El control del estrés en adultos por medio de una intervención cognitivo conductual.

El objetivo de la presente investigación a continuación fue evaluar la efectividad del Programa para el Control del estrés en una muestra de adultos mayores a 30 años. Se empleó el diseño Cuasi experimental con Preprueba–posprueba con un solo grupo. La muestra estaba compuesta por cinco docentes mayores a 30 años, del Centro Básico Potrero Grande en La Chorrera; las mismas fueron elegidas acorde con criterios de inclusión y exclusión. La intervención empleada fue una adaptación del Programa para el Control del Estrés de Humbelina Robles y María Isabel Peralta (2010), dicho programa está estructurado con base en la Terapia Cognitivo Conductual, específicamente en la Terapia Racional Emotivo Conductual de Albert Ellis. Esta intervención estuvo compuesta por 8 sesiones de una hora y media cada una, de aplicación semanal. Los sujetos de la muestra fueron evaluados por medio de la Escala de Apreciación del Estrés de J.L. Fernández-Seara y M. Mielgo (2017). Los resultados muestran que hubo diferencia entre los datos obtenidos del pretest y el postest, dando como conclusión que fue efectiva la intervención

Exploring Relationships between Demersal Resources and Environmental Factors in the Ionian Sea (Central Mediterranean)

The relationships between the abundance of demersal resources, environmental variables, and fishing pressure in the north-western Ionian Sea in the last two decades were evaluated. Data on the density collected during seventeen trawl surveys carried out from 1985 to 2005 were used. The following species were considered:Aristaeomorpha foliacea, Nephrops norvegicus,andParapenaeus longirostrisfor crustaceans;Merluccius merluccius, Phycis blennoides,andMullus barbatusfor teleost fish. The recruitment index was also considered forN. norvegicus, P. longirostris, M. merlucciusandMullus barbatus. Six candidate models were evaluated for each density and recruitment data set either combining fishing effort with global (NAO) and regional (SST and precipitation) climatic indices, or models separately involving fishing effort, NAO, or regional climatic indices as the only predictive variable. Model selection was carried out using an information-theoretical approach that applies Akaike's Information Criterion (AIC). High changes over time were observed for the density data and recruitment indices in each species. Apart from hake abundance and recruitment data, for which a clear positive relationship with the NAO index alone was detected, the changes observed in the other species seem to be the consequence of the interaction between bottom-up effects linked to changes in physical environment and top-down ones due to the fishing pressure

The Enhanced Principal Rank Characteristic Sequence

The enhanced principal rank characteristic sequence (epr-sequence) of a symmetric n×n matrix is a sequence ℓ1ℓ2⋯ℓn where ℓk is A, S, or N according as all, some, or none of its principal minors of order k are nonzero. Such sequences give more information than the (0,1) pr-sequences previously studied (where basically the kth entry is 0 or 1 according as none or at least one of its principal minors of order k is nonzero). Various techniques including the Schur complement are introduced to establish that certain subsequences such as NAN are forbidden in epr-sequences over fields of characteristic not two. Using probabilistic methods over fields of characteristic zero, it is shown that any sequence of As and Ss ending in A is attainable, and any sequence of As and Ss followed by one or more Ns is attainable; additional families of attainable epr-sequences are constructed explicitly by other methods. For real symmetric matrices of orders 2, 3, 4, and 5, all attainable epr-sequences are listed with justifications

Identification and characterization of microRNAs in Phaseolus vulgaris by high-throughput sequencing

<p>Abstract</p> <p>Background</p> <p>MicroRNAs (miRNAs) are endogenously encoded small RNAs that post-transcriptionally regulate gene expression. MiRNAs play essential roles in almost all plant biological processes. Currently, few miRNAs have been identified in the model food legume <it>Phaseolus vulgaris </it>(common bean). Recent advances in next generation sequencing technologies have allowed the identification of conserved and novel miRNAs in many plant species. Here, we used Illumina's sequencing by synthesis (SBS) technology to identify and characterize the miRNA population of <it>Phaseolus vulgaris</it>.</p> <p>Results</p> <p>Small RNA libraries were generated from roots, flowers, leaves, and seedlings of <it>P. vulgaris</it>. Based on similarity to previously reported plant miRNAs,114 miRNAs belonging to 33 conserved miRNA families were identified. Stem-loop precursors and target gene sequences for several conserved common bean miRNAs were determined from publicly available databases. Less conserved miRNA families and species-specific common bean miRNA isoforms were also characterized. Moreover, novel miRNAs based on the small RNAs were found and their potential precursors were predicted. In addition, new target candidates for novel and conserved miRNAs were proposed. Finally, we studied organ-specific miRNA family expression levels through miRNA read frequencies.</p> <p>Conclusions</p> <p>This work represents the first massive-scale RNA sequencing study performed in <it>Phaseolus vulgaris </it>to identify and characterize its miRNA population. It significantly increases the number of miRNAs, precursors, and targets identified in this agronomically important species. The miRNA expression analysis provides a foundation for understanding common bean miRNA organ-specific expression patterns. The present study offers an expanded picture of <it>P. vulgaris </it>miRNAs in relation to those of other legumes.</p

IoTRec: The IoT Recommender for Smart Parking System

This paper proposes a General Data Protection Regulation (GDPR)-compliant Internet of Things (IoT) Recommender (IoTRec) system, developed in the framework of H2020 EU-KR WISE-IoT (Worldwide Interoperability for Semantic IoT) project, which provides the recommendations of parking spots and routes while protecting users’ privacy. It provides recommendations by exploiting the IoT technology (parking and traffic sensors). The IoTRec provides four-fold functions. Firstly, it helps the user to find a free parking spot based on different metrics (such as the nearest or nearest trusted parking spot). Secondly, it recommends a route (the least crowded or the shortest route) leading to the recommended parking spot from the user’s current location. Thirdly, it provides the real-time provision of expected availability of parking areas (comprised of parking spots organized into groups) in a user-friendly manner. Finally, it provides a GDPR-compliant implementation for operating in a privacy-aware environment. The IoTRec is integrated into the smart parking use case of the WISE-IoT project and is evaluated by the citizens of Santander, Spain through a prototype, but it can be applied to any IoT-enabled locality. The evaluation results show the citizen’s satisfaction with the quality, functionalities, ease of use and reliability of the recommendations/services offered by the IoTRec

The principal rank characteristic sequence over various fields

Given an n x n matrix, its principal rank characteristic sequence is a sequence of length n+1 of 0s and 1s where, for k = 0, 1, . . . , n, a 1 in the kth position indicates the existence of a principal submatrix of rank k and a 0 indicates the absence of such a submatrix. The principal rank characteristic sequences for symmetric matrices over various fields are investigated, with all such attainable sequences determined for all n over any field with characteristic 2. A complete list of attainable sequences for real symmetric matrices of order 7 is reported

MicroRNA-1 Regulates Smooth Muscle Cell Differentiation by Repressing Kruppel-Like Factor 4

The role of microRNA-1 (miR-1) has been studied in cardiac and skeletal muscle differentiation. However, it remains unexplored in vascular smooth muscle cells (SMCs) differentiation. The aim of this study was to uncover novel targets of and shed light on the function of miR-1 in the context of embryonic stem cell (ESC) differentiation of SMCs in vitro. miR-1 expression is steadily increased during differentiation of mouse ESC to SMCs. Loss-of-function approaches using miR-1 inhibitors uncovered that miR-1 is required for SMC lineage differentiation in ESC-derived SMC cultures, as evidenced by downregulation of SMC-specific markers and decrease of derived SMC population. In addition, bioinformatics analysis unveiled a miR-1 binding site on the Kruppel-like factor 4 (KLF4) 3' untranslated region (3-UTR), in a region that is highly conserved across species. Consistently, miR-1 mimic reduced KLF4 3-UTR luciferase activity, which can be rescued by mutating the miR-1 binding site on the KLF4 3-UTR in the reporter construct. Additionally, repression of the miR-1 expression by miR-1 inhibitor can reverse KLF4 downregulation during ESC-SMC differentiation, which subsequently inhibits SMC differentiation. We conclude that miR-1 plays a critical role in the determination of SMC fate during retinoid acid-induced ESC/SMC differentiation, which may indicate that miR-1 has a role to promote SMC differentiation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90488/1/scd-2E2010-2E0283.pd

Can ‘eugenics’ be defended?

In recent years, bioethical discourse around the topic of ‘genetic enhancement’ has become increasingly politicized. We fear there is too much focus on the semantic question of whether we should call particular practices and emerging bio-technologies such as CRISPR ‘eugenics’, rather than the more important question of how we should view them from the perspective of ethics and policy. Here, we address the question of whether ‘eugenics’ can be defended and how proponents and critics of enhancement should engage with each other

DIAGN 3STICO PRENATAL Y HALLAZGOS ANATOMOPATOL 3GICOS EN FETO CON S\ucdNDROME DE TURNER

Adolescente de 15 a\uf1os de edad con embarazo de 18 semanas. El eco p\ue9lvico revela tumefacci\uf3n econegativa bilobulada con base en la calota de 96.4 x 58.7 mm. mayor que la cabeza fetal, oligoamnios. El cariotipo del l\uedquido amni\uf3tico revela un complemento cromos\uf3mico de 45,X. Se diagnostica S\uedndrome de Turner. A las 19 semanas de gestaci\uf3n la paciente expulsa feto macerado de 25 cm. de longitud, de 630 gr de peso. A nivel del cuello y hemicara derecha presenta Higroma qu\uedstico de 10x5x5 cm., recubierto de piel, al corte de aspecto qu\uedstico, multilocular. Abdomen globoso, edema en miembros superiores e inferiores, cardiopulmonar normal, ri\uf1ones hipoplasicos, el derecho con doble ur\ue9ter permeable, terminan en una estructura com\ufan de 10x5 cm. conformada por vejiga y cuello uterino. Anexo izquierdo con bandaleta ov\ue1rica, anexo derecho normal. El sigmoide termina en fondo de saco. Ano imperforado. Estudio histopatol\uf3gico: Bandeleta izquierda: estroma ov\ue1rico sin elementos foliculares y abundante tejido conectivo. En ovario derecho se observan abundantes fol\uedculos primordiales. Con este caso demostramos la presencia de un ovario de aspecto y configuraci\uf3n normal en un feto con S\uedndrome de Turner. SUMMARY An ultrasound to 18th week pregnant, in a 15 years old woman, revealed an occipital cystic hygroma, measuring 96,4x58,7 mm larger than the fetal head and oligoamnios. Chromosomes obtained through amniocentesis revealed a 45,X complement, the diagnosis was Turner Syndrome. She went into labour on the 19th week of gestation, and delivered a dead fetus weighting 630 gr and measuring 25 cm with an occipital tumor that extended from the nuchal region to the upper right side of the face, measuring 10x5x5 cm. It looked like cystic higroma. The fetus also showed prominent abdomen, edema of the hands and feet, imperforated anus, hypoplastic kidneys whit duplication of ureter on the right side, the ureteres ended in a sac which included rudimentary uterus and bladder. The left ovary was reduced to streak gonad and the right ovary was normal, with a lot of oocytes. The sygmoid colon ended in a sac; no cardiovascular abnormalities. With this case we are documenting a normal ovary in a fetus with Turner Syndrome