Social representations about the disease of women with cervico-uterine cancer

Objective: understanding the social representation of women about cervical cancer and its implications for care of themselves. Method: this is a qualitative study of a descriptive approach that used as a theoretical role the social representations, taking the interview as a technique for data collection of information. We worked with 35 outpatient women of a referral public hospital in oncology. Results: within the dialogs it was observed that the concept of cervical cancer was closely related to the feeling factor, leading fear and sadness. The evidences also showed that women focused on sexuality and treatment as a life change along the disease. Conclusion: cancer of the cervix produces a great change of life in women who passed through the problem, not just by the physical factors, but quite by the subjective side in fighting the disease

Osteoporosis in the Aged Woman: a tracking in the nursing's office

Objective: To describe characteristics rose in historical nursing of elderly pointing to osteoporosis and the risk of a same Outreach Program of Nursing, Fluminense Federal University. Results: It was found that 48 (12,4%) of elderly nursing historical records had problems related to osteoporosis, which stimulated the construction of an extension project for osteoporosis prevention and health promotion seeking to minimize the problem. It was used as strategy, consultations, distributing informative folder and stimulate the maintenance of healthy habits. Conclusion: This problem goes beyond individuality to reach the public space. An isolated action reaches only the intended population, but when other institutions are engaging in this care will contribute with their customers, which is reflected in the well-being of the entire community

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension

OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo

Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab

The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension

Global survival trends for brain tumors, by histology: analysis of individual records for 556,237 adults diagnosed in 59 countries during 2000–2014 (CONCORD-3)

Background: Survival is a key metric of the effectiveness of a health system in managing cancer. We set out to provide a comprehensive examination of worldwide variation and trends in survival from brain tumors in adults, by histology. Methods: We analyzed individual data for adults (15–99 years) diagnosed with a brain tumor (ICD-O-3 topography code C71) during 2000–2014, regardless of tumor behavior. Data underwent a 3-phase quality control as part of CONCORD-3. We estimated net survival for 11 histology groups, using the unbiased nonparametric Pohar Perme estimator. Results: The study included 556,237 adults. In 2010–2014, the global range in age-standardized 5-year net survival for the most common sub-types was broad: in the range 20%–38% for diffuse and anaplastic astrocytoma, from 4% to 17% for glioblastoma, and between 32% and 69% for oligodendroglioma. For patients with glioblastoma, the largest gains in survival occurred between 2000–2004 and 2005–2009. These improvements were more noticeable among adults diagnosed aged 40–70 years than among younger adults. Conclusions: To the best of our knowledge, this study provides the largest account to date of global trends in population-based survival for brain tumors by histology in adults. We have highlighted remarkable gains in 5-year survival from glioblastoma since 2005, providing large-scale empirical evidence on the uptake of chemoradiation at population level. Worldwide, survival improvements have been extensive, but some countries still lag behind. Our findings may help clinicians involved in national and international tumor pathway boards to promote initiatives aimed at more extensive implementation of clinical guidelines

Percepções de portadores de diabetes sobre a doença: contribuições da Enfermagem Percepciones de personas con diabetes acerca de la enfermedad: contribuciones de la Enfermería Perceptions of people with diabetes about the disease: nursing contributions

Este estudo objetivou descrever a percepção dos usuários sobre a diabetes. A pesquisa foi descritiva e exploratória, com abordagem qualitativa; o cenário foi um hospital na cidade de Belém-PA, com participação de 32 sujeitos. Empregando-se a técnica de análise de conteúdo temática, emergiram quatro categorias: Controle do diabetes: a enfermagem na automonitorização da glicemia; O diabético e a enfermagem: uma interação para o autocuidado; Consulta de enfermagem ao diabético: a intervenção no processo saúde-doença; Diabetes e suas complicações: o medo repercutido na perda de funções. Observou-se que o paciente começa a se cuidar impulsionado pelo medo de perder sua saúde, obrigando-o ao autocuidado. O enfermeiro está diretamente ligado com o controle da diabetes, a partir do momento que realiza os cuidados e orientações da automonitorização da doença.Este estudio tuve el objetivo de describir la percepción de los usuarios acerca de la diabetes. Realizó-se una investigación con enfoque descriptivo, exploratorio y cualitativo, en un hospital en la ciudad de Belém-Pará, Brasil, siendo entrevistados 32 sujetos. Fue empleada la técnica de análisis de contenido temático, siendo evidenciadas cuatro categorías: Control de la diabetes: la enfermería en el autocontrol de la glucemia; El diabético y la enfermería: una interacción para el autocuidado; Consulta de enfermería al paciente diabético: intervención en el proceso salud-enfermedad; Diabetes y sus complicaciones: el miedo refletado en la pérdida de funciones. Fue observado que el paciente comienza a cuidar impulsado por el miedo de perder su salud, y que el miedo hace que el paciente tenga el auto-cuidado de sí mismo. El enfermero está directamente conectado con el control de la diabetes, desde el momento en que realiza el cuidado y la orientación para la automonitorización de la enfermedad.This study aimed to identify the perceptions of patients concerning diabetes. This is a descriptive exploratory study with a qualitative approach, which was conducted with 32 subjects, in a hospital in the city of Belem-PA, Brazil. The thematic content analysis was used, from which four categories emerged: Diabetes control: nursing in the self-monitoring of blood glucose; The diabetic individual and nursing: an interaction with self-care; Nursing consultations provided to diabetic individuals: an intervention in the health-disease continuum; Diabetes and its complications: fear of loosing functioning. It was observed that patients start self-care driven by the fear of losing their health, that is, fear forces the patient to practice self-care. Nurses are directly linked to diabetes control as they start providing care and guidance for patients who self-monitor their disease

Percepciones de personas con diabetes acerca de la enfermedad: contribuciones de la Enfermería

This study aimed to identify the perceptions of patients concerning diabetes. This is a descriptive exploratory study with a qualitative approach, which was conducted with 32 subjects, in a hospital in the city of Belem-PA, Brazil. The thematic content analysis was used, from which four categories emerged: Diabetes control: nursing in the self-monitoring of blood glucose; The diabetic individual and nursing: an interaction with self-care; Nursing consultations provided to diabetic individuals: an intervention in the health-disease continuum; Diabetes and its complications: fear of loosing functioning. It was observed that patients start self-care driven by the fear of losing their health, that is, fear forces the patient to practice self-care. Nurses are directly linked to diabetes control as they start providing care and guidance for patients who self-monitor their disease.Este estudo objetivou descrever a percepção dos usuários sobre a diabetes. A pesquisa foi descritiva e exploratória, com abordagem qualitativa; o cenário foi um hospital na cidade de Belém-PA, com participação de 32 sujeitos. Empregando-se a técnica de análise de conteúdo temática, emergiram quatro categorias: Controle do diabetes: a enfermagem na automonitorização da glicemia; O diabético e a enfermagem: uma interação para o autocuidado; Consulta de enfermagem ao diabético: a intervenção no processo saúde-doença; Diabetes e suas complicações: o medo repercutido na perda de funções. Observou-se que o paciente começa a se cuidar impulsionado pelo medo de perder sua saúde, obrigando-o ao autocuidado. O enfermeiro está diretamente ligado com o controle da diabetes, a partir do momento que realiza os cuidados e orientações da automonitorização da doença.Este estudio tuve el objetivo de describir la percepción de los usuarios acerca de la diabetes. Realizó-se una investigación con enfoque descriptivo, exploratorio y cualitativo, en un hospital en la ciudad de Belém-Pará, Brasil, siendo entrevistados 32 sujetos. Fue empleada la técnica de análisis de contenido temático, siendo evidenciadas cuatro categorías: Control de la diabetes: la enfermería en el autocontrol de la glucemia; El diabético y la enfermería: una interacción para el autocuidado; Consulta de enfermería al paciente diabético: intervención en el proceso salud-enfermedad; Diabetes y sus complicaciones: el miedo refletado en la pérdida de funciones. Fue observado que el paciente comienza a cuidar impulsado por el miedo de perder su salud, y que el miedo hace que el paciente tenga el auto-cuidado de sí mismo. El enfermero está directamente conectado con el control de la diabetes, desde el momento en que realiza el cuidado y la orientación para la automonitorización de la enfermedad