Experimental Analysis of Hydrocarbons as Drop-in Replacement in Household Heat Pump Tumble Dryers

Abstract Mainly HFCs are nowadays used as refrigerants in commercial household heat pump tumble dryers; it is however crucial to look for long-term alternatives with low environmental impact. Hydrocarbons are considered a suitable alternative for this application. According to their characteristics and based on theoretical analysis, R290 and R441A were selected as substitutes of R407C in a commercial unit. While maintaining exactly the same components, the compressor was changed to comply with the required heating capacity and the expansion device was modulated to meet proper working conditions. Experimental results confirmed that R290 meets the reference energy performances; at the specific conditions, R441A underperforms R407C, due to increased compressor consumption. Technological focus on components is therefore important when refrigerant replacement takes place

Do We Train on Test Data? The Impact of Near-Duplicates on License Plate Recognition

This work draws attention to the large fraction of near-duplicates in the training and test sets of datasets widely adopted in License Plate Recognition (LPR) research. These duplicates refer to images that, although different, show the same license plate. Our experiments, conducted on the two most popular datasets in the field, show a substantial decrease in recognition rate when six well-known models are trained and tested under fair splits, that is, in the absence of duplicates in the training and test sets. Moreover, in one of the datasets, the ranking of models changed considerably when they were trained and tested under duplicate-free splits. These findings suggest that such duplicates have significantly biased the evaluation and development of deep learning-based models for LPR. The list of near-duplicates we have found and proposals for fair splits are publicly available for further research at https://raysonlaroca.github.io/supp/lpr-train-on-test/Comment: Accepted for presentation at the International Joint Conference on Neural Networks (IJCNN) 202

Examination and evaluation of a coastal environment contamination at a formed shooting area.

In the recent past a very beautiful area along the interior coastal environment of Venice lagoon was used as a Clay Pigeon Shooting for a wide period. The sport of Clay Pigeon Shooting involves using a shotgun to shoot at and break a circular flying target made from a fragile material. It is released from a trap positioned in front of, or at the back of, a shooter; then, a typical target flight area characterizes each shooting site, where, in time, pellets (leadshot), shot cartridge, clay pigeon fragments and generic ammunition residues are found. So, in a brackish water contest soil/sediment treatment, waste removal and potential re-use are extremely delicate processes. The first step of our work was investigate if heavy metal (Pb, As and Sb) release and following leaching event occurred. Therefore, soil/sediment profiles in three hot sites of the target flight area has been performed and metal’s total and bioavailable fraction has been investigated. As well, grassy layer coating the sites and organisms living into has been picked, in order to verify a potential uptake and bioaccumulation

Cooperative Localization Enhancement through GNSS Raw Data in Vehicular Networks

The evolution and integration of communication networks and positioning technologies are evolving at a fast pace in the framework of vehicular systems. The mutual dependency of such two capabilities can enable several new cooperative paradigms, whose adoption is however slowed down by the lack of suitable open protocols, especially related to the positioning and navigation domain. In light of this, the paper introduces a novel vehicular message type, namely the Cooperative Enhancement Message (CEM), and an associated open protocol to enable the sharing of Global Navigation Satellite Systems (GNSS) raw measurements among connected vehicles. The proposed CEM aims at extending existent approaches such as Cooperative Awareness Messages (CAM) and Collective Perception Messages (CPM) by complementing their paradigms with a cooperative enhancement of the localization accuracy, precision, and integrity proposed by state-of-the-art solutions. Besides the definition of CEMs and a related protocol, a validation of the approach is proposed through a novel simulation framework. A preliminary analysis of the network performance is presented in the case where CEM and CAM transmissions coexist and are concurrently used to support cooperative vehicle applications

In situ remediation of contaminated marinesediment: an overview

Sediment tends to accumulate inorganic and persistent hydrophobic organic contaminants representing one of the main sinks and sources of pollution. Generally, contaminated sediment poses medium- and long-term risks to humans and ecosystem health; dredging activities or natural resuspension phenomena (i.e., strongly adverse weather conditions) can remobilize pollution releasing it into the water column. Thus, ex situ traditional remediation activities (i.e., dredging) can be hazardous compared to in situ techniques that try to keep to a minimum sediment mobilization, unless dredging is compulsory to reach a desired bathymetric level. We reviewed in situ physico-chemical (i.e., active mixing and thin capping, solidification/stabilization, chemical oxidation, dechlorination, electrokinetic separation, and sediment flushing) and bio-assisted treatments, including hybrid solutions (i.e., nanocomposite reactive capping, bioreactive capping, microbial electrochemical technologies). We found that significant gaps still remain into the knowledge about the application of in situ contaminated sediment remediation techniques from the technical and the practical viewpoint. Only activated carbon-based technologies are well developed and currently applied with several available case studies. The environmental implication of in situ remediation technologies was only shortly investigated on a long-term basis after its application, so it is not clear how they can really perform

The LuGRE project: a scientific opportunity to study GNSS signals at the Moon

The Lunar GNSS Receiver Experiment (LuGRE) is a joint NASA-Italian Space Agency (ASI) payload on the Firefly Blue Ghost Mission 1 with the goal to demonstrate GNSS-based positioning, navigation, and timing at the Moon. When launched, LuGRE will collect GPS and Galileo measurements in transit between Earth and the Moon, in lunar orbit, and on the lunar surface, and will conduct onboard and ground-based navigation experiments using the collected data. These investigations will be based on the observation of the data collected by a custom development performed by the company Qascom, based on the Qascom QN400-Space GNSS receiver. The receiver is able to provide, PVT solutions, the GNSS raw observables obtained by the real time operation, as well as snapshots of IF digital samples collected by the RF front-end at frequencies L1/E1 and L5/E5. These data will be the input for the different science investigations, that require then the development of proper analysis tools that will be the core of the ground segment during the mission. The current work done by the science team of NASA and ASI, which is supported by a research team at Politecnico di Torino, is planning the data acquisitions during the time windows dedicated to the LuGRE payload in the checkout, transit and surface mission phases

Cancer Immunotherapy by Blocking Immune Checkpoints on Innate Lymphocytes.

Immune checkpoints refer to a plethora of inhibitory pathways of the immune system that play a crucial role in maintaining self-tolerance and in tuning the duration and amplitude of physiological immune responses to minimize collateral tissue damages. The breakdown of this delicate balance leads to pathological conditions, including cancer. Indeed, tumor cells can develop multiple mechanisms to escape from immune system defense, including the activation of immune checkpoint pathways. The development of monoclonal antibodies, targeting inhibitory immune checkpoints, has provided an immense breakthrough in cancer therapy. Immune checkpoint inhibitors (ICI), initially developed to reverse functional exhaustion in T cells, recently emerged as important actors in natural killer (NK)-cell-based immunotherapy. Moreover, the discovery that also helper innate lymphoid cells (ILCs) express inhibitory immune checkpoints, suggests that these molecules might be targeted on ILCs, to modulate their functions in the tumor microenvironment. Recently, other strategies to achieve immune checkpoint blockade have been developed, including miRNA exploiting systems. Herein, we provide an overview of the current knowledge on inhibitory immune checkpoints on NK cells and ILCs and we discuss how to target these innate lymphocytes by ICI in both solid tumors and hematological malignancies

Fludarabine, high-dose cytarabine and idarubicin-based induction may overcome the negative prognostic impact of flt3-itd in npm1 mutated aml, irrespectively of flt3-itd allelic Burden

The mutations of NPM1 and FLT3-ITD represent the most frequent genetic aberration in acute myeloid leukemia. Indeed, the presence of an NPM1 mutation reduces the negative prognostic impact of FLT3-ITD in patients treated with conventional \u201c3+7\u201d induction. However, little information is available on their prognostic role with intensified regimens. Here, we investigated the efficacy of a fludarabine, high-dose cytarabine and idarubicin induction (FLAI) in 149 consecutive fit AML patients (median age 52) carrying the NPM1 and/or FLT3-ITD mutation, treated from 2008 to 2018. One-hundred-and-twenty-nine patients achieved CR (86.6%). After a median follow up of 68 months, 3-year overall survival was 58.6%. Multivariate analysis disclosed that both NPM1mut (p < 0.05) and ELN 2017 risk score (p < 0.05) were significant predictors of survival. NPM1-mutated patients had a favorable outcome, with no significant differences between patients with or without concomitant FLT3-ITD (p = 0.372), irrespective of FLT3-ITD allelic burden. Moreover, in landmark analysis, performing allogeneic transplantation (HSCT) in first CR proved to be beneficial only in ELN 2017 high-risk patients. Our data indicate that FLAI exerts a strong anti-leukemic effect in younger AML patients with NPM1mut and question the role of HSCT in 1st CR in NPM1mut patients with concomitant FLT3-ITD

Fludarabine, high-dose cytarabine and idarubicin-based induction may overcome the negative prognostic impact of flt3-itd in npm1 mutated aml, irrespectively of flt3-itd allelic Burden

The mutations of NPM1 and FLT3-ITD represent the most frequent genetic aberration in acute myeloid leukemia. Indeed, the presence of an NPM1 mutation reduces the negative prognostic impact of FLT3-ITD in patients treated with conventional “3+7” induction. However, little information is available on their prognostic role with intensified regimens. Here, we investigated the efficacy of a fludarabine, high-dose cytarabine and idarubicin induction (FLAI) in 149 consecutive fit AML patients (median age 52) carrying the NPM1 and/or FLT3-ITD mutation, treated from 2008 to 2018. One-hundred-and-twenty-nine patients achieved CR (86.6%). After a median follow up of 68 months, 3-year overall survival was 58.6%. Multivariate analysis disclosed that both NPM1mut (p &lt; 0.05) and ELN 2017 risk score (p &lt; 0.05) were significant predictors of survival. NPM1-mutated patients had a favorable outcome, with no significant differences between patients with or without concomitant FLT3-ITD (p = 0.372), irrespective of FLT3-ITD allelic burden. Moreover, in landmark analysis, performing allogeneic transplantation (HSCT) in first CR proved to be beneficial only in ELN 2017 high-risk patients. Our data indicate that FLAI exerts a strong anti-leukemic effect in younger AML patients with NPM1mut and question the role of HSCT in 1st CR in NPM1mut patients with concomitant FLT3-ITD