195 research outputs found
Reduction in Renal Function After Renal Arteriography and After Renal Artery Angioplasty
AbstractObjective: to investigate the incidence and risk factors for renal function deterioration after renal angiography and angioplasty or stenting.Methods: a retrospective study of 85 consecutive patients undergoing selective renal artery arteriography (n=53) or renal artery angioplasty % (PTRA) stenting (n=32) for renal artery stenosis. Multivariate logistic regression analysis was used to determine independent predictors of deterioration of renal function, defined as an increase of serum creatinine by at least one third within 24h.Results: deterioration of renal function occurred in 13 patients (15%), [8/53 (15%) after angiography and 5/32 (16%) after PTRA/stenting]. Only pre-existing renal impairment (se-creatinine≥177μmol/l) (Odds ratio: 40; 95% confidence interval 1.2–72, p=0.02) and administered dosage of contrast agent (more than 225ml) (OR 67; 95% CI1 1.8–100, p=0.02) were independently associated with renal function deterioration.Conclusion: transient renal dysfunction after renal artery angiography or PTRA/stenting occurs in about 15% of patients, but persistent renal failure is uncommon. Pre-existing renal impairment and amount of contrast agent are independent risk factors. Endovascular treatment of renal artery stenosis is not associated with a higher risk of renal deterioration compared to selective renal angiography
Analisis Faktor Faktor yang Mempengaruhi Produksi Pembenihan Ikan Lele Dumbo (Clarias Gariepenus) di Kabupaten Wonogiri
This research are for: (1) To analysis the cost and income of Catfish hatchery farm in Wonogiri District. (2) To analysis the influence factors of Catfish hatchery production in Wonogiri District. (3) To analysis the efficiency level of feed production, natural food, and labour. The basic method of the research is description analysis method and the conduct of the research is using a census method. This research had conducted in the district of Wonogiri which consist of 45 respondents, analyzed data included hatchery income, R/C ratio, elasticity, efficiency, and multiple linier regression test. The result of the research showed that the relation between factors and hatchery of Dumbo Catfish production showed in multiple linier regression model, they are : LnP = 7.472 - 0.047LnX1 + 0.312LnX2 + 0.388LnX3 + 0.304LnX4 + 0.136LnX5 + 0.016LnX6 + 0.108LnD1 + 0.058LnD2. The result of the analysis showed the number of broodstock, feed, natural food, labour, hatchery technology and counseling which were significant influenced in Catfish hatchery production, meanwhile the land area and hatchery process were not really influences to the Catfish hatchery production. The result of the research had obtained the income of Catfish hatchery with the price of Rp. 2.369.533,-, value of R/C ratio was 2,67, feed production value, natural food, and labour were >1 which showed inefficient, the elasticity value of all independent variable was elastic
Utility of neutrophil Fcgamma receptor I (CD64) index as a biomarker for mucosal inflammation in pediatric Crohn\u27s disease
BACKGROUND: Neutrophil expression of the Fcgamma receptor I (CD64) is upregulated in adult patients with clinically active inflammatory bowel disease (IBD). We tested the relationship of CD64 with mucosal inflammation and clinical relapse in pediatric Crohn\u27s disease (CD). METHODS: In a cohort of 208 newly diagnosed CD and 43 non-IBD controls, ileal expression of FcgammaRI/S100A9 was determined by RNA sequencing from biopsies obtained at ileocolonoscopy. In a second cohort, we tested for the peripheral blood polymorphonuclear neutrophil (PMN) CD64 index from 26 newly diagnosed CD, 30 non-IBD controls, and 83 children with established CD. RESULTS: Ileal FcgammaRIA mRNA expression was significantly elevated in CD at diagnosis compared with non-IBD controls (P \u3c 0.001), and correlated with ileal S100A9 (calprotectin) expression (r = 0.83, P \u3c 0.001). The median (range) PMN CD64 index for newly diagnosed CD was 2.3 (0.74-9.3) compared with 0.76 (0.39-1.2) for non-IBD controls (P \u3c 0.001) with 96% sensitivity and 90% specificity at the cut point of 1.0. The PMN CD64 index significantly correlated with mucosal injury as measured by the simple endoscopic score for CD (r = 0.62, P \u3c 0.001). Patients with CD in clinical remission receiving maintenance therapy with a PMN CD64 index1.0 (P \u3c 0.01). CONCLUSIONS: An elevated PMN CD64 index is associated with both mucosal inflammation and an increased risk for clinical relapse in pediatric CD. The PMN CD64 index is a reliable marker for sustained remission in patients with CD receiving maintenance therapy
Momentum-resolved electronic structure at a buried interface from soft x-ray standing-wave angle-resolved photoemission
Angle-resolved photoemission spectroscopy (ARPES) is a powerful technique for
the study of electronic structure, but it lacks a direct ability to study
buried interfaces between two materials. We address this limitation by
combining ARPES with soft x-ray standing-wave (SW) excitation (SWARPES), in
which the SW profile is scanned through the depth of the sample. We have
studied the buried interface in a prototypical magnetic tunnel junction
La0.7Sr0.3MnO3/SrTiO3. Depth- and momentum-resolved maps of Mn 3d eg and t2g
states from the central, bulk-like and interface-like regions of La0.7Sr0.3MnO3
exhibit distinctly different behavior consistent with a change in the Mn
bonding at the interface. We compare the experimental results to
state-of-the-art density-functional and one-step photoemission theory, with
encouraging agreement that suggests wide future applications of this technique.Comment: 18 pages, 4 figures and Supplementary Informatio
Diagnostic accuracy of endometrial biopsy in endometrial carcinoma grading, correlated to the amount of tissue
Identifying the electronic character and role of the Mn states in the valence band of (Ga,Mn)As
We report high-resolution hard x-ray photoemission spectroscopy results on
(Ga,Mn)As films as a function of Mn doping. Supported by theoretical
calculations we identify, over the entire 1% to 13% Mn doping range, the
electronic character of the states near the top of the valence band.
Magnetization and temperature dependent core-level photoemission spectra reveal
how the delocalized character of the Mn states enables the bulk ferromagnetic
properties of (Ga,Mn)As.Comment: prl submitte
The CECAM Electronic Structure Library and the modular software development paradigm
First-principles electronic structure calculations are very widely used thanks to the many successful software packages available. Their traditional coding paradigm is monolithic, i.e., regardless of how modular its internal structure may be, the code is built independently from others, from the compiler up, with the exception of linear-algebra and message-passing libraries. This model has been quite successful for decades. The rapid progress in methodology, however, has resulted in an ever increasing complexity of those programs, which implies a growing amount of replication in coding and in the recurrent re-engineering needed to adapt to evolving hardware architecture. The Electronic Structure Library (\esl) was initiated by CECAM (European Centre for Atomic and Molecular Calculations) to catalyze a paradigm shift away from the monolithic model and promote modularization, with the ambition to extract common tasks from electronic structure programs and redesign them as free, open-source libraries. They include ``heavy-duty'' ones with a high degree of parallelisation, and potential for adaptation to novel hardware within them, thereby separating the sophisticated computer science aspects of performance optimization and re-engineering from the computational science done by scientists when implementing new ideas. It is a community effort, undertaken by developers of various successful codes, now facing the challenges arising in the new model. This modular paradigm will improve overall coding efficiency and enable specialists (computer scientists or computational scientists) to use their skills more effectively. It will lead to a more sustainable and dynamic evolution of software as well as lower barriers to entry for new developers
Nonmagnetic band gap at the Dirac point of the magnetic topological insulator Bi1 xMnx 2 Se3
Magnetic doping is expected to open a band gap at the Dirac point of
topological insulators by breaking time-reversal symmetry and to enable novel
topological phases. Epitaxial (BiMn)Se is a
prototypical magnetic topological insulator with a pronounced surface band gap
of meV. We show that this gap is neither due to ferromagnetic order
in the bulk or at the surface nor to the local magnetic moment of the Mn,
making the system unsuitable for realizing the novel phases. We further show
that Mn doping does not affect the inverted bulk band gap and the system
remains topologically nontrivial. We suggest that strong resonant scattering
processes cause the gap at the Dirac point and support this by the observation
of in-gap states using resonant photoemission. Our findings establish a novel
mechanism for gap opening in topological surface states which challenges the
currently known conditions for topological protection.Comment: 26 pages, 7 figure
CD34+/M-cadherin+ Bone Marrow Progenitor Cells Promote Arteriogenesis in Ischemic Hindlimbs of ApoE−/− Mice
BACKGROUND: Cell-based therapy shows promise in treating peripheral arterial disease (PAD); however, the optimal cell type and long-term efficacy are unknown. In this study, we identified a novel subpopulation of adult progenitor cells positive for CD34 and M-cadherin (CD34⁺/M-cad⁺ BMCs) in mouse and human bone marrow. We also examined the long-lasting therapeutic efficacy of mouse CD34⁺/M-cad⁺ BMCs in restoring blood flow and promoting vascularization in an atherosclerotic mouse model of PAD. METHODS AND FINDINGS: Colony-forming cell assays and flow cytometry analysis showed that CD34⁺/M-cad⁺ BMCs have hematopoietic progenitor properties. When delivered intra-arterially into the ischemic hindlimbs of ApoE⁻/⁻ mice, CD34⁺/M-cad⁺ BMCs alleviated ischemia and significantly improved blood flow compared with CD34⁺/M-cad⁻ BMCs, CD34⁻/M-cad⁺ BMCs, or unselected BMCs. Significantly more arterioles were seen in CD34⁺/M-cad⁺ cell-treated limbs than in any other treatment group 60 days after cell therapy. Furthermore, histologic assessment and morphometric analyses of hindlimbs treated with GFP⁺ CD34⁺/M-cad⁺ cells showed that injected cells incorporated into solid tissue structures at 21 days. Confocal microscopic examination of GFP⁺ CD34⁺/M-cad⁺ cell-treated ischemic legs followed by immunostaining indicated the vascular differentiation of CD34⁺/M-cad⁺ progenitor cells. A cytokine antibody array revealed that CD34⁺/M-cad⁺ cell-conditioned medium contained higher levels of cytokines in a unique pattern, including bFGF, CRG-2, EGF, Flt-3 ligand, IGF-1, SDF-1, and VEGFR-3, than did CD34⁺/M-cad⁻ cell-conditioned medium. The proangiogenic cytokines secreted by CD34⁺/M-cad⁺ cells induced oxygen- and nutrient-depleted endothelial cell sprouting significantly better than CD34⁺/M-cad⁻ cells during hypoxia. CONCLUSION: CD34⁺/M-cad⁺ BMCs represent a new progenitor cell type that effectively alleviates hindlimb ischemia in ApoE⁻/⁻ mice by consistently improving blood flow and promoting arteriogenesis. Additionally, CD34⁺/M-cad⁺ BMCs contribute to microvascular remodeling by differentiating into vascular cells and releasing proangiogenic cytokines and growth factors
Energetic, spatial and momentum character of a buried interface: the two-dimensional electron gas between two metal oxides
The interfaces between two condensed phases often exhibit emergent physical
properties that can lead to new physics and novel device applications, and are
the subject of intense study in many disciplines. We here apply novel
experimental and theoretical techniques to the characterization of one such
interesting interface system: the two-dimensional electron gas (2DEG) formed in
multilayers consisting of SrTiO (STO) and GdTiO (GTO). This system has
been the subject of multiple studies recently and shown to exhibit very high
carrier charge densities and ferromagnetic effects, among other intriguing
properties. We have studied a 2DEG-forming multilayer of the form [6 unit cells
STO/3 unit cells of GTO] using a unique array of photoemission
techniques including soft and hard x-ray excitation, soft x-ray angle-resolved
photoemission, core-level spectroscopy, resonant excitation, and standing-wave
effects, as well as theoretical calculations of the electronic structure at
several levels and of the actual photoemission process. Standing-wave
measurements below and above a strong resonance have been introduced as a
powerful method for studying the 2DEG depth distribution. We have thus
characterized the spatial and momentum properties of this 2DEG with
unprecedented detail, determining via depth-distribution measurements that it
is spread throughout the 6 u.c. layer of STO, and measuring the momentum
dispersion of its states. The experimental results are supported in several
ways by theory, leading to a much more complete picture of the nature of this
2DEG, and suggesting that oxygen vacancies are not the origin of it. Similar
multi-technique photoemission studies of such states at buried interfaces,
combined with comparable theory, will be a very fruitful future approach for
exploring and modifying the fascinating world of buried-interface physics and
chemistry.Comment: 34 pages, 10 figure
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