Exploring the Nature of Weak Chandra Sources near the Galactic Centre

We present results from the first near-IR imaging of the weak X-ray sources discovered in the Chandra/ACIS-I survey (Wang et al. 2002) towards the Galactic Centre (GC). These ~800 discrete sources, which contribute significantly to the GC X-ray emission, represent an important and previously unknown population within the Galaxy. From our VLT observations we will identify likely IR counterparts to a sample of the hardest sources, which are most likely X-ray binaries. With these data we can place constraints on the nature of the discrete weak X-ray source population of the GC.Comment: In Proc. of ``Interacting Binaries: Accretion, Evolution, and Outcomes'', eds. L. A. Antonelli et al., AIP, Cefalu, Sicily, 200

Scaling and Universality in City Space Syntax: between Zipf and Matthew

We report about universality of rank-integration distributions of open spaces in city space syntax similar to the famous rank-size distributions of cities (Zipf's law). We also demonstrate that the degree of choice an open space represents for other spaces directly linked to it in a city follows a power law statistic. Universal statistical behavior of space syntax measures uncovers the universality of the city creation mechanism. We suggest that the observed universality may help to establish the international definition of a city as a specific land use pattern.Comment: 24 pages, 5 *.eps figure

Stellar Mass Black Hole Binaries as ULXs

Ultraluminous X-ray sources (ULXs) with Lx > 10^{39} ergs/s have been discovered in great numbers in external galaxies with ROSAT, Chandra, and XMM. The central question regarding this important class of sources is whether they represent an extension in the luminosity function of binary X-ray sources containing neutron stars and stellar-mass black holes (BHs), or a new class of objects, e.g., systems containing intermediate-mass black holes (100-1000 Msun). We have carried out a theoretical study to test whether a large fraction of the ULXs, especially those in galaxies with recent star formation activity, can be explained with binary systems containing stellar-mass black holes. To this end, we have applied a unique set of binary evolution models for black-hole X-ray binaries, coupled to a binary population synthesis code, to model the ULXs observed in external galaxies. We find that for donor stars with initial masses >10 Msun the mass transfer driven by the normal nuclear evolution of the donor star is sufficient to potentially power most ULXs. This is the case during core hydrogen burning and, to an even more pronounced degree, while the donor star ascends the giant branch, though the latter phases lasts only ~5% of the main sequence phase. We show that with only a modest violation of the Eddington limit, e.g., a factor of ~10, both the numbers and properties of the majority of the ULXs can be reproduced. One of our conclusions is that if stellar-mass black-hole binaries account for a significant fraction of ULXs in star-forming galaxies, then the rate of formation of such systems is ~3 x 10^{-7} per year normalized to a core-collapse supernova rate of 0.01 per year.Comment: 15 pages, 12 figure

Statistical mechanics of violent relaxation in stellar systems

We discuss the statistical mechanics of violent relaxation in stellar systems following the pioneering work of Lynden-Bell (1967). The solutions of the gravitational Vlasov-Poisson system develop finer and finer filaments so that a statistical description is appropriate to smooth out the small-scales and describe the ``coarse-grained'' dynamics. In a coarse-grained sense, the system is expected to reach an equilibrium state of a Fermi-Dirac type within a few dynamical times. We describe in detail the equilibrium phase diagram and the nature of phase transitions which occur in self-gravitating systems. Then, we introduce a small-scale parametrization of the Vlasov equation and propose a set of relaxation equations for the coarse-grained dynamics. These relaxation equations, of a generalized Fokker-Planck type, are derived from a Maximum Entropy Production Principle (MEPP). We make a link with the quasilinear theory of the Vlasov-Poisson system and derive a truncated model appropriate to collisionless systems subject to tidal forces. With the aid of this kinetic theory, we qualitatively discuss the concept of ``incomplete relaxation'' and the limitations of Lynden-Bell's theory

Effect of spirometry on intra-thoracic pressures

Due to the high intra-thoracic pressures associated with forced vital capacity manoeuvres, spirometry is contraindicated for vulnerable patients. However, the typical pressure response to spirometry has not been reported. Eight healthy, recreationally-active men performed spirometry while oesophageal pressure was recorded using a latex balloon-tipped catheter. Peak oesophageal pressure during inspiration was - 47 ± 9 cmH O (37 ± 10% of maximal inspiratory pressure), while peak oesophageal pressure during forced expiration was 102 ± 34 cmH O (75 ± 17% of maximal expiratory pressure). The deleterious consequences of spirometry might be associated with intra-thoracic pressures that approach maximal values during forced expiration

Mid-infrared frequency comb spanning an octave based on an Er fiber laser and difference-frequency generation

We describe a coherent mid-infrared continuum source with 700 cm-1 usable bandwidth, readily tuned within 600 - 2500 cm-1 (4 - 17 \mum) and thus covering much of the infrared "fingerprint" molecular vibration region. It is based on nonlinear frequency conversion in GaSe using a compact commercial 100-fs-pulsed Er fiber laser system providing two amplified near-infrared beams, one of them broadened by a nonlinear optical fiber. The resulting collimated mid-infrared continuum beam of 1 mW quasi-cw power represents a coherent infrared frequency comb with zero carrier-envelope phase, containing about 500,000 modes that are exact multiples of the pulse repetition rate of 40 MHz. The beam's diffraction-limited performance enables long-distance spectroscopic probing as well as maximal focusability for classical and ultraresolving near-field microscopies. Applications are foreseen also in studies of transient chemical phenomena even at ultrafast pump-probe scale, and in high-resolution gas spectroscopy for e.g. breath analysis.Comment: 8 pages, 2 figures revised version, added reference

Effects of study design and allocation on participant behaviour-ESDA: study protocol for a randomized controlled trial

Background: What study participants think about the nature of a study has been hypothesised to affect subsequent behaviour and to potentially bias study findings. In this trial we examine the impact of awareness of study design and allocation on participant drinking behaviour. Methods/Design: A three-arm parallel group randomised controlled trial design will be used. All recruitment, screening, randomisation, and follow-up will be conducted on-line among university students. Participants who indicate a hazardous level of alcohol consumption will be randomly assigned to one of three groups. Group A will be informed their drinking will be assessed at baseline and again in one month (as in a cohort study design). Group B will be told the study is an intervention trial and they are in the control group. Group C will be told the study is an intervention trial and they are in the intervention group. All will receive exactly the same brief educational material to read. After one month, alcohol intake for the past 4 weeks will be assessed. Discussion: The experimental manipulations address subtle and previously unexplored ways in which participant behaviour may be unwittingly influenced by standard practice in trials. Given the necessity of relying on self-reported outcome, it will not be possible to distinguish true behaviour change from reporting artefact. This does not matter in the present study, as any effects of awareness of study design or allocation involve bias that is not well understood. There has been little research on awareness effects, and our outcomes will provide an indication of the possible value of further studies of this type and inform hypothesis generation

REDUCE-IT USA: Results From the 3146 Patients Randomized in the United States.

BackgroundSome trials have found that patients from the United States derive less benefit than patients enrolled outside the United States. This prespecified REDUCE-IT (Reduction of Cardiovascular Events with Icosapent Ethyl - Intervention Trial) subgroup analysis was conducted to determine the degree of benefit of icosapent ethyl in the United States.MethodsREDUCE-IT randomized 8179 statin-treated patients with qualifying triglycerides ≥135 and <500 mg/dL and low-density lipoprotein cholesterol >40 and ≤100 mg/dL and a history of atherosclerosis or diabetes mellitus to icosapent ethyl 4 g/d or placebo. The primary composite end point was cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, or hospitalization for unstable angina. The key secondary composite end point was cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke. A hierarchy was prespecified for examination of individual and composite end points.ResultsA total of 3146 US patients (38.5% of the trial) were randomized and followed for a median of 4.9 years; 32.3% were women and 9.7% were Hispanic. The primary composite end point occurred in 24.7% of placebo-treated patients versus 18.2% of icosapent ethyl-treated patients (hazard ratio [HR], 0.69 [95% CI, 0.59-0.80]; P=0.000001); the key secondary composite end point occurred in 16.6% versus 12.1% (HR, 0.69 [95% CI, 0.57-0.83]; P=0.00008). All prespecified hierarchical end points were meaningfully and significantly reduced, including cardiovascular death (6.7% to 4.7%; HR, 0.66 [95% CI, 0.49-0.90]; P=0.007), myocardial infarction (8.8% to 6.7%; HR, 0.72 [95% CI, 0.56-0.93]; P=0.01), stroke (4.1% to 2.6%; HR, 0.63 [95% CI, 0.43-0.93]; P=0.02), and all-cause mortality (9.8% to 7.2%; HR, 0.70 [95% CI, 0.55-0.90]; P=0.004); for all-cause mortality in the US versus non-US patients, Pinteraction=0.02. Safety and tolerability findings were consistent with the full study cohort.ConclusionsWhereas the non-US subgroup showed significant reductions in the primary and key secondary end points, the US subgroup demonstrated particularly robust risk reductions across a variety of individual and composite end points, including all-cause mortality.Clinical trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT01492361

Crack coalescence in granite

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 2008.Includes bibliographical references.This thesis experimentally investigates crack coalescence in prismatic Barre Granite specimens with two pre-cut, open flaws under uniaxial compression. Using a high-speed video system, crack initiation, propagation, and coalescence are observed. Flaw geometries are chosen to allow one to compare the results with those of studies in other materials as well as to better understand fracturing and coalescence processes. Specifically, the effect of ligament length (L), flaw inclination angle (p3), and bridging angle (a) on coalescence is investigated. The same crack types as in other materials are observed. Coalescence patterns observed fit into a previously developed framework (for molded gypsum and Carrara marble) with the exception of one new coalescence pattern. Crack processes and coalescence patterns suggest a more tensile behavior as grain size increases from gypsum to marble to granite. Similar to previous work in marble and granite, white patches are observed during compression tests. These white patches can be categorized as either diffuse or linear, with linear white patches further subdivided into two more types, namely boundary-following and through-going. The white patches are essentially process zones. The effect of water pressure on coalescence pattern is also investigated. Flaw water pressure is seen to affect coalescence in granite, although further work is needed.by James Thomas Miller.S.M

Implementation of routine outcome measurement in child and adolescent mental health services in the United Kingdom: a critical perspective

The aim of this commentary is to provide an overview of clinical outcome measures that are currently recommended for use in UK Child and Adolescent Mental Health Services (CAMHS), focusing on measures that are applicable across a wide range of conditions with established validity and reliability, or innovative in their design. We also provide an overview of the barriers and drivers to the use of Routine Outcome Measurement (ROM) in clinical practice