The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline

QUESTION: Should patients with newly-diagnosed metastatic brain tumors undergo open surgical resection versus whole brain radiation therapy (WBRT) and/or other treatment modalities such as radiosurgery, and in what clinical settings? TARGET POPULATION: These recommendations apply to adults with a newly diagnosed single brain metastasis amenable to surgical resection. RECOMMENDATIONS: Surgical resection plus WBRT versus surgical resection alone Level 1 Surgical resection followed by WBRT represents a superior treatment modality, in terms of improving tumor control at the original site of the metastasis and in the brain overall, when compared to surgical resection alone. Surgical resection plus WBRT versus SRS + or - WBRT Level 2 Surgical resection plus WBRT, versus stereotactic radiosurgery (SRS) plus WBRT, both represent effective treatment strategies, resulting in relatively equal survival rates. SRS has not been assessed from an evidence-based standpoint for larger lesions (\u3e3 cm) or for those causing significant mass effect (\u3e1 cm midline shift). Level 3 Underpowered class I evidence along with the preponderance of conflicting class II evidence suggests that SRS alone may provide equivalent functional and survival outcomes compared with resection + WBRT for patients with single brain metastases, so long as ready detection of distant site failure and salvage SRS are possible. Note The following question is fully addressed in the WBRT guideline paper within this series by Gaspar et al. Given that the recommendation resulting from the systematic review of the literature on this topic is also highly relevant to the discussion of the role of surgical resection in the management of brain metastases, this recommendation has been included below

Mainstreaming African Diasporic Foodways When Academia Is Not Enough

More than a decade after Britain's bicentennial commemoration of the 1807 Abolition Act to end the Transatlantic Slave Trade, Scotland still struggles to reconcile her colonial past. Unlike in North America, historical archaeology centered on the history and legacy of the transatlantic slave trade is still highly marginalized in British academia. Furthermore, Scotland's roles in slave-based economies is only recently being considered a relevant area of historical studies. This paper emerges from my evolving perspective as a Black American scholar and resident in the United Kingdom, as I strive to create intellectual spaces in and outside of academia. Through civic engagement, I use my work on African diasporic foodways in the French Caribbean to link with a similar material basis of resistance in the British Caribbean and engage British audiences whose connections to Atlantic slavery are yet to be fully recognized