437 research outputs found

    Hybrid Imaging in Head and Neck Sarcoidosis

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    To determine the prevalence of head and neck sarcoidosis (HNS) and evaluate the role of hybrid molecular imaging in HNS. Between 2010 and 2018, 222 patients with chronic sarcoidosis and presence of prolonged symptoms of active disease were referred to FDG PET/CT. Active disease was found in 169 patients, and they were all screened for the presence of HNS. All patients underwent MDCT and assessment of the serum ACE level. Follow-up FDG PET/CT examination was done 19.84 ± 8.98 months after the baseline. HNS was present in 38 out of 169 patients. FDG uptake was present in: cervical lymph nodes (38/38), submandibular glands (2/38), cerebrum (2/38), and bone (1/38). The majority of patients had more than two locations of disease. After FDG PET/CT examination, therapy was changed in most patients. Fourteen patients returned to follow-up FDG PET/CT examination in order to assess the therapy response. PET/CT revealed active disease in 12 patients and complete remission in two patients. Follow-up ACE levels had no correlation with follow-up SUVmax level (ρ = −0.18, p = 0.77). FDG PET/CT can be useful in the detection of HNS and in the evaluation of the therapy response. It may replace the use of non-purposive mounds of insufficiently informative laboratory and radiological procedures

    Cultivation With Powdered Meteorite (NWA 1172) as the Substrate Enhances Low-Temperature Preservation of the Extreme Thermoacidophile Metallosphaera sedula

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    Recent studies have uncovered a vast number of thermophilic species in icy environments, permanently cold ocean sediments, cold sea waters, and cool soils. The survival of thermophiles in psychrobiotic habitats requires thorough investigation of the physiological and molecular mechanisms behind their natural cryopreservation. Such investigations are mainly impeded due to a restricted cultivation of thermophiles at low temperatures under the laboratory conditions. Artificial culture media used under the laboratory conditions usually fail to support cultivation of thermophiles at low-temperature range. In this study we cultivated the extreme thermoacidophilic archaeonMetallosphaera sedulawith the preliminary powdered and sterilized multimetallic extraterrestrial mineral material (the meteorite NWA 1172) under a low temperature regime in laboratory conditions. Our data indicate thatM. sedulawithstands cold stress and can be maintained at low temperatures, when supplemented with the meteorite NWA 1172 as the sole energy source. Cultivation with the meteorite NWA 1172 opens up new, previously unknown psychrotolerant characteristics ofM. sedula, emphasizing that culture conditions (i.e., the "nutritional environment") may affect the microbial survival potential in stress related situations. These observations facilitate further investigation of strategies and underlying molecular mechanisms of the survival of thermophilic species in permanently cold habitats

    Milan Milojevic (Art Forum)

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    Milan Milojevic is head of printmaking at the Tasmanian School of Art. He discusses work made during a recent residency at COFA at UNSW, where he researched 18th and 19th century prints depicting the natural world

    Decision Making in Patients Undergoing Coronary Artery Revascularization : A New Era in Clinical Trial Design and Evidence-Based Practice

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    The clinical goals for the care of each patient with complex coronary artery disease are to ensure that the most appropriate treatment is selected, and the best available evidence is used to guide procedural techniques and modify risk factors that could impact life expectancy and health-related quality of life. In this thesis, ef

    Common fixed points for self-mappings on partial metric spaces

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    In this paper, we prove some results of a common fixed point for two self-mappings on partial metric spaces. Our results generalize some interesting results of Ilic et al. (Appl. Math. Lett. 24:1326-1330, 2011). We conclude with a result of the existence of a fixed point for set-valued mappings in the context of 0-complete partial metric spaces
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