the age progresses

EFFECT OF LUBRICANTS ON THE STABILITY OF CLOPIDOGREL BISULPHATE TABLETS

The objective of the current study was to develop oral formulation of Clopidogrel Bisulphate 75mg tablet and perform the accelerated stability study to obtain the stable product by using the various lubricants like magnesium stearate, stearic acid and pregelatinized starch. Three different formulations of tablets were prepared and coded as F1, F2 and F3 containing the various lubricants i.e. magnesium stearate, stearic acid and combination of magnesium stearate and pregelatinized starch respectively. Tablets were prepared by direct compression method and the compressed tablets were film coated. The tablets were placed in a stability chamber and accelerated stability studies at 400C and 75% RH were carried out at time 0, 3 and 6 months duration. In accelerated stability study, various tests were performed including hardness, disintegration, chemical assay and in-vitro dissolution test. After preparation of tablets, the physical and chemical parameters of tablets at zero period of time were tested, and were found within their specification. After test the tablets were kept in the stability chamber for six months. After three and six months the physical and chemical parameters of tablets were also tested. According to the results, the formulations containing the magnesium stearate and stearic acid degraded with the passage of time but the formulation containing the combination of pre-gelatinized starch and magnesium stearate were more stable as compared to the formulations containing the lubricants as magnesium stearate and stearic acid. Key words: Clopidogrel Bisulphate, Pregelatinized starch, Accelerated stability studies, In-vitro dissolution

Impact of Participative Leadership on Organizational Citizenship Behavior: Mediating Role of Trust and Moderating Role of Continuance Commitment: Evidence from the Pakistan Hotel Industry

The present study examines the mediating role of affective and cognitive trust, and the moderating role of continuous commitment on participative leadership and organizational citizenship behavior (OCB) relationships. Four hundred employees were recruited from the hotel industry in Pakistan. The bootstrapping method was used for an estimation of the mediation effect by the process macro. This study employs confirmatory factor analysis and structural equation modeling. Results revealed that affective trust significantly mediates the relationship between participative leadership and OCB. Moreover, continuous commitment significantly plays a moderating role in the relationship between participative leadership and OCB. This study provides unique insight into the OCB in the hotel industry. Affective and cognitive trust as a mediator and moderator of continuance commitment are examined, which is the novel characteristic of this study. Managerial implications, limitations, and future directions are discussed

REVIEW KOHL (SURMA): RETROSPECT AND PROSPECT

ABSTRACT Kohl, since antiquity has always been given a prime importance in ophthalmology for the protection and treatment of various eye ailments. However, for decades various conflicting reports in the literature have been published relating to Kohl application to eyes being responsible for causing higher blood lead concentration, which may cause lead poisoning. While at the same time, a number of research studies and reports have also been published negating any such links with increased blood lead level upon Kohl (surma) application. In view of the above mentioned facts, this review article is written with the objective to highlight various data from past and present research studies and reports about Kohl, so as to provide valuable information to both the users and the research workers about it's scientific background and effects when applied into eyes. A large number of items and topics (such as Kohl, surma, eye cosmetic, traditional eye preparations, environmental lead pollution, galena, lead sulphide etc.) have been taken into consideration while compiling this review article. In conclusion, the authors of this review article feel that the relation between Kohl and toxicity or increased blood lead concentration upon it's application to eyes as reported elsewhere is likely to be more of theoretical nature rather than a practical health hazard