Review of research in primary reading at Boston University: 1954-1959.

Thesis (Ed.M.)--Boston Universit

Metastatic Ewing's sarcoma to the right ventricle

Ewing's sarcoma is a round cell neoplasm derived from neural crest cells that is part of the primitive neuroectodermal tumor (PNET) family. It is a rare, aggressive malignancy that affects young people, most commonly in the second decade of life. The treatment of localized disease has improved greatly over the past four decades, but the prognosis for metastatic disease remains poor. Cardiac metastases of Ewing's sarcoma are exceedingly rare, with only a few reported cases. This article presents a case of a 22 year old man with a history of Ewing's sarcoma of the bone involving the right kneepeer-reviewe

Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties

Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH4) contribute to impaired vasodilation in pulmonary hypertension Due to the chemically unstable nature of BH4 it was hypothesised that oxidatively stable analogues of BR, would be able to support NO synthesis to improve Endothelial dysfunction in pulmonary hypertension Two analogues of BH4 namely 6-hydroxymethyl pterin (HMP) and 6-acetyl 7 7-dimethyl 7 8-dihydropterin (ADDP) were evaluated for vasodilator activity on precontracted rat pulmonary artery rings ADDP was administered to pulmonary hypertensive rats followed by measurement of pulmonary vascular resistance in perfused lungs and eNOS expression by immunohistochemistry ADDP and HMP caused significant relaxation in vitro in rat pulmonary arteries depleted of BH4 with a maximum relaxation at 0 3 mu M (both P<005) Vasodilator activity of ADDP and HMP was completely abolished following preincubation with the NO synthase inhibitor L-NAME ADDP and HMP did not alter relaxation induced by carbachol or spermine NONOate BH4 Itself did not produce relaxation In rats receiving ADDP 141 mg/kg/day pulmonary vasodilation induced by calcium ionophore A23187 was augmented and eNOS immunoreactivity was increased In conclusion ADDP and HMP are two analogues of BH4 which can act as oxidatively stable alternatives to BH4 in causing NO-mediated vasorelaxation Chronic treatment with ADDP resulted in Improvement of NO-mediated pulmonary artery dilation and enhanced expression of eNOS in the pulmonary vascular endothelium Chemically stable analogue, of BH4 may be able to limit endothelial dysfunction in the pulmonary vasculatur

MIXED MODELS APPROACH TO ON-FARM TRIALS: AN ALTERNATIVE TO META-ANALYSIS FOR COMPARING ONE TREATMENT TO POSSIBLY DIFFERENT CONTROLS

The estimator of effect size, the sample mean difference divided by the sample standard error of the difference is studied in the context of mixed models and is related to the analysis of on-farm trials. A single treatment is compared against possibly different controls using a completely randomized design on each farm. A lower (1-α)100% confidence limit on mean difference of the treatment and the average control is obtained. The best linear unbiased predictors (BLUPs) of the mean difference of the treatment and the individual controls as well as the lower (1-α)100% prediction limits are provided. The effect of omitting or not omitting the farm-by-treatment interaction variance component in the weighting process is assessed using two numerical examples

OVERCOMING RESISTANCE TO MULTIVARIATE ANALYSIS OVER TIME

One aspect of statistical consulting is assessing a clients needs. Sometimes the need for simplicity beclouds the information contained in the experiment. As an example, an experiment was performed as a multivariate study with repeated measures, yet the client preferred numerous univariate analyses that ignored time. The challenge was to show how a more sophisticated analysis provided additional insight into the biological process. Various covariance structures were employed to illustrate the usefulness of progressively more complex analyses. Multivariate methods were performed to utilize the correlation among variables to illuminate biological concepts. To complicate the whole process, an additional problem occurred where extreme variability among experimental units within treatment groups led to the identification and clumping of homogeneous units to increase precision. Power studies were performed to determine required sample sizes to minimize potential error reoccurrences in future trials

The Space Physics Data System - Cosmic and Heliospheric Nodes

The Space Physics Data System (SPDS) is a community- driven network of information sources, linked and interfaced by World Wide Web software. The SPDS coordinators are community representatives to the NASA Space Physics Division, who are soliciting additional Web nodes, trying to keep the nodes organized, and soliciting information/suggestions about older data in danger of loss. Here we present a guide to data in Cosmic and Heliospheric nodes of the SPDS. New contributions to this system are being solicited and some funds may be available to assist with their development

Pre-phase A study for an analysis of a reusable space tug. Volume 3 - Mission and operations analysis Final report

Mission model for operational and design requirements of space tug concept

Silicon Detector Studies with an Interferometric Thickness Mapper

A laser-interferometer system has been developed to precisely map the thickness variations of large-area silicon detectors. We describe the design and operation of the apparatus and the data processing carried out to derive thickness maps. We compare the results with a map made using accelerator beams of energetic heavy ions

Self-Injury and the Role of the Human Service Professional

Given the broad field of human services, human service professionals are likely to encounter self-injury. Thus it is critical that they become knowledgeable about self-injury and understand how to best intervene with clients who self-injure. Through case studies the readers will learn about helpful ways to respond to a client who harms him/her self through the use of a non-judgmental and supportive stance. This manuscript has direct implications for direct human service providers, human service educators, human service students, and supervisors by demonstrating the wide continuum of services humans service professionals can provide to clients who self-injure including: utilizing basic helping skills, educating oneself, issues of confidentiality, how to make referrals, and the importance of creating self-injury protocols

Inflation Pressure Effects in the Nondimensional Tire Model

Inflation pressure affects every aspect of tire performance. Most tire models, including the Radt/Milliken Nondimensional Tire Model, are restricted to modeling a single inflation pressure at a time. This is a reasonable limitation, in that the Nondimensional model forms an input/output relationship between tire operating conditions and force &amp; moment outputs. Traditional operating conditions are normal load, slip angle, inclination angle, slip ratio and road surface friction coefficient. Tire pressure is more like a tire parameter than a tire operating condition. Since the Nondimensional Tire Model is semi-empirical it does not specifically deal with tire parameters like sidewall height or tread compound. Still, tire pressure is the easiest tire parameter to change, and as the air temperature within the tire varies during use so does the inflation pressure. Thus, it is desirable to incorporate inflation pressure into the Nondimensional Tire Model as an input. This paper discusses the effects of tire pressure on tire force and moment output. Effects on lateral force and aligning torque are investigated in detail. Additionally, the effects on cornering stiffness, friction coefficients, peak aligning torque coefficient and peak shape are reviewed. New techniques to implement pressure effects in the Nondimensional Model are presented. Applications of these techniques are shown on a Formula SAE tire and a full-size radial racing tire. Additionally, the effects of inflation pressure on tire spring rate and loaded radius are investigated. While these are not modeled using Nondimensional techniques, they are important variables accompanying any tire model