Effect Of Defaults And Credit Deterioration On Yields Of Corporate Bonds

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91112/1/j.1540-6261.1961.tb02839.x.pd

Examining Intervening Variables Of The EC Consumer Behavior Model: The Powersellertm And Phenomenon Search Products

The EC consumer behavioral model is an effort to describe the electronic commerce environment, which includes electronic auctions. The model identifies intervening variables that are related to vendors such as trustworthiness (merchant characteristic) and product brand and availability (product characteristics).  In this paper, we have attempted to explore PowerSellersTM, a specific intermediary characteristic for electronic auctions.  Specifically, we analyzed PowerSellersTM on products with limited availability and high demand.  Linear regression models were used to analyze the intermediary characteristics and purchase price.   Findings support the possibility that phenomenon search products attenuate the impact of a seller’s rating on auctions prices. This paper serves as a specific investigation to better understand consumer online purchase intensions within the EC consumer behavior model

IS Programs Responding to Industry Demands for Data Scientists: A Comparison Between 2011-2016

The term data scientist has only been in common use since 2008, but in 2016 it is considered one of the top careers in the United States. The purpose of this paper is to explore the growth of data science content areas such as analytics, business intelligence, and big data in AACSB Information Systems (IS) programs between 2011 and 2016. A secondary purpose is to analyze the effect of IS programs’ adherence to IS 2010 Model Curriculum Guidelines for undergraduate MIS programs, as well as the impact of IS programs offering an advanced database course in 2011 on data science course offerings in 2016. A majority (60%) of AACSB IS programs added data science-related courses between 2011 and 2016. Results indicate dramatic increases in courses offered in big data analytics (583%), visualization (300%), business data analysis (260%), and business intelligence (236%). ANOVA results also find a significant effect of departments offering advanced database courses in 2011 on new analytics course offerings in 2016. A Chi-Square analysis did not find an effect of IS 2010 Model Curriculum adherence on analytics course offerings in 2016. Implications of our findings for an MIS department’s ability to respond to changing needs of the marketplace and its students are discussed

Cybergriping: Violating the Law while E-Complaining

The emergence of Web communications has given rise to complaint sites which serve as central forums for both consumers and employees to share their bad experiences. These complaint sites provide for cybergriping in various forms. This paper explores the concept of cybergriping and its relevance to the hospitality and tourism industry from employee and customer perspectives. Court cases in which cybergriping played a key role are reviewed, and recommendations are offered on how hospitality and tourism businesses can address the problem of cybergriping

Teaching versus Research: An Imbalance of Importance?

This article features two essays presenting the major argumentative positions advanced by teams Robert E. Pruett and James E. Sayer and Norbert H. Mills and David E. Tucker, regarding the topic: Resolved: that teaching and research are mutually-exclusive activities. Pruett and Sayer upheld the affirmative position on the resolution, while Mills and Tucker upheld the negative. In the traditional sense, it is easy to claim that the function of a professor is twofold: to be an effective and creative teacher and, at the same time, be able to accumulate and disseminate knowledge through research. Regardless of what is said, teaching has become subservient to research and, while the responsibility of faculty members is to remain current in their fields, research is a separate activity that does not necessarily make one a better teacher and certainly is exclusive from the teaching function. N. Mills and D. Tucker contend that there is no constituency because teaching has been devalued and separated from research

Questioning the rise of gelatinous zooplankton in the World's oceans

During the past several decades, high numbers of gelatinous zooplankton species have been reported in many estuarine and coastal ecosystems. Coupled with media-driven public perception, a paradigm has evolved in which the global ocean ecosystems are thought to be heading toward being dominated by “nuisance” jellyfish. We question this current paradigm by presenting a broad overview of gelatinous zooplankton in a historicalcontext to develop the hypothesis that population changes reflect the human-mediated alteration of global ocean ecosystems. To this end, we synthesize information related to the evolutionary context of contemporary gelatinous zooplankton blooms, the human frame of reference forchanges in gelatinous zooplankton populations, and whether sufficient data are available to have established the paradigm. We conclude that the current paradigm in which it is believed that there has been a global increase in gelatinous zooplankton is unsubstantiated, and we develop a strategy for addressing the critical questions about long-term, human-related changes in the sea as they relate to gelatinous zooplankton blooms

Regulation of Class-Switch Recombination and Plasma Cell Differentiation by Phosphatidylinositol 3-Kinase Signaling

SummaryClass-switch recombination (CSR) is essential for humoral immunity. However, the regulation of CSR is not completely understood. Here we demonstrate that phosphatidylinositol 3-kinase (PI3K) actively suppressed the onset and frequency of CSR in primary B cells. Consistently, mice lacking the lipid phosphatase, PTEN, in B cells exhibited a hyper-IgM condition due to impaired CSR, which could be restored in vitro by specific inhibition of PI3Kδ. Inhibition of CSR by PI3K was partially dependent on the transcription factor, BLIMP1, linking plasma cell commitment and cessation of CSR. PI3K-dependent activation of the serine-threonine kinase, Akt, suppressed CSR, in part, through the inactivation of the Forkhead Box family (Foxo) of transcription factors. Reduced PI3K signaling enhanced the expression of AID (activation-induced cytidine deaminase) and accelerated CSR. However, ectopic expression of AID could not fully overcome inhibition of CSR by PI3K, suggesting that PI3K regulates both the expression and function of AID

The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer

<p>Abstract</p> <p>Background</p> <p>Dietary or therapeutic interventions to counteract the loss of PTEN expression could contribute to the prevention of prostate carcinogenesis or reduce the rate of cancer progression. In this study, we investigate the interaction between sulforaphane, a dietary isothiocyanate derived from broccoli, PTEN expression and gene expression in pre malignant prostate tissue.</p> <p>Results</p> <p>We initially describe heterogeneity in expression of PTEN in non-malignant prostate tissue of men deemed to be at risk of prostate cancer. We subsequently use the mouse prostate-specific PTEN deletion model, to show that sulforaphane suppresses transcriptional changes induced by PTEN deletion and induces additional changes in gene expression associated with cell cycle arrest and apoptosis in PTEN null tissue, but has no effect on transcription in wild type tissue. Comparative analyses of changes in gene expression in mouse and human prostate tissue indicate that similar changes can be induced in humans with a broccoli-rich diet. Global analyses of exon expression demonstrated that sulforaphane interacts with PTEN deletion to modulate alternative gene splicing, illustrated through a more detailed analysis of DMBT1 splicing.</p> <p>Conclusion</p> <p>To our knowledge, this is the first report of how diet may perturb changes in transcription induced by PTEN deletion, and the effects of diet on global patterns of alternative gene splicing. The study exemplifies the complex interaction between diet, genotype and gene expression, and the multiple modes of action of small bioactive dietary components.</p