Estratégias de Fomento ao Empreendedorismo e à Inovação da Agência USP de Inovação: um estudo de caso

Abstract The USP Innovation Agency (AUSPIN) is responsible for managing the innovation policy of the University of São Paulo-USP, through disclosure of ownership of the Institution's technologies that are available for commercialization. This article aimed to highlight the importance of Auspin for strategies to promote entrepreneurship and innovation. Qualitative, descriptive and bibliographical research methodologies were used, through articles, legislation, and databases on the electronic pages of Auspin, the National Institute of Industrial Property (INPI) and USP. It was possible to verify the partnership relationship between the Agency and other Public and Private Institutions and the productive sector. Auspin is made up of a team of qualified people who work with forms of intellectual property protection, in order to search for prior art, prospect and guide researchers about the stage of the patent at the national and international level.A Agência USP de Inovação (AUSPIN) é responsável pela gestão da política de inovação da Universidade de São Paulo-USP, por meio de divulgação da titularidade das tecnologias da Instituição que estão disponíveis para comercialização. Este artigo teve por objetivo destacar a importância da Auspin para as estratégias de fomento ao empreendedorismo e inovação. Foram utilizadas como metodologias de pesquisa a qualitativa, a descritiva e bibliográfica, por meio de artigos, legislação, e bancos de dados nas páginas eletrônicas da Auspin, do Instituto Nacional da Propriedade Industrial (INPI) e da USP. Foi possível verificar a relação de parceria entre a Agência e outras Instituições Públicas, Privadas e setor produtivo. A Auspin é formada por uma equipe de pessoas capacitadas que atuam com as formas de proteção de propriedade intelectual, a fim de fazer a busca de anterioridade, prospecção e orientar os(as) pesquisadores(as) sobre os estágios das patentes em âmbito nacional e internacional.

Use Of the Open Journal System Platform: Ojs as A Tool for The Development of The Technological Showcase of The Federal Institute of Education, Science and Technology of Rondônia (IFRO)

An institution that has a portfolio of intangible assets of intellectual property products may, through business planning and management, use it as a way to establish contracts and transfer technology to other organizations, enabling financial returns and partnerships. The present study proposes the creation of a technological showcase for the dissemination of the institution\u27s technology assets using the Open Journal System - OJS platform . The survey of intellectual property assets was carried out through prospecting in the Databases of the National Institute of Intellectual Property (INPI). The qualification of the technological showcases was carried out through the information present on the websites of 41 institutions of the Federal Network of Vocational and Technological Education. The use of the OJS Platform for the construction of the IFRO\u27s technological showcase was developed considering the criteria of usability, usefulness of the content, adequacy of information and accessibility and interaction (http://vitrinetecnologica.pvhzonanorte.ifro.edu.br)

Gomesin, a peptide produced by the spider Acanthoscurria gomesiana, is a potent anticryptococcal agent that acts in synergism with fluconazole

Gomesin is an 18-residue cysteine-rich antimicrobial peptide produced by hemocytes of the spider Acanthoscurria gomesiana. in the present study, the antifungal properties of gomesin against Cryptococcus neoformans, the etiologic agent of cryptococcosis, were evaluated. Gomesin bound to the cell surface of cryptococci, which resulted in cell death associated with membrane permeabilization. Antifungal concentrations of gomesin were not toxic for human brain cells. Supplementation of cryptococcal cultures with the peptide (1 mu M) caused a decrease in capsule expression and rendered fungal cells more susceptible to killing by human brain phagocytes. the possible use of gomesin in combination with fluconazole, a standard antifungal drug, was also evaluated. in association with fluconazole, gomesin concentrations with low antimicrobial activity (0.1-1 mu M) inhibited fungal growth and enhanced the antimicrobial activity of brain phagocytes. These results reveal the potential of gomesin to promote inhibition of cryptococcal growth directly or by enhancing the effectiveness of host defenses.Univ Fed Rio de Janeiro, Inst Microbiol Prof Paulo Goes, Dept Microbiol Geral, Lab Estudos Integrados Bioquim Microbiana, BR-21941590 Rio de Janeiro, BrazilUniv São Paulo, Inst Ciencias Biomed, Dept Parasitol, BR-05508 São Paulo, BrazilUniv Texas, Dept Biol Sci, El Paso, TX 79968 USAUniversidade Federal de São Paulo, Dept Biofis, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biofis, São Paulo, BrazilWeb of Scienc

Research on ionic homeostatic equilibrium may change our view about epilepsy

Universidade Federal de Sao Joao Del Rei (UFSJ) Departamento de Engenharia de Biossistemas (DEPEB) Laboratorio de Neurociencia Experimental e Computacional Dr Aristides Azevedo Pacheco LeaoUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de Neurologia ExperimentalUNIFESP, EPM, Disciplina de Neurologia ExperimentalSciEL

PROSPECÇÃO TECNOLÓGICA DO POTENCIAL TERAPÊUTICO DE MOLÉCULAS EXTRAÍDAS DE ACMELLA OLERACEA (L.) R.K. JANSEN (SPILANTHES OLERACEA)

The objective of this study is to carry out a technological search for patent documents related to the use of compounds extracted from Acmella oleracea (L.) R.K. Jansen for medicinal purposes. Technological prospecting was carried out using the Orbit Intelligence database, using the keywords “acmella oleracea” and “spilanthes oleracea”, and the A61K patent classification, without temporal or spatial delimitation, with the aim of identifying and understanding the innovations that are driving this sector. A total of 114 patent families were found, which showed a growing investment trend until 2022, with a drop in 2023. With regard to current patents, the United States, China and Germany stand out as the main depositors, while Brazil comes in fourth place. The strong presence of the United States is reinforced with the presence of Nulixir, BodyBio and Mary Kay among the top five depositing companies. In Brazil, IES stands out as the main depositorsO objetivo deste estudo é realizar uma prospecção tecnológica de documentos de patentes relacionados à utilização de compostos extraídos da  Acmella oleracea (L.) R.K. Jansen para fins medicinais. A prospecção tecnológica foi realizada por meio da base de dados Orbit Intelligence, utilizando as palavras-chave “acmella oleracea” e “spilanthes oleracea”, e a classificação de patentes A61K, sem delimitação temporal ou espacial, com o intuito de identificar e compreender as inovações que estão impulsionando esse setor. Foram encontradas ao todo 114 famílias de patentes, as quais apresentaram uma tendência crescente de investimento até o ano de 2022, com queda em 2023. No que se refere às patentes vigentes, Estados Unidos, China e Alemanha se destacaram como principais depositantes, enquanto o Brasil surge em quarto lugar. A forte presença dos Estados Unidos é reforçada com a presença das empresas Nulixir, BodyBio e Mary Kay entre as cinco principais empresas depositantes. No Brasil, as IES se destacam como as principais depositantes

Chitin-Like Molecules Associate with Cryptococcus neoformans Glucuronoxylomannan To Form a Glycan Complex with Previously Unknown Properties

In prior studies, we demonstrated that glucuronoxylomannan (GXM), the major capsular polysaccharide of the fungal pathogen Cryptococcus neoformans, interacts with chitin oligomers at the cell wall-capsule interface. the structural determinants regulating these carbohydrate-carbohydrate interactions, as well as the functions of these structures, have remained unknown. in this study, we demonstrate that glycan complexes composed of chitooligomers and GXM are formed during fungal growth and macrophage infection by C. neoformans. To investigate the required determinants for the assembly of chitin-GXM complexes, we developed a quantitative scanning electron microscopy-based method using different polysaccharide samples as inhibitors of the interaction of chitin with GXM. This assay revealed that chitin-GXM association involves noncovalent bonds and large GXM fibers and depends on the N-acetyl amino group of chitin. Carboxyl and O-acetyl groups of GXM are not required for polysaccharide-polysaccharide interactions. Glycan complex structures composed of cryptococcal GXM and chitin-derived oligomers were tested for their ability to induce pulmonary cytokines in mice. They were significantly more efficient than either GXM or chitin oligomers alone in inducing the production of lung interleukin 10 (IL-10), IL-17, and tumor necrosis factor alpha (TNF-alpha). These results indicate that association of chitin-derived structures with GXM through their N-acetyl amino groups generates glycan complexes with previously unknown properties.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)NIHCenter for AIDS Research at EinsteinUniv Fed Rio de Janeiro, Inst Microbiol Prof Paulo de Goes, Rio de Janeiro, BrazilUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Lab Ultraestrutura Celular Hertha Meyer, BR-21941 Rio de Janeiro, BrazilAlbert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USAAlbert Einstein Coll Med, Div Infect Dis, Dept Med, Bronx, NY 10467 USAUniversidade Federal de São Paulo, Disciplina Biol Celular, São Paulo, BrazilFiocruz MS, Fundacao Oswaldo Cruz, Ctr Desenvolvimento Tecnol, BR-21045900 Rio de Janeiro, BrazilUniversidade Federal de São Paulo, Disciplina Biol Celular, São Paulo, BrazilNIH: AI033142NIH: AI033774NIH: AI052733NIH: HL059842Web of Scienc

ISP - IFRO SLICE PROTEIN: automatizing the process of protein fragments extraction

Macromolecules are proteins formed by amino acids joined by peptide bonds, and can be described in different structural levels: primary, secondary, tertiary and quaternary. It’s possible to extract a small part of the three dimensional structure of the protein to be used as a ligand. However, the extraction of fragments by experimental methods is expensive and time-consuming. In this context, the development of a web service to extract fragments of three-dimensional proteins makes the process more assertive and less costly. The methods used for the development of the protein slicer web service were the Python programming language, and the Javascript, PHP and HTML languages are being used. And for the testing of the system, three-dimensional structures of proteins present in the RCSB Protein Data Bank (RCSB PDB) were used

MERCÚRIO EM SISTEMAS AQUÁTICOS: FATORES AMBIENTAIS QUE AFETAM A METILAÇÃO

Methylmercury is a highly neurotoxic contaminant that accumulates in organisms and biomagnifies along the food chain. Methylmercury is formed through the transfer of a methyl group to the inorganic mercury (Hg2+). This reaction is mainly mediated by microorganisms living in anoxic environments like bottom sediments and macrophytes rhizosphere. Abiotic methylation can also occur, however in most cases with lower rates than biological methylation. Mercury methylation rates in aquatic systems are influenced by both the speciation and bioavailability of mercury. Many interrelated environmental variables such as biological activity, nutrient availability, pH, temperature, redox potential, and the presence of inorganic and organic complexing agents can also affects the net rate of methylmercury production. Which factors dominate methylmercury production is likely to differ from one ecosystem to other.O metilmercúrio é um poluente altamente neurotóxico que se acumula nos organismos e biomagnifica ao longo da cadeia trófica. O metilmercúrio é formado através de uma reação de transferência de um grupamento metil para o mercúrio inorgânico. Essa transformação, denominada metilação, é mediada principalmente por microrganismos que habitam ambientes anóxicos. A metilação pode ser abiótica como resultado de uma reação não-enzimática na transferência do grupamento metil por via fotoquímica ou interação com substâncias húmicas presentes nos corpos d'água, porém com uma taxa de metilação menor do que pela mediada por microrganismos. As taxas de metilação de mercúrio em sistemas aquáticos são influenciadas tanto pela especiação do mercúrio quanto por sua biodisponibilidade. Diversas variáveis ambientais, que se interrelacionam, tais como a atividade biológica dos microrganismos metiladores, disponibilidade de nutrientes, pH, temperatura, potencial redox, e a presença de complexos orgânicos e inorgânicos podem afetar as taxas de metilação. A importância de cada um desses fatores na produção de metilmercúrio pode variar em diferentes ecossistemas

A Paracoccidioides brasiliensis glycan shares serologic and functional properties with cryptococcal glucuronoxylomannan

The cell wall of the yeast form of the dimorphic fungus Paracoccidioides brasiliensis is enriched with alpha 1,3-glucans. in Cryptococcus neoformans, alpha 1,3-glucans interact with glucuronoxylomannan (GXM), a hetero-polysaccharide that is essential for fungal virulence. in this study, we investigated the occurrence of P. brasiliensis glycans sharing properties with cryptococcal GXM. Protein database searches in P. brasiliensis revealed the presence of sequences homologous to those coding for enzymes involved in the synthesis of GXM and capsular architecture in C. neoformans. in addition, monoclonal antibodies (mAbs) raised to cryptococcal GXM bound to P. brasiliensis cells. Using protocols that were previously established for extraction and analysis of C neoformans GXM, we recovered a P. brasiliensis glycan fraction composed of mannose and galactose, in addition to small amounts of glucose, xylose and rhamnose. in comparison with the C. neoformans GXM, the P. brasiliensis glycan fraction components had smaller molecular dimensions. the P. brasiliensis components, nevertheless, reacted with different GXM-binding mAbs. Extracellular vesicle fractions of P. brasiliensis also reacted with a GXM-binding mAb, suggesting that the polysaccharide-like molecule is exported to the extracellular space in secretory vesicles. An acapsular mutant of C. neoformans incorporated molecules from the P. brasiliensis extract onto the cell wall, resulting in the formation of surface networks that resembled the cryptococcal capsule. Coating the C. neoformans acapsular mutant with the P. brasiliensis glycan fraction resulted in protection against phagocytosis by murine macrophages. These results suggest that P. brasiliensis and C. neoformans share metabolic pathways required for the synthesis of similar polysaccharides and that P. brasiliensis yeast cell walls have molecules that mimic certain aspects of C. neoformans GXM. These findings are important because they provide additional evidence for the sharing of antigenically similar components across phylogenetically distant fungal species. Since GXM has been shown to be important for the pathogenesis of C neoformans and to elicit protective antibodies, the finding of similar molecules in P. brasiliensis raises the possibility that these glycans play similar functions in paracoccidiomycosis. (C) 2012 Elsevier Inc. All rights reserved.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)NIHCenter for AIDS Research at EinsteinInterhemispheric Research Training Grant in Infectious Diseases, Fogarty International CenterDepartment of EnergyFiocruz MS, CDTS, BR-21040360 Rio de Janeiro, BrazilUniv Fed Rio de Janeiro, Inst Microbiol Prof Paulo de Goes, BR-21941902 Rio de Janeiro, BrazilAlbert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USAUniversidade Federal de São Paulo, Disciplina Biol Celular, BR-04023062 São Paulo, BrazilUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Lab Ultraestrutura Celular Hertha Meyer, BR-21941903 Rio de Janeiro, BrazilAlbert Einstein Coll Med, Div Infect Dis, Dept Med, Bronx, NY 10461 USAUniversidade Federal de São Paulo, Disciplina Biol Celular, BR-04023062 São Paulo, BrazilNIH: AI033142NIH: AI033774NIH: AI052733NIH: HL059842Interhemispheric Research Training Grant in Infectious Diseases, Fogarty International Center: NIH D43-TW007129Department of Energy: DE-FG-9-93ER-20097Web of Scienc

A large case-based reasoner for legal cases

Case-Based Reasoning Research and Development: Proceedings of the 2nd International Conference on Case-Based Reasoning, ICCBR 1997: pp. 190-199.In this paper we propose a large case-based reasoner for the legal domain. Analyzing legal texts for indexing purposes makes the implementation of large case bases a complex task. We present a methodology to automatically convert legal texts into legal cases guided by domain expert knowledge in a rule-based system with Natural Language Processing (NLP) techniques. This methodology can be generalized to be applied in different domains making Case-Based Reasoning (CBR) paradigm a powerful technology to solve real world problems with large knowledge sources