Effect of Transition Aerodynamics on Aeroassist Flight Experiment Trajectories

Various transition methods are used here to study the viscous effects encountered in low density, hypersonic flight, through the transition from free molecular to continuum flow. Methods utilizing Viking data, Shuttle Orbiter data, a Potter number parameter, and a Shock Reynolds number were implemented in the Program to Optimize Simulated Trajectories (POST). Simulations of the Aeroassist Flight Experiment (AFE) using open loop guidance were used to assess the aerodynamic performance of the vehicle. A bank angle was found for each transition method that would result in a 200 nautical-mile apogee. Once this was done, the open loop guidance was replaced by the proposed guidance algorithm for the AFE. Simulations were again conducted using that guidance and the different transitions for comparison. For the gains used, the guidance system showed some sensitivity in apogee altitude to the transition method assumed, but the guidance was able to successfully complete the mission

Two CYP3A-like genes in the marine mussel Mytilus edulis: mRNA expression modulation following short-term exposure to endocrine disruptors

Members of the vertebrate CYP3A subfamily are involved in the metabolism of steroids and a wide range of xenobiotics. In this study two CYP3A- like mRNAs have been isolated from the mussel (Mytilus edulis), and their seasonal expression profile and modulation by estrogens examined. Sexual dimorphism of CYP3A- like mRNA expression was not observed in mussel gonads of individuals collected throughout a year. Nevertheless, natural variation in gonadal CYP3A- like mRNA expression was observed, with highest levels of CYP3A isoform1 and lowest levels of CYP3A isoform2 mRNA during the maturation and spawning season. Exposure to a 10% sewage treatment works extract did not result in any significant changes in mRNA expression of CYP3A-like. In contrast, exposure to E2 (200ng/L) and TBT (100ng/L) significantly down-regulated the expression of CYP3A- like isoform1 but not CYP3A-like isoform2 suggesting differential regulation. Understanding xenobiotic metabolism pathways in aquatic invertebrates

Urbanization, climate and species traits shape mammal communities from local to continental scales

Human-driven environmental changes shape ecological communities from local to global scales. Within cities, landscape-scale patterns and processes and species characteristics generally drive local-scale wildlife diversity. However, cities differ in their structure, species pools, geographies and histories, calling into question the extent to which these drivers of wildlife diversity are predictive at continental scales. In partnership with the Urban Wildlife Information Network, we used occurrence data from 725 sites located across 20 North American cities and a multi-city, multi-species occupancy modelling approach to evaluate the effects of ecoregional characteristics and mammal species traits on the urbanization-diversity relationship. Among 37 native terrestrial mammal species, regional environmental characteristics and species traits influenced within-city effects of urbanization on species occupancy and community composition. Species occupancy and diversity were most negatively related to urbanization in the warmer, less vegetated cities. Additionally, larger-bodied species were most negatively impacted by urbanization across North America. Our results suggest that shifting climate conditions could worsen the effects of urbanization on native wildlife communities, such that conservation strategies should seek to mitigate the combined effects of a warming and urbanizing world