Customer Active Probability and Customer Lifetime Value Analysis in Internet

As the age of digital information, marketers are in information overload. A mass of customers’ data is available but may be useless only if it can be turned into business intelligence and implement appropriate database marketing. This research aims to assist managers in discriminating and learning from their right customers that helps to serve high value customers and create successful marketing programs targeted at the prospected ones. Transaction data on the purchasing of VCD at an online retailer was used as empirical analysis; Pareto/NBD model and customer lifetime value model were applied to capture customer active probability and construct profitable customer profile. The results demonstrated four priority ranks of online customers for managers to choose the prospects that best match the profitable customer profile by observing their purchase behaviors

Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway.

BackgroundDevelopment of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions. Previously, our group identified a highly conserved neural protein called thrombospondin type I domain containing 7A (THSD7A). Soluble THSD7A promoted and guided endothelial cell migration, tube formation and sprouting. In addition, we showed that thsd7a could be detected in the nervous system and was required for intersegmental vessels (ISV) patterning during zebrafish development. However, the exact origin of THSD7A and its effect on neurovascular interaction remains unclear.ResultsIn this study, we discovered that zebrafish thsd7a was expressed in the primary motor neurons. Knockdown of Thsd7a disrupted normal primary motor neuron formation and ISV sprouting in the Tg(kdr:EGFP/mnx1:TagRFP) double transgenic zebrafish. Interestingly, we found that Thsd7a morphants displayed distinct phenotypes that are very similar to the loss of Notch-delta like 4 (dll4) signaling. Transcript profiling further revealed that expression levels of notch1b and its downstream targets, vegfr2/3 and nrarpb, were down-regulated in the Thsd7a morphants. These data supported that zebrafish Thsd7a could regulate angiogenic sprouting via Notch-dll4 signaling during development.ConclusionsOur results suggested that motor neuron-derived Thsd7a plays a significant role in neurovascular interactions. Thsd7a could regulate ISV angiogenesis via Notch-dll4 signaling. Thus, Thsd7a is a potent angioneurin involved in the development of both neural and vascular systems

Intelligent Wireless Remote Control System Design for a Biped Robot

This paper presents the design and implementation of an intelligent wireless remote control system for a biped robot. A recurrent cerebellar model neural network (RCMNN) is introduced, then it is used for the walking control of a biped robot. Furthermore, the remote communication module is designed for the remote control of a robot. Finally, experimental results show that the developed system can achieve satisfactory control performance for the walking control of a high-order nonlinear biped robot