STARRED: a two-channel deconvolution method with Starlet regularization

The spatial resolution of astronomical images is limited by atmospheric turbulence and diffraction in the telescope optics, resulting in blurred images. This makes it difficult to accurately measure the brightness of blended objects because the contributions from adjacent objects are mixed in a time-variable manner due to changes in the atmospheric conditions. However, this effect can be corrected by characterizing the Point Spread Function (PSF), which describes how a point source is blurred on a detector. This function can be estimated from the stars in the field of view, which provides a natural sampling of the PSF across the entire field of view. Once the PSF is estimated, it can be removed from the data through the so-called deconvolution process, leading to images of improved spatial resolution. The deconvolution operation is an ill-posed inverse problem due to noise and pixelization of the data. To solve this problem, regularization is necessary to guarantee the robustness of the solution. Regularization can take the form of a sparse prior, meaning that the recovered solution can be represented with only a few basis eigenvectors. STARRED is a Python package developed in the context of the COSMOGRAIL collaboration and applies to a vast variety of astronomical problems. It proposes to use an isotropic wavelet basis, called Starlets, to regularize the solution of the deconvolution problem. This family of wavelets has been shown to be well-suited to represent astronomical objects. STARRED provides two modules to first reconstruct the PSF, and then perform the deconvolution. It is based on two key concepts: i) the image is reconstructed in two separate channels, one for the point sources and one for the extended sources, and ii) the code relies on the deliberate choice of not completely removing the effect of the PSF, but rather bringing the image to a higher resolution

Age and sex-selective predation moderate the overall impact of predators

© 2014 The Authors. Journal of Animal Ecology published by John Wiley & Sons Ltd on behalf of British Ecological Society. Acknowledgements: Thanks to J. Reid, S. Redpath, A. Beckerman and an anonymous reviewer for their helpful comments on a previous version of the manuscript. This work was partly funded by a Natural Environment Research Council studentship NE/J500148/1 to SH and a grant NE/F021402/1 to XL and by Natural Research Limited. Forest Research funded all the fieldwork on goshawks, tawny owls and field voles during 1973–1996. We thank B. Little, P. Hotchin, D. Anderson and all field assistants for their help with data collection and Forest Enterprise, T. Dearnley and N. Geddes for allowing and facilitating work in Kielder Forest. In addition, we are grateful to English Nature and the BTO for kindly issuing licences annually visit goshawk nest sites. Data accessibility: All data associated with the study which have not already been given in the text are available from the Dryad Digital Repository: http://doi.org/10.5061/dryad.h1289 (Hoy et al. 2014).Peer reviewedPublisher PD

Strong gravitational lensing by AGNs as a probe of the quasar-host relations in the distant Universe

The tight correlations found between the mass of the supermassive black holes (SMBH) and their host galaxy luminosity, stellar mass, and velocity dispersion are often interpreted as a sign of their co-evolution. Studying these correlations across redshift provides a powerful insight into the evolutionary path followed by the quasar and its host galaxy. While the mass of the black hole is accessible from single-epoch spectra, measuring the mass of its host galaxy is challenging as the quasar largely overshines its host. Here, we present a novel technique to probe quasar-host relations beyond the local universe with strong gravitational lensing, hence overcoming the use of stellar population models or velocity dispersion measurements, both prone to degeneracies. We study in detail one of the three known cases of strong lensing by a quasar to accurately measure the mass of its host and to infer a total lensing mass of $\log_{10}(M_{\rm Tot, h}/M_{\odot}) = 10.27^{+0.06}_{-0.07}~$ within the Einstein radius of 1.2 kpc. The lensing measurement is more precise than any other alternative techniques and compatible with the local $M_{BH}$-$M_{\star, h}$ scaling relation. The sample of such quasar-galaxy or quasar-quasar lensing systems should reach a few hundreds with Euclid and Rubin-LSST, thus enabling the application of such a method with statistically significant sample sizes.Comment: Author's pre-review version, published in Nature Astronomy, 13 pages, 5 figure

A Microlensing Accretion Disk Size Measurement in the Lensed Quasar WFI 2026-4536

We use thirteen seasons of R-band photometry from the 1.2m Leonard Euler Swiss Telescope at La Silla to examine microlensing variability in the quadruply-imaged lensed quasar WFI 2026-4536. The lightcurves exhibit ${\sim}\,0.2\,\text{mag}$ of uncorrelated variability across all epochs and a prominent single feature of ${\sim}\,0.1\,\text{mag}$ within a single season. We analyze this variability to constrain the size of the quasar's accretion disk. Adopting a nominal inclination of 60$^\text{o}$, we find an accretion disk scale radius of $\log(r_s/\text{cm}) = 15.74^{+0.34}_{-0.29}$ at a rest-frame wavelength of 2043\,\unicode{xC5}, and we estimate a black hole mass of $\log(M_{\text{BH}}/M_{\odot}) = 9.18^{+0.39}_{-0.34}$, based on the CIV line in VLT spectra. This size measurement is fully consistent with the Quasar Accretion Disk Size - Black Hole Mass relation, providing another system in which the accretion disk is larger than predicted by thin disk theory.Comment: 26 pages, 8 figures, Appendix with data table, pg 12-2

The Big Three Perfectionism Scale: A new measure of perfectionism

This article introduces a new measure of dispositional perfectionism: the Big Three Perfectionism Scale (BTPS). The BTPS assesses three higher-order global factors (rigid perfectionism, self-critical perfectionism, narcissistic perfectionism) via 10 lower-order perfectionism facets (self-oriented perfectionism, self-worth contingencies, concern over mistakes, doubts about actions, self-criticism, socially prescribed perfectionism, other-oriented perfectionism, hypercriticism, grandiosity, entitlement). The present investigation examined the structure of the BTPS using exploratory factor analysis in Study 1 (288 undergraduates), and confirmatory factor analyses in Study 2 (352 community adults) and Study 3 (290 undergraduates). Additionally, in Study 3 the relationships among the BTPS, other measures of perfectionism, and the five-factor model of personality were investigated. Overall, findings provide first evidence for the reliability and validity of the BTPS as a multidimensional measure of perfectionism

Liver X Receptor Activation with an Intranasal Polymer Therapeutic Prevents Cognitive Decline without Altering Lipid Levels

The progressive accumulation of amyloid-beta (Aβ) in specific areas of the brain is a common prelude to late-onset of Alzheimer's disease (AD). Although activation of liver X receptors (LXR) with agonists decreases Aβ levels and ameliorates contextual memory deficit, concomitant hypercholesterolemia/hypertriglyceridemia limits their clinical application. DMHCA (N,N-dimethyl-3β-hydroxycholenamide) is an LXR partial agonist that, despite inducing the expression of apolipoprotein E (main responsible of Aβ drainage from the brain) without increasing cholesterol/triglyceride levels, shows nil activity in vivo because of a low solubility and inability to cross the blood brain barrier. Herein, we describe a polymer therapeutic for the delivery of DMHCA. The covalent incorporation of DMHCA into a PEG-dendritic scaffold via carboxylate esters produces an amphiphilic copolymer that efficiently self-assembles into nanometric micelles that exert a biological effect in primary cultures of the central nervous system (CNS) and experimental animals using the intranasal route. After CNS biodistribution and effective doses of DMHCA micelles were determined in nontransgenic mice, a transgenic AD-like mouse model of cerebral amyloidosis was treated with the micelles for 21 days. The benefits of the treatment included prevention of memory deterioration and a significant reduction of hippocampal Aβ oligomers without affecting plasma lipid levels. These results represent a proof of principle for further clinical developments of DMHCA delivery systems.Fil: Navas Guimaraes, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Catolica de Cuyo. Facultad de Ciencias Medicas. Instituto de Investigacion En Ciencias Biomedicas.; ArgentinaFil: Lopez Blanco, Roi. Universidad de Santiago de Compostela; EspañaFil: Correa, Juan. Universidad de Santiago de Compostela; EspañaFil: Fernandez Villamarin, Marcos. Universidad de Santiago de Compostela; EspañaFil: Bistue Millon, Maria Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Catolica de Cuyo. Facultad de Ciencias Medicas. Instituto de Investigacion En Ciencias Biomedicas.; ArgentinaFil: Martino Adami, Pamela Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Morelli, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Kumar, Vijay. University of Colorado; Estados UnidosFil: Wempe, Michael F.. University of Colorado; Estados UnidosFil: Cuello, A. C.. McGill University; CanadáFil: Fernandez Megia, Eduardo. Universidad de Santiago de Compostela; EspañaFil: Bruno, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Catolica de Cuyo. Facultad de Ciencias Medicas. Instituto de Investigacion En Ciencias Biomedicas.; Argentin

Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson's disease

Oxidative distress and mitochondrial dysfunction, are key factors involved in the pathophysiology of Parkinson's disease (PD). The pleiotropic hormone insulin-like growth factor II (IGF-II) has shown neuroprotective and antioxidant effects in some neurodegenerative diseases. In this work, we demonstrate the protective effect of IGF-II against the damage induced by 1-methyl-4-phenylpyridinium (MPP+) in neuronal dopaminergic cell cultures and a mouse model of progressive PD. In the neuronal model, IGF-II counteracts the oxidative distress produced by MPP + protecting dopaminergic neurons. Improved mitochondrial function, increased nuclear factor (erythroid-derived 2)-like2 (NRF2) nuclear translocation along with NRF2-dependent upregulation of antioxidative enzymes, and modulation of mammalian target of rapamycin (mTOR) signalling pathway were identified as mechanisms leading to neuroprotection and the survival of dopaminergic cells. The neuroprotective effect of IGF-II against MPP + -neurotoxicity on dopaminergic neurons depends on the specific IGF-II receptor (IGF-IIr). In the mouse model, IGF-II prevents behavioural dysfunction and dopaminergic nigrostriatal pathway degeneration and mitigates neuroinflammation induced by MPP+. Our work demonstrates that hampering oxidative stress and normalising mitochondrial function through the interaction of IGF-II with its specific IGF-IIr are neuroprotective in both neuronal and mouse models. Thus, the modulation of the IGF-II/IGF-IIr signalling pathway may be a useful therapeutic approach for the prevention and treatment of PD

Proteomic analysis of integrin-associated complexes from mesenchymal stem cells

PURPOSE: Multipotent mesenchymal stem cells (MSCs) have the capability to differentiate down adipocyte, osteocyte and chondrocyte lineages and as such offer a range of potential therapeutic applications. The composition and stiffness of the extracellular matrix (ECM) environment that surrounds cells dictates their transcriptional programme, thereby affecting stem cell lineage decision‐making. Cells sense force via linkages between themselves and their microenvironment, and this is transmitted by integrin receptors and associated adhesion signalling complexes. To identify regulators of MSC force sensing, we sought to catalogue MSC integrin‐associated adhesion complex composition. EXPERIMENTAL DESIGN: Adhesion complexes formed by MSCs plated on the ECM ligand fibronectin were isolated and characterised by MS. Identified proteins were interrogated by comparison to a literature‐based reference set of cell adhesion‐related components and using ontological and protein–protein interaction network analyses. RESULTS: Adhesion complex‐specific proteins in MSCs were identified that comprised predominantly cell adhesion‐related adaptors and actin cytoskeleton regulators. Furthermore, LIM domain‐containing proteins in MSC adhesion complexes were highlighted, which may act as force‐sensing components. CONCLUSION AND CLINICAL RELEVANCE: These data provide a valuable resource of information regarding the molecular connections that link integrins and adhesion signalling in MSCs, and as such may present novel opportunities for therapeutic intervention