6,171 research outputs found
Inspiring Public Trust in the Domestic Legal System: The Impact of the Extraordinary Chambers in the Courts of Cambodia (ECCC)
Physical Activity Recognition based on Rotated Acceleration Data using Orientation Filter
The purpose of the study was to examine the accuracy of physical activity (PA) classification algorithms using a rotational analysis
Electronic structure of biased alternating-twist multilayer graphene
We theoretically study the energy and optical absorption spectra of
alternating twist multilayer graphene (ATMG) under a perpendicular electric
field. We obtain analytically the low-energy effective Hamiltonian of ATMG up
to pentalayer in the presence of the interlayer bias by means of first-order
degenerate-state perturbation theory, and present general rules for
constructing the effective Hamiltonian for an arbitrary number of layers. Our
analytical results agree to an excellent degree of accuracy with the numerical
calculations for twist angles that are larger than
the typical range of magic angles. We also calculate the optical conductivity
of ATMG and determine its characteristic optical spectrum, which is tunable by
the interlayer bias. When the interlayer potential difference is applied
between consecutive layers of ATMG, the Dirac cones at the two moir\'{e}
Brillouin zone corners and acquire different Fermi
velocities, generally smaller than that of monolayer graphene, and the cones
split proportionally in energy resulting in a step-like feature in the optical
conductivity.Comment: 11 pages, 11 figures, 2 table
Postnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation
Mechanical signal transduction in bone tissue begins with load-induced activation of several cellular pathways in the osteocyte population. A key pathway that participates in mechanotransduction is Wnt/Lrp5 signaling. A putative downstream mediator of activated Lrp5 is the nucleocytoplasmic shuttling protein β-catenin (βcat), which migrates to the nucleus where it functions as a transcriptional co-activator. We investigated whether osteocytic βcat participates in Wnt/Lrp5-mediated mechanotransduction by conducting ulnar loading experiments in mice with or without chemically induced βcat deletion in osteocytes. Mice harboring βcat floxed loss-of-function alleles (βcat(f/f)) were bred to the inducible osteocyte Cre transgenic (10)(kb)Dmp1-CreERt2. Adult male mice were induced to recombine the βcat alleles using tamoxifen, and intermittent ulnar loading sessions were applied over the following week. Although adult-onset deletion of βcat from Dmp1-expressing cells reduced skeletal mass, the bone tissue was responsive to mechanical stimulation as indicated by increased relative periosteal bone formation rates in recombined mice. However, load-induced improvements in cross sectional geometric properties were compromised in recombined mice. The collective results indicate that the osteoanabolic response to loading can occur on the periosteal surface when β-cat levels are significantly reduced in Dmp1-expressing cells, suggesting that either (i) only low levels of β-cat are required for mechanically induced bone formation on the periosteal surface, or (ii) other additional downstream mediators of Lrp5 might participate in transducing load-induced Wnt signaling
Proteomic Validation of Multifunctional Molecules in Mesenchymal Stem Cells Derived from Human Bone Marrow, Umbilical Cord Blood and Peripheral Blood
Mesenchymal stem cells (MSCs) are one of the most attractive therapeutic resources in clinical application owing to their multipotent capability, which means that cells can differentiate into various mesenchymal tissues such as bone, cartilage, fat, tendon, muscle and marrow stroma. Depending on the cellular source, MSCs exhibit different application potentials according to their different in vivo functions, despite similar phenotypic and cytological characteristics. To understand the different molecular conditions that govern the different application or differentiation potential of each MSC according to cellular source, we generated a proteome reference map of MSCs obtained from bone marrow (BM), umbilical cord blood (CB) and peripheral blood (PB). We identified approximately 30 differentially regulated (or expressed) proteins. Most up-regulated proteins show a cytoskeletal and antioxidant or detoxification role according to their functional involvement. Additionally, these proteins are involved in the increase of cell viability, engraftment and migration in pathological conditions in vivo. In summary, we examined differentially expressed key regulatory factors of MSCs obtained from several cellular sources, demonstrated their differentially expressed proteome profiles and discussed their functional role in specific pathological conditions. With respect to the field of cell therapy, it may be particularly crucial to determine the most suitable cell sources according to target disease
Nearly flat bands in twisted triple bilayer graphene
We investigate the electronic structure of alternating-twist triple
Bernal-stacked bilayer graphene (t3BG) as a function of interlayer coupling
, twist angle , interlayer potential difference , and
top-bottom bilayers sliding vector for three possible
configurations AB/AB/AB, AB/BA/AB, and AB/AB/BA. The parabolic low-energy band
dispersions in a Bernal-stacked bilayer and gap-opening through a finite
interlayer potential difference allows the flattening of bands in t3BG
down to ~meV for twist angles regardless
of the stacking types. The easier isolation of the flat bands and associated
reduction of Coulomb screening thanks to the intrinsic gaps of bilayer graphene
for finite facilitate the formation of correlation-driven gaps when it
is compared to the metallic phases of twisted trilayer graphene under electric
fields. We obtain the stacking dependent Coulomb energy versus bandwidth ratios in the and parameter space. We also present
the expected -valley Chern numbers for the lowest-energy nearly flat bands.Comment: 15 pages, 10 figure
trans-Diazido(1,8-dibenzyl-1,3,6,8,10,13-hexaazacyclotetradecane)nickel(II)
In the centrosymmetric title compound, [Ni(N3)2(C22H34N6)], the NiII ion is coordinated by the four secondary N atoms of the macrocyclic ligand in a square-planar fashion with two N atoms of the azide ions in axial positions, resulting in a tetragonally distorted octahedron. An N—H⋯N hydrogen-bonding interaction between the secondary amine N atom of the macrocycle and an adjacent azide ion gives rise to a chain structure
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